{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:45:20Z","timestamp":1783532720540,"version":"3.55.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Central Region of Denmark"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Endosc"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Antireflux surgery (ARS) has been found to be an effective treatment of gastro-esophageal reflux disease (GERD); however, the long-term effects are uncertain. This study aimed to evaluate the long-term efficacy of ARS on quality of life, symptom severity, and use of proton pump inhibitors (PPIs).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A validated GERD Health-Related Quality of Life (GERD-HRQL) Questionnaire was sent to 419 patients who underwent ARS at Aarhus University Hospital from January 2012 to April 2020. Patient records were reviewed retrospectively. The Danish National Prescription Registry was used to collect data on the use of PPIs before and after ARS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A response rate of 71% resulted in a total of 164 patients included in the study with a median follow-up time of 4.8\u00a0years (interquartile range: 2.5\u20136.7). The total GERD-HRQL median score at follow-up was 11.5 (IQR: 4\u201322). The proportion of patients experiencing daily symptoms of heartburn and regurgitation was significantly reduced pre- to postoperatively from 90 to 70% to 32% and 29%, respectively. Five years after surgery, 47% of patients had completely ceased PPI usage, while 44% were long-term users.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>A lasting long-term effect of ARS on GERD symptoms was found, although almost a third of patients still experience heartburn and\/or regurgitation daily. Almost half of patients were not taking PPIs 5\u00a0years after ARS, but 44% became long-term users. Patients should be made aware that long-term PPI therapy often is necessary following ARS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Graphical Abstract<\/jats:title>\n          <\/jats:sec>","DOI":"10.1007\/s00464-025-11608-5","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T18:30:27Z","timestamp":1739903427000},"page":"2354-2363","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long-term efficacy and quality of life after antireflux surgery"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-1428-9380","authenticated-orcid":false,"given":"Philip K.","family":"Bang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naja H.","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Hvid-Jensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels Christian","family":"Bjerregaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.","family":"Kjaer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,2,18]]},"reference":[{"key":"11608_CR1","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1111\/j.1572-0241.2006.00630.x","volume":"101","author":"N Vakil","year":"2006","unstructured":"Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R, Global Consensus G (2006) The montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 101:1900\u20131920","journal-title":"Am J Gastroenterol"},{"key":"11608_CR2","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1056\/NEJMoa1103042","volume":"365","author":"F Hvid-Jensen","year":"2011","unstructured":"Hvid-Jensen F, Pedersen L, Drewes AM, S\u00f8rensen HT, Funch-Jensen P (2011) Incidence of adenocarcinoma among patients with Barrett\u2019s esophagus. N Engl J Med 365:1375\u20131383","journal-title":"N Engl J Med"},{"key":"11608_CR3","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1136\/gutjnl-2012-304269","volume":"63","author":"HB El-Serag","year":"2014","unstructured":"El-Serag HB, Sweet S, Winchester CC, Dent J (2014) Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut 63:871\u2013880","journal-title":"Gut"},{"key":"11608_CR4","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1038\/ajg.2009.391","volume":"104","author":"JM Hansen","year":"2009","unstructured":"Hansen JM, Wildner-Christensen M, Schaffalitzky de Muckadell OB (2009) Gastroesophageal reflux symptoms in a danish population: a prospective follow-up analysis of symptoms, quality of life, and health-care use. Am J Gastroenterol 104:2394\u20132403","journal-title":"Am J Gastroenterol"},{"key":"11608_CR5","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/j.1365-2036.2008.03671.x","volume":"27","author":"P Wahlqvist","year":"2008","unstructured":"Wahlqvist P, Karlsson M, Johnson D, Carlsson J, Bolge SC, Wallander MA (2008) Relationship between symptom load of gastro-oesophageal reflux disease and health-related quality of life, work productivity, resource utilization and concomitant diseases: survey of a US cohort. Aliment Pharmacol Ther 27:960\u2013970","journal-title":"Aliment Pharmacol Ther"},{"key":"11608_CR6","doi-asserted-by":"crossref","first-page":"7","DOI":"10.5009\/gnl16615","volume":"12","author":"DS Sandhu","year":"2018","unstructured":"Sandhu DS, Fass R (2018) Current trends in the management of gastroesophageal reflux disease. Gut Liver 12:7\u201316","journal-title":"Gut Liver"},{"key":"11608_CR7","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1572-0241.2002.05532.x","volume":"97","author":"DO Castell","year":"2002","unstructured":"Castell DO, Kahrilas PJ, Richter JE, Vakil NB, Johnson DA, Zuckerman S, Skammer W, Levine JG (2002) Esomeprazole (40 mg) compared with lansoprazole (30 mg) in the treatment of erosive esophagitis. Am J Gastroenterol 97:575\u2013583","journal-title":"Am J Gastroenterol"},{"key":"11608_CR8","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S1091-255X(99)80071-7","volume":"3","author":"GM Campos","year":"1999","unstructured":"Campos GM, Peters JH, DeMeester TR, Oberg S, Crookes PF, Tan S, DeMeester SR, Hagen JA, Bremner CG (1999) Multivariate analysis of factors predicting outcome after laparoscopic nissen fundoplication. J Gastrointest Surg 3:292\u2013300","journal-title":"J Gastrointest Surg"},{"key":"11608_CR9","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1007\/s00464-014-3431-z","volume":"28","author":"KH Fuchs","year":"2014","unstructured":"Fuchs KH, Babic B, Breithaupt W, Dallemagne B, Fingerhut A, Furnee E, Granderath F, Horvath P, Kardos P, Pointner R, Savarino E, Van Herwaarden-Lindeboom M, Zaninotto G (2014) EAES recommendations for the management of gastroesophageal reflux disease. Surg Endosc 28:1753\u20131773","journal-title":"Surg Endosc"},{"key":"11608_CR10","doi-asserted-by":"crossref","unstructured":"Garg SK, Gurusamy KS (2015) Laparoscopic fundoplication surgery versus medical management for gastro-oesophageal reflux disease (GORD) in adults. Cochrane Database Syst Rev:Cd003243","DOI":"10.1002\/14651858.CD003243.pub3"},{"key":"11608_CR11","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1007\/s00464-021-08358-5","volume":"35","author":"SK McKinley","year":"2021","unstructured":"McKinley SK, Dirks RC, Walsh D, Hollands C, Arthur LE, Rodriguez N, Jhang J, Abou-Setta A, Pryor A, Stefanidis D, Slater BJ (2021) Surgical treatment of GERD: systematic review and meta-analysis. Surg Endosc 35:4095\u20134123","journal-title":"Surg Endosc"},{"key":"11608_CR12","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.3109\/00365521.2013.834378","volume":"48","author":"S Van Meer","year":"2013","unstructured":"Van Meer S, Bogte A, Siersema PD (2013) Long-term follow up in patients with gastroesophageal reflux disease with specific emphasis on reflux symptoms, use of anti-reflux medication and anti-reflux surgery outcome: a retrospective study. Scand J Gastroenterol 48:1242\u20131248","journal-title":"Scand J Gastroenterol"},{"key":"11608_CR13","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/ans.13358","volume":"87","author":"AG Robertson","year":"2017","unstructured":"Robertson AG, Patel RN, Couper GW, de Beaux AC, Paterson-Brown S, Lamb PJ (2017) Long-term outcomes following laparoscopic anterior and Nissen fundoplication. ANZ J Surg 87:300\u2013304","journal-title":"ANZ J Surg"},{"key":"11608_CR14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/00015458.2020.1860551","volume":"122","author":"B Pascotto","year":"2022","unstructured":"Pascotto B, Henrard A, Maillart JF, Arenas-Sanchez M, Postal A, Legrand M (2022) Quality of life and gastric acid-suppression medication post-laparoscopic fundoplication: a ten years retrospective study. Acta Chir Belg 122:321\u2013327","journal-title":"Acta Chir Belg"},{"key":"11608_CR15","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/ans.15471","volume":"90","author":"M Campanello","year":"2020","unstructured":"Campanello M, Westin E, Unosson J, Lindskog S (2020) Quality of life and gastric acid-suppression medication 20 years after laparoscopic fundoplication. ANZ J Surg 90:76\u201380","journal-title":"ANZ J Surg"},{"key":"11608_CR16","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doab032","author":"KH Fuchs","year":"2022","unstructured":"Fuchs KH, Breithaupt W, Varga G, Babic B, Schulz T, Meining A (2022) Primary laparoscopic fundoplication in selected patients with gastroesophageal reflux disease. Dis Esophagus. https:\/\/doi.org\/10.1093\/dote\/doab032","journal-title":"Dis Esophagus"},{"key":"11608_CR17","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1007\/s00464-014-4012-x","volume":"29","author":"B Robinson","year":"2015","unstructured":"Robinson B, Dunst CM, Cassera MA, Reavis KM, Sharata A, Swanstrom LL (2015) 20 years later: laparoscopic fundoplication durability. Surg Endosc 29:2520\u20132524","journal-title":"Surg Endosc"},{"key":"11608_CR18","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.jamcollsurg.2007.05.024","volume":"205","author":"JJ Kelly","year":"2007","unstructured":"Kelly JJ, Watson DI, Chin KF, Devitt PG, Game PA, Jamieson GG (2007) Laparoscopic nissen fundoplication: clinical outcomes at 10 years. J Am Coll Surg 205:570\u2013575","journal-title":"J Am Coll Surg"},{"key":"11608_CR19","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1007\/s00464-018-6396-5","volume":"33","author":"M Nikolic","year":"2019","unstructured":"Nikolic M, Schwameis K, Semmler G, Asari R, Semmler L, Steindl A, Mosleh BO, Schoppmann SF (2019) Persistent dysphagia is a rare problem after laparoscopic nissen fundoplication. Surg Endosc 33:1196\u20131205","journal-title":"Surg Endosc"},{"key":"11608_CR20","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1136\/gutjnl-2013-306532","volume":"63","author":"A Lodrup","year":"2014","unstructured":"Lodrup A, Pottegard A, Hallas J, Bytzer P (2014) Use of proton pump inhibitors after antireflux surgery: a nationwide register-based follow-up study. Gut 63:1544\u20131549","journal-title":"Gut"},{"key":"11608_CR21","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1442-2050.2007.00658.x","volume":"20","author":"V Velanovich","year":"2007","unstructured":"Velanovich V (2007) The development of the GERD-HRQL symptom severity instrument. Dis Esophagus 20:130\u2013134","journal-title":"Dis Esophagus"},{"key":"11608_CR22","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1001\/archsurg.143.5.482","volume":"143","author":"DW Gee","year":"2008","unstructured":"Gee DW, Andreoli MT, Rattner DW (2008) Measuring the effectiveness of laparoscopic antireflux surgery: long-term results. Arch Surg 143:482\u2013487","journal-title":"Arch Surg"},{"key":"11608_CR23","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ijsu.2017.08.580","volume":"46","author":"D Prassas","year":"2017","unstructured":"Prassas D, Krieg A, Rolfs TM, Schumacher FJ (2017) Long-term outcome of laparoscopic nissen fundoplication in a regional hospital setting. Int J Surg 46:75\u201378","journal-title":"Int J Surg"},{"key":"11608_CR24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00464-005-0174-x","volume":"20","author":"B Dallemagne","year":"2006","unstructured":"Dallemagne B, Weerts J, Markiewicz S, Dewandre JM, Wahlen C, Monami B, Jehaes C (2006) Clinical results of laparoscopic fundoplication at ten years after surgery. Surg Endosc 20:159\u2013165","journal-title":"Surg Endosc"},{"key":"11608_CR25","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1001\/jama.2011.626","volume":"305","author":"JP Galmiche","year":"2011","unstructured":"Galmiche JP, Hatlebakk J, Attwood S, Ell C, Fiocca R, Eklund S, L\u00e5ngstr\u00f6m G, Lind T, Lundell L (2011) Laparoscopic antireflux surgery vs esomeprazole treatment for chronic GERD: the Lotus randomized clinical trial. JAMA 305:1969\u20131977","journal-title":"JAMA"},{"key":"11608_CR26","doi-asserted-by":"crossref","first-page":"f1908","DOI":"10.1136\/bmj.f1908","volume":"346","author":"AM Grant","year":"2013","unstructured":"Grant AM, Cotton SC, Boachie C, Ramsay CR, Krukowski ZH, Heading RC, Campbell MK (2013) Minimal access surgery compared with medical management for gastro-oesophageal reflux disease: five year follow-up of a randomised controlled trial (REFLUX). BMJ 346:f1908","journal-title":"BMJ"},{"key":"11608_CR27","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1001\/jama.2017.10981","volume":"318","author":"J Maret-Ouda","year":"2017","unstructured":"Maret-Ouda J, Wahlin K, El-Serag HB, Lagergren J (2017) Association between laparoscopic antireflux surgery and recurrence of gastroesophageal reflux. JAMA 318:939\u2013946","journal-title":"JAMA"},{"key":"11608_CR28","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1001\/archsurg.137.9.1008","volume":"137","author":"YS Khajanchee","year":"2002","unstructured":"Khajanchee YS, O\u2019Rourke RW, Lockhart B, Patterson EJ, Hansen PD, Swanstrom LL (2002) Postoperative symptoms and failure after antireflux surgery. Arch Surg 137:1008\u20131014","journal-title":"Arch Surg"},{"key":"11608_CR29","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1002\/bjs.11672","volume":"107","author":"JS Ljungdalh","year":"2020","unstructured":"Ljungdalh JS, Rubin KH, Durup J, Houlind KC (2020) Reoperation after antireflux surgery: a population-based cohort study. Br J Surg 107:1633\u20131639","journal-title":"Br J Surg"},{"key":"11608_CR30","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s00464-014-3660-1","volume":"29","author":"T Zhou","year":"2015","unstructured":"Zhou T, Harnsberger C, Broderick R, Fuchs H, Talamini M, Jacobsen G, Horgan S, Chang D, Sandler B (2015) Reoperation rates after laparoscopic fundoplication. Surg Endosc 29:510\u2013514","journal-title":"Surg Endosc"},{"key":"11608_CR31","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00464-007-9705-y","volume":"22","author":"P Funch-Jensen","year":"2008","unstructured":"Funch-Jensen P, Bendixen A, Iversen MG, Kehlet H (2008) Complications and frequency of redo antireflux surgery in Denmark: a nationwide study, 1997\u20132005. Surg Endosc 22:627\u2013630","journal-title":"Surg Endosc"},{"key":"11608_CR32","doi-asserted-by":"crossref","unstructured":"Ljungdalh JS, Rubin KH, Durup J, Houlind KC (2020) Trends of anti-reflux surgery in Denmark 2000\u20132017: a nationwide registry-based cohort study. Surg Endosc","DOI":"10.1007\/s00464-020-07845-5"},{"key":"11608_CR33","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1056\/NEJMoa1811424","volume":"381","author":"SJ Spechler","year":"2019","unstructured":"Spechler SJ, Hunter JG, Jones KM, Lee R, Smith BR, Mashimo H, Sanchez VM, Dunbar KB, Pham TH, Murthy UK, Kim T, Jackson CS, Wallen JM, von Rosenvinge EC, Pearl JP, Laine L, Kim AW, Kaz AM, Tatum RP, Gellad ZF, Lagoo-Deenadayalan S, Rubenstein JH, Ghaferi AA, Lo WK, Fernando RS, Chan BS, Paski SC, Provenzale D, Castell DO, Lieberman D, Souza RF, Chey WD, Warren SR, Davis-Karim A, Melton SD, Genta RM, Serpi T, Biswas K, Huang GD (2019) Randomized trial of medical versus surgical treatment for refractory heartburn. N Engl J Med 381:1513\u20131523","journal-title":"N Engl J Med"},{"key":"11608_CR34","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1001\/jamasurg.2014.3859","volume":"150","author":"MG Patti","year":"2015","unstructured":"Patti MG, Allaix ME, Fisichella PM (2015) Analysis of the causes of failed antireflux surgery and the principles of treatment: a review. JAMA Surg 150:585\u2013590","journal-title":"JAMA Surg"}],"container-title":["Surgical Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-025-11608-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00464-025-11608-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-025-11608-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T03:41:49Z","timestamp":1743046909000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00464-025-11608-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,18]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["11608"],"URL":"https:\/\/doi.org\/10.1007\/s00464-025-11608-5","relation":{},"ISSN":["0930-2794","1432-2218"],"issn-type":[{"value":"0930-2794","type":"print"},{"value":"1432-2218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,18]]},"assertion":[{"value":"25 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 February 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Dr. Philip Kragsig Bang, Dr. Naja Helt Andersen, Dr. Frederik Hvid-Jensen, Dr. Niels Chrstian Bjerregaard, and Dr. Daniel Willy Kjaer have no conflicts of interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}