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The aim of this study was to assess the short- and long-term outcomes of LLR versus open liver resection (OLR) for patients with huge HCC from real-life data from consecutive patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Data regarding all consecutive patients undergoing liver resection for huge HCC were retrospectively collected from a Korean referral HPB center. Primary outcomes were the postoperative results, while secondary outcomes were the oncologic survivals.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Sixty-three patients were included in the study: 46 undergoing OLR and 17 LLR. Regarding postoperative outcomes, there were no statistically significant differences in estimated blood loss, operation time, transfusions, postoperative bile leak, ascites, severe complications, and R1 resection rates. After a median follow-up of 48.4 (95% CI 8.9\u201386.8) months, there were no statistically significant differences in 3\u00a0years OS (59.3\u2009\u00b1\u20098.7\u00a0months vs. 85.2\u2009\u00b1\u20099.8\u00a0months) and 5\u00a0years OS (31.1\u2009\u00b1\u20099\u00a0months vs. 73.1\u2009\u00b1\u200914.1\u00a0months), after OLR and LLR, respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.10). Similarly, there was not a statistically significant difference in both 3\u00a0years DFS (23.5%\u2009\u00b1\u20098.1\u00a0months vs. 51.6\u2009\u00b1\u2009months) and 5\u00a0years DFS (15.7\u2009\u00b1\u20097.1\u00a0months vs. 38.7\u2009\u00b1\u200915.3\u00a0months), respectively (<jats:italic>p<\/jats:italic>\u2009=\u20090.13), despite a potential clinically significant difference.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>LLR for huge HCC may be safe and effective in selected cases. Further studies with larger sample size and more appropriate design are needed to confirm these results.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Graphical abstract<\/jats:title>\n                \n              <\/jats:sec>","DOI":"10.1007\/s00464-024-11091-4","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T18:02:42Z","timestamp":1724781762000},"page":"6324-6331","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Laparoscopic versus open liver resection for huge hepatocellular carcinoma (\u2265\u2009than 10\u00a0cm): a retrospective analysis from a high-volume referral center"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9185-2054","authenticated-orcid":false,"given":"Gianluca","family":"Cassese","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho-Seong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boram","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jai Young","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,8,27]]},"reference":[{"issue":"3","key":"11091_CR1","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3322\/caac.21660","volume":"71","author":"H Sung","year":"2021","unstructured":"Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A et al (2021) Global Cancer Statistics 2020: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries. 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