{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:39:09Z","timestamp":1785893949016,"version":"3.56.0"},"reference-count":12,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Endosc"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Per-oral endoscopic myotomy has been used for a diagnosis of achalasia and non-achalasia motility disorders. Little is known about the manometric function of the esophageal body and LES after POEM. This study focuses on examination of the changes before and after POEM in the treatment of all 3 achalasia types as well as esophagogastric junction outflow obstruction and jackhammer esophagus.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A prospectively maintained IRB approved database was retrospectively reviewed to find patients who were diagnosed with any type of achalasia, esophagogastric junction outflow obstruction, and jackhammer esophagus, and underwent POEM. Patients were included if they had pre-operative and post-operative high-resolution manometry. Primary endpoints were to identify changes in peristalsis as well as other manometric findings.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>There were 265 patients who met the inclusion criteria. Type 1 achalasia showed the most change in restoration of peristalsis after POEM at 45.5% of patients. Type 2 achalasia improved peristalsis, but not significant from 46.8 to 60.3%. Type 3 achalasia patients lost some peristalsis from 82.5% of patient having peristalsis to 64.5% of patients after POEM. The DCI in these patients returned to a normal range after the procedure. Similar findings were seen in jackhammer esophagus where the DCI returned to a normal range. Esophagogastric junction outflow obstruction showed the biggest changes after POEM losing some peristalsis, but the DCI and wave amplitude significantly decreased (4993.2 to 902.5, 111 to 43.8, respectively).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Per-oral endoscopic myotomy is used for treatment of all types of achalasia and non-achalasia motility disorders. Peristalsis is regained in some patients with Type 1 and 2 achalasia, where some peristalsis is lost in Type 3 achalasia. Type 3 and jackhammer esophagus have normal DCI after the procedure, and esophagogastric junction outflow obstruction shows the poorest outcomes with some patients losing peristalsis, decrease in DCI and wave amplitude.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1007\/s00464-025-12096-3","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T16:01:19Z","timestamp":1756396879000},"page":"6915-6923","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Changes in peristalsis following per oral endoscopic myotomy in common esophageal motility disorders"],"prefix":"10.1007","volume":"39","author":[{"given":"Siddarth","family":"Vyas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"Ward","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany","family":"Buckmaster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bola","family":"Aladegbami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald O.","family":"Ogola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7045-8864","authenticated-orcid":false,"given":"Steven G.","family":"Leeds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"12096_CR1","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.suc.2024.06.011","volume":"105","author":"CG Provenza","year":"2025","unstructured":"Provenza CG, Romanelli JR (2025) Achalasia: diagnosis and management. Surg Clin North Am 105:143\u2013158. https:\/\/doi.org\/10.1016\/j.suc.2024.06.011","journal-title":"Surg Clin North Am"},{"key":"12096_CR2","doi-asserted-by":"publisher","first-page":"655","DOI":"10.20524\/aog.2024.0923","volume":"37","author":"A Dimopoulou","year":"2024","unstructured":"Dimopoulou A, Dimopoulou D, Analitis A, Dimopoulou K, Dellaportas D, Zavras N (2024) Laparoscopic Heller myotomy versus peroral endoscopic myotomy in children with esophageal achalasia: a systematic review and meta-analysis. Ann Gastroenterol 37:655\u2013664. https:\/\/doi.org\/10.20524\/aog.2024.0923","journal-title":"Ann Gastroenterol"},{"key":"12096_CR3","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1002\/ags3.12807","volume":"8","author":"N Fukushima","year":"2024","unstructured":"Fukushima N, Masuda T, Tsuboi K, Watanabe J, Yano F (2024) Long-term outcomes of treatment for achalasia: Laparoscopic Heller myotomy versus POEM. Ann Gastroenterol Surg 8:750\u2013760. https:\/\/doi.org\/10.1002\/ags3.12807","journal-title":"Ann Gastroenterol Surg"},{"key":"12096_CR4","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1007\/s10388-024-01063-x","volume":"21","author":"J Sobral","year":"2024","unstructured":"Sobral J, Machado M, Barbosa JP, Barbosa J (2024) Achalasia: laparoscopic Heller myotomy with fundoplication versus peroral endoscopic myotomy\u2014a systematic review and meta-analysis. Esophagus 21:298\u2013305. https:\/\/doi.org\/10.1007\/s10388-024-01063-x","journal-title":"Esophagus"},{"key":"12096_CR5","doi-asserted-by":"publisher","first-page":"2834","DOI":"10.3748\/wjg.v30.i22.2834","volume":"30","author":"I Samarasam","year":"2024","unstructured":"Samarasam I, Joel RK, Pulimood AB (2024) Gastroesophageal reflux following per-oral endoscopic myotomy: can we improve outcomes? World J Gastroenterol 30:2834\u20132838. https:\/\/doi.org\/10.3748\/wjg.v30.i22.2834","journal-title":"World J Gastroenterol"},{"key":"12096_CR6","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1053\/j.gastro.2024.08.038","volume":"167","author":"D Yang","year":"2024","unstructured":"Yang D, Bechara R, Dunst CM, Konda VJA (2024) AGA clinical practice update on advances in per-oral endoscopic myotomy (POEM) and remaining questions\u2014what we have learned in the past decade: expert review. Gastroenterology 167:1483\u20131490. https:\/\/doi.org\/10.1053\/j.gastro.2024.08.038","journal-title":"Gastroenterology"},{"key":"12096_CR7","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/doae014","volume":"37","author":"A Rengarajan","year":"2024","unstructured":"Rengarajan A, Aadam AA (2024) Peroral endoscopic myotomy and its use in non-achalasia disorders. Dis Esophagus 37:doae014. https:\/\/doi.org\/10.1093\/dote\/doae014","journal-title":"Dis Esophagus"},{"key":"12096_CR8","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.gie.2022.10.039","volume":"97","author":"Y Hata","year":"2023","unstructured":"Hata Y, Sato H, Shimamura Y, Abe H, Shiwaku A, Shiota J, Sato C, Ominami M, Fukuda H, Ogawa R, Nakamura J, Tatsuta T, Ikebuchi Y, Yokomichi H, Ihara E, Inoue H (2023) Impact of peroral endoscopic myotomy on high-resolution manometry findings and their association with the procedure\u2019s outcomes. Gastrointest Endosc 97:673\u2013683. https:\/\/doi.org\/10.1016\/j.gie.2022.10.039","journal-title":"Gastrointest Endosc"},{"key":"12096_CR9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0178414","volume":"12","author":"CW Huh","year":"2017","unstructured":"Huh CW, Youn YH, Chung H, Lee YC, Park H (2017) Functional restoration of the esophagus after peroral endoscopic myotomy for achalasia. PLoS ONE 12:e0178414. https:\/\/doi.org\/10.1371\/journal.pone.0178414","journal-title":"PLoS ONE"},{"key":"12096_CR10","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1001\/2013.jamasurg.38","volume":"148","author":"S Roman","year":"2013","unstructured":"Roman S, Kahrilas PJ, Mion F, Nealis TB, Soper NJ, Poncet G, Nicod\u00e8me F, Hungness E, Pandolfino JE (2013) Partial recovery of peristalsis after myotomy for achalasia: more the rule than the exception. JAMA Surg 148:157\u2013164. https:\/\/doi.org\/10.1001\/2013.jamasurg.38","journal-title":"JAMA Surg"},{"key":"12096_CR11","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1111\/1751-2980.13192","volume":"24","author":"LL Shi","year":"2023","unstructured":"Shi LL, Yang T, Jiang N, Lyu Y, Guo HM, Yang H, Yin Q, Zou XP, Zhang NN (2023) A comprehensive analysis of partial peristalsis recovery after peroral endoscopic myotomy in patients with achalasia. J Dig Dis 24:224\u2013230. https:\/\/doi.org\/10.1111\/1751-2980.13192","journal-title":"J Dig Dis"},{"key":"12096_CR12","doi-asserted-by":"publisher","first-page":"e14058","DOI":"10.1111\/nmo.14058","volume":"33","author":"R Yadlapati","year":"2021","unstructured":"Yadlapati R, Kahrilas PJ, Fox MR, Bredenoord AJ, Gyawali CP, Roman S, Babaei A, Mittal RK, Rommel N, Savarino E, Sifrim D, Smout A, Vaezi MF, Zerbib F, Akiyama J, Bhatia S, Bor S, Carlson DA, Chen JW, Cisternas D, Cock C, Coss-Adame E, de Bortoli N, Defilippi C, Fass R, Ghoshal UC, Gonlachanvit S, Hani A, Hebbard GS, Jung KW, Katz P, Katzka DA, Khan A, Kohn GP, Lazarescu A, Lenglinger J, Mittal SK, Omari T, Park MI, Penagini R, Pohl D, Richter JE, Serra J, Sweis R, Tack J, Tatum RP, Tutuian R, Vela MF, Wong RK, Wu JC, Xiao Y, Pandolfino JE (2021) Esophageal motility disorders on high-resolution manometry: Chicago classification version 40. Neurogastroenterol Motil 33:e14058. https:\/\/doi.org\/10.1111\/nmo.14058","journal-title":"Neurogastroenterol Motil"}],"container-title":["Surgical Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-025-12096-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00464-025-12096-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-025-12096-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:05:05Z","timestamp":1759781105000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00464-025-12096-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,28]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["12096"],"URL":"https:\/\/doi.org\/10.1007\/s00464-025-12096-3","relation":{},"ISSN":["0930-2794","1432-2218"],"issn-type":[{"value":"0930-2794","type":"print"},{"value":"1432-2218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,28]]},"assertion":[{"value":"2 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Siddarth Vyas, Marc Ward, Brittany Buckmaster, Bola Aladegbami, Christine Wang, Gerald Ogola, and Steven Leeds have no conflicts of interest or financial ties to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}