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Long-term follow-up after direct comparison of these two minimally invasive approaches is scarce. The aim of the present study was to assess long-term disease-specific symptoms and quality of life (QOL) in patients with gastroesophageal reflux disease (GERD) treated with RALF or CLF after 12\u00a0years in the randomized ROLAF trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In the ROLAF trial 40 patients with GERD were randomized to RALF (<jats:italic>n<\/jats:italic>\u2009=\u200920) or CLF (<jats:italic>n<\/jats:italic>\u2009=\u200920) between August 2004 and December 2005. At 12\u00a0years after surgery, all patients were invited to complete the standardized Gastrointestinal Symptom Rating Scale (GSRS) and the Quality of Life in Reflux and Dyspepsia questionnaire (QOLRAD). Failure of treatment was assessed according to Lundell score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The GSRS score was similar for RALF (<jats:italic>n<\/jats:italic>\u2009=\u200915) and CLF (<jats:italic>n<\/jats:italic>\u2009=\u200915) at 12\u00a0years\u00b4 follow-up (2.1\u2009\u00b1\u20090.7 vs. 2.2\u2009\u00b1\u20091.3,<jats:italic>p<\/jats:italic>\u2009=\u20090.740). There was no difference in QOLRAD score (RALF 6.4\u2009\u00b1\u20091.2; CLF 6.4\u2009\u00b1\u20091.5,<jats:italic>p<\/jats:italic>\u2009=\u20090.656) and the QOLRAD score sub items. Long-term failure of treatment according to the definition by Lundell was not different between RALF and CLF [46% (6\/13) vs. 33% (4\/12),<jats:italic>p<\/jats:italic>\u2009=\u20090.806].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In accordance with previous short-term outcome studies, the long-term results 12\u00a0years after surgery showed no difference between RALF and CLF regarding postoperative symptoms, QOL and failure of treatment. Relief of symptoms and patient satisfaction were high after both procedures on the long-term. Registration number: DRKS00014690 (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.drks.de\">https:\/\/www.drks.de<\/jats:ext-link>).<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00464-021-08969-y","type":"journal-article","created":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T16:54:21Z","timestamp":1643129661000},"page":"5627-5634","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Randomized controlled trial of robotic-assisted versus conventional laparoscopic fundoplication: 12\u00a0years follow-up"],"prefix":"10.1007","volume":"36","author":[{"given":"F.","family":"Lang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. 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