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The present study aimed to compare the rate of eradication and efficacy between bc-EIS and endoscopic variceal ligation (EVL) in the management of EVs.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Ninety-five patients with esophageal variceal bleeding (EVB) were randomly assigned to receive bc-EIS or ligation alone. Additional treatment sessions were held 1 month later and then at 3-month intervals until eradication of the varices was achieved. Endoscopic follow-up examinations were carried out at 6-month intervals in the absence of recurrence or immediately if there was any recurrent bleeding.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The mean physical injection points per session were 2.89\u2009\u00b1\u20090.79, and the mean volume of lauromacrogol used per session was 17.74\u2009\u00b1\u20097.09\u00a0ml in the bc-EIS group. The mean band per session was 6.13\u2009\u00b1\u20090.86. The rate of eradication after one to three rounds of bc-EIS was obviously higher than that of the EVL group (89.36%, 97.87%, and 100% vs. 37.5%, 43.75%, and 47.92%, respectively). Retrosternal pain or discomfort in the bc-EIS group was slightly lower than that in the EVL group (23.4%, 11\/47 vs. 31.25%, 15\/48). Two and five patients showed mild abdominal bloating and distension between the bc-EIS and EVL groups, respectively (2\/47, 4.26% vs. 5\/48, 10.42% <jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). Nausea and vomiting were reported in one patient (1\/47, 2.13%) in the bc-EIS group and three patients (3\/48, 6.25%) in the EVL group. However, there were no statistically significant differences between the two groups (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05). No fatal or severe complications, such as esophageal perforation, esophageal stricture or ectopic embolism, were observed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The bc-EIS method was effective in eradicating EVs and was accompanied by fewer complications.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00464-022-09412-6","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T18:14:31Z","timestamp":1658772871000},"page":"7839-7847","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Novel balloon compression-assisted endoscopic injection sclerotherapy and endoscopic variceal ligation in the treatment of esophageal varices: a prospective randomized study"],"prefix":"10.1007","volume":"36","author":[{"given":"Qianqian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ZeXue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3273-5760","authenticated-orcid":false,"given":"Derun","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"key":"9412_CR1","doi-asserted-by":"publisher","first-page":"365","DOI":"10.4253\/wjge.v12.i10.365","volume":"12","author":"J Krige","year":"2020","unstructured":"Krige J, Jonas E, Kotze U, Kloppers C, Gandhi K, Allam H, Bernon M, Burmeister S, Setshedi M (2020) Defining the advantages and exposing the limitations of endoscopic variceal ligation in controlling acute bleeding and achieving complete variceal eradication. 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