{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T09:57:43Z","timestamp":1790071063912,"version":"4.0.1"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100010552","name":"Departament de Salut, Generalitat de Catalunya","doi-asserted-by":"publisher","award":["PERIS 2022-2027 - (Code SLT033)"],"award-info":[{"award-number":["PERIS 2022-2027 - (Code SLT033)"]}],"id":[{"id":"10.13039\/501100010552","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005774","name":"Universitat de Barcelona","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005774","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Endosc"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Introduction<\/jats:title>\n            <jats:p>In major hepatobiliopancreatic surgery, an accurate preoperative planning is essential. Postoperative impaired blood supply due to arterial disease or variants can cause postoperative complications. Computational fluid dynamics has previously been successful in revealing distinct features of haemodynamic disturbances. The purpose of our study is to describe the feasibility of a computational fluid dynamics model to predict hepatic artery flow and its variations following gastroduodenal (GDA) or common hepatic (CHA) artery ligation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Material and methods<\/jats:title>\n            <jats:p>This is a pilot study including 20 patients undergoing robotic pancreaticoduodenectomy at a single centre. Preoperative images and intraoperative vascular flows were used to the computational model. Three scenarios of the hepatic artery were analysed: (1) without any clamps, (2) clamped GDA and (3) clamped CHA. Patients 1 to 15 were used to develop the model, and patients 15 to 20 were used for model validation. Finally, the model was tested in 3 abnormal cases: celiac trunk stenosis (2) and replaced right hepatic artery (1).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The selected methodology proved to be reproducible, with the CFD model demonstrating 100% accuracy in predicting blood flow redistribution after gastroduodenal artery (GDA) clamping and 80% accuracy following common hepatic artery (CHA) clamping. The model accurately simulated reversed GDA flow in cases of celiac trunk stenosis and displayed independent flow distribution in patients with anatomical variations, even without prior specific model training.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>The developed computational model accurately predicts flow variations in the proper hepatic artery in case of gastroduodenal\u00a0artery and common hepatic artery clamping. Further studies are needed to validate this methodology.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00464-025-11536-4","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T02:59:34Z","timestamp":1743735574000},"page":"3127-3136","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Computational fluid dynamics for vascular assessment in hepatobiliopancreatic surgery: a pilot study and future perspectives"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1810-6973","authenticated-orcid":false,"given":"Carolina","family":"Gonz\u00e1lez-Ab\u00f3s","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda","family":"Almirante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"V\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Ausania","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"11536_CR1","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1002\/jhbp.636","volume":"26","author":"GS Desai","year":"2019","unstructured":"Desai GS, Pande PM (2019) Gastroduodenal artery: single key for many locks. J Hepatobiliary Pancreat Sci 26:281\u2013291. https:\/\/doi.org\/10.1002\/jhbp.636","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"11536_CR2","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/0002-9610(66)90201-7","volume":"112","author":"NA Michels","year":"1966","unstructured":"Michels NA (1966) Newer anatomy of the liver and its variant blood supply and collateral circulation. Am J Surg 112:337\u2013347. https:\/\/doi.org\/10.1016\/0002-9610(66)90201-7","journal-title":"Am J Surg"},{"key":"11536_CR3","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1097\/SLA.0b013e3181930249","volume":"249","author":"S Gaujoux","year":"2009","unstructured":"Gaujoux S, Sauvanet A, Vullierme MP, Cortes A, Dokmak S, Sibert A, Vilgrain V, Belghiti J (2009) Ischemic complications after pancreaticoduodenectomy: incidence, prevention, and management. Ann Surg 249:111\u2013117. https:\/\/doi.org\/10.1097\/SLA.0b013e3181930249","journal-title":"Ann Surg"},{"key":"11536_CR4","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1002\/ca.23511","volume":"33","author":"A Gkaragkounis","year":"2020","unstructured":"Gkaragkounis A, Fanariotis M, Tepetes K, Fezoulidis I, Vassiou K (2020) Celiac trunk and hepatic arteries: anatomical variations of liver arterial supply as detected with multidetector computed tomography in 1520 patients and its clinical importance. Clin Anat 33:1091\u20131101. https:\/\/doi.org\/10.1002\/ca.23511","journal-title":"Clin Anat"},{"issue":"1","key":"11536_CR5","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s40792-022-01387-9","volume":"8","author":"L Schumacher","year":"2022","unstructured":"Schumacher L, Albrecht HC, Gretschel S (2022) A significant vascular variant in oncologic pancreaticoduodenectomy: the arc of Buhler. Surg Case Rep 8(1):37. https:\/\/doi.org\/10.1186\/s40792-022-01387-9","journal-title":"Surg Case Rep"},{"key":"11536_CR6","doi-asserted-by":"publisher","first-page":"e885","DOI":"10.1097\/SLA.0000000000005383","volume":"277","author":"M Al-Saeedi","year":"2023","unstructured":"Al-Saeedi M, Sauer HB, Ramouz A et al (2023) Celiac axis stenosis is an underestimated risk factor for increased morbidity after pancreatoduodenectomy. Ann Surg 277:e885\u2013e892. https:\/\/doi.org\/10.1097\/SLA.0000000000005383","journal-title":"Ann Surg"},{"key":"11536_CR7","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.jviscsurg.2020.10.005","volume":"158","author":"J Dembinski","year":"2021","unstructured":"Dembinski J, Robert B, Sevestre MA, Freyermuth M, Yzet T, Dokmak S, Regimbeau JM (2021) Celiac axis stenosis and digestive disease: diagnosis, consequences and management. J Visc Surg 158:133\u2013144. https:\/\/doi.org\/10.1016\/j.jviscsurg.2020.10.005","journal-title":"J Visc Surg"},{"key":"11536_CR8","doi-asserted-by":"publisher","first-page":"19886","DOI":"10.1038\/s41598-022-23864-9","volume":"12","author":"O Bane","year":"2022","unstructured":"Bane O, Stocker D, Kennedy P, Hectors SJ, Bollache E, Schnell S, Schiano T et al (2022) 4D flow MRI in abdominal vessels: prospective comparison of k-t accelerated free breathing acquisition to standard respiratory navigator gated acquisition. Sci Rep 12:19886. https:\/\/doi.org\/10.1038\/s41598-022-23864-9","journal-title":"Sci Rep"},{"key":"11536_CR9","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/j.jamcollsurg.2007.09.002","volume":"206","author":"GH Sakorafas","year":"2008","unstructured":"Sakorafas GH, Sarr MG, Peros G (2008) Celiac artery stenosis: an underappreciated and unpleasant surprise in patients undergoing pancreaticoduodenectomy. J Am Coll Surg 206:349\u2013356. https:\/\/doi.org\/10.1016\/j.jamcollsurg.2007.09.002","journal-title":"J Am Coll Surg"},{"key":"11536_CR10","first-page":"934","volume":"128","author":"A Dodek","year":"1983","unstructured":"Dodek A, Boone JA, Hooper RO, Kavanagh-Gray D, Macdonald IL, Peretz DI (1983) Complications of coronary arteriography. Can Med Assoc J 128:934\u2013936","journal-title":"Can Med Assoc J"},{"key":"11536_CR11","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/55166688","author":"JP O\u2019Connor","year":"2011","unstructured":"O\u2019Connor JP, Tofts PS, Miles KA, Parkes LM, Thompson G, Jackson A (2011) Dynamic contrast-enhanced imaging techniques: CT and MRI. Br J Radiol. https:\/\/doi.org\/10.1259\/bjr\/55166688","journal-title":"Br J Radiol"},{"key":"11536_CR12","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.medengphy.2017.06.029","volume":"47","author":"F Scardulla","year":"2017","unstructured":"Scardulla F, Bellavia D, D\u2019Acquisto L, Raffa GM, Pasta S (2017) Particle image velocimetry study of the celiac trunk hemodynamic induced by continuous-flow left ventricular assist device. Med Eng Phys 47:47\u201354. https:\/\/doi.org\/10.1016\/j.medengphy.2017.06.029","journal-title":"Med Eng Phys"},{"key":"11536_CR13","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1002\/cnm.2625","volume":"30","author":"JM Zhang","year":"2014","unstructured":"Zhang JM, Zhong L, Su B, Wan M, Yap JS, Tham JP, Chua LP, Ghista DN, Tan RS (2014) Perspective on CFD studies of coronary artery disease lesions and hemodynamics: a review. Int J Numer Methods Biomed Eng 30:659\u2013680. https:\/\/doi.org\/10.1002\/cnm.2625","journal-title":"Int J Numer Methods Biomed Eng"},{"key":"11536_CR14","doi-asserted-by":"publisher","first-page":"368504231180092","DOI":"10.1177\/00368504231180092","volume":"106","author":"S Akhtar","year":"2023","unstructured":"Akhtar S, Hussain Z, Nadeem S, Najjar IMR, Sadoun AM (2023) CFD analysis on blood flow inside a symmetric stenosed artery: physiology of a coronary artery disease. Sci Prog 106:368504231180092. https:\/\/doi.org\/10.1177\/00368504231180092","journal-title":"Sci Prog"},{"key":"11536_CR15","doi-asserted-by":"publisher","first-page":"64","DOI":"10.3390\/bioengineering7030064","volume":"7","author":"A Taebi","year":"2020","unstructured":"Taebi A, Pillai RM, Roudsari BS, Vu CT, Roncali E (2020) Computational modeling of the liver arterial blood flow for microsphere therapy: effect of boundary conditions. Bioengineering (Basel, Switzerland) 7:64. https:\/\/doi.org\/10.3390\/bioengineering7030064","journal-title":"Bioengineering (Basel, Switzerland)"},{"key":"11536_CR16","doi-asserted-by":"publisher","DOI":"10.1002\/mp.17184","author":"C Xie","year":"2024","unstructured":"Xie C, Sun S, Huang H, Li X, Qu W, Song H (2024) A hemodynamic study of the relationship between the left and right liver volumes and the blood flow distribution in portal vein branches. Med Phys. https:\/\/doi.org\/10.1002\/mp.17184","journal-title":"Med Phys"},{"key":"11536_CR17","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.jjcc.2022.05.007","volume":"80","author":"H Kamada","year":"2022","unstructured":"Kamada H, Nakamura M, Ota H, Higuchi S, Takase K (2022) Blood flow analysis with computational fluid dynamics and 4D-flow MRI for vascular diseases. J Cardiol 80:386\u2013396. https:\/\/doi.org\/10.1016\/j.jjcc.2022.05.007","journal-title":"J Cardiol"},{"issue":"2","key":"11536_CR18","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.pan.2020.12.019","volume":"21","author":"F Ausania","year":"2021","unstructured":"Ausania F, Mart\u00ednez-P\u00e9rez A, Senra Del Rio P, Borin A, Melendez R, Casal-Nu\u00f1ez JE (2021). Multifactorial mitigation strategy to reduce clinically relevant pancreatic fistula in high-risk pancreatojejunostomy following pancreaticoduodenectomy.\u00a0Pancreatol 21(2):466\u2013472. https:\/\/doi.org\/10.1016\/j.pan.2020.12.019","journal-title":"Off J Int Assoc Pancreat (IAP) ... [et al.]"},{"key":"11536_CR19","doi-asserted-by":"publisher","first-page":"1323","DOI":"10.1016\/j.mri.2012.05.001","volume":"30","author":"A Fedorov","year":"2012","unstructured":"Fedorov A, Beichel R, Kalpathy-Cramer J, Finet J, Fillion-Robin J-C, Pujol S, Bauer C, Jennings D, Fennessy FM, Sonka M, Buatti J, Aylward SR, Miller JV, Pieper S, Kikinis R (2012) 3D slicer as an image computing platform for the quantitative imaging network. Magn Reson Imag 30:1323\u20131341","journal-title":"Magn Reson Imag"},{"key":"11536_CR20","unstructured":"Cadence (n.d.) ANSA: the advanced CAE pre-processing software for complete model build up. https:\/\/www.beta-cae.com\/ansa.htm"},{"key":"11536_CR21","unstructured":"Luo S. Patient-specific modelling and simulation of blood flow in human arteries: from magnetic resonance imaging to computational fluid dynamics and flow visualization. PhD thesis, MA thesis. University of Pennsylvania, 2019."},{"key":"11536_CR22","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.jocs.2015.12.007","volume":"14","author":"M V\u00e1zquez","year":"2016","unstructured":"V\u00e1zquez M, Houzeaux G, Koric S, Artigues A, Aguado-Sierra J, Aris R et al (2016) Alya: towards exascale for engineering simulation codes. J Comput Sci 14:15\u201327. https:\/\/doi.org\/10.1016\/j.jocs.2015.12.007","journal-title":"J Comput Sci"},{"key":"11536_CR23","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.jacc.2018.10.056","volume":"73","author":"RS Driessen","year":"2019","unstructured":"Driessen RS, Danad I, Stuijfzand WJ, Raijmakers PG, Schumacher SP, van Diemen PA, Leipsic JA, Knuuti J, Underwood SR, van de Ven PM, van Rossum AC, Taylor CA, Knaapen P (2019) Comparison of coronary computed tomography angiography, fractional flow reserve, and perfusion imaging for ischemia diagnosis. J Am Coll Cardiol 73:161\u2013173. https:\/\/doi.org\/10.1016\/j.jacc.2018.10.056","journal-title":"J Am Coll Cardiol"},{"key":"11536_CR24","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1007\/s00270-021-02956-5","volume":"45","author":"J Aramburu","year":"2022","unstructured":"Aramburu J, Ant\u00f3n R, Rodr\u00edguez-Fraile M, Sangro B, Bilbao JI (2022) Computational fluid dynamics modeling of liver radioembolization: a review. Cardiovasc Intervent Radiol 45:12\u201320. https:\/\/doi.org\/10.1007\/s00270-021-02956-5","journal-title":"Cardiovasc Intervent Radiol"},{"key":"11536_CR25","doi-asserted-by":"publisher","first-page":"106725","DOI":"10.1016\/j.compbiomed.2023.106725","volume":"157","author":"H Song","year":"2023","unstructured":"Song H, Li X, Huang H, Xie C, Qu W (2023) Postoperative virtual pressure difference as a new index for the risk assessment of liver resection from biomechanical analysis. Comput Biol Med 157:106725. https:\/\/doi.org\/10.1016\/j.compbiomed.2023.106725","journal-title":"Comput Biol Med"},{"key":"11536_CR26","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.29271\/jcpsp.2023.12.1439","volume":"33","author":"C Ceylan","year":"2023","unstructured":"Ceylan C, Kocaaslan H, Baran NT, Kulus M, Saglam K, Aydin C (2023) Predictive factors of postoperative pancreatic fistula in geriatric patients undergoing pancreatoduodenectomy for periampullary malignancy. J Coll Physicians Surg Pak 33:1439\u20131444. https:\/\/doi.org\/10.29271\/jcpsp.2023.12.1439","journal-title":"J Coll Physicians Surg Pak"},{"issue":"6","key":"11536_CR27","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1002\/lt.20380","volume":"11","author":"T Aoki","year":"2005","unstructured":"Aoki T, Imamura H, Kaneko J, Sakamoto Y, Matsuyama Y, Kokudo N, Sugawara Y, Makuuchi M (2005) Intraoperative direct measurement of hepatic arterial buffer response in patients with or without cirrhosis. Liver Transplant 11(6):684\u2013691. https:\/\/doi.org\/10.1002\/lt.20380","journal-title":"Liver Transplant"}],"container-title":["Surgical Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-025-11536-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00464-025-11536-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-025-11536-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T17:32:12Z","timestamp":1745947932000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00464-025-11536-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,1]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["11536"],"URL":"https:\/\/doi.org\/10.1007\/s00464-025-11536-4","relation":{},"ISSN":["0930-2794","1432-2218"],"issn-type":[{"value":"0930-2794","type":"print"},{"value":"1432-2218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,1]]},"assertion":[{"value":"8 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Dr. Fabio Ausania declares financial support was provided by Government of Catalonia Catalan Health Service. Dr. Carolina Gonz\u00e1lez-Ab\u00f3s, Roberto Molina, Sofia Almirante and Mariano V\u00e1zquez have no conflicts of interest or financial ties to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}},{"value":"Committee ethical approval of the centre\u00a0was obtained on the 08th of June of 2023, with the study code HCB\/2023\/0531.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval and consent to participate"}}]}}