{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T17:16:43Z","timestamp":1775063803813,"version":"3.50.1"},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100008743","name":"Society of American Gastrointestinal and Endoscopic Surgeons","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008743","id-type":"DOI","asserted-by":"publisher"}]},{"name":"St. Joseph's Foundation"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Endosc"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The role of gastroesophageal reflux in progressive lung damage is increasingly recognized. We have proposed, based on our work with lung transplant recipients, a novel immune mechanism of pulmonary injury after aspiration of gastric contents, during which higher levels of normally sequestered lung self-antigens (SAgs) collagen V (Col-V) and K-alpha-1 tubulin (K\u03b11T) in circulating small extracellular vesicles (EVs) induce the production of self-antibodies (SAbs) anti-Col-V and anti-K\u03b11T. Thus, we aimed to determine whether levels of SAbs or SAgs increased in an animal model of aspiration-induced lung damage in a nontransplant setting.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We created a murine model of repetitive lung aspiration using C57BL\/6J mice. Mice were aspirated weekly with 1\u00a0mL\/kg of hydrochloric acid (n\u2009=\u20099), human gastric contents (n\u2009=\u20099), or combined (1:1) fluid (n\u2009=\u20099) once, three, or six times (n\u2009=\u20093 in each subgroup; control group, n\u2009=\u20099). Blood samples were periodically obtained, and all animals were sacrificed at day 90 for pathological assessment. SAbs were measured using an enzyme-linked immunosorbent assay; SAgs and NF-\u03baB contained in small EVs were assessed by western blot.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Aspirated mice weighed significantly less than controls throughout the study and had histological evidence of pulmonary injury at day 90. Overall, aspirated mice developed higher concentrations of anti-Col-V at day 28 (53.9\u2009\u00b1\u200928.7 vs. 29.9\u2009\u00b1\u20094.5\u00a0ng\/mL, p\u2009&lt;\u20090.01), day 35 (42.6\u2009\u00b1\u200919.8 vs. 28.6\u2009\u00b1\u20097.2\u00a0ng\/mL, p\u2009=\u20090.038), and day 90 (59.7\u2009\u00b1\u200927.7 vs. 34.1\u2009\u00b1\u20093.2\u00a0ng\/mL, p\u2009=\u20090.014) than the control group. Circulating small EVs isolated from aspirated mice on day 90 contained higher levels of Col-V (0.7\u2009\u00b1\u20090.56 vs. 0.18\u2009\u00b1\u20090.6\u00a0m.o.d., p\u2009=\u20090.009) and NF-\u03baB (0.42\u2009\u00b1\u20090.27 vs. 0.27\u2009\u00b1\u20090.09\u00a0m.o.d., p\u2009=\u20090.095) than those from controls.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>This experimental study supports the theory that gastroesophageal reflux leads to the development of lung damage and an increase of humoral markers that may serve as noninvasive biomarkers to detect asymptomatic lung injury among patients with gastroesophageal reflux disease.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00464-024-11180-4","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T20:33:06Z","timestamp":1726173186000},"page":"7491-7502","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Noninvasive biomarkers for the detection of GERD-induced pulmonary injury"],"prefix":"10.1007","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3401-8623","authenticated-orcid":false,"given":"Andr\u00e9s R.","family":"Latorre-Rodr\u00edguez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2760-3891","authenticated-orcid":false,"given":"Sumeet K.","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2188-7029","authenticated-orcid":false,"given":"Ranjithkumar","family":"Ravichandran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Austin","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1569-969X","authenticated-orcid":false,"given":"Andr\u00e9s","family":"Isaza-Restrepo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jahanvi","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary F.","family":"Hahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2216-9109","authenticated-orcid":false,"given":"Ross M.","family":"Bremner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9873-4018","authenticated-orcid":false,"given":"Thalachallour","family":"Mohanakumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"11180_CR1","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1136\/gutjnl-2012-304269","volume":"63","author":"HB El-Serag","year":"2014","unstructured":"El-Serag HB, Sweet S, Winchester CC, Dent J (2014) Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut 63:871\u2013880","journal-title":"Gut"},{"key":"11180_CR2","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1513\/AnnalsATS.201906-427CME","volume":"17","author":"AS Lee","year":"2020","unstructured":"Lee AS, Lee JS, He Z, Ryu JH (2020) Reflux-aspiration in chronic lung disease. Ann Am Thorac Soc 17:155\u2013164","journal-title":"Ann Am Thorac Soc"},{"key":"11180_CR3","doi-asserted-by":"publisher","first-page":"1804","DOI":"10.1164\/ajrccm.158.6.9804105","volume":"158","author":"RW Tobin","year":"1998","unstructured":"Tobin RW, Pope CE 2nd, Pellegrini CA, Emond MJ, Sillery J, Raghu G (1998) Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 158:1804\u20131808","journal-title":"Am J Respir Crit Care Med"},{"key":"11180_CR4","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/148086","volume":"2013","author":"OI Emilsson","year":"2013","unstructured":"Emilsson OI, G\u00edslason T, Olin AC, Janson C, Olafsson I (2013) Biomarkers for gastroesophageal reflux in respiratory diseases. Gastroenterol Res Pract 2013:148086","journal-title":"Gastroenterol Res Pract"},{"key":"11180_CR5","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.bpg.2013.06.005","volume":"27","author":"PJ Kahrilas","year":"2013","unstructured":"Kahrilas PJ, Boeckxstaens G, Smout AJ (2013) Management of the patient with incomplete response to PPI therapy. Best Pract Res Clin Gastroenterol 27:401\u2013414","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"11180_CR6","first-page":"e54700","volume":"120","author":"R Alluri","year":"2017","unstructured":"Alluri R, Kutscher HL, Mullan BA, Davidson BA, Knight PR (2017) Open tracheostomy gastric acid aspiration murine model of acute lung injury results in maximal acute nonlethal lung injury. J Vis Exp. 120:e54700","journal-title":"J Vis Exp."},{"key":"11180_CR7","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1097\/ALN.0b013e318173f64f","volume":"108","author":"M Amigoni","year":"2008","unstructured":"Amigoni M, Bellani G, Scanziani M, Masson S, Bertoli E, Radaelli E, Patroniti N, Di Lelio A, Pesenti A, Latini R (2008) Lung injury and recovery in a murine model of unilateral acid aspiration: functional, biochemical, and morphologic characterization. Anesthesiology 108:1037\u20131046","journal-title":"Anesthesiology"},{"key":"11180_CR8","doi-asserted-by":"publisher","first-page":"84","DOI":"10.6002\/ect.2017.0152","volume":"17","author":"JC Chang","year":"2019","unstructured":"Chang JC, Finn SM, Davis RP, Sanders NL, Holzknecht ZE, Everett ML, Barbas AS, Parker W, Lin SS (2019) Early immune response to acute gastric fluid aspiration in a rat model of lung transplantation. Exp Clin Transplant 17:84\u201392","journal-title":"Exp Clin Transplant"},{"key":"11180_CR9","first-page":"e60024","volume":"150","author":"AH Tavares","year":"2019","unstructured":"Tavares AH, Colby JK, Levy BD, Abdulnour RE (2019) A model of self-limited acute lung injury by unilateral intra-bronchial acid instillation. J Vis Exp. 150:e60024","journal-title":"J Vis Exp."},{"key":"11180_CR10","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/1465-9921-8-87","volume":"8","author":"JZ Appel 3rd","year":"2007","unstructured":"Appel JZ 3rd, Lee SM, Hartwig MG, Li B, Hsieh CC, Cantu E 3rd, Yoon Y, Lin SS, Parker W, Davis RD (2007) Characterization of the innate immune response to chronic aspiration in a novel rodent model. Respir Res 8:87","journal-title":"Respir Res"},{"key":"11180_CR11","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/j.jtcvs.2005.06.054","volume":"131","author":"MG Hartwig","year":"2006","unstructured":"Hartwig MG, Appel JZ, Li B, Hsieh CC, Yoon YH, Lin SS, Irish W, Parker W, Davis RD (2006) Chronic aspiration of gastric fluid accelerates pulmonary allograft dysfunction in a rat model of lung transplantation. J Thorac Cardiovasc Surg 131:209\u2013217","journal-title":"J Thorac Cardiovasc Surg"},{"key":"11180_CR12","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1053\/j.semtcvs.2022.02.006","volume":"35","author":"D Razia","year":"2023","unstructured":"Razia D, Mittal SK, Bansal S, Ravichandran R, Giulini L, Smith MA, Walia R, Mohanakumar T, Bremner RM (2023) Association between antibodies against lung self-antigens and gastroesophageal reflux in lung transplant candidates. Semin Thorac Cardiovasc Surg 35:177\u2013186","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"11180_CR13","doi-asserted-by":"publisher","DOI":"10.1016\/j.trre.2023.100796","volume":"38","author":"AR Latorre-Rodr\u00edguez","year":"2024","unstructured":"Latorre-Rodr\u00edguez AR, Razia D, Omar A, Bremner RM, Mittal SK (2024) Pulmonary and esophageal function in lung transplantation: fundamental principles and clinical application. Transplant Rev (Orlando) 38:100796","journal-title":"Transplant Rev (Orlando)"},{"key":"11180_CR14","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1016\/j.athoracsur.2010.06.009","volume":"90","author":"A Bharat","year":"2010","unstructured":"Bharat A, Saini D, Steward N, Hachem R, Trulock EP, Patterson GA, Meyers BF, Mohanakumar T (2010) Antibodies to self-antigens predispose to primary lung allograft dysfunction and chronic rejection. Ann Thorac Surg 90:1094\u20131101","journal-title":"Ann Thorac Surg"},{"key":"11180_CR15","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.cellimm.2018.06.003","volume":"331","author":"S Bansal","year":"2018","unstructured":"Bansal S, Sharma M, R R, Mohanakumar T, (2018) The role of exosomes in allograft immunity. Cell Immunol 331:85\u201392","journal-title":"Cell Immunol"},{"key":"11180_CR16","doi-asserted-by":"publisher","first-page":"e23","DOI":"10.1016\/j.jtcvs.2022.03.009","volume":"165","author":"MT Olson","year":"2023","unstructured":"Olson MT, Liu W, Mohanakumar T, Bremner RM (2023) A potential mechanism by which aspiration of duodenogastric fluid augments the risk for bronchiolitis obliterans syndrome after lung transplantation. J Thorac Cardiovasc Surg 165:e23\u2013e37","journal-title":"J Thorac Cardiovasc Surg"},{"key":"11180_CR17","doi-asserted-by":"publisher","first-page":"2359","DOI":"10.1111\/ajt.12908","volume":"14","author":"V Subramanian","year":"2014","unstructured":"Subramanian V, Ramachandran S, Banan B, Bharat A, Wang X, Benshoff N, Kreisel D, Gelman AE, Mohanakumar T (2014) Immune response to tissue-restricted self-antigens induces airway inflammation and fibrosis following murine lung transplantation. Am J Transplant 14:2359\u20132366","journal-title":"Am J Transplant"},{"key":"11180_CR18","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3109\/01902148.2016.1139213","volume":"42","author":"JH Leung","year":"2016","unstructured":"Leung JH, Chang JC, Foltz E, Bell SM, Pi C, Azad S, Everett ML, Holzknecht ZE, Sanders NL, Parker W, Davis RD, Keshavjee S, Lin SS (2016) Clearance of bile and trypsin in rat lungs following aspiration of human gastric fluid. Exp Lung Res 42:37\u201343","journal-title":"Exp Lung Res"},{"issue":"507\u2013511","key":"11180_CR19","first-page":"514","volume":"44","author":"RH H\u00fcbner","year":"2008","unstructured":"H\u00fcbner RH, Gitter W, El Mokhtari NE, Mathiak M, Both M, Bolte H, Freitag-Wolf S, Bewig B (2008) Standardized quantification of pulmonary fibrosis in histological samples. Biotechniques 44(507\u2013511):514\u2013507","journal-title":"Biotechniques"},{"key":"11180_CR20","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1093\/dote\/doab052.801","volume":"34","author":"D Razia","year":"2021","unstructured":"Razia D, Ravichandran R, Bansal S, Fournier S, Baboli K, Bremner RM, Mohanakumar T, Mittal SK (2021) 801 exosomes containing lung self-antigens collagen-V and K\u03b11-tubulin are prevalent in patients with symptomatic gastroesophageal reflux: results from a pilot study. Dis Esophagus 34:52\u2013801","journal-title":"Dis Esophagus"},{"key":"11180_CR21","doi-asserted-by":"publisher","first-page":"115","DOI":"10.4103\/1817-1737.53347","volume":"4","author":"GS Gaude","year":"2009","unstructured":"Gaude GS (2009) Pulmonary manifestations of gastroesophageal reflux disease. Ann Thorac Med 4:115\u2013123","journal-title":"Ann Thorac Med"},{"key":"11180_CR22","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.3390\/jcm9082559","volume":"9","author":"M Durazzo","year":"2020","unstructured":"Durazzo M, Lupi G, Cicerchia F, Ferro A, Barutta F, Beccuti G, Gruden G, Pellicano R (2020) Extra-esophageal presentation of gastroesophageal reflux disease: 2020 update. J Clin Med 9:2559","journal-title":"J Clin Med"},{"key":"11180_CR23","doi-asserted-by":"publisher","first-page":"2314","DOI":"10.21037\/jtd-22-1757","volume":"15","author":"L Zhang","year":"2023","unstructured":"Zhang L, Aierken A, Zhang M, Qiu Z (2023) Pathogenesis and management of gastroesophageal reflux disease-associated cough: a narrative review. J Thorac Dis 15:2314\u20132323","journal-title":"J Thorac Dis"},{"key":"11180_CR24","doi-asserted-by":"publisher","first-page":"1517","DOI":"10.1016\/j.healun.2021.08.016","volume":"40","author":"R Ravichandran","year":"2021","unstructured":"Ravichandran R, Itabashi Y, Liu W, Bansal S, Rahman M, Poulson C, Fleming T, Bremner RM, Smith M, Mohanakumar T (2021) A decline in club cell secretory proteins in lung transplantation is associated with release of natural killer cells exosomes leading to chronic rejection. J Heart Lung Transplant 40:1517\u20131528","journal-title":"J Heart Lung Transplant"},{"key":"11180_CR25","doi-asserted-by":"publisher","first-page":"3498","DOI":"10.1172\/JCI28031","volume":"117","author":"WJ Burlingham","year":"2007","unstructured":"Burlingham WJ, Love RB, Jankowska-Gan E, Haynes LD, Xu Q, Bobadilla JL, Meyer KC, Hayney MS, Braun RK, Greenspan DS, Gopalakrishnan B, Cai J, Brand DD, Yoshida S, Cummings OW, Wilkes DS (2007) IL-17-dependent cellular immunity to collagen type V predisposes to obliterative bronchiolitis in human lung transplants. J Clin Invest 117:3498\u20133506","journal-title":"J Clin Invest"},{"key":"11180_CR26","doi-asserted-by":"publisher","first-page":"1210","DOI":"10.1016\/j.healun.2020.07.001","volume":"39","author":"M Sharma","year":"2020","unstructured":"Sharma M, Gunasekaran M, Ravichandran R, Fisher CE, Limaye AP, Hu C, McDyer J, Kaza V, Bharat A, Tokman S, Omar A, Arjuna A, Walia R, Bremner RM, Smith MA, Hachem RR, Mohanakumar T (2020) Circulating exosomes with lung self-antigens as a biomarker for chronic lung allograft dysfunction: a retrospective analysis. J Heart Lung Transplant 39:1210\u20131219","journal-title":"J Heart Lung Transplant"},{"key":"11180_CR27","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.healun.2013.06.003","volume":"32","author":"V Tiriveedhi","year":"2013","unstructured":"Tiriveedhi V, Gautam B, Sarma NJ, Askar M, Budev M, Aloush A, Hachem R, Trulock E, Myers B, Patterson AG, Mohanakumar T (2013) Pre-transplant antibodies to K\u03b11 tubulin and collagen-V in lung transplantation: clinical correlations. J Heart Lung Transplant 32:807\u2013814","journal-title":"J Heart Lung Transplant"},{"key":"11180_CR28","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1097\/00007890-198912000-00025","volume":"48","author":"K Rao","year":"1989","unstructured":"Rao K, Lund RD, Kunz HW, Gill TJ 3rd (1989) The role of MHC and non-MHC antigens in the rejection of intracerebral allogeneic neural grafts. Transplantation 48:1018\u20131021","journal-title":"Transplantation"},{"key":"11180_CR29","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/S0022-5223(05)80013-3","volume":"110","author":"S Hein","year":"1995","unstructured":"Hein S, Scheffold T, Schaper J (1995) Ischemia induces early changes to cytoskeletal and contractile proteins in diseased human myocardium. J Thorac Cardiovasc Surg 110:89\u201398","journal-title":"J Thorac Cardiovasc Surg"},{"key":"11180_CR30","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/j.1348-0421.2006.tb03776.x","volume":"50","author":"Y Tanaka","year":"2006","unstructured":"Tanaka Y, Nakamura M, Matsui T, Iizuka N, Kondo H, Tohma S, Masuko K, Yudoh K, Nakamura H, Nishioka K, Koizuka I, Kato T (2006) Proteomic surveillance of autoantigens in relapsing polychondritis. Microbiol Immunol 50:117\u2013126","journal-title":"Microbiol Immunol"},{"key":"11180_CR31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076451","volume":"8","author":"R Vittal","year":"2013","unstructured":"Vittal R, Mickler EA, Fisher AJ, Zhang C, Rothhaar K, Gu H, Brown KM, Emtiazjoo A, Lott JM, Frye SB, Smith GN, Sandusky GE, Cummings OW, Wilkes DS (2013) Type V collagen induced tolerance suppresses collagen deposition, TGF-\u03b2 and associated transcripts in pulmonary fibrosis. PLoS ONE 8:e76451","journal-title":"PLoS ONE"},{"key":"11180_CR32","doi-asserted-by":"publisher","first-page":"416","DOI":"10.1038\/modpathol.2011.166","volume":"25","author":"GJ Nuovo","year":"2012","unstructured":"Nuovo GJ, Hagood JS, Magro CM, Chin N, Kapil R, Davis L, Marsh CB, Folcik VA (2012) The distribution of immunomodulatory cells in the lungs of patients with idiopathic pulmonary fibrosis. Mod Pathol 25:416\u2013433","journal-title":"Mod Pathol"},{"key":"11180_CR33","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.cyto.2018.11.003","volume":"120","author":"K Ramani","year":"2019","unstructured":"Ramani K, Biswas PS (2019) Interleukin-17: friend or foe in organ fibrosis. Cytokine 120:282\u2013288","journal-title":"Cytokine"},{"key":"11180_CR34","doi-asserted-by":"publisher","DOI":"10.1097\/TXD.0000000000001294","volume":"8","author":"D Razia","year":"2022","unstructured":"Razia D, Mittal SK, Bansal S, Ravichandran R, Smith MA, Walia R, Bremner RM, Mohanakumar T, Tokman S (2022) Lung transplant candidates with pretransplant gastroesophageal reflux and antibodies to lung self-antigens have shorter CLAD-free survival after transplant. Transplant Direct 8:e1294","journal-title":"Transplant Direct"},{"key":"11180_CR35","doi-asserted-by":"publisher","first-page":"S-1893","DOI":"10.1016\/S0016-5085(24)04840-6","volume":"166","author":"AR Latorre-Rodr\u00edguez","year":"2024","unstructured":"Latorre-Rodr\u00edguez AR, Ravichandran R, Shacker M, Mohanakumar T, Bremner R, Mittal SK (2024) Prevalence of antibodies to self-antigens K-\u03b1-1 tubulin and collagen-V in patients undergoing antireflux surgery. Gastroenterology 166:S-1893","journal-title":"Gastroenterology"}],"container-title":["Surgical Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-024-11180-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00464-024-11180-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-024-11180-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T17:05:32Z","timestamp":1733245532000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00464-024-11180-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,12]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["11180"],"URL":"https:\/\/doi.org\/10.1007\/s00464-024-11180-4","relation":{},"ISSN":["0930-2794","1432-2218"],"issn-type":[{"value":"0930-2794","type":"print"},{"value":"1432-2218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,12]]},"assertion":[{"value":"15 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Andr\u00e9s R Latorre-Rodr\u00edguez, Sumeet K. Mittal, Ranjithkumar Ravichandran, Austin Reynolds, Andr\u00e9s Isaza-Restrepo, Jahanvi Mittal, Mary F. Hahn, Ross M. Bremner, and Thalachallour Mohanakumar have no conflicts of interest or financial ties to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}},{"value":"The abstract of this manuscript was presented as a podium presentation at the 2024 annual meeting of the Society of American Gastrointestinal and Endoscopic (SAGES), April 17th-20th, 2024. Cleveland, OH, USA.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Meeting Presentation"}}]}}