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The hypothetical downside of caffeine in the surgical field is the potential interaction with the ergonomics of movement and the central nervous system. The objective of this trial was to investigate the influence of caffeine on laparoscopic performance.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Fifty laparoscopic novices participated in this prospective randomized, blinded crossover trial and were trained in a modified FLS curriculum until reaching a predefined proficiency. Subsequently, all participants performed four laparoscopic tasks twice, once after consumption of a placebo and once after a caffeinated (200\u00a0mg) beverage.<\/jats:p>\n                <jats:p>Comparative analysis was performed between the cohorts. Primary endpoint analysis included task time, task errors, OSATS score and a performance analysis with an instrument motion analysis (IMA) system.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Fifty participants completed the study. Sixty-eight percent of participants drank coffee daily. The time to completion for each task was comparable between the <jats:italic>caffeine<\/jats:italic> and <jats:italic>placebo<\/jats:italic> cohorts for PEG transfer (119\u00a0s vs 121\u00a0s; <jats:italic>p<\/jats:italic>\u2009=\u20090.73), precise cutting (157\u00a0s vs 163\u00a0s; <jats:italic>p<\/jats:italic>\u2009=\u20090.74), gallbladder resection (190\u00a0s vs 173\u00a0s; <jats:italic>p<\/jats:italic>\u2009=\u20090.6) and surgical knot (171\u00a0s vs 189\u00a0s; <jats:italic>p<\/jats:italic>\u2009=\u20090.68). The instrument motion analysis showed no significant differences between the caffeine and placebo groups in any parameters: instrument volume, path length, idle, velocity, acceleration, and instrument out of view. Additionally, OSATS scores did not differ between groups, regardless of task. Major errors occurred similarly in both groups, except for one error criteria during the circle cutting task, which occurred significantly more often in the caffeine group (34% vs. 16%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The objective IMA and performance scores of laparoscopic skills revealed that caffeine consumption does not enhance or impair the overall laparoscopic performance of surgical novices. The occurrence of major errors is not conclusive but could be negatively influenced in part by caffeine intake.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00464-021-08783-6","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T18:02:27Z","timestamp":1636999347000},"page":"4359-4368","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Does caffeine consumption affect laparoscopic skills in a motion tracking analysis? 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