{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:42:43Z","timestamp":1740109363426,"version":"3.37.3"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100008375","name":"University of Basel","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008375","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Endosc"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Transrectal Natural Orifice Transluminal Endoscopic Surgery is currently limited by the inherent risk of surgical site infection due to peritoneal contamination after rectotomy. Coloshield has been developed as a temporary colon occlusion device to facilitate rectal washout. However, effectiveness and safety has not been evaluated in humans.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Twenty-two patients have been randomly assigned to undergo proctological intervention with a rectal washout with and without the use of Coloshield. Patients and assessors were blinded. Boston Bowel Preparation Scale (BBPS) has been determined 30\u00a0min as well as immediately after rectal washout. Feasibility, pain, intra- and postoperative morbidity as well as bowel function and continence 6\u00a0weeks after surgery were assessed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>BBPS 30\u00a0min after rectal washout with and without Coloshield was in mean 2.42\u2009\u00b1\u20091.02 and 2.12\u2009\u00b1\u20090.89 (<jats:italic>p<\/jats:italic>\u2009=\u20090.042). Mean BBPS immediately after rectal washout was 2.39\u2009\u00b1\u20091.02 and 2.24\u2009\u00b1\u20090.66 (<jats:italic>p<\/jats:italic>\u2009=\u20090.269). Mean BBPS immediately after rectal washout and 30\u00a0min thereafter did not differ (<jats:italic>p<\/jats:italic>\u2009=\u20090.711). Coloshield application was feasible without any complications. The median (interquartile range) numeric rating scale for pain 4\u00a0h after surgery was 1 (0\u20131) and 3 (0\u20134) (<jats:italic>p<\/jats:italic>\u2009=\u20090.212). Six weeks after surgery 0\/11 and 1\/11 patients suffered from evacuation difficulties (<jats:italic>p<\/jats:italic>\u2009=\u20091.0) and the median Vaizey\u2013Wexner score was 1 (0\u20133) and 1 (0\u20132) (<jats:italic>p<\/jats:italic>\u2009=\u20090.360).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Coloshield application in humans is feasible and safe. Slight benefits in rectal preparation by washout are found when Coloshield is used. Colon occlusion by Coloshield for transrectal NOTES should be evaluated within clinical studies.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>Clinicaltrials.gov NCT02579330<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00464-020-07992-9","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T16:04:15Z","timestamp":1600877055000},"page":"5078-5087","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Randomized clinical trial on the use of a colon-occlusion device to assist rectal washout"],"prefix":"10.1007","volume":"35","clinical-trial-number":[{"clinical-trial-number":"nct02579330","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Carolin","family":"Cordewener","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Z\u00fcrcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip C.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beat P.","family":"M\u00fcller-Stich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Zerz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg R.","family":"Linke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4111-2909","authenticated-orcid":false,"given":"Daniel C.","family":"Steinemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"key":"7992_CR1","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1007\/DCR.0b013e3182083b84","volume":"54","author":"RO Perez","year":"2011","unstructured":"Perez RO, Habr-Gama A, Sao Juliao GP et al (2011) Transanal endoscopic microsurgery for residual rectal cancer after neoadjuvant chemoradiation therapy is associated with significant immediate pain and hospital readmission rates. 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No further compensations, however, were obtained. C. Cordewener, M. Z\u00fcrcher, P.C. M\u00fcller, B.P.M\u00fcller-Stich, A. Zerz, G.R. Linke, and D.C.Steinemann have no conflicts of interest or financial ties to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}