{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T01:06:09Z","timestamp":1759799169135,"version":"build-2065373602"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Med-X Innovation Programme of Med-X Center for Materials, Sichuan University","award":["MCM202302"],"award-info":[{"award-number":["MCM202302"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Endosc"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1007\/s00464-025-12108-2","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T15:30:44Z","timestamp":1756395044000},"page":"7035-7043","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Innovative staining for endoscopic screening of early esophageal cancer and precancerous lesions: a preclinical study"],"prefix":"10.1007","volume":"39","author":[{"given":"Yuan","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiachang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaopeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shishuai","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2272-747X","authenticated-orcid":false,"given":"Bing","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,8,28]]},"reference":[{"key":"12108_CR1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15030765","volume":"15","author":"M Sheikh","year":"2023","unstructured":"Sheikh M, Roshandel G, McCormack V, Malekzadeh R (2023) Current status and future prospects for esophageal cancer. Cancers (Basel) 15:765","journal-title":"Cancers (Basel)"},{"key":"12108_CR2","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.gtc.2022.06.005","volume":"51","author":"DC Codipilly","year":"2022","unstructured":"Codipilly DC, Wang KK (2022) Squamous cell carcinoma of the esophagus. Gastroenterol Clin North Am 51:457\u2013484","journal-title":"Gastroenterol Clin North Am"},{"key":"12108_CR3","doi-asserted-by":"publisher","first-page":"3799","DOI":"10.1038\/s41467-023-39530-1","volume":"14","author":"M Zhou","year":"2023","unstructured":"Zhou M, Bao S, Gong T, Wang Q, Sun J, Li J, Lu M, Sun W, Su J, Chen H, Liu Z (2023) The transcriptional landscape and diagnostic potential of long non-coding RNAs in esophageal squamous cell carcinoma. Nat Commun 14:3799","journal-title":"Nat Commun"},{"key":"12108_CR4","doi-asserted-by":"publisher","first-page":"39","DOI":"10.21037\/tgh.2019.12.06","volume":"5","author":"R Singh","year":"2020","unstructured":"Singh R, Chiam KH, Leiria F, Pu LZCT, Choi KC, Militz M (2020) Chromoendoscopy: role in modern endoscopic imaging. Transl Gastroenterol Hepatol 5:39","journal-title":"Transl Gastroenterol Hepatol"},{"key":"12108_CR5","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/j.gie.2019.11.041","volume":"91","author":"O Pech","year":"2020","unstructured":"Pech O (2020) Lugol staining for early esophageal neoplasia: less is sometimes more. Gastrointest Endosc 91:771\u2013772","journal-title":"Gastrointest Endosc"},{"key":"12108_CR6","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.gie.2019.10.022","volume":"91","author":"T Gotoda","year":"2020","unstructured":"Gotoda T, Kanzaki H, Okamoto Y, Obayashi Y, Baba Y, Hamada K, Sakae H, Abe M, Iwamuro M, Kawano S, Kawahara Y, Okada H (2020) Tolerability and efficacy of the concentration of iodine solution during esophageal chromoendoscopy: a double-blind randomized controlled trial. Gastrointest Endosc 91:763\u2013770","journal-title":"Gastrointest Endosc"},{"key":"12108_CR7","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.764111","volume":"8","author":"X Tian","year":"2021","unstructured":"Tian X, Yang W, Chen WQ (2021) Comparative efficacy and safety of anterograde vs. retrograde iodine staining during esophageal chromoendoscopy: a single-center, prospective, parallel-group, randomized, controlled, single-blind trial. Front Med 8:764111","journal-title":"Front Med"},{"key":"12108_CR8","doi-asserted-by":"publisher","first-page":"75","DOI":"10.4103\/1319-3767.203366","volume":"23","author":"K Kandiah","year":"2017","unstructured":"Kandiah K, Chedgy FJ, Subramaniam S, Thayalasekaran S, Kurup A, Bhandari P (2017) Early squamous neoplasia of the esophagus: the endoscopic approach to diagnosis and management. Saudi J Gastroenterol 23:75\u201381","journal-title":"Saudi J Gastroenterol"},{"key":"12108_CR9","first-page":"315","volume":"31","author":"V Meves","year":"2015","unstructured":"Meves V, Behrens A, Pohl J (2015) Diagnostics and early diagnosis of esophageal cancer. Viszeralmedizin 31:315\u2013318","journal-title":"Viszeralmedizin"},{"key":"12108_CR10","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.gtc.2024.08.019","volume":"53","author":"K Jung","year":"2024","unstructured":"Jung K, Haug RM, Wang AY (2024) Advanced esophageal endoscopy. Gastroenterol Clin North Am 53:603\u2013626","journal-title":"Gastroenterol Clin North Am"},{"key":"12108_CR11","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1159\/000067480","volume":"20","author":"U Peitz","year":"2002","unstructured":"Peitz U, Malfertheiner P (2002) Chromoendoscopy: from a research tool to clinical progress. Dig Dis 20:111\u2013119","journal-title":"Dig Dis"},{"key":"12108_CR12","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1208\/s12249-020-01909-4","volume":"22","author":"Y Luo","year":"2021","unstructured":"Luo Y, Hong Y, Shen L, Wu F, Lin X (2021) Multifunctional role of polyvinylpyrrolidone in pharmaceutical formulations. AAPS PharmSciTech 22:34","journal-title":"AAPS PharmSciTech"},{"key":"12108_CR13","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1080\/09205063.2022.2155778","volume":"34","author":"KN Mangang","year":"2023","unstructured":"Mangang KN, Thakran P, Halder J, Yadav KS, Ghosh G, Pradhan D, Rath G, Rai VK (2023) PVP-microneedle array for drug delivery: mechanical insight, biodegradation, and recent advances. J Biomater Sci Polym Ed 34:986\u20131017","journal-title":"J Biomater Sci Polym Ed"},{"key":"12108_CR14","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/S0016-5085(79)80133-X","volume":"76","author":"PH Guth","year":"1979","unstructured":"Guth PH, Aures D, Paulsen G (1979) Topical aspirin plus HCl gastric lesions in the rat. Cytoprotective effect of prostaglandin, cimetidine, and probanthine. Gastroenterology 76:88\u201393","journal-title":"Gastroenterology"},{"key":"12108_CR15","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/S1052-5157(18)30506-3","volume":"4","author":"MB Fennerty","year":"1994","unstructured":"Fennerty MB (1994) Tissue staining. Gastrointest Endosc Clin N Am 4:297\u2013311","journal-title":"Gastrointest Endosc Clin N Am"},{"key":"12108_CR16","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1055\/a-1811-7025","volume":"54","author":"P Pimentel-Nunes","year":"2022","unstructured":"Pimentel-Nunes P, Lib\u00e2nio D, Bastiaansen BAJ, Bhandari P, Bisschops R, Bourke MJ, Esposito G, Lemmers A, Maselli R, Messmann H, Pech O, Pioche M, Vieth M, Weusten BLAM, van Hooft JE, Deprez PH, Dinis-Ribeiro M (2022) Endoscopic submucosal dissection for superficial gastrointestinal lesions: European Society of Gastrointestinal Endoscopy (ESGE) guideline-update 2022. Endoscopy 54:591\u2013622","journal-title":"Endoscopy"},{"key":"12108_CR17","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.gtc.2006.07.004","volume":"35","author":"R Kiesslich","year":"2006","unstructured":"Kiesslich R, Neurath MF (2006) Chromoendoscopy and other novel imaging techniques. Gastroenterol Clin North Am 35:605\u2013619","journal-title":"Gastroenterol Clin North Am"},{"key":"12108_CR18","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/639462","volume":"2015","author":"K Goda","year":"2015","unstructured":"Goda K, Dobashi A, Yoshimura N, Kato M, Aihara H, Sumiyama K, Toyoizumi H, Kato T, Ikegami M, Tajiri H (2015) Narrow-band imaging magnifying endoscopy versus Lugol chromoendoscopy with pink-color sign assessment in the diagnosis of superficial esophageal squamous neoplasms: a randomised noninferiority trial. Gastroenterol Res Pract 2015:639462","journal-title":"Gastroenterol Res Pract"},{"key":"12108_CR19","doi-asserted-by":"publisher","DOI":"10.3390\/ma17030574","volume":"17","author":"S Jebali","year":"2024","unstructured":"Jebali S, Vayer M, Belal K, Sinturel C (2024) Engineered nanocomposite coatings: from water-soluble polymer to advanced hydrophobic performances. Materials 17:574","journal-title":"Materials"},{"key":"12108_CR20","doi-asserted-by":"publisher","first-page":"13731","DOI":"10.1039\/D0NR00988A","volume":"12","author":"Y Liu","year":"2020","unstructured":"Liu Y, Wang Q, Bi S, Zhang W, Zhou H, Jiang X (2020) Water-processable liquid metal nanoparticles by single-step polymer encapsulation. Nanoscale 12:13731\u201313741","journal-title":"Nanoscale"},{"key":"12108_CR21","first-page":"418","volume":"23","author":"SB Prado","year":"2019","unstructured":"Prado SB, Ayora ACR, Campa AT (2019) Measurement of free iodine in different formulations of povidone-iodine eye drops 5. Int J Pharm Compd 23:418\u2013421","journal-title":"Int J Pharm Compd"},{"key":"12108_CR22","first-page":"59","volume":"31","author":"ME Abdullah","year":"1981","unstructured":"Abdullah ME, Said SA (1981) Release and organ distribution of 125I from povidone-iodine under the influence of certain additives. Arzneimittelforschung 31:59\u201361","journal-title":"Arzneimittelforschung"},{"key":"12108_CR23","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1111\/cxo.12899","volume":"102","author":"S Lee","year":"2019","unstructured":"Lee S, Khun D, Kumarasinghe GL, De Zoysa GH, Sarojini V, Vellara HR, Rupenthal ID, Thakur SS (2019) Ex vivo evaluation of the stability, safety and antibacterial efficacy of an extemporaneous povidone-iodine preparation for ophthalmic applications. Clin Exp Optom 102:583\u2013589","journal-title":"Clin Exp Optom"},{"key":"12108_CR24","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/0195-6701(95)90289-9","volume":"29","author":"W Gottardi","year":"1995","unstructured":"Gottardi W (1995) The uptake and release of molecular iodine by the skin: chemical and bactericidal evidence of residual effects caused by povidone-iodine preparations. J Hosp Infect 29:9\u201318","journal-title":"J Hosp Infect"},{"key":"12108_CR25","doi-asserted-by":"publisher","DOI":"10.1093\/dote\/dox155","author":"BE Louie","year":"2018","unstructured":"Louie BE, Hofstetter W, Triadafilopoulos G, Weusten BL (2018) Evaluation of a novel cryoballoon swipe ablation system in bench, porcine, and human esophagus models. Dis Esophagus. https:\/\/doi.org\/10.1093\/dote\/dox155","journal-title":"Dis Esophagus"},{"key":"12108_CR26","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","volume":"22","author":"S Reagan-Shaw","year":"2008","unstructured":"Reagan-Shaw S, Nihal M, Ahmad N (2008) Dose translation from animal to human studies revisited. FASEB J 22:659\u2013661","journal-title":"FASEB J"}],"container-title":["Surgical Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-025-12108-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00464-025-12108-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-025-12108-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:04:40Z","timestamp":1759781080000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00464-025-12108-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,28]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["12108"],"URL":"https:\/\/doi.org\/10.1007\/s00464-025-12108-2","relation":{},"ISSN":["0930-2794","1432-2218"],"issn-type":[{"type":"print","value":"0930-2794"},{"type":"electronic","value":"1432-2218"}],"subject":[],"published":{"date-parts":[[2025,8,28]]},"assertion":[{"value":"15 April 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 August 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}},{"value":"Drs. Yuan Gao, Jiachang Li, Xiaopeng Xu, Bin Yu, Shishuai Xiang, Long He, Yuhang Zhang, Jia Xie, Jiang Du, and Bing Hu have no conflicts of interest or financial ties to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}