{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:29:20Z","timestamp":1789421360125,"version":"build-2803163510"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Endosc"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The implementation of minimally invasive liver surgery (MILS) for perihilar (PHC) and intrahepatic cholangiocarcinoma (IHC) remains limited and a systematic review including only comparative studies of MILS versus the open approach is lacking. This systematic review and meta-analysis aimed to assess the safety and efficacy of minimally invasive surgery in patients with hilar and intrahepatic cholangiocarcinomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Systematic review in the PubMed, Embase, and Cochrane databases for original studies comparing at least five patients undergoing MILS with open liver surgery for PHC and IHC. Meta-analysis included the primary outcomes of morbidity and mortality. Secondary outcomes included post-operative outcomes, recurrence, disease-free survival, and resection margins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Overall, 37 comparative non-randomised studies with 4863 patients were included, of which 24% PHC and 76% IHC. In 21 studies, propensity score matching was performed. In total, 2106 laparoscopic, 75 robotic, and 2662 open procedures were analysed. The conversion rate was median 11.5% [IQR 10.0\u201312.5]. MILS probably resulted in reduced rates of major morbidity, 13.3% vs 18.8% (OR 0.75, 95%CI 0.62\u20130.90), mortality, 3.0% vs 4.5% (OR 0.69, 95%CI 0.49\u20130.97), and shorter hospital stay, 8.0 vs 10.9\u00a0days (MD -2.1, 95%CI -2.8 \u2013 -1.5). MILS resulted in higher rate of R0 resections in PSM cohort, 90.4% vs 81.4%, (OR 1.40, 95%CI 1.13\u20131.74) and better 3-year disease-free survival rate (49.9% vs 38.5%, HR\n                      <jats:sub>3-year<\/jats:sub>\n                      3.2, 95%CI 3.1\u20133.3). In the subgroup of 1180 patients in whom a hepatico-jejunostomy was performed (498 laparoscopic, 65 robotic, 617 open) MILS remained associated with reduced major morbidity, 20.9% vs 27.6% (OR 0.88, 95%CI 0.64\u20131.21) and resulted in better mortality, 4.2% vs 4.9% (OR 0.51, 95%CI 0.30\u20130.86), as compared to the open approach. Overall, the rate of biliary leakage was likely similar, 10.6% versus 11.7% (OR 0.83, 95%CI 0.52\u20130.77).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This systematic review of non-randomised comparative studies suggests that MILS for PHC and IHC may result in a similar safety profile with benefits in patient recovery and oncological outcomes as compared to OLS. Prospective comparative studies, especially including robotic MILS, are warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00464-025-11900-4","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T19:10:01Z","timestamp":1757531401000},"page":"7141-7159","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Minimally invasive liver surgery for perihilar and intrahepatic cholangiocarcinoma: systematic review and meta-analysis of comparative studies"],"prefix":"10.1007","volume":"39","author":[{"given":"Joey","family":"de Hondt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurice J. W.","family":"Zwart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bas A.","family":"Uijterwijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George L.","family":"Burchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burak","family":"G\u00f6rge\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babs","family":"Zonderhuis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"Kazemier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris","family":"Erdmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc G.","family":"Besselink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rutger-Jan","family":"Swijnenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"11900_CR1","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1097\/00000658-199201000-00005","volume":"215","author":"H Bismuth","year":"1992","unstructured":"Bismuth H, Nakache R, Diamond T (1992) Management strategies in resection for hilar cholangiocarcinoma. Ann Surg 215:31\u201338. https:\/\/doi.org\/10.1097\/00000658-199201000-00005","journal-title":"Ann Surg"},{"issue":"6","key":"11900_CR2","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1245\/s10434-010-0985-4","volume":"17","author":"SB Edge","year":"2010","unstructured":"Edge SB, Compton CC (2010) The American joint committee on cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 17(6):1471\u20131474","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"11900_CR3","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/j.hpb.2015.11.00","volume":"18","author":"PB Olthof","year":"2016","unstructured":"Olthof PB, Coelen RJ, Wiggers JK, Besselink MG, Busch OR, van Gulik TM (2016) External biliary drainage following major liver resection for perihilar cholangiocarcinoma: impact on development of liver failure and biliary leakage. HPB 18(4):348\u2013353. https:\/\/doi.org\/10.1016\/j.hpb.2015.11.00","journal-title":"HPB"},{"key":"11900_CR4","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1186\/s12885-020-07357-4","volume":"20","author":"J Zhao","year":"2020","unstructured":"Zhao J et al (2020) Survival analysis of patients with stage T2a and T2b perihilar cholangiocarcinoma treated with radical resection. BMC Cancer 20:849. https:\/\/doi.org\/10.1186\/s12885-020-07357-4","journal-title":"BMC Cancer"},{"key":"11900_CR5","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1007\/s00423-015-1320-0","volume":"400","author":"S Andrianello","year":"2015","unstructured":"Andrianello S et al (2015) Pancreaticoduodenectomy for distal cholangiocarcinoma: surgical results, prognostic factors, and long-term follow-up. Langenbecks Arch Surg 400:623\u2013628. https:\/\/doi.org\/10.1007\/s00423-015-1320-0","journal-title":"Langenbecks Arch Surg"},{"key":"11900_CR6","first-page":"1892","volume":"60","author":"X Tan","year":"2013","unstructured":"Tan X et al (2013) Prognostic factors of distal cholangiocarcinoma after curative surgery: a series of 84 cases. Hepatogastroenterology 60:1892\u20131895","journal-title":"Hepatogastroenterology"},{"key":"11900_CR7","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1007\/s11605-011-1414-0","volume":"15","author":"JM Regimbeau","year":"2011","unstructured":"Regimbeau JM et al (2011) Surgery for hilar cholangiocarcinoma: a multi-institutional update on practice and outcome by the AFC-HC study group. J Gastrointest Surg 15:480\u2013488","journal-title":"J Gastrointest Surg"},{"key":"11900_CR8","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1007\/s00423-014-1210-x","volume":"399","author":"I Popescu","year":"2014","unstructured":"Popescu I, Dumitrascu T (2014) Curative-intent surgery for hilar cholangiocarcinoma: prognostic factors for clinical decision making. Langenbecks Arch Surg 399:693\u2013705. https:\/\/doi.org\/10.1007\/s00423-014-1210-x","journal-title":"Langenbecks Arch Surg"},{"key":"11900_CR9","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1097\/SLA.0b013e3182708b57","volume":"258","author":"M Nagino","year":"2013","unstructured":"Nagino M et al (2013) Evolution of surgical treatment for perihilar cholangiocarcinoma: a single-center 34-year review of 574 consecutive resections. Ann Surg 258:129\u2013140. https:\/\/doi.org\/10.1097\/SLA.0b013e3182708b57","journal-title":"Ann Surg"},{"key":"11900_CR10","doi-asserted-by":"publisher","unstructured":"Ciria R, Cherqui D, Geller DA, Briceno J, Wakabayashi G (2016) Comparative short-term benefits of laparoscopic liver resection: 9000 cases and climbing. Ann Surg 263:761\u2013777. https:\/\/doi.org\/10.1097\/SLA.0000000000001413","DOI":"10.1097\/SLA.0000000000001413"},{"key":"11900_CR11","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1097\/SLA.0b013e3181b0c4df","volume":"250","author":"KT Nguyen","year":"2009","unstructured":"Nguyen KT, Gamblin TC, Geller DA (2009) World review of laparoscopic liver resection-2804 patients. Ann Surg 250:831\u2013841. https:\/\/doi.org\/10.1097\/SLA.0b013e3181b0c4df","journal-title":"Ann Surg"},{"key":"11900_CR12","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1007\/s11701-019-00964-9","volume":"13","author":"LC Franken","year":"2019","unstructured":"Franken LC et al (2019) Minimally invasive surgery for perihilar cholangiocarcinoma: a systematic review. J Robot Surg 13:717\u2013727. https:\/\/doi.org\/10.1007\/s11701-019-00964-9","journal-title":"J Robot Surg"},{"key":"11900_CR13","doi-asserted-by":"publisher","first-page":"34","DOI":"10.17235\/reed.2019.6343\/2019","volume":"112","author":"D Lin","year":"2020","unstructured":"Lin D et al (2020) Laparoscopic versus open pancreatoduodenectomy: a meta-analysis of randomized controlled trials. Rev Esp Enferm Dig 112:34\u201340. https:\/\/doi.org\/10.17235\/reed.2019.6343\/2019","journal-title":"Rev Esp Enferm Dig"},{"key":"11900_CR14","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1097\/SLA.0000000000003309","volume":"271","author":"F Nickel","year":"2020","unstructured":"Nickel F et al (2020) Laparoscopic versus open pancreaticoduodenectomy: a systematic review and meta-analysis of randomized controlled trials. Ann Surg 271:54\u201366. https:\/\/doi.org\/10.1097\/SLA.0000000000003309","journal-title":"Ann Surg"},{"key":"11900_CR15","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1007\/s13304-020-00916-1","volume":"73","author":"A Aiolfi","year":"2021","unstructured":"Aiolfi A, Lombardo F, Bonitta G, Danelli P, Bona D (2021) Systematic review and updated network meta-analysis comparing open, laparoscopic, and robotic pancreaticoduodenectomy. Updates Surg 73:909\u2013922. https:\/\/doi.org\/10.1007\/s13304-020-00916-1","journal-title":"Updates Surg"},{"key":"11900_CR16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1002\/jhbp.662","volume":"27","author":"F Cipriani","year":"2020","unstructured":"Cipriani F et al (2020) Pure laparoscopic versus open hemihepatectomy: a critical assessment and realistic expectations - a propensity score-based analysis of right and left hemihepatectomies from nine European tertiary referral centers. J Hepatobiliary Pancreat Sci 27:3\u201315. https:\/\/doi.org\/10.1002\/jhbp.662","journal-title":"J Hepatobiliary Pancreat Sci"},{"key":"11900_CR17","doi-asserted-by":"publisher","first-page":"e0248534","DOI":"10.1371\/journal.pone.0248534","volume":"16","author":"W Tang","year":"2021","unstructured":"Tang W et al (2021) Minimally invasive versus open radical resection surgery for hilar cholangiocarcinoma: comparable outcomes associated with advantages of minimal invasiveness. PLoS ONE 16:e0248534","journal-title":"PLoS ONE"},{"key":"11900_CR18","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1007\/s13304-021-01006-6","volume":"73","author":"F Cipriani","year":"2021","unstructured":"Cipriani F, Ratti F, Fiorentini G, Reineke R, Aldrighetti L (2021) Systematic review of perioperative and oncologic outcomes of minimally-invasive surgery for hilar cholangiocarcinoma. Updates Surg 73:359\u2013377","journal-title":"Updates Surg"},{"key":"11900_CR19","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s13304-020-00930-3","volume":"73","author":"N Machairas","year":"2021","unstructured":"Machairas N et al (2021) Meta-analysis of laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma. Updates Surg 73:59\u201368","journal-title":"Updates Surg"},{"key":"11900_CR20","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1007\/s11605-020-04639-x","volume":"24","author":"AA Rahnemai-Azar","year":"2020","unstructured":"Rahnemai-Azar AA, Abbasi A, Tsilimigras DI, Weber SM, Pawlik TM (2020) Current advances in minimally invasive surgical management of perihilar cholangiocarcinoma. J Gastrointest Surg 24:2143\u20132149. https:\/\/doi.org\/10.1007\/s11605-020-04639-x","journal-title":"J Gastrointest Surg"},{"key":"11900_CR21","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1111\/ans.15948","volume":"91","author":"W Wang","year":"2021","unstructured":"Wang W et al (2021) Laparoscopic surgery and robotic surgery for hilar cholangiocarcinoma: an updated systematic review. ANZ J Surg 91:42\u201348. https:\/\/doi.org\/10.1111\/ans.15948","journal-title":"ANZ J Surg"},{"key":"11900_CR22","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1007\/s00423-020-01877-0","volume":"405","author":"GP Guerrini","year":"2020","unstructured":"Guerrini GP et al (2020) Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: the first meta-analysis. Langenbecks Arch Surg 405:265\u2013275. https:\/\/doi.org\/10.1007\/s00423-020-01877-0","journal-title":"Langenbecks Arch Surg"},{"key":"11900_CR23","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1002\/jso.25821","volume":"121","author":"DK Shiraiwa","year":"2020","unstructured":"Shiraiwa DK et al (2020) The role of minimally invasive hepatectomy for hilar and intrahepatic cholangiocarcinoma: a systematic review of the literature. J Surg Oncol 121:863\u2013872. https:\/\/doi.org\/10.1002\/jso.25821","journal-title":"J Surg Oncol"},{"key":"11900_CR24","doi-asserted-by":"publisher","DOI":"10.1007\/s11701-024-01966-y","author":"J Wu","year":"2024","unstructured":"Wu J, Wang L, Yu F, Wang L, Leng Z (2024) Robotic-assisted radical resection versus open surgery for cholangiocarcinoma: a systematic review and meta-analysis. J Robotic Surg. https:\/\/doi.org\/10.1007\/s11701-024-01966-y","journal-title":"J Robotic Surg"},{"issue":"4","key":"11900_CR25","doi-asserted-by":"publisher","first-page":"e59404","DOI":"10.7759\/cureus.59404","volume":"16","author":"S Domene","year":"2024","unstructured":"Domene S, Quiroz Flores M, Fulginiti D, Thomas Garcia KD, Abera Woldehana N, Nunez Jimenez KM, Lagos Herrarte VM, Guevara Benavides JA, Alegr\u00eda Perdomo CR, Estrella-Gaibor C, Arruarana VS, Martinez RM (2024) Comparative outcomes of minimally invasive versus open pancreatoduodenectomy in distal cholangiocarcinoma: a systematic review and meta-analysis. Cureus 16(4):e59404. https:\/\/doi.org\/10.7759\/cureus.59404","journal-title":"Cureus"},{"issue":"8","key":"11900_CR26","doi-asserted-by":"publisher","first-page":"4888","DOI":"10.1245\/s10434-023-13498-0","volume":"30","author":"D Aliseda","year":"2023","unstructured":"Aliseda D, Sapisochin G, Mart\u00ed-Cruchaga P, Zozaya G, Blanco N, Goh BKP, Rotellar F (2023) Association of laparoscopic surgery with improved perioperative and survival outcomes in patients with resectable intrahepatic cholangiocarcinoma: a systematic review and meta-analysis from propensity-score matched studies. Ann Surg Oncol 30(8):4888\u20134901. https:\/\/doi.org\/10.1245\/s10434-023-13498-0","journal-title":"Ann Surg Oncol"},{"key":"11900_CR27","volume-title":"The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses","author":"GA Wells","year":"2014","unstructured":"Wells GA, Shea B, O\u2019Connell D, Peterson J, Welch V, Losos M, Tugwell P (2014) The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. Ottawa Hospital Research Institute, Ottawa"},{"issue":"9","key":"11900_CR28","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","volume":"25","author":"A Stang","year":"2010","unstructured":"Stang A (2010) Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25(9):603\u2013605","journal-title":"Eur J Epidemiol"},{"key":"11900_CR29","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jclinepi.2019.10.014","volume":"119","author":"N Santesso","year":"2020","unstructured":"Santesso N, Glenton C, Dahm P et al (2020) GRADE guidelines 26: informative statements to communicate the findings of systematic reviews of interventions. J Clin Epidemiol 119:126\u2013135. https:\/\/doi.org\/10.1016\/j.jclinepi.2019.10.014","journal-title":"J Clin Epidemiol"},{"key":"11900_CR30","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1471-2288-5-13","volume":"5","author":"SP Hozo","year":"2005","unstructured":"Hozo SP, Djulbegovic B, Hozo I (2005) Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol 5:13. https:\/\/doi.org\/10.1186\/1471-2288-5-13","journal-title":"BMC Med Res Methodol"},{"key":"11900_CR31","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1186\/1471-2288-14-135","volume":"14","author":"X Wan","year":"2014","unstructured":"Wan X, Wang W, Liu J, Tong T (2014) Estimating the sample mean and standard deviation from the sample size, median, range and\/or interquartile range. BMC Med Res Methodol 14:135. https:\/\/doi.org\/10.1186\/1471-2288-14-135","journal-title":"BMC Med Res Methodol"},{"key":"11900_CR32","doi-asserted-by":"publisher","first-page":"419","DOI":"10.1093\/bjs\/znaa110","volume":"108","author":"C Hobeika","year":"2021","unstructured":"Hobeika C et al (2021) Laparoscopic versus open resection of intrahepatic cholangiocarcinoma: nationwide analysis. Br J Surg 108:419\u2013426. https:\/\/doi.org\/10.1093\/bjs\/znaa110","journal-title":"Br J Surg"},{"key":"11900_CR33","doi-asserted-by":"publisher","first-page":"3646","DOI":"10.1007\/s00464-016-5399-3","volume":"31","author":"F Wei","year":"2017","unstructured":"Wei F et al (2017) Can laparoscopic liver resection provide a favorable option for patients with large or multiple intrahepatic cholangiocarcinomas? Surg Endosc 31:3646\u20133655. https:\/\/doi.org\/10.1007\/s00464-016-5399-3","journal-title":"Surg Endosc"},{"key":"11900_CR34","doi-asserted-by":"publisher","first-page":"5382","DOI":"10.1007\/s00464-021-08842-y","volume":"36","author":"O Salehi","year":"2022","unstructured":"Salehi O et al (2022) Selection criteria for minimally invasive resection of intrahepatic cholangiocarcinoma-a word of caution: a propensity score matched analysis using the national cancer database. Surg Endosc 36:5382\u20135391. https:\/\/doi.org\/10.1007\/s00464-021-08842-y","journal-title":"Surg Endosc"},{"key":"11900_CR35","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1245\/s10434-022-12647-1","volume":"30","author":"T Qin","year":"2023","unstructured":"Qin T et al (2023) The long-term outcome of laparoscopic resection for perihilar cholangiocarcinoma compared with the open approach: a real-world multicentric analysis. Ann Surg Oncol 30:1366\u20131378. https:\/\/doi.org\/10.1245\/s10434-022-12647-1","journal-title":"Ann Surg Oncol"},{"key":"11900_CR36","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1089\/lap.2014.0233","volume":"25","author":"BJ Uy","year":"2015","unstructured":"Uy BJ, Han HS, Yoon YS, Cho JY (2015) Laparoscopic liver resection for intrahepatic cholangiocarcinoma. J Laparoendosc Adv Surg Tech A 25:272\u2013277. https:\/\/doi.org\/10.1089\/lap.2014.0233","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"11900_CR37","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10132828","author":"F Ratti","year":"2021","unstructured":"Ratti F et al (2021) Laparoscopic surgery for intrahepatic cholangiocarcinoma: a focus on oncological outcomes. J Clin Med. https:\/\/doi.org\/10.3390\/jcm10132828","journal-title":"J Clin Med"},{"key":"11900_CR38","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1007\/s00464-015-4430-4","volume":"30","author":"F Ratti","year":"2016","unstructured":"Ratti F et al (2016) Safety and feasibility of laparoscopic liver resection with associated lymphadenectomy for intrahepatic cholangiocarcinoma: a propensity score-based case-matched analysis from a single institution. Surg Endosc 30:1999\u20132010. https:\/\/doi.org\/10.1007\/s00464-015-4430-4","journal-title":"Surg Endosc"},{"key":"11900_CR39","doi-asserted-by":"publisher","first-page":"4835","DOI":"10.1007\/s00464-016-4817-x","volume":"30","author":"W Lee","year":"2016","unstructured":"Lee W et al (2016) Comparison of perioperative and oncologic outcomes between open and laparoscopic liver resection for intrahepatic cholangiocarcinoma. Surg Endosc 30:4835\u20134840. https:\/\/doi.org\/10.1007\/s00464-016-4817-x","journal-title":"Surg Endosc"},{"key":"11900_CR40","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.suronc.2020.01.001","volume":"33","author":"SH Kang","year":"2020","unstructured":"Kang SH et al (2020) Laparoscopic liver resection versus open liver resection for intrahepatic cholangiocarcinoma: 3-year outcomes of a cohort study with propensity score matching. Surg Oncol 33:63\u201369. https:\/\/doi.org\/10.1016\/j.suronc.2020.01.001","journal-title":"Surg Oncol"},{"key":"11900_CR41","doi-asserted-by":"publisher","first-page":"376","DOI":"10.5582\/bst.2020.03293","volume":"14","author":"J Wu","year":"2020","unstructured":"Wu J et al (2020) Safety and feasibility of laparoscopic versus open liver resection with associated lymphadenectomy for intrahepatic cholangiocarcinoma. Biosci Trends 14:376\u2013383. https:\/\/doi.org\/10.5582\/bst.2020.03293","journal-title":"Biosci Trends"},{"key":"11900_CR42","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.1007\/s00464-020-07588-3","volume":"35","author":"F Ratti","year":"2021","unstructured":"Ratti F et al (2021) Intrahepatic cholangiocarcinoma as the new field of implementation of laparoscopic liver resection programs. A comparative propensity score-based analysis of open and laparoscopic liver resections. Surg Endosc 35:1851\u20131862. https:\/\/doi.org\/10.1007\/s00464-020-07588-3","journal-title":"Surg Endosc"},{"key":"11900_CR43","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1089\/lap.2020.0215","volume":"30","author":"PK Haber","year":"2020","unstructured":"Haber PK et al (2020) Laparoscopic liver resection for intrahepatic cholangiocarcinoma: a single-center experience. J Laparoendosc Adv Surg Tech A 30:1354\u20131359. https:\/\/doi.org\/10.1089\/lap.2020.0215","journal-title":"J Laparoendosc Adv Surg Tech A"},{"key":"11900_CR44","doi-asserted-by":"publisher","first-page":"3060","DOI":"10.1007\/s00464-016-4925-7","volume":"30","author":"Y Xu","year":"2016","unstructured":"Xu Y et al (2016) Robotic radical resection for hilar cholangiocarcinoma: perioperative and long-term outcomes of an initial series. Surg Endosc 30:3060\u20133070. https:\/\/doi.org\/10.1007\/s00464-016-4925-7","journal-title":"Surg Endosc"},{"key":"11900_CR45","doi-asserted-by":"publisher","first-page":"3721","DOI":"10.1007\/s00464-021-08686-6","volume":"36","author":"D Ma","year":"2022","unstructured":"Ma D et al (2022) Laparoscopic versus open surgery for hilar cholangiocarcinoma: a retrospective cohort study on short-term and long-term outcomes. Surg Endosc 36:3721\u20133731. https:\/\/doi.org\/10.1007\/s00464-021-08686-6","journal-title":"Surg Endosc"},{"key":"11900_CR46","doi-asserted-by":"publisher","first-page":"60","DOI":"10.16931\/1995-5464.2020460-70","volume":"25","author":"MG Efanov","year":"2020","unstructured":"Efanov MG et al (2020) Robot-assisted and open resections for perihilar cholangiocarcinoma. Comparative analysis of the immediate outcomes. Ann HPB Surg 25:60\u201370. https:\/\/doi.org\/10.16931\/1995-5464.2020460-70","journal-title":"Ann HPB Surg"},{"key":"11900_CR47","doi-asserted-by":"publisher","first-page":"4382","DOI":"10.1007\/s00464-019-07211-0","volume":"34","author":"Y Zhang","year":"2020","unstructured":"Zhang Y et al (2020) Total laparoscopic versus open radical resection for hilar cholangiocarcinoma. Surg Endosc 34:4382\u20134387. https:\/\/doi.org\/10.1007\/s00464-019-07211-0","journal-title":"Surg Endosc"},{"key":"11900_CR48","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1007\/s13304-020-00752-3","volume":"72","author":"F Ratti","year":"2020","unstructured":"Ratti F et al (2020) Perihilar cholangiocarcinoma: are we ready to step towards minimally invasiveness? Updates Surg 72:423\u2013433. https:\/\/doi.org\/10.1007\/s13304-020-00752-3","journal-title":"Updates Surg"},{"key":"11900_CR49","doi-asserted-by":"publisher","DOI":"10.1177\/00031348221093933","author":"EA Shapera","year":"2022","unstructured":"Shapera EA et al (2022) Analysis of oncological outcomes after robotic liver resection for intrahepatic cholangiocarcinoma. Am Surg. https:\/\/doi.org\/10.1177\/00031348221093933","journal-title":"Am Surg"},{"key":"11900_CR50","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1016\/j.surg.2021.08.015","volume":"171","author":"R Brustia","year":"2022","unstructured":"Brustia R et al (2022) Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: report of an international multicenter cohort study with propensity score matching. Surgery 171:1290\u20131302. https:\/\/doi.org\/10.1016\/j.surg.2021.08.015","journal-title":"Surgery"},{"key":"11900_CR51","doi-asserted-by":"publisher","first-page":"6724","DOI":"10.1007\/s00464-021-08948-3","volume":"36","author":"I Sucandy","year":"2022","unstructured":"Sucandy I et al (2022) Propensity score matched comparison of robotic and open major hepatectomy for malignant liver tumors. Surg Endosc 36:6724\u20136732. https:\/\/doi.org\/10.1007\/s00464-021-08948-3","journal-title":"Surg Endosc"},{"key":"11900_CR52","doi-asserted-by":"publisher","first-page":"1003948","DOI":"10.3389\/fsurg.2022.1003948","volume":"9","author":"J Wang","year":"2022","unstructured":"Wang J et al (2022) Laparoscopic vs. open anatomical hepatectomy for intrahepatic cholangiocarcinoma: a retrospective cohort study. Front Surg 9:1003948. https:\/\/doi.org\/10.3389\/fsurg.2022.1003948","journal-title":"Front Surg"},{"key":"11900_CR53","doi-asserted-by":"publisher","first-page":"e18307","DOI":"10.1097\/MD.0000000000018307","volume":"98","author":"Y Zhu","year":"2019","unstructured":"Zhu Y, Song J, Xu X, Tan Y, Yang J (2019) Safety and feasibility of laparoscopic liver resection for patients with large or multiple intrahepatic cholangiocarcinomas: a propensity score based case-matched analysis from a single institute. Medicine (Baltimore) 98:e18307. https:\/\/doi.org\/10.1097\/MD.0000000000018307","journal-title":"Medicine (Baltimore)"},{"key":"11900_CR54","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1245\/s10434-018-6811-0","volume":"26","author":"F Ratti","year":"2019","unstructured":"Ratti F et al (2019) Perioperative and long-term outcomes of laparoscopic versus open lymphadenectomy for biliary tumors: a propensity-score-based, case-matched analysis. Ann Surg Oncol 26:564\u2013575. https:\/\/doi.org\/10.1245\/s10434-018-6811-0","journal-title":"Ann Surg Oncol"},{"key":"11900_CR55","doi-asserted-by":"publisher","first-page":"goad018","DOI":"10.1093\/gastro\/goad018","volume":"11","author":"XT Huang","year":"2023","unstructured":"Huang XT et al (2023) Evaluation of the short-term outcomes of robotic-assisted radical resection for perihilar cholangiocarcinoma: a propensity-scored matching analysis. Gastroenterol Rep (Oxf) 11:goad018. https:\/\/doi.org\/10.1093\/gastro\/goad018","journal-title":"Gastroenterol Rep (Oxf)"},{"key":"11900_CR56","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1004974","author":"Y He","year":"2022","unstructured":"He Y, Huang W, Ren Q, Li J, Yang F, Deng C, Li L, Peng X, Tang Y, Zheng L, Huang X, Li Y (2022) Comparison of efficacy and safety between laparoscopic and open radical resection for hilar cholangiocarcinoma\u2014a propensity score-matching analysis. Front Oncol. https:\/\/doi.org\/10.3389\/fonc.2022.1004974","journal-title":"Front Oncol"},{"issue":"5","key":"11900_CR57","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1080\/00365521.2022.2143724","volume":"58","author":"MA Sahakyan","year":"2022","unstructured":"Sahakyan MA, Aghayan DL, Edwin B, Alikhanov R, Britskaia N, Brudvik KW, D\u2019Hondt M, De Meyere C, Efanov M, Fretland \u00c5A, Hoff R, Ismail W, Ivanecz A, Kazaryan AM, Lassen K, Magdaleni\u0107 T, Parmentier I, R\u00f8sok BI, Villanger O, Yaqub S (2022) Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: a multicenter propensity score-matched study. Scand J Gastroenterol 58(5):489\u2013496. https:\/\/doi.org\/10.1080\/00365521.2022.2143724","journal-title":"Scand J Gastroenterol"},{"issue":"3","key":"11900_CR58","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.hpb.2022.12.006","volume":"25","author":"R Pery","year":"2023","unstructured":"Pery R, Gudmundsdottir H, Nagorney DM, Pencovich N, Smoot RL, Thiels CA, Truty MJ, Vierkant RA, Warner SG, Kendrick ML, Cleary SP (2023) Laparoscopic versus open liver resections for intrahepatic cholangiocarcinoma and gallbladder cancer: the Mayo clinic experience. HPB 25(3):339\u2013346. https:\/\/doi.org\/10.1016\/j.hpb.2022.12.006","journal-title":"HPB"},{"key":"11900_CR59","doi-asserted-by":"publisher","unstructured":"Madelin, Yang Jinhuan, Du Gang, et al. Vergelijkend onderzoek naar de werkzaamheid van laparoscopische chirurgie en laparotomie bij de behandeling van intrahepatisch cholangiocarcinoom [J]. 651. https:\/\/doi.org\/10.3760\/cma.j.cn113884-20201231-00645.","DOI":"10.3760\/cma.j.cn113884-20201231-00645"},{"key":"11900_CR60","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-023-10942-y","author":"W Liu","year":"2023","unstructured":"Liu W, Xiong F, Wu G, Wang Q, Wang B, Chen Y (2023) Biliary-enteric reconstruction in laparoscopic radical resection of hilar cholangiocarcinoma: a single-center retrospective cohort study. BMC Cancer. https:\/\/doi.org\/10.1186\/s12885-023-10942-y","journal-title":"BMC Cancer"},{"key":"11900_CR61","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.742544","author":"Y Jinhuan","year":"2022","unstructured":"Jinhuan Y, Yi W, Yuanwen Z, Delin M, Xiaotian C, Yan W, Liming D, Haitao Y, Lijun W, Tuo D, Kaiyu C, Jiawei H, Chongming Z, Daojie W, Bin J, Gang C (2022) Laparoscopic versus open surgery for early-stage intrahepatic cholangiocarcinoma after mastering the learning curve: a multicenter data-based matched study. Front Oncol. https:\/\/doi.org\/10.3389\/fonc.2021.742544","journal-title":"Front Oncol"},{"issue":"4","key":"11900_CR62","doi-asserted-by":"publisher","first-page":"31","DOI":"10.16931\/1995-5464.2022-4-31-40","volume":"27","author":"MG Efanov","year":"2022","unstructured":"Efanov MG, Alikhanov RB, Kazakov IV, Koroleva AA, Vankovich AN, Melekhina OV, Kulezneva YV, Tarakanov PV, Kaminsky MN, Britskaia NN, Fisenko DV, Tsvirkun VV, Khatkov IE (2022) Long-term and immediate results of robot-assisted resection of liver and bile ducts in portal cholangiocarcinoma. Annaly Khirurgicheskoy Gepatologii Annals of HPB Surg 27(4):31\u201340. https:\/\/doi.org\/10.16931\/1995-5464.2022-4-31-40","journal-title":"Annaly Khirurgicheskoy Gepatologii Annals of HPB Surg"},{"key":"11900_CR63","doi-asserted-by":"publisher","unstructured":"Dou Changwei, Liu Jie, Zhang Chunxu, et al. Vergelijking van de werkzaamheid op korte termijn van laparoscopische en open radicale resectie van hilair cholangiocarcinoom. https:\/\/doi.org\/10.3760\/cma.j.cn113884-20200731-00410","DOI":"10.3760\/cma.j.cn113884-20200731-00410"},{"key":"11900_CR64","doi-asserted-by":"publisher","unstructured":"Chen Tai\u2019an, Yang Facai, Li Meng, et al. Analyse van de veiligheid en werkzaamheid van laparoscopische leverresectie bij de behandeling van intrahepatisch cholangiocarcinoom. https:\/\/doi.org\/10.3760\/cma.j.cn113884-20210118-00025","DOI":"10.3760\/cma.j.cn113884-20210118-00025"},{"issue":"2","key":"11900_CR65","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/j.asjsur.2022.07.158","volume":"46","author":"F Xiong","year":"2023","unstructured":"Xiong F, Peng F, Li X, Chen Y (2023) Preliminary comparison of total laparoscopic and open radical resection for hepatic hilar cholangiocarcinoma a single-center cohort study. Asian J Surg 46(2):856\u2013862. https:\/\/doi.org\/10.1016\/j.asjsur.2022.07.158","journal-title":"Asian J Surg"},{"issue":"1","key":"11900_CR66","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1186\/s12885-023-10783-9.PMID:37138243;PMCID:PMC10157952","volume":"23","author":"M Wang","year":"2023","unstructured":"Wang M, Qin T, Zhang H, Li J, Deng X, Zhang Y, Zhao W, Fan Y, Li D, Chen X, Feng Y, Zhu S, Xing Z, Yu G, Xu J, Xie J, Dou C, Ma H, Liu G, Shao Y, Chen W, Liu J, Liu J, Yin X, Qin R (2023) Laparoscopic versus open surgery for perihilar cholangiocarcinoma: a multicenter propensity score analysis of short- term outcomes. BMC Cancer 23(1):394. https:\/\/doi.org\/10.1186\/s12885-023-10783-9.PMID:37138243;PMCID:PMC10157952","journal-title":"BMC Cancer"},{"issue":"1","key":"11900_CR67","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/s12957-023-03004-x.PMID:37032348;PMCID:PMC10084635","volume":"21","author":"Z Shen","year":"2023","unstructured":"Shen Z, Tao L, Cai J, Zheng J, Sheng Y, Yang Z, Gong L, Song C, Gao J, Ying H, Xu J, Liang X (2023) Safety and feasibility of laparoscopic liver resection for intrahepatic cholangiocarcinoma: a propensity score-matched study. World J Surg Oncol 21(1):126. https:\/\/doi.org\/10.1186\/s12957-023-03004-x.PMID:37032348;PMCID:PMC10084635","journal-title":"World J Surg Oncol"},{"key":"11900_CR68","unstructured":"Schumemann H, Bro\u017cek J, Guyatt G, Oxman A (2013) GRADE handbook. Grading of recommendations assessment, development and evaluation"},{"key":"11900_CR69","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.4251\/wjgo.v13.i12.2203","volume":"13","author":"R Patrone","year":"2021","unstructured":"Patrone R et al (2021) Minimally invasive surgical treatment of intrahepatic cholangiocarcinoma: a systematic review. World J Gastrointest Oncol 13:2203\u20132215. https:\/\/doi.org\/10.4251\/wjgo.v13.i12.2203","journal-title":"World J Gastrointest Oncol"},{"key":"11900_CR70","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1007\/s00464-022-09579-y","volume":"37","author":"DJ Song","year":"2023","unstructured":"Song DJ et al (2023) Perioperative and oncologic outcomes of laparoscopic versus open liver resection for combined hepatocellular-cholangiocarcinoma: a propensity score matching analysis. Surg Endosc 37:967\u2013976. https:\/\/doi.org\/10.1007\/s00464-022-09579-y","journal-title":"Surg Endosc"},{"issue":"4","key":"11900_CR71","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.ejso.2023.02.010","volume":"49","author":"HJ Li","year":"2023","unstructured":"Li HJ, Wang Q, Yang ZL, Zhu FF, Xiang ZQ, Long ZT, Dai XM, Zhu Z (2023) Laparoscopic versus open hepatectomy for intrahepatic cholangiocarcinoma: systematic review and meta-analysis of propensity score-matched studies. Eur J Surg Oncol 49(4):700\u2013708. https:\/\/doi.org\/10.1016\/j.ejso.2023.02.010","journal-title":"Eur J Surg Oncol"},{"issue":"7","key":"11900_CR72","doi-asserted-by":"publisher","first-page":"4445","DOI":"10.1245\/s10434-024-15162-7","volume":"31","author":"F Procopio","year":"2024","unstructured":"Procopio F, Mauri G, Milana F, Braciforte B, Galvanin J, Costa G, Pasetti C, Torzilli G (2024) ICG-enhanced compression anatomical segment 7 segmentectomy in laparoscopic and robotic approach. Ann Surg Oncol 31(7):4445\u20134446. https:\/\/doi.org\/10.1245\/s10434-024-15162-7","journal-title":"Ann Surg Oncol"},{"key":"11900_CR73","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/s11701-024-01966-y","volume":"18","author":"J Wu","year":"2024","unstructured":"Wu J, Wang L, Yu F et al (2024) Robotic-assisted radical resection versus open surgery for cholangiocarcinoma: a systematic review and meta-analysis. J Robotic Surg 18:201. https:\/\/doi.org\/10.1007\/s11701-024-01966-y","journal-title":"J Robotic Surg"},{"issue":"11","key":"11900_CR74","doi-asserted-by":"publisher","first-page":"3048","DOI":"10.3390\/cancers15113048","volume":"15","author":"G Berardi","year":"2023","unstructured":"Berardi G, Lucarini A, Colasanti M, Mariano G, Ferretti S, Meniconi RL, Guglielmo N, Angrisani M, Usai S, Borcea MC, Canali G, Moschetta G, Ettorre GM (2023) Minimally invasive surgery for perihilar cholangiocarcinoma: a systematic review of the short- and long-term results. Cancers (Basel) 15(11):3048. https:\/\/doi.org\/10.3390\/cancers15113048","journal-title":"Cancers (Basel)"},{"issue":"12","key":"11900_CR75","doi-asserted-by":"publisher","first-page":"1001838","DOI":"10.3389\/fonc.2022.1001838","volume":"28","author":"A Brolese","year":"2022","unstructured":"Brolese A, Rigoni M, Pasquale A, Viel G, Brolese M, Ciarleglio FA (2022) The role of robotic surgery for the treatment of hilar cholangiocarcinoma: a systematic review. Front Oncol 28(12):1001838. https:\/\/doi.org\/10.3389\/fonc.2022.1001838","journal-title":"Front Oncol"}],"container-title":["Surgical Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-025-11900-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00464-025-11900-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-025-11900-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T18:36:23Z","timestamp":1763145383000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00464-025-11900-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,10]]},"references-count":75,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["11900"],"URL":"https:\/\/doi.org\/10.1007\/s00464-025-11900-4","relation":{},"ISSN":["0930-2794","1432-2218"],"issn-type":[{"value":"0930-2794","type":"print"},{"value":"1432-2218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,10]]},"assertion":[{"value":"22 September 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No specific funding was acquired for this study. Maurice J.W. Zwart and Marc G. Besselink received funding from the Amsterdam UMC for studies on safe implementation of robotic and laparoscopic pancreatic surgery; funding from the Dutch Digestive Foundation (MLDS; Grant Number I16-05), for studies on the aforementioned topics and funding from Intuitive (Grant Reference\ua789 Evidence-based implementation of robotic pancreatoduodenectomy using simulation training, LAELAPS-3) for the nationwide Dutch LAELAPS-3 training program for robotic pancreatoduodenectomy. The other authors have nothing to disclose. Joey de Hondt, Bas A. Uijterwijk, George L. Burchell;, Burak G\u00f6rge\u00e7, Babs Zonderhuis, Geert Kazemier, Joris Erdmann, and Rutger-Jan Swijnenburg have no conflicts of interest or financial ties to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}