{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:04:08Z","timestamp":1792011848340,"version":"4.4.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T00:00:00Z","timestamp":1580169600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Endosc"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS\/HIPEC) is an established treatment for pseudomyxoma peritonei (PMP) from perforated low-grade appendiceal mucinous neoplasms (LAMN II). In a selected group of LAMN II patients without established PMP, CRS\/HIPEC can be performed laparoscopically (L-CRS\/HIPEC); however the short-term benefits and safety of this approach have yet to be determined. This study aims to determine the short-term outcomes from a series of L-CRS\/HIPEC LAMN II patients compared to those who have undergone a similar open operation (O-CRS\/HIPEC) for low-volume PMP.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>LAMN II patients undergoing L-CRS\/HIPEC at a UK national peritoneal tumour centre were compared to O-CRS\/HIPEC patients (peritoneal cancer index\u2009\u2264\u20097). Outcomes of interest included Clavien\u2013Dindo complication grade, operative time, blood transfusions, high dependency unit (HDU) admission, length of hospital stay, and histopathological findings.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>55 L-CRS\/HIPEC were compared to 29 O-CRS\/HIPEC patients (2003\u20132017). Groups were matched for age, sex, and procedures. Median operative time was 8.8 (IQR 8.1\u20139.5) h for L-CRS\/HIPEC versus 7.3 (IQR 6.7\u20138) h for O-CRS\/HIPEC (Mann\u2013Whitney test <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Post-operative HDU admission was 56% versus 97% (OR 0.04 95% CI 0.01\u20130.34) and median length of stay\u2009=\u20096 (IQR 5\u20138) versus 10 (IQR 8\u201311) days (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) for L- versus O-CRS\/HIPEC. Despite a normal pre-operative CT scan, 13\/55 (23.6%) L-CRS\/HIPEC patients had acellular mucin and 2\/55 (3.5%) had mucin with epithelium present in their specimens. Residual appendix tumour was identified in 2\/55 patients (3.6%). Clavien\u2013Dindo Grade 1\u20134 complications were similar in both groups with no mortality.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>L-CRS\/HIPEC for LAMN II takes longer; however patients have significantly reduced length of HDU and overall stay, without increased post-operative complications. A significant proportion of LAMN II patients undergoing L-CRS\/HIPEC have extra-appendiceal acellular mucin with some cases demonstrating residual cellular epithelium from the LAMN II. The risk of these patients developing PMP without surgery is under current review.\n<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00464-019-07349-x","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T22:10:32Z","timestamp":1580249432000},"page":"5516-5521","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Laparoscopic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for perforated low-grade appendiceal mucinous neoplasms"],"prefix":"10.1007","volume":"34","author":[{"given":"Haytham","family":"Abudeeb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelliah R.","family":"Selvasekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah T.","family":"O\u2019Dwyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bipasha","family":"Chakrabarty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Malcolmson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew G.","family":"Renehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm S.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3765-2702","authenticated-orcid":false,"given":"Omer","family":"Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,1,28]]},"reference":[{"key":"7349_CR1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-46875-3","volume-title":"Encyclopedia of cancer","author":"M Schwab","year":"2017","unstructured":"Schwab M (2017) Encyclopedia of cancer, 4th edn. 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