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They were classified into treatment-na\u00efve patients (POEM1) and patients who had at least one previous endoscopic and\/or surgical treatment for achalasia (POEM2).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>A total of 105 patients were included, 52 in the POEM1 group and 53 in the POEM2 group. Clinical success (defined as an Eckardt score\u2009\u2264\u20093) at 6\u00a0months was observed in 93% of POEM1 patients and 84% of POEM2 patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.18). Technical success rate was not significantly different between the two groups (100% vs 96%, respectively; <jats:italic>p<\/jats:italic>\u2009=\u20090.50). No significant difference was noted in terms of adverse event rate (19% vs 19%, respectively; <jats:italic>p<\/jats:italic>\u2009=\u20091.00). Post-procedure pain occurred in 12% of treatment-naive and 9% of non-na\u00efve patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.76). The median length of hospital stay was 3\u00a0days in both groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.17). Symptomatic gastroesophageal reflux occurred in 25% of POEM1 patients and 16% of POEM2 patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.24).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Efficacy, feasibility and safety of POEM are not different between treatment-na\u00efve and non-na\u00efve patients. POEM is a valuable second-line approach in patients with persistent symptoms of achalasia after surgical or endoscopic treatments.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00464-021-08767-6","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T20:50:49Z","timestamp":1674247849000},"page":"3760-3768","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Peroral endoscopic myotomy: is it better to perform it in naive patients or as second-line therapy? 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Drs. Raphael Olivier, Charl\u00e8ne Brochard, S Bruley des Varannes, Timoth\u00e9e Wallenhorst and No\u00e9mi Reboux have no conflicts of interest or financial ties to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}