{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T21:13:47Z","timestamp":1793913227379,"version":"4.8.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T00:00:00Z","timestamp":1752105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/100019779","name":"Qatar National Library","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019779","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007833","name":"Hamad Medical Corporation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100007833","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Endosc"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Recurrence of hepatic hydatid cysts after laparoscopic surgery poses a significant challenge in pediatric patients. The administration of albendazole therapy pre- and post-operatively is proposed to reduce recurrence rates, yet its impact requires further investigation. This study aims to identify predictive factors associated with recurrence of hepatic hydatid cysts in children following laparoscopic surgery, focusing on cyst characteristics and perioperative albendazole therapy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A retrospective cross-sectional analytical study was conducted using medical records of pediatric patients under 16 years of age who underwent laparoscopic surgery for hepatic hydatid cysts between 2006 and 2021. Collected data included patient demographics, cyst characteristics (size, location, and number), preoperative and postoperative albendazole therapy, surgical duration, and intraoperative complications. Logistic regression analysis was used to identify factors associated with cyst recurrence during the follow-up period, with statistical significance set at p\u2009&lt;\u20090.05.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>A total of 152 pediatric patients were included, with a mean age of 7.9\u2009\u00b1\u20093.3 years. The recurrence rate was 12% (<jats:italic>n<\/jats:italic>\u2009=\u200918). In multivariate analysis, longer surgical duration (HR\u2009=\u20091.02; 95% CI 1.00\u20131.03; <jats:italic>p<\/jats:italic>\u2009=\u20090.013) and cysts located outside liver segment II (HR\u2009=\u20090.11; 95% CI 0.01\u20130.9; <jats:italic>p<\/jats:italic>\u2009=\u20090.039) were independently associated with recurrence. Albendazole therapy, administered pre- or post-operatively, was more frequent in the non-recurrence group but did not reach statistical significance. No cases of peritoneal hydatidosis were recorded during follow-up.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Key predictors of post-laparoscopy recurrence included extended surgical duration and cyst location. Although perioperative albendazole therapy was more frequent in the non-recurrence group, it did not reach statistical significance in reducing recurrence rates. These findings highlight the importance of tailored surgical approaches and careful postoperative monitoring to improve patient outcomes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00464-025-11965-1","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T16:11:01Z","timestamp":1752163861000},"page":"5586-5595","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pediatric hepatic hydatid cysts: recurrence risk factors following laparoscopic surgery\u2013a 16-year cohort analysis"],"prefix":"10.1007","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1314-6713","authenticated-orcid":false,"given":"Marwa","family":"Messaoud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9369-1933","authenticated-orcid":false,"given":"Amani N.","family":"Alansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhouene Ben","family":"Salah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Sfar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9712-2945","authenticated-orcid":false,"given":"Basma","family":"Haggui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4847-7257","authenticated-orcid":false,"given":"Amine","family":"Ksia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4513-2184","authenticated-orcid":false,"given":"Mongi","family":"Mekki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7822-0463","authenticated-orcid":false,"given":"Lassaad","family":"Sahnoun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,7,10]]},"reference":[{"issue":"1","key":"11965_CR1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3390\/pathogens14010053","volume":"14","author":"CM Mihai","year":"2025","unstructured":"Mihai CM et al (2025) A Comprehensive analysis of echinococcus granulosus infections in children and adolescents: results of a 7-year retrospective study and literature review. Pathogens 14(1):53","journal-title":"Pathogens"},{"issue":"13","key":"11965_CR2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/diagnostics14131399","volume":"14","author":"A Mihetiu","year":"2024","unstructured":"Mihetiu A et al (2024) Therapeutic options in hydatid hepatic cyst surgery: a retrospective analysis of three surgical approaches. Diagnostics 14(13):13","journal-title":"Diagnostics"},{"key":"11965_CR3","volume-title":"Hydatid cysts in children","author":"AL Delgado","year":"2022","unstructured":"Delgado AL et al (2022) Hydatid cysts in children. IntechOpen"},{"issue":"10","key":"11965_CR4","doi-asserted-by":"publisher","first-page":"3603","DOI":"10.1007\/s00436-021-07297-3","volume":"120","author":"VD Zavoikin","year":"2021","unstructured":"Zavoikin VD, Zelya OP, Tumolskaya NI (2021) Clinical tolerance and efficacy of anti-parasitic treatment with albendazole in patients with alveolar echinococcosis: long-term follow-up observation in 117 patients. Parasitol Res 120(10):3603\u20133610","journal-title":"Parasitol Res"},{"issue":"3","key":"11965_CR5","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s11686-023-00699-6","volume":"68","author":"M Shmueli","year":"2023","unstructured":"Shmueli M et al (2023) Albendazole monotherapy for pediatric cystic echinococcosis: a case series. Acta Parasitol 68(3):651\u2013658","journal-title":"Acta Parasitol"},{"issue":"1","key":"11965_CR6","first-page":"100","volume":"18","author":"S Mahmoodi","year":"2023","unstructured":"Mahmoodi S et al (2023) A 20 years retrospective descriptive study of human cystic echinococcosis and the role of albendazole concurrent with surgical treatment: 2001\u20132021. Iran J Parasitol 18(1):100\u2013106","journal-title":"Iran J Parasitol"},{"issue":"3","key":"11965_CR7","first-page":"385","volume":"21","author":"A Mirshemirani","year":"2011","unstructured":"Mirshemirani A et al (2011) Liver hydatid cyst in children (A 14-year review). Iran J Pediatr 21(3):385\u2013389","journal-title":"Iran J Pediatr"},{"issue":"3","key":"11965_CR8","doi-asserted-by":"publisher","first-page":"360","DOI":"10.4103\/jmas.JMAS_220_20","volume":"18","author":"PF Masood","year":"2022","unstructured":"Masood PF et al (2022) Comparison of laparoscopic and open surgery in hepatic hydatid disease in children: feasibility, efficacy and safety. J Min Access Surg 18(3):360","journal-title":"J Min Access Surg"},{"issue":"12","key":"11965_CR9","doi-asserted-by":"publisher","first-page":"3218","DOI":"10.1007\/s00268-017-4129-x","volume":"41","author":"SV Minaev","year":"2017","unstructured":"Minaev SV et al (2017) Laparoscopic treatment in children with hydatid cyst of the liver. World J Surg 41(12):3218\u20133223","journal-title":"World J Surg"},{"issue":"5","key":"11965_CR10","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1016\/j.gassur.2005.10.013","volume":"10","author":"M Kapan","year":"2006","unstructured":"Kapan M et al (2006) Postoperative recurrence in hepatic hydatid disease. J Gastrointest Surg: Off J Soc Surg Alimentary Tract 10(5):734\u2013739","journal-title":"J Gastrointest Surg: Off J Soc Surg Alimentary Tract"},{"issue":"4","key":"11965_CR11","first-page":"314","volume":"83","author":"A Tan","year":"1998","unstructured":"Tan A et al (1998) The results of surgical treatment and percutaneous drainage of hepatic hydatid disease. Int Surg 83(4):314\u2013316","journal-title":"Int Surg"},{"issue":"5","key":"11965_CR12","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1590\/0037-8682-0223-2015","volume":"48","author":"A Abdelraouf","year":"2015","unstructured":"Abdelraouf A et al (2015) Clinical and serological outcomes with different surgical approaches for human hepatic hydatidosis. Rev Soc Bras Med Trop 48(5):587\u2013593","journal-title":"Rev Soc Bras Med Trop"},{"issue":"1072","key":"11965_CR13","doi-asserted-by":"publisher","first-page":"20160640","DOI":"10.1259\/bjr.20160640","volume":"90","author":"TA Shera","year":"2017","unstructured":"Shera TA et al (2017) A comparison of imaging guided double percutaneous aspiration injection and surgery in the treatment of cystic echinococcosis of liver. Br J Radiol 90(1072):20160640","journal-title":"Br J Radiol"},{"issue":"1","key":"11965_CR14","doi-asserted-by":"publisher","first-page":"194","DOI":"10.18203\/2349-2902.isj20215156","volume":"9","author":"FM Lee","year":"2022","unstructured":"Lee FM, Gaszynski R, Merrett N (2022) Recurrent hydatid disease, a case report and literature review. Int Surg J 9(1):194\u2013199","journal-title":"Int Surg J"},{"issue":"4","key":"11965_CR15","first-page":"483","volume":"17","author":"A Vahidirad","year":"2022","unstructured":"Vahidirad A et al (2022) Efficacy of preoperative albendazole on protoscoleces viability in hydatid cyst of the liver. Iran J Parasitol 17(4):483\u2013487","journal-title":"Iran J Parasitol"},{"issue":"5","key":"11965_CR16","doi-asserted-by":"publisher","first-page":"343","DOI":"10.4103\/1319-3767.84493","volume":"17","author":"SH Arif","year":"2011","unstructured":"Arif SH et al (2011) Role of albendazole in the management of hydatid cyst liver. Saudi J Gastroenterol 17(5):343\u2013347","journal-title":"Saudi J Gastroenterol"},{"issue":"28","key":"11965_CR17","first-page":"10782","volume":"7","author":"DM Albahadili","year":"2021","unstructured":"Albahadili DM, Majeed DAW, Al-Badry DSS (2021) Incidence of hydatid cyst in liver surgery, recurrence rate within 5 years, role of albendazole in its treatments. NVEO-Nat Volatiles Essential Oils J 7(28):10782\u201310788","journal-title":"NVEO-Nat Volatiles Essential Oils J"},{"issue":"12","key":"11965_CR18","doi-asserted-by":"publisher","first-page":"2362","DOI":"10.1016\/j.jpedsurg.2023.07.003","volume":"58","author":"Y Kerkani","year":"2023","unstructured":"Kerkani Y et al (2023) Predictive factors of liver hydatid cyst recurrence in children. J Pediatr Surg 58(12):2362\u20132367","journal-title":"J Pediatr Surg"},{"key":"11965_CR19","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.actatropica.2018.09.024","volume":"189","author":"E Mirabile","year":"2019","unstructured":"Mirabile E et al (2019) Progress towards international adoption of the World Health Organization ultrasound classification of cystic echinococcosis. Acta Trop 189:6\u20139","journal-title":"Acta Trop"},{"issue":"6","key":"11965_CR20","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1007\/s002689910115","volume":"24","author":"B Gollackner","year":"2000","unstructured":"Gollackner B et al (2000) Radical surgical therapy of abdominal cystic hydatid disease: factors of recurrence. World J Surg 24(6):717\u2013721","journal-title":"World J Surg"},{"issue":"3","key":"11965_CR21","first-page":"1","volume":"6","author":"K Duman","year":"2016","unstructured":"Duman K, Girgin M (2016) Uncomplicated hydatid cysts of the liver: clinical presentation, diagnosis and treatment. J Gastrointest Digest Syst 6(3):1\u20135","journal-title":"J Gastrointest Digest Syst"},{"issue":"1","key":"11965_CR22","first-page":"15","volume":"107","author":"CM Cre\u0163u","year":"2012","unstructured":"Cre\u0163u CM et al (2012) Albendazole associated to surgery or minimally invasive procedures for hydatid disease\u2014How much and how long. Chirurgia 107(1):15\u201321","journal-title":"Chirurgia"},{"issue":"2","key":"11965_CR23","first-page":"101","volume":"19","author":"AB Dehkordi","year":"2019","unstructured":"Dehkordi AB et al (2019) Albendazole and treatment of hydatid cyst: review of the literature. Infect Disorders-Drug Targets 19(2):101\u2013104","journal-title":"Infect Disorders-Drug Targets"},{"issue":"1","key":"11965_CR24","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.asjsur.2024.09.038","volume":"48","author":"M Alzoubi","year":"2025","unstructured":"Alzoubi M et al (2025) The recurrence rate after primary resection of cystic echinococcosis: a meta-analysis and systematic literature review. Asian J Surg 48(1):78\u201388","journal-title":"Asian J Surg"},{"key":"11965_CR25","doi-asserted-by":"publisher","first-page":"S854","DOI":"10.1016\/j.hpb.2021.08.385","volume":"23","author":"D L\u00f3pez Guerra","year":"2021","unstructured":"L\u00f3pez Guerra D et al (2021) Recurrence of liver hydatid cyst and predictive factors. HPB 23:S854","journal-title":"HPB"},{"issue":"1","key":"11965_CR26","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1503\/cjs.013010","volume":"55","author":"J Prousalidis","year":"2012","unstructured":"Prousalidis J et al (2012) Postoperative recurrence of cystic hydatidosis. Can J Surg 55(1):15\u201320","journal-title":"Can J Surg"},{"issue":"24","key":"11965_CR27","doi-asserted-by":"publisher","first-page":"3040","DOI":"10.3748\/wjg.v16.i24.3040","volume":"16","author":"A Akcan","year":"2010","unstructured":"Akcan A et al (2010) Predisposing factors and surgical outcome of complicated liver hydatid cysts. World J Gastroenterol: WJG 16(24):3040\u20133048","journal-title":"World J Gastroenterol: WJG"},{"issue":"2","key":"11965_CR28","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s13304-016-0368-x","volume":"68","author":"G Vennarecci","year":"2016","unstructured":"Vennarecci G et al (2016) Major liver resection for recurrent hydatid cyst of the liver after suboptimal treatment. Updat Surg 68(2):179\u2013184","journal-title":"Updat Surg"},{"issue":"3","key":"11965_CR29","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1148\/radiographics.20.3.g00ma06795","volume":"20","author":"I Pedrosa","year":"2000","unstructured":"Pedrosa I et al (2000) Hydatid disease: radiologic and pathologic features and complications: (CME available in print version and on RSNA Link). Radiographics 20(3):795\u2013817","journal-title":"Radiographics"},{"issue":"1","key":"11965_CR30","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ijid.2014.01.012","volume":"24","author":"T Tuxun","year":"2014","unstructured":"Tuxun T et al (2014) World review of laparoscopic treatment of liver cystic echinococcosis\u2014914 patients. Int J Infect Dis 24(1):43\u201350","journal-title":"Int J Infect Dis"},{"issue":"6","key":"11965_CR31","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1097\/SLA.0b013e31825ffed3","volume":"256","author":"T Ishizawa","year":"2012","unstructured":"Ishizawa T et al (2012) Laparoscopic segmentectomy of the liver: from segment I to VIII. Ann Surg 256(6):959\u2013964","journal-title":"Ann Surg"},{"issue":"1","key":"11965_CR32","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1007\/s00464-014-3637-0","volume":"29","author":"H Jerraya","year":"2015","unstructured":"Jerraya H et al (2015) Predictive factors of recurrence after surgical treatment for liver hydatid cyst. Surg Endosc 29(1):86\u201393","journal-title":"Surg Endosc"},{"issue":"3","key":"11965_CR33","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1097\/01.mcg.0000225572.50514.e6","volume":"41","author":"N Bildik","year":"2007","unstructured":"Bildik N et al (2007) Efficacy of preoperative albendazole use according to months in hydatid cyst of the liver. J Clin Gastroenterol 41(3):312\u2013316","journal-title":"J Clin Gastroenterol"},{"issue":"6","key":"11965_CR34","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/j.ijsu.2008.08.003","volume":"6","author":"SH Arif","year":"2008","unstructured":"Arif SH et al (2008) Albendazole as an adjuvant to the standard surgical management of hydatid cyst liver. Int J Surg 6(6):448\u2013451","journal-title":"Int J Surg"}],"container-title":["Surgical Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-025-11965-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00464-025-11965-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-025-11965-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T18:02:01Z","timestamp":1756922521000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00464-025-11965-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,10]]},"references-count":34,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["11965"],"URL":"https:\/\/doi.org\/10.1007\/s00464-025-11965-1","relation":{},"ISSN":["0930-2794","1432-2218"],"issn-type":[{"value":"0930-2794","type":"print"},{"value":"1432-2218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,10]]},"assertion":[{"value":"24 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 July 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Marwa Messaoud, Amani N. Alansari, Radhouene Ben Salah, Sami Sfar, Basma Haggui, Amine Ksia, Mongi Mekki and Lassaad Sahnoun have no conflicts of interest or financial ties to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}