{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:04:09Z","timestamp":1792011849074,"version":"4.4.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100007911","name":"University of California, San Diego","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007911","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Endosc"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Open cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is associated with high morbidity, which limits the degree to which patients may benefit from this therapy. This study aimed to determine the feasibility of laparoscopic CRS\/HIPEC.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>This was a single institution prospective clinical trial and comparative study using historical controls. Patients with histologically confirmed peritoneal surface malignancy (PSM) of appendiceal, colorectal, ovarian, or primary peritoneal origin, peritoneal carcinomatosis index (PCI) <jats:inline-formula><jats:alternatives><jats:tex-math>$$\\le$$<\/jats:tex-math><mml:math xmlns:mml=\"http:\/\/www.w3.org\/1998\/Math\/MathML\">\n                    <mml:mo>\u2264<\/mml:mo>\n                  <\/mml:math><\/jats:alternatives><\/jats:inline-formula> 10 were eligible.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Clinical trial: 18 patients (median age 57\u00a0years, 39% female) with appendiceal (15) or colorectal (3) primary PSM underwent laparoscopic CRS\/HIPEC. Median and range outcomes were: operative time 219\u00a0min (134\u2013378), EBL 10\u00a0mL (0\u2013100), time to return to bowel function 3\u00a0days (1\u20137), duration IV narcotic use 3\u00a0days (1\u20138), length of stay 6\u00a0days (3\u201311). All patients had a complete cytoreduction (CC-score 0). Three (17%) experienced minor morbidity, with no major morbidity or mortality. Median DFS and OS were not reached with median follow-up of 48\u00a0months. Comparative analysis: Laparoscopic approach associated with reduced time to return of bowel function (3 versus 4\u00a0days, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), length of stay (8 versus 5\u00a0days, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and morbidity (16% versus 42%, <jats:italic>p<\/jats:italic>\u2009=\u20090.008). Independent predictors of DFS included prior chemotherapy (HR 5.07, 95% CI 1.85, 13.89; <jats:italic>p<\/jats:italic>\u2009=\u20090.002), and CC-score\u2009&gt;\u20090 (HR 3.31, 95% CI 1.19, 9.41; <jats:italic>p<\/jats:italic>\u2009=\u20090.025), but not surgical approach. CC-score\u2009&gt;\u20090 was the only independent predictor of OS (HR 10.12, 95% CI 2.16, 47.30, <jats:italic>p<\/jats:italic>\u2009=\u20090.003).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions and relevance<\/jats:title>\n                <jats:p>Laparoscopic CRS\/HIPEC should be considered for patients with PSM with low-volume disease, including those with adenocarcinoma histology.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Trial registration<\/jats:title>\n                <jats:p>Clinicaltrials.gov; NCT02463877.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00464-022-09589-w","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T16:03:56Z","timestamp":1670429036000},"page":"5644-5651","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Laparoscopic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a prospective clinical trial and comparative analysis"],"prefix":"10.1007","volume":"37","clinical-trial-number":[{"clinical-trial-number":"nct02463877","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Chae Yun","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jula","family":"Veerapong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel M.","family":"Baumgartner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew M.","family":"Lowy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9999-038X","authenticated-orcid":false,"given":"Kaitlyn J.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"9589_CR1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-08843-6","author":"AC Gamboa","year":"2020","unstructured":"Gamboa AC, Lee RM, Turgeon MK, Zaidi MY, Kimbrough CW, Grotz TE, Leiting J, Fournier K, Lee AJ, Dineen SP, Powers BD, Veerapong J, Baumgartner JM, Clarke CN, Mogal H, Patel SH, Lee TC, Lambert LA, Hendrix RJ, Abbott DE, Pokrzywa C, Raoof M, Eng OS, Johnston FM, Greer J, Cloyd JM, Maithel SK, Staley CA (2020) Implications of postoperative complications for survival after cytoreductive surgery and HIPEC: a multi-institutional analysis of the US HIPEC collaborative. 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