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Besides surgery, endoscopic treatment options exist, but the size and location of the perforation can limit their application. We present a retrospective study, demonstrating a successful application of endoscopic vacuum therapy (EVT) for duodenal leaks.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We performed a retrospective study of all patients who underwent EVT for duodenal perforations between 2016 and 2021 at two tertiary centers. We analyzed demographic and clinical patient characteristics, surgical outcomes, leak characteristics, sponge-related complications, and success rate.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Indications for treatment with EVT in the duodenum consisted of leak after duodenal suture of a perforated ulcer (<jats:italic>n<\/jats:italic>\u2009=\u20094), iatrogenic perforation after endoscopic resection (<jats:italic>n<\/jats:italic>\u2009=\u20092), iatrogenic perforation during surgery (<jats:italic>n<\/jats:italic>\u2009=\u20092), and anastomotic leak after upper gastrointestinal surgery (<jats:italic>n<\/jats:italic>\u2009=\u20092). EVT was used as a first-line treatment in seven patients and as a second-line treatment in three patients. EVT was successfully applied in all interventions (<jats:italic>n<\/jats:italic>\u2009=\u200910, 100%). Overall, EVT lead to definitive closure of the defects in eight out of ten patients (80%). No severe EVT-related adverse events occurred.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>EVT is safe and technically feasible, so it emerges as a promising endoscopic treatment option for duodenal leaks. However, multidisciplinary collaboration and management are important to reduce the occurrence of postoperative complications, and to improve recovery rates.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00464-022-09686-w","type":"journal-article","created":{"date-parts":[[2022,10,14]],"date-time":"2022-10-14T20:10:55Z","timestamp":1665778255000},"page":"1846-1853","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Outcome of endoscopic vacuum therapy for duodenal perforation"],"prefix":"10.1007","volume":"37","author":[{"given":"Mickael","family":"Chevallay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Lorenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Bichard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Frossard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Goeser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane Josephine","family":"Bruns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan P.","family":"M\u00f6nig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8923-6428","authenticated-orcid":false,"given":"Seung-Hun","family":"Chon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,14]]},"reference":[{"key":"9686_CR1","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1007\/s00464-003-8266-y","volume":"18","author":"H Lau","year":"2004","unstructured":"Lau H (2004) Laparoscopic repair of perforated peptic ulcer: a meta-analysis. 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M\u00f6nig, Prof., Seung-Hun Chon, M.D.) have no conflicts of interest or financial ties to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}