{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T07:16:57Z","timestamp":1783408617952,"version":"3.54.6"},"reference-count":66,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T00:00:00Z","timestamp":1586390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T00:00:00Z","timestamp":1586390400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Endosc"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n<jats:title>Background<\/jats:title>\n<jats:p>Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) has gained both interest and controversy, as an alternative to portal vein embolisation (PVE) by inducing future liver remnant hypertrophy in patients at risk of liver failure following major hepatectomy. Open ALPPS induces more extensive hypertrophy in a shorter timespan than PVE; however, it is also associated with higher complication rates and mortality. Minimally invasive surgery (MIS), with its known benefits, has been applied to ALPPS in the hope of reducing the surgical insult and improving functional recovery time while preserving the extensive FLR hypertrophy.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>A search of the PubMed, Medline, EMBASE and Cochrane Library databases was conducted on 10 July 2019. 1231 studies were identified and screened. 19 open ALPPS studies, 3 MIS ALPPS and 1 study reporting on both were included in the analysis.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>1088 open and 46 MIS-ALPPS cases were included in the analysis. There were significant differences in the baseline characteristic: open ALPPS patients had a more diverse profile of underlying pathologies (<jats:italic>p<\/jats:italic>\u2009=\u20090.028) and comparatively more right extended hepatectomies (<jats:italic>p<\/jats:italic>\u2009=\u20090.006) as compared to right hepatectomy and left extended hepatectomy performed. Operative parameters (time and blood loss) did not differ between the two groups. MIS ALPPS had a lower rate of severe Clavien\u2013Dindo complications (\u2265\u2009IIIa) following stage 1 (<jats:italic>p<\/jats:italic>\u2009=\u20090.063) and significantly lower median mortality (0.00% vs 8.45%) (<jats:italic>p<\/jats:italic>\u2009=\u20090.007) compared to open ALPPS.<\/jats:p>\n<\/jats:sec><jats:sec>\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Although MIS ALPPS would seem to be better than open ALPPS with reduced morbidity and mortality rates, there is still limited evidence on MIS ALPPS. There is a need for a higher quality of evidence on MIS ALPPS vs. open ALPPS to answer whether MIS ALPPS can replace open ALPPS.<\/jats:p>\n<\/jats:sec>","DOI":"10.1007\/s00464-020-07437-3","type":"journal-article","created":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T14:02:56Z","timestamp":1586440976000},"page":"2379-2389","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["A better route to ALPPS: minimally invasive vs open ALPPS"],"prefix":"10.1007","volume":"34","author":[{"given":"Kawka","family":"Michal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mak","family":"Sau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gall M. H.","family":"Tamara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao R.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,4,9]]},"reference":[{"issue":"4","key":"7437_CR1","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1097\/SLA.0b013e3181b674df","volume":"250","author":"Y Kishi","year":"2009","unstructured":"Kishi Y, Abdalla EK, Chun YS, Zorzi D, Madoff DC, Wallace MJ et al (2009) Three hundred and one consecutive extended right hepatectomies: evaluation of outcome based on systematic liver volumetry. Ann Surg 250(4):540\u2013547","journal-title":"Ann Surg"},{"key":"7437_CR2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jamcollsurg.2006.05.290","volume":"203","author":"H Lang","year":"2006","unstructured":"Lang H, Sotiropoulos GC, Brokalaki EI, Radtke A, Frilling A, Molmenti EP et al (2006) Left hepatic trisectionectomy for hepatobiliary malignancies. J Am Coll Surg 203:311\u2013321","journal-title":"J Am Coll Surg"},{"issue":"4","key":"7437_CR3","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10434-001-0347-3","volume":"8","author":"R Adam","year":"2001","unstructured":"Adam R, Avisar E, Ariche A, Giachetti S, Azoulay D, Castaing D et al (2001) Five-year survival following hepatic resection after neoadjuvant therapy for nonresectable colorectal. Ann Surg Oncol 8(4):347\u2013353","journal-title":"Ann Surg Oncol"},{"issue":"5","key":"7437_CR4","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1097\/SLA.0000000000001450","volume":"262","author":"E Schadde","year":"2015","unstructured":"Schadde E, Raptis DA, Schnitzbauer AA, Ardiles V, Tschuor C, Lesurtel M et al (2015) Prediction of mortality after ALPPS stage-1: an analysis of 320 patients from the international ALPPS registry. Ann Surg 262(5):78\u201386","journal-title":"Ann Surg"},{"issue":"4","key":"7437_CR5","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1177\/1553350617697187","volume":"24","author":"X Cai","year":"2017","unstructured":"Cai X, Tong Y, Yu H, Liang X, Wang Y, Liang Y et al (2017) The ALPPS in the treatment of hepatitis B-related hepatocellular carcinoma With cirrhosis: a single-center study and literature review. Surg Innov 24(4):358\u2013364","journal-title":"Surg Innov"},{"issue":"6","key":"7437_CR6","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1097\/SLA.0b013e3181907fd9","volume":"248","author":"DA Wicherts","year":"2008","unstructured":"Wicherts DA, Miller R, de Haas RJ, Bitsakou G, Vibert E, Veilhan LA et al (2008) Long-term results of two-stage hepatectomy for irresectable colorectal cancer liver metastases. Ann Surg 248(6):994\u20131005","journal-title":"Ann Surg"},{"issue":"3","key":"7437_CR7","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/00000658-199909000-00004","volume":"230","author":"Y Fong","year":"1999","unstructured":"Fong Y, Fortner J, Sun RL, Brennan MF, Blumgart LH (1999) Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases. Ann Surg 230(3):309","journal-title":"Ann Surg"},{"issue":"5","key":"7437_CR8","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1159\/000176063","volume":"25","author":"V Pamecha","year":"2008","unstructured":"Pamecha V, Nedjat-Shokouhi B, Gurusamy K, Glantzounis GK, Sharma D, Davidson BR (2008) Prospective evaluation of two-stage hepatectomy combined with selective portal vein embolisation and systemic chemotherapy for patients with unresectable bilobar colorectal liver metastases. Dig Surg 25(5):387\u2013393","journal-title":"Dig Surg"},{"issue":"1","key":"7437_CR9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00270-012-0440-y","volume":"36","author":"KP van Lienden","year":"2013","unstructured":"van Lienden KP, van den Esschert JW, de Graaf W, Bipat S, Lameris JS, van Gulik TM et al (2013) Portal vein embolization before liver resection: a systematic review. Cardiovasc Intervent Radiol 36(1):25\u201334","journal-title":"Cardiovasc Intervent Radiol"},{"issue":"1","key":"7437_CR10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/SLA.0b013e31815f6e5b","volume":"247","author":"A Abulkhir","year":"2008","unstructured":"Abulkhir A, Limongelli P, Healey AJ, Damrah O, Tait P, Jackson J et al (2008) Preoperative portal vein embolization for major liver resection: a meta-analysis. Ann Surg 247(1):49\u201357","journal-title":"Ann Surg"},{"issue":"3","key":"7437_CR11","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/SLA.0b013e31824856f5","volume":"255","author":"AA Schnitzbauer","year":"2012","unstructured":"Schnitzbauer AA, Lang SA, Goessmann H, Nadalin S, Baumgart J, Farkas SA et al (2012) Right portal vein ligation combined with in situ splitting induces rapid left lateral liver lobe hypertrophy enabling 2-staged extended right hepatic resection in small-for-size settings. Ann Surg 255(3):405\u2013414","journal-title":"Ann Surg"},{"issue":"5","key":"7437_CR12","first-page":"83","volume":"260","author":"A Schlegel","year":"2014","unstructured":"Schlegel A, Lesurtel M, Melloul E, Limani P, Tschuor C, Graf R et al (2014) ALPPS: from human to mice highlighting accelerated and novel mechanisms of liver regeneration. Ann Surg 260(5):83\u201387","journal-title":"Ann Surg"},{"issue":"1","key":"7437_CR13","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/SLA.0000000000002797","volume":"269","author":"H Lang","year":"2019","unstructured":"Lang H, de Santibanes E, Schlitt HJ, Malago M, van Gulik T, Machado MA et al (2019) 10th anniversary of ALPPS-lessons learned and quo vadis. Ann Surg 269(1):114\u2013119","journal-title":"Ann Surg"},{"issue":"5","key":"7437_CR14","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1097\/SLA.0000000000002511","volume":"267","author":"P Sandstrom","year":"2018","unstructured":"Sandstrom P, Rosok BI, Sparrelid E, Larsen PN, Larsson AL, Lindell G et al (2018) ALPPS improves resectability compared with conventional two-stage hepatectomy in patients with advanced colorectal liver metastasis: results from a scandinavian multicenter randomized controlled trial (LIGRO trial). Ann Surg 267(5):833\u2013840","journal-title":"Ann Surg"},{"issue":"5","key":"7437_CR15","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/SLA.0000000000000947","volume":"260","author":"E Schadde","year":"2014","unstructured":"Schadde E, Ardiles V, Robles-Campos R, Malago M, Machado M, Hernandez-Alejandro R et al (2014) Early survival and safety of ALPPS: first report of the international ALPPS registry. Ann Surg 260(5):82\u201388","journal-title":"Ann Surg"},{"issue":"9","key":"7437_CR16","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/bjs.9547","volume":"101","author":"R Robles","year":"2014","unstructured":"Robles R, Parrilla P, Lopez-Conesa A, Brusadin R, de la Pena J, Fuster M et al (2014) Tourniquet modification of the associating liver partition and portal ligation for staged hepatectomy procedure. Br J Surg 101(9):112\u2013134 discussion 1134","journal-title":"Br J Surg"},{"issue":"5","key":"7437_CR17","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.surg.2015.12.004","volume":"159","author":"K Matsuo","year":"2016","unstructured":"Matsuo K, Murakami T, Kawaguchi D, Hiroshima Y, Koda K, Yamazaki K et al (2016) Histologic features after surgery associating liver partition and portal vein ligation for staged hepatectomy versus those after hepatectomy with portal vein embolization. Surgery 159(5):1289\u20131298","journal-title":"Surgery"},{"issue":"4","key":"7437_CR18","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/SLA.0000000000001087","volume":"261","author":"H Petrowsky","year":"2015","unstructured":"Petrowsky H, Gyori G, de Oliveira M, Lesurtel M, Clavien PA (2015) Is partial-ALPPS safer than ALPPS? A single-center experience. Ann Surg 261(4):90","journal-title":"Ann Surg"},{"issue":"4","key":"7437_CR19","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s00423-016-1424-1","volume":"401","author":"E de Santibanes","year":"2016","unstructured":"de Santibanes E, Alvarez FA, Ardiles V, Pekolj J, de Santibanes M (2016) Inverting the ALPPS paradigm by minimizing first stage impact: the Mini-ALPPS technique. Langenbeck's Arch Surg 401(4):557\u2013563","journal-title":"Langenbeck's Arch Surg"},{"issue":"1","key":"7437_CR20","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/SLA.0000000000000845","volume":"263","author":"J Li","year":"2016","unstructured":"Li J, Kantas A, Ittrich H, Koops A, Achilles EG, Fischer L et al (2016) Avoid \"All-Touch\" by hybrid ALPPS to achieve oncological efficacy. Ann Surg 263(1):6","journal-title":"Ann Surg"},{"issue":"2","key":"7437_CR21","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/SLA.0000000000000606","volume":"261","author":"E Gringeri","year":"2015","unstructured":"Gringeri E, Boetto R, D'Amico FE, Bassi D, Cillo U (2015) Laparoscopic microwave ablation and portal vein ligation for staged hepatectomy (LAPS): a minimally invasive first-step approach. Ann Surg 261(2):42","journal-title":"Ann Surg"},{"issue":"2","key":"7437_CR22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/SLA.0000000000000607","volume":"261","author":"TM Gall","year":"2015","unstructured":"Gall TM, Sodergren MH, Frampton AE, Fan R, Spalding DR, Habib NA et al (2015) Radio-frequency-assisted liver partition with portal vein ligation (RALPP) for liver regeneration. Ann Surg 261(2):45","journal-title":"Ann Surg"},{"issue":"4","key":"7437_CR23","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.surg.2015.11.013","volume":"159","author":"MJ Edmondson","year":"2016","unstructured":"Edmondson MJ, Sodergren MH, Pucher PH, Darzi A, Li J, Petrowsky H et al (2016) Variations and adaptations of associated liver partition and portal vein ligation for staged hepatectomy (ALPPS): many routes to the summit. Surgery 159(4):1058\u20131072","journal-title":"Surgery"},{"issue":"16","key":"7437_CR24","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.2217\/fon.15.145","volume":"11","author":"M Donati","year":"2015","unstructured":"Donati M, Basile F, Oldhafer KJ (2015) Present status and future perspectives of ALPPS (associating liver partition and portal vein ligation for staged hepatectomy). Future Oncol 11(16):2255\u20132258","journal-title":"Future Oncol"},{"issue":"3","key":"7437_CR25","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3390\/cancers11030302","volume":"11","author":"LR Jiao","year":"2019","unstructured":"Jiao LR, Fajardo Puerta AB, Gall TMH, Sodergren MH, Frampton AE, Pencavel T et al (2019) Rapid induction of liver regeneration for major hepatectomy (REBIRTH): a randomized controlled trial of portal vein embolisation versus ALPPS assisted with radiofrequency. Cancers 11(3):302","journal-title":"Cancers"},{"issue":"4","key":"7437_CR26","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1097\/SLA.0000000000001848","volume":"264","author":"TT Cheung","year":"2016","unstructured":"Cheung TT, Dai WC, Tsang SH, Chan AC, Chok KS, Chan SC et al (2016) Pure laparoscopic hepatectomy versus open hepatectomy for hepatocellular carcinoma in 110 patients with liver cirrhosis: a propensity analysis at a single center. Ann Surg 264(4):612\u2013620","journal-title":"Ann Surg"},{"issue":"8","key":"7437_CR27","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1007\/s00464-009-0859-7","volume":"24","author":"MA Machado","year":"2010","unstructured":"Machado MA, Makdissi FF, Surjan RC, Kappaz GT, Yamaguchi N (2010) Two-stage laparoscopic liver resection for bilateral colorectal liver metastasis. Surg Endosc 24(8):2044\u20132047","journal-title":"Surg Endosc"},{"issue":"2","key":"7437_CR28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jamcollsurg.2010.10.012","volume":"212","author":"Z Shafaee","year":"2011","unstructured":"Shafaee Z, Kazaryan AM, Marvin MR, Cannon R, Buell JF, Edwin B et al (2011) Is laparoscopic repeat hepatectomy feasible? A tri-institutional analysis. J Am Coll Surg 212(2):171\u2013179","journal-title":"J Am Coll Surg"},{"issue":"3","key":"7437_CR29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.11622\/smedj.2017092","volume":"59","author":"BK Goh","year":"2018","unstructured":"Goh BK, Lee SY, Chan CY, Wong JS, Cheow PC, Chung AY et al (2018) Early experience with robot-assisted laparoscopic hepatobiliary and pancreatic surgery in Singapore: single-institution experience with 20 consecutive patients. Singap Med J 59(3):133\u2013138","journal-title":"Singap Med J"},{"issue":"3","key":"7437_CR30","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1007\/s00464-015-4306-7","volume":"30","author":"J Qiu","year":"2016","unstructured":"Qiu J, Chen S, Chengyou D (2016) A systematic review of robotic-assisted liver resection and meta-analysis of robotic versus laparoscopic hepatectomy for hepatic neoplasms. Surg Endosc 30(3):862\u2013875","journal-title":"Surg Endosc"},{"issue":"3","key":"7437_CR31","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1007\/s00464-012-2547-2","volume":"27","author":"C Ho","year":"2013","unstructured":"Ho C, Wakabayashi G, Nitta H, Ito N, Hasegawa Y, Takahara T (2013) Systematic review of robotic liver resection. Surg Endosc 27(3):732\u2013739. https:\/\/doi.org\/10.1007\/s00464-012-2547-2","journal-title":"Surg Endosc"},{"issue":"1","key":"7437_CR32","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1472-6963-5-25","volume":"5","author":"D Atkins","year":"2005","unstructured":"Atkins D, Briss PA, Eccles M, Flottorp S, Guyatt GH, Harbour RT, Hill S, Jaeschke R, Liberati A, Magrini N, Mason J, O'Connell D, Oxman AD, Phillips B, Sch\u00fcnemann H, Edejer TT, Vist GE, Williams JW Jr, GRADE Working Group (2005) Systems for grading the quality of evidence and the strength of recommendations II: pilot study of a new system. BMC Health Serv Res 5(1):25","journal-title":"BMC Health Serv Res"},{"issue":"5","key":"7437_CR33","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s00534-005-0999-7","volume":"12","author":"SM Strasberg","year":"2005","unstructured":"Strasberg SM (2005) Nomenclature of hepatic anatomy and resections: a review of the Brisbane 2000 system. J Hepatobiliary Pancreat Surg 12(5):351\u2013355","journal-title":"J Hepatobiliary Pancreat Surg"},{"issue":"1","key":"7437_CR34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2288-5-13","volume":"5","author":"SP Hozo","year":"2005","unstructured":"Hozo SP, Djulbegovic B, Hozo I (2005) Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 5(1):13","journal-title":"BMC Med Res Methodol"},{"issue":"1","key":"7437_CR35","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.hpb.2016.10.004","volume":"19","author":"MA Machado","year":"2017","unstructured":"Machado MA, Makdissi FF, Surjan RC, Basseres T, Schadde E (2017) Transition from open to laparoscopic ALPPS for patients with very small FLR: the initial experience. HPB 19(1):59\u201366","journal-title":"HPB"},{"issue":"1","key":"7437_CR36","doi-asserted-by":"crossref","first-page":"269","DOI":"10.5604\/01.3001.0012.7937","volume":"18","author":"S Truant","year":"2019","unstructured":"Truant S, El Amrani M, Baillet C, Ploquin A, Lecolle K, Ernst O et al (2019) Laparoscopic partial ALPPS: Much Better Than ALPPS! Ann Hepatol 18(1):269\u2013273","journal-title":"Ann Hepatol"},{"issue":"1","key":"7437_CR37","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jamcollsurg.2013.03.004","volume":"217","author":"J Shindoh","year":"2013","unstructured":"Shindoh J, Vauthey JN, Zimmitti G, Curley SA, Huang SY, Mahvash A et al (2013) Analysis of the efficacy of portal vein embolization for patients with extensive liver malignancy and very low future liver remnant volume, including a comparison with the associating liver partition with portal vein ligation for staged hepatectomy approach. J Am Coll Surg 217(1):12\u201314","journal-title":"J Am Coll Surg"},{"issue":"1","key":"7437_CR38","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1590\/S0102-67202013000100009","volume":"26","author":"OJ Torres","year":"2013","unstructured":"Torres OJ, Fernandes Ede S, Oliveira CV, Lima CX, Waechter FL, Moraes-Junior JM et al (2013) Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): the Brazilian experience. Arq Bras Cir Dig 26(1):40\u201343","journal-title":"Arq Bras Cir Dig"},{"issue":"6","key":"7437_CR39","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1007\/s00268-014-2513-3","volume":"38","author":"E Schadde","year":"2014","unstructured":"Schadde E, Ardiles V, Slankamenac K, Tschuor C, Sergeant G, Amacker N et al (2014) ALPPS offers a better chance of complete resection in patients with primarily unresectable liver tumors compared with conventional-staged hepatectomies: results of a multicenter analysis. World J Surg 38(6):1510\u20131519","journal-title":"World J Surg"},{"issue":"4","key":"7437_CR40","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1097\/SLA.0000000000001046","volume":"261","author":"FA Alvarez","year":"2015","unstructured":"Alvarez FA, Ardiles V, de Santibanes M, Pekolj J, de Santibanes E (2015) Associating liver partition and portal vein ligation for staged hepatectomy offers high oncological feasibility with adequate patient safety: a prospective study at a single center. Ann Surg 261(4):723\u2013732","journal-title":"Ann Surg"},{"issue":"5","key":"7437_CR41","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.surg.2015.10.004","volume":"159","author":"BI Rosok","year":"2016","unstructured":"Rosok BI, Bjornsson B, Sparrelid E, Hasselgren K, Pomianowska E, Gasslander T et al (2016) Scandinavian multicenter study on the safety and feasibility of the associating liver partition and portal vein ligation for staged hepatectomy procedure. Surgery 159(5):1279\u20131286","journal-title":"Surgery"},{"issue":"5","key":"7437_CR42","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.ejso.2015.01.004","volume":"41","author":"S Truant","year":"2015","unstructured":"Truant S, Scatton O, Dokmak S, Regimbeau JM, Lucidi V, Laurent A et al (2015) Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS): impact of the inter-stages course on morbi-mortality and implications for management. Eur J Surg Oncol 41(5):674\u2013682","journal-title":"Eur J Surg Oncol"},{"issue":"10","key":"7437_CR43","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.hpb.2016.07.005","volume":"18","author":"P Kambakamba","year":"2016","unstructured":"Kambakamba P, Stocker D, Reiner CS, Nguyen-Kim TD, Linecker M, Eshmuminov D et al (2016) Liver kinetic growth rate predicts postoperative liver failure after ALPPS. HPB 18(10):800\u2013805","journal-title":"HPB"},{"issue":"2","key":"7437_CR44","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.surg.2016.08.004","volume":"161","author":"M Linecker","year":"2017","unstructured":"Linecker M, Kambakamba P, Reiner CS, Linh Nguyen-Kim TD, Stavrou GA, Jenner RM et al (2017) How much liver needs to be transected in ALPPS? A translational study investigating the concept of less invasiveness. Surgery 161(2):453\u2013464","journal-title":"Surgery"},{"issue":"5","key":"7437_CR45","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.hpb.2016.02.003","volume":"18","author":"M Serenari","year":"2016","unstructured":"Serenari M, Zanello M, Schadde E, Toschi E, Ratti F, Gringeri E et al (2016) Importance of primary indication and liver function between stages: results of a multicenter Italian audit of ALPPS 2012\u20132014. HPB 18(5):419\u2013427","journal-title":"HPB"},{"issue":"2","key":"7437_CR46","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.surg.2016.07.029","volume":"161","author":"ACY Chan","year":"2017","unstructured":"Chan ACY, Chok K, Dai JWC, Lo CM (2017) Impact of split completeness on future liver remnant hypertrophy in associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in hepatocellular carcinoma: complete-ALPPS versus partial-ALPPS. Surgery 161(2):357\u2013364","journal-title":"Surgery"},{"issue":"4","key":"7437_CR47","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.surg.2017.09.044","volume":"163","author":"KN Wanis","year":"2018","unstructured":"Wanis KN, Ardiles V, Alvarez FA, Tun-Abraham ME, Linehan D, de Santibanes E et al (2018) Intermediate-term survival and quality of life outcomes in patients with advanced colorectal liver metastases undergoing associating liver partition and portal vein ligation for staged hepatectomy. Surgery 163(4):691\u2013697","journal-title":"Surgery"},{"issue":"4","key":"7437_CR48","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1159\/000471930","volume":"35","author":"M Serenari","year":"2018","unstructured":"Serenari M, Alvarez FA, Ardiles V, de Santibanes M, Pekolj J, de Santibanes E (2018) The ALPPS approach for colorectal liver metastases: impact of KRAS mutation status in survival. Dig Surg 35(4):303\u2013310","journal-title":"Dig Surg"},{"issue":"3","key":"7437_CR49","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.surg.2018.02.026","volume":"164","author":"AA Schnitzbauer","year":"2018","unstructured":"Schnitzbauer AA, Schadde E, Linecker M, Machado MA, Adam R, Malago M et al (2018) Indicating ALPPS for colorectal liver metastases: a critical analysis of patients in the international ALPPS registry. Surgery 164(3):387\u2013394","journal-title":"Surgery"},{"key":"7437_CR50","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000002942","author":"Z Wang","year":"2018","unstructured":"Wang Z, Peng Y, Hu J, Wang X, Sun H, Sun J et al (2018) Associating liver partition and portal vein ligation for staged hepatectomy for unresectable hepatitis B virus-related hepatocellular carcinoma: a single center study of 45 patients. Ann Surg. https:\/\/doi.org\/10.1097\/SLA.0000000000002942","journal-title":"Ann Surg"},{"issue":"9","key":"7437_CR51","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1007\/s00268-019-05031-w","volume":"43","author":"R Robles-Campos","year":"2019","unstructured":"Robles-Campos R, Brusadin R, Lopez-Conesa A, Lopez-Lopez V, Navarro-Barrios A, Lopez-Espin JJ et al (2019) Long-term outcome after conventional two-stage hepatectomy versus tourniquet-ALPPS in colorectal liver metastases: a propensity score matching analysis. World J Surg 43(9):2281\u20132289","journal-title":"World J Surg"},{"key":"7437_CR52","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.hpb.2019.04.001","volume":"21","author":"G Torzilli","year":"2019","unstructured":"Torzilli G, Serenari M, Vigano L, Cimino M, Benini C, Massani M et al (2019) Outcomes of enhanced one-stage ultrasound-guided hepatectomy for bilobar colorectal liver metastases compared to those of ALPPS: a multicenter case-match analysis. HPB 21:1411\u20131418","journal-title":"HPB"},{"issue":"1","key":"7437_CR53","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s13304-018-0596-3","volume":"71","author":"G Vennarecci","year":"2019","unstructured":"Vennarecci G, Ferraro D, Tudisco A, Levi Sandri GB, Guglielmo N, Berardi G et al (2019) The ALPPS procedure: hepatocellular carcinoma as a main indication. An Italian single-center experience. Updates Surg 71(1):67\u201375","journal-title":"Updates Surg"},{"issue":"9","key":"7437_CR54","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1007\/s00464-014-4000-1","volume":"29","author":"L Xiao","year":"2015","unstructured":"Xiao L, Li JW, Zheng SG (2015) Totally laparoscopic ALPPS in the treatment of cirrhotic hepatocellular carcinoma. Surg Endosc 29(9):2800\u20132801","journal-title":"Surg Endosc"},{"issue":"Suppl 5","key":"7437_CR55","first-page":"88","volume":"23","author":"U Boggi","year":"2016","unstructured":"Boggi U, Napoli N, Kauffmann EF, Presti GL, Moglia A (2016) Laparoscopic microwave liver ablation and portal vein ligation: an alternative approach to the conventional ALPPS procedure in Hilar cholangiocarcinoma. Ann Surg Oncol 23(Suppl 5):88","journal-title":"Ann Surg Oncol"},{"issue":"3","key":"7437_CR56","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s12262-017-1713-0","volume":"80","author":"J Krishnamurthy","year":"2018","unstructured":"Krishnamurthy J, Naragund AV, Mahadevappa B (2018) First ever robotic stage one ALPPS procedure in india: for colorectal liver metastases. Indian J Surg 80(3):269\u2013271","journal-title":"Indian J Surg"},{"issue":"Suppl 1","key":"7437_CR57","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0168-8278(12)60009-9","volume":"56","author":"CR de Lope","year":"2012","unstructured":"de Lope CR, Tremosini S, Forner A, Reig M, Bruix J (2012) Management of HCC. J Hepatol 56(Suppl 1):75","journal-title":"J Hepatol"},{"key":"7437_CR58","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2019.05.035","author":"JM Phelip","year":"2019","unstructured":"Phelip JM, Tougeron D, Leonard D, Benhaim L, Desolneux G, Dupre A et al (2019) Metastatic colorectal cancer (mCRC): French intergroup clinical practice guidelines for diagnosis, treatments and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, SFR). Dig Liver Dis. https:\/\/doi.org\/10.1016\/j.dld.2019.05.035","journal-title":"Dig Liver Dis"},{"issue":"4","key":"7437_CR59","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1245\/s10434-016-5620-6","volume":"24","author":"MA Machado","year":"2017","unstructured":"Machado MA, Surjan R, Basseres T, Makdissi F (2017) Total Laparoscopic reversal ALPPS. Ann Surg Oncol 24(4):1048\u20131049","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"7437_CR60","doi-asserted-by":"crossref","first-page":"382","DOI":"10.21037\/hbsn.2016.05.02","volume":"5","author":"LR Jiao","year":"2016","unstructured":"Jiao LR, Hakim DN, Gall TM, Fajardo A, Pencavel TD, Fan R et al (2016) A totally laparoscopic associating liver partition and portal vein ligation for staged hepatectomy assisted with radiofrequency (radiofrequency assisted liver partition with portal vein ligation) for staged liver resection. Hepatobil Surg Nutr 5(4):382\u2013387","journal-title":"Hepatobil Surg Nutr"},{"issue":"6","key":"7437_CR61","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1007\/s00464-003-9233-3","volume":"18","author":"CN Gutt","year":"2004","unstructured":"Gutt CN, Oniu T, Schemmer P, Mehrabi A, Buchler MW (2004) Fewer adhesions induced by laparoscopic surgery? Surg Endosc 18(6):898\u2013906","journal-title":"Surg Endosc"},{"issue":"6","key":"7437_CR62","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1007\/s00464-001-8122-x","volume":"16","author":"SE Burpee","year":"2002","unstructured":"Burpee SE, Kurian M, Murakame Y, Benevides S, Gagner M (2002) The metabolic and immune response to laparoscopic versus open liver resection. Surg Endosc 16(6):899\u2013904","journal-title":"Surg Endosc"},{"issue":"2","key":"7437_CR63","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s11605-017-3512-0","volume":"22","author":"R Deal","year":"2018","unstructured":"Deal R, Frederiks C, Williams L, Olthof PB, Dirscherl K, Keutgen X et al (2018) Rapid liver hypertrophy after portal vein occlusion correlates with the degree of collateralization between Lobes-a Study in pigs. J Gastrointest Surg 22(2):203\u2013213","journal-title":"J Gastrointest Surg"},{"key":"7437_CR64","first-page":"e69","volume":"18","author":"E Solomonov","year":"2016","unstructured":"Solomonov E, Nesher E, Aizner S, Mor E (2016) Robotic associating liver partition with simultaneous portal vein ligation for staged hepatectomy (ALPPS): major liver surgery may be performed safely through a minimally invasive approach. a presentation of five cases. HPB 18:e69\u2013e694","journal-title":"HPB"},{"issue":"8","key":"7437_CR65","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1001\/jama.2018.9219","volume":"320","author":"CP Childers","year":"2018","unstructured":"Childers CP, Maggard-Gibbons M (2018) Estimation of the acquisition and operating costs for robotic surgery. JAMA 320(8):835\u2013836","journal-title":"JAMA"},{"issue":"3","key":"7437_CR66","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1007\/s00464-011-1936-2","volume":"26","author":"G Turchetti","year":"2012","unstructured":"Turchetti G, Palla I, Pierotti F, Cuschieri A (2012) Economic evaluation of da Vinci-assisted robotic surgery: a systematic review. Surg Endosc 26(3):598\u2013606","journal-title":"Surg Endosc"}],"container-title":["Surgical Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-020-07437-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00464-020-07437-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-020-07437-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T23:26:02Z","timestamp":1617924362000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00464-020-07437-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,9]]},"references-count":66,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["7437"],"URL":"https:\/\/doi.org\/10.1007\/s00464-020-07437-3","relation":{},"ISSN":["0930-2794","1432-2218"],"issn-type":[{"value":"0930-2794","type":"print"},{"value":"1432-2218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,9]]},"assertion":[{"value":"25 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Mr. Michal Kawka, Mr. Sau Mak, Ms. Tamara MH Gall and Prof. Jiao R. Long have no conflicts of interest and no financial ties to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}},{"value":"IRB approval was not required for the methodology of this\nstudy.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}