{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T00:35:37Z","timestamp":1793752537879,"version":"4.6.1"},"reference-count":132,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Endosc"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Laparoscopic cholecystectomy is increasingly performed in an ever ageing population; however, the risks are poorly quantified. The study aims to review the current evidence to quantify further the postoperative risk of cholecystectomy in the elderly population compared to younger patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A systematic literature search of PubMed, EMBASE and the Cochrane Library databases were conducted including studies reporting laparoscopic cholecystectomy in the elderly population. A meta-analysis was reported in accordance with the recommendations of the Cochrane Library and PRISMA guidelines. Primary outcome was overall complications and secondary outcomes were conversion to open surgery, bile leaks, postoperative mortality and length of stay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This review identified 99 studies incorporating 326,517 patients. Increasing age was significantly associated with increased rates of overall complications (OR 2.37, CI\n                      <jats:sub>95%<\/jats:sub>\n                      2.00\u20132.78), major complication (OR 1.79, CI\n                      <jats:sub>95%<\/jats:sub>\n                      1.45\u20132.20), risk of conversion to open cholecystectomy (OR 2.17, CI\n                      <jats:sub>95%<\/jats:sub>\n                      1.84\u20132.55), risk of bile leaks (OR 1.50, CI\n                      <jats:sub>95%<\/jats:sub>\n                      1.07\u20132.10), risk of postoperative mortality (OR 7.20, CI\n                      <jats:sub>95%<\/jats:sub>\n                      4.41\u201311.73) and was significantly associated with increased length of stay (MD 2.21\u00a0days, CI\n                      <jats:sub>95%<\/jats:sub>\n                      1.24\u20133.18).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Postoperative outcomes such as overall and major complications appear to be significantly higher in all age cut-offs in this meta-analysis. This study demonstrated there is a sevenfold increase in perioperative mortality which increases by tenfold in patients &gt;\u200980\u00a0years old. This study appears to confirm preconceived suspicions of higher risks in elderly patients undergoing cholecystectomy and may aid treatment planning and informed consent.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00464-020-07805-z","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T10:02:43Z","timestamp":1594634563000},"page":"4727-4740","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Perioperative outcomes after laparoscopic cholecystectomy in elderly patients: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2748-0011","authenticated-orcid":false,"given":"Sivesh K.","family":"Kamarajah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santhosh","family":"Karri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Bundred","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P. 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Dr Santhosh Karri has no conflicts of interest or financial ties to disclose. Dr James Bundred has no conflicts of interest or financial ties to disclose. Mr Richard PT Evans has no conflicts of interest or financial ties to disclose. Mr Aaron Lin has no conflicts of interest or financial ties to disclose. Miss Tania Kew has no conflicts of interest or financial ties to disclose. Miss Chinenye Ekeozor has no conflicts of interest or financial ties to disclose. Dr Susan L Powell has no conflicts of interest or financial ties to disclose. Mr Pritam Singh has no conflicts of interest or financial ties to disclose. Mr Ewen Griffiths has no conflicts of interest or financial ties to disclose.Dr Sivesh K Kamarajah has no conflicts of interest or financial ties to disclose. Dr Santhosh Karri has no conflicts of interest or financial ties to disclose. Dr James Bundred has no conflicts of interest or financial ties to disclose. Mr Richard PT Evans has no conflicts of interest or financial ties to disclose. Mr Aaron Lin has no conflicts of interest or financial ties to disclose. Miss Tania Kew has no conflicts of interest or financial ties to disclose. Miss Chinenye Ekeozor has no conflicts of interest or financial ties to disclose. Dr Susan L Powell has no conflicts of interest or financial ties to disclose. Mr Pritam Singh has no conflicts of interest or financial ties to disclose. Mr Ewen Griffiths has no conflicts of interest or financial ties to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}