{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:30:07Z","timestamp":1791217807314,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Endosc"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>Gastrointestinal anastomoses with classical sutures and\/or metal staples have resulted in significant bleeding and leak rates. This multi-site study evaluated the feasibility, safety, and preliminary effectiveness of a novel linear magnetic compression anastomosis device, the Magnet System (MS), to form a side-to-side duodeno-ileostomy (DI) diversion for weight loss and type 2 diabetes (T2D) resolution.\n<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>In patients with class II and III obesity (body mass index [BMI, kg\/m<jats:sup>2<\/jats:sup>]\u2009\u2265\u200935.0\u2013\u2009\u2264\u200950.0 with\/without T2D [HbA1C\u2009&gt;\u20096.5%]), two linear MS magnets were delivered endoscopically to the duodenum and ileum with laparoscopic assistance and aligned, initiating DI; sleeve gastrectomy (SG) was added. There were no bowel incisions or retained sutures\/staples. Fused magnets were expelled naturally. Adverse events (AEs) were graded by Clavien-Dindo Classification (CDC).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Between November 22, 2021 and July 18, 2022, 24 patients (83.3% female, mean\u2009\u00b1\u2009SEM weight 121.9\u2009\u00b1\u20093.3\u00a0kg, BMI 44.4\u2009\u00b1\u20090.8) in three centers underwent magnetic DI. Magnets were expelled at a median 48.5\u00a0days. Respective mean BMI, total weight loss, and excess weight loss at 6\u00a0months (n\u2009=\u200924): 32.0\u2009\u00b1\u20090.8, 28.1\u2009\u00b1\u20091.0%, and 66.2\u2009\u00b1\u20093.4%; at 12\u00a0months (n\u2009=\u20095), 29.3\u2009\u00b1\u20091.5, 34.0\u2009\u00b1\u20091.4%, and 80.2\u2009\u00b1\u20096.6%. Group mean respective mean HbA1<jats:sub>C<\/jats:sub> and glucose levels dropped to 1.1\u2009\u00b1\u20090.4% and 24.8\u2009\u00b1\u20096.6\u00a0mg\/dL (6\u00a0months); 2.0\u2009\u00b1\u20091.1% and 53.8\u2009\u00b1\u20096.3\u00a0mg\/dL (12\u00a0months). There were 0 device-related AEs, 3 procedure-related serious AEs. No anastomotic bleeding, leakage, stricture, or mortality.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>In a multi-center study, side-to-side Magnet System duodeno-ileostomy with SG in adults with class III obesity appeared feasible, safe, and effective for weight loss and T2D resolution in the short term.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00464-023-10134-6","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T17:02:59Z","timestamp":1684774979000},"page":"6452-6463","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Side-to-side magnet anastomosis system duodeno-ileostomy with sleeve gastrectomy: early multi-center results"],"prefix":"10.1007","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6068-0333","authenticated-orcid":false,"given":"Michel","family":"Gagner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy-Bernard","family":"Cadiere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Sanchez-Pernaute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Abuladze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd","family":"Krinke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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Guy-Bernard Cadi\u00e8re is a consultant for GT Metabolic Solutions and member of the scientific advisory board without remuneration. Andres Sanchez-Pernaute is a consultant and received fees from Novo Nordisk, Medtronic, Johnson & Johnson, and Gore Medical. David Abuladze is a consultant for GT Metabolic Solutions without remuneration. Todd Krinke is an employee with GT patents and stock options. Jane Buchwald is a GT consultant with GT stock options; she received grants from Ethicon, Inc., M.I.D., Society of Bariatric and Metabolic Surgeons of Kazakhstan, Medical Faculty of Mannheim, Holy Family Hospital, Israel, and the American College of Surgeons. Nathalie Van Sante was an employee of GT Metabolic Solutions, Inc. during the study and drafting of the manuscript. Lamees Almutlaq holds stock options in GT Metabolic Solutions. Antonio Torres is a consultant for, and has received a grant from GT Metabolic Solutions. Marc Van Gossum, Jana Dziakova, Levan Koiava, Maja Odovic, and Mathilde Poras, have no potential conflicts of interest and nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}},{"value":"The study was conducted in compliance with the registered Clinicaltrials.gov protocol (#NCT05322122) and in accord with the ethical standards of the institutional research committee, and with the 1964 Helsinki declaration and its later amendments, as well as with ISO14155 regulations, 21 CFR Parts 11, 50, 54, 56, and 812 Good Clinical Practices.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed Consent was obtained with adequate understanding and consent of participating patients.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}