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However, long-term outcomes regarding clinical efficacy, patient satisfaction, and the prevalence of post-POEM gastro-esophageal reflux disease (GERD) remains elusive and thus require further investigation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This retrospective cohort study followed 63 patients treated for achalasia with POEM. Clinical success (Eckardt-score\u2009\u2264\u20093, and no subsequent treatments), GERD prevalence (GerdQ-score\u2009\u2265\u20098), and patient satisfaction were assessed via medical record reviews and telephone interviews. Statistical analyses identified risk factors for treatment failure, lower levels of satisfaction, and GERD.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>At a median follow-up of 10\u00a0years, clinical success was 74%. The average Eckardt-score improved from 7,6 pre-POEM to 2,16 (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). The majority of treatment failures occurred within three months post-POEM, with no new failures after 5\u00a0years. GERD symptoms were reported by 33% of patients. Patient satisfaction was high with 91% reporting to be satisfied or very satisfied. Treatment-na\u00efve patients had higher success rates (85%) compared to those with prior Heller\u2019s myotomy (40%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). No other risk factors for clinical failure were found. RePOEM showed superior outcomes for salvage treatment compared to balloon dilation, botulinum toxin injections, and Heller\u2019s myotomy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>POEM has a good and lasting efficacy at a median follow-up of 10\u00a0years. Clinical failure was not observed beyond 5\u00a0years post-POEM. The majority of patients were satisfied with POEM at follow-up. Symptomatic GERD was a highly experienced side effect at follow-up, however, not associated with lower levels of satisfaction.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00464-025-11832-z","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T13:16:35Z","timestamp":1750079795000},"page":"4806-4814","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Peroral endoscopic myotomy: a Danish single center 10-year follow-up study"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0030-5605","authenticated-orcid":false,"given":"Martin H.","family":"Pedersen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels Christian","family":"Bjerregaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederik","family":"Hvid-Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel W.","family":"Kjaer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,6,16]]},"reference":[{"key":"11832_CR1","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1750-1172-2-38","volume":"2","author":"F Farrokhi","year":"2007","unstructured":"Farrokhi F, Vaezi MF (2007) Idiopathic (primary) achalasia. 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