{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T01:54:46Z","timestamp":1788400486407,"version":"build-2803163510"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Endosc"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1007\/s00464-025-12521-7","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T20:59:06Z","timestamp":1767646746000},"page":"2461-2473","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Autoimmune gastritis potentiates polypoid nodule scar formation after endoscopic resection: implications for risk-stratified surveillance"],"prefix":"10.1007","volume":"40","author":[{"given":"Shiyun","family":"Mai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"12521_CR1","doi-asserted-by":"publisher","first-page":"628","DOI":"10.4253\/wjge.v8.i17.628","volume":"8","author":"V Arantes","year":"2016","unstructured":"Arantes V, Uedo N, Pedrosa MS, Tomita Y (2016) Clinical relevance of aberrant polypoid nodule scar after endoscopic submucosal dissection. World J Gastrointest Endosc 8:628\u2013634","journal-title":"World J Gastrointest Endosc"},{"key":"12521_CR2","doi-asserted-by":"publisher","first-page":"1673","DOI":"10.1182\/blood-2005-09-3534","volume":"107","author":"C Hershko","year":"2006","unstructured":"Hershko C, Ronson A, Souroujon M, Maschler I, Heyd J, Patz J (2006) Variable hematologic presentation of autoimmune gastritis: age-related progression from iron deficiency to cobalamin depletion. Blood 107:1673\u20131679","journal-title":"Blood"},{"key":"12521_CR3","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.4251\/wjgo.v15.i8.1451","volume":"15","author":"S Massironi","year":"2023","unstructured":"Massironi S, Gallo C, Elvevi A, Stegagnini M, Coltro LA, Invernizzi P (2023) Incidence and prevalence of gastric neuroendocrine tumors in patients with chronic atrophic autoimmune gastritis. World J Gastrointest Oncol 15:1451\u20131460","journal-title":"World J Gastrointest Oncol"},{"key":"12521_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41572-020-0187-8","volume":"6","author":"MV Lenti","year":"2020","unstructured":"Lenti MV, Rugge M, Lahner E, Miceli E, Toh B-H, Genta RM, De Block C, Hershko C, Di Sabatino A (2020) Autoimmune gastritis. Nat Rev Dis Primers 6:1\u201319","journal-title":"Nat Rev Dis Primers"},{"key":"12521_CR5","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/j.autrev.2014.01.048","volume":"13","author":"B-H Toh","year":"2014","unstructured":"Toh B-H (2014) Diagnosis and classification of autoimmune gastritis. Autoimmun Rev 13:459\u2013462","journal-title":"Autoimmun Rev"},{"key":"12521_CR6","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000003235","author":"A Jove","year":"2024","unstructured":"Jove A, Lin C, Hwang JH, Balasubramanian V, Fernandez-Becker NQ, Huang RJ (2024) Serum gastrin levels are associated with prevalent neuroendocrine tumors in autoimmune metaplastic atrophic gastritis. Am J Gastroenterol. https:\/\/doi.org\/10.14309\/ajg.0000000000003235","journal-title":"Am J Gastroenterol"},{"key":"12521_CR7","doi-asserted-by":"publisher","first-page":"E1198","DOI":"10.1055\/a-0607-2452","volume":"6","author":"V Arantes","year":"2018","unstructured":"Arantes V, Uedo N, Morita Y et al (2018) Polypoid nodule scar after gastric endoscopic submucosal dissection: results from a multicenter study. Endosc Int Open 6:E1198\u2013E1203","journal-title":"Endosc Int Open"},{"key":"12521_CR8","doi-asserted-by":"publisher","first-page":"e70094","DOI":"10.1002\/deo2.70094","volume":"5","author":"N Masuda","year":"2025","unstructured":"Masuda N, Yamazaki K, Maruyama Y, Kushima R, Hasebe N, Ozawa N, Shimizu S, Shimizu M (2025) Revealing autoimmune gastritis: polypoid nodule scar development after endoscopic submucosal dissection for early gastric cancer. DEN Open 5:e70094","journal-title":"DEN Open"},{"key":"12521_CR9","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/den.13883","volume":"33","author":"H Ono","year":"2021","unstructured":"Ono H, Yao K, Fujishiro M et al (2021) Guidelines for endoscopic submucosal dissection and endoscopic mucosal resection for early gastric cancer (second edition). Dig Endosc 33:4\u201320","journal-title":"Dig Endosc"},{"key":"12521_CR10","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.3390\/cancers16071310","volume":"16","author":"C Castellana","year":"2024","unstructured":"Castellana C, Eusebi LH, Dajti E, Iascone V, Vestito A, Fusaroli P, Fuccio L, D\u2019Errico A, Zagari RM (2024) Autoimmune atrophic gastritis: a clinical review. Cancers 16:1310","journal-title":"Cancers"},{"key":"12521_CR11","doi-asserted-by":"publisher","first-page":"1172","DOI":"10.1111\/apt.15540","volume":"50","author":"E Miceli","year":"2019","unstructured":"Miceli E, Vanoli A, Lenti MV et al (2019) Natural history of autoimmune atrophic gastritis: a prospective, single centre, long-term experience. Aliment Pharmacol Ther 50:1172\u20131180","journal-title":"Aliment Pharmacol Ther"},{"key":"12521_CR12","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1080\/00365521.2017.1288758","volume":"52","author":"V Villanacci","year":"2017","unstructured":"Villanacci V, Casella G, Lanzarotto F, Di Bella C, Sidoni A, Cadei M, Salviato T, Dore MP, Bassotti G (2017) Autoimmune gastritis: relationships with anemia and helicobacter pylori status. Scand J Gastroenterol 52:674\u2013677","journal-title":"Scand J Gastroenterol"},{"key":"12521_CR13","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1111\/den.14175","volume":"34","author":"T Kamada","year":"2022","unstructured":"Kamada T, Maruyama Y, Monobe Y, Haruma K (2022) Endoscopic features and clinical importance of autoimmune gastritis. Dig Endosc: Off J Jpn Gastroenterol Endosc Soc 34:700\u2013713","journal-title":"Dig Endosc: Off J Jpn Gastroenterol Endosc Soc"},{"key":"12521_CR14","doi-asserted-by":"publisher","first-page":"12793","DOI":"10.12998\/wjcc.v10.i34.12793","volume":"10","author":"BC Jin","year":"2022","unstructured":"Jin BC, Ahn AR, Kim S-H, Seo SY (2022) Regression of gastric endoscopic submucosal dissection induced polypoid nodular scar after Helicobacter pylori eradication: a case report. World J Clin Cases 10:12793\u201312798","journal-title":"World J Clin Cases"},{"key":"12521_CR15","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1093\/qjmed\/hcaf028","volume":"118","author":"T Zhang","year":"2025","unstructured":"Zhang T, Tang X (2025) Beyond metaplasia: unraveling the complex pathogenesis of autoimmune atrophic gastritis and its implications for gastric cancer risk. QJM Int J Med 118:203","journal-title":"QJM Int J Med"},{"key":"12521_CR16","doi-asserted-by":"publisher","first-page":"837","DOI":"10.14309\/ajg.0000000000002619","volume":"119","author":"E Miceli","year":"2024","unstructured":"Miceli E, Lenti MV, Gentile A et al (2024) Long-term natural history of autoimmune gastritis: results from a prospective monocentric series. Am J Gastroenterol 119:837\u2013845","journal-title":"Am J Gastroenterol"},{"key":"12521_CR17","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1111\/den.13500","volume":"32","author":"S Terao","year":"2020","unstructured":"Terao S, Suzuki S, Yaita H et al (2020) Multicenter study of autoimmune gastritis in Japan: clinical and endoscopic characteristics. Dig Endosc 32:364\u2013372","journal-title":"Dig Endosc"},{"key":"12521_CR18","doi-asserted-by":"publisher","first-page":"522","DOI":"10.3390\/cancers16030522","volume":"16","author":"G Privitera","year":"2024","unstructured":"Privitera G, Williams JJ, De Salvo C (2024) The importance of Th2 immune responses in mediating the progression of gastritis-associated metaplasia to gastric cancer. Cancers 16:522","journal-title":"Cancers"},{"key":"12521_CR19","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1186\/s13045-022-01307-2","volume":"15","author":"L Xu","year":"2022","unstructured":"Xu L, Zou C, Zhang S et al (2022) Reshaping the systemic tumor immune environment (STIE) and tumor immune microenvironment (TIME) to enhance immunotherapy efficacy in solid tumors. J Hematol Oncol 15:87","journal-title":"J Hematol Oncol"},{"key":"12521_CR20","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1111\/jgh.12144","volume":"28","author":"H Nishiura","year":"2013","unstructured":"Nishiura H, Iwamoto S, Kido M, Aoki N, Maruoka R, Ikeda A, Chiba T, Watanabe N (2013) Interleukin-21 and tumor necrosis factor-\u03b1 are critical for the development of autoimmune gastritis in mice. J Gastroenterol Hepatol 28:982\u2013991","journal-title":"J Gastroenterol Hepatol"},{"key":"12521_CR21","doi-asserted-by":"publisher","first-page":"1450558","DOI":"10.3389\/fphar.2024.1450558","volume":"15","author":"G Cascetta","year":"2024","unstructured":"Cascetta G, Colombo G, Eremita G, Garcia JGN, Lenti MV, Di Sabatino A, Travelli C (2024) Pro- and anti-inflammatory cytokines: the hidden keys to autoimmune gastritis therapy. Front Pharmacol 15:1450558","journal-title":"Front Pharmacol"},{"key":"12521_CR22","doi-asserted-by":"publisher","first-page":"3783","DOI":"10.3748\/wjg.v30.i32.3783","volume":"30","author":"V Isakov","year":"2024","unstructured":"Isakov V (2024) Autoimmune gastritis studies and gastric cancer: true renaissance or bibliometric illusion. World J Gastroenterol 30:3783\u20133790","journal-title":"World J Gastroenterol"},{"key":"12521_CR23","doi-asserted-by":"publisher","first-page":"5263","DOI":"10.3390\/cimb45070334","volume":"45","author":"M Iwamuro","year":"2023","unstructured":"Iwamuro M, Tanaka T, Otsuka M (2023) Update in molecular aspects and diagnosis of autoimmune gastritis. Curr Issues Mol Biol 45:5263\u20135275","journal-title":"Curr Issues Mol Biol"},{"key":"12521_CR24","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jcmgh.2014.12.008","volume":"1","author":"M Kidd","year":"2015","unstructured":"Kidd M, Modlin IM, Bodei L, Drozdov I (2015) Decoding the molecular and mutational ambiguities of gastroenteropancreatic neuroendocrine neoplasm pathobiology. Cell Mol Gastroenterol Hepatol 1:131\u2013153","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"12521_CR25","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1194\/jlr.M800668-JLR200","volume":"50","author":"MR Paillasse","year":"2009","unstructured":"Paillasse MR, de Medina P, Amouroux G, Mhamdi L, Poirot M, Silvente-Poirot S (2009) Signaling through cholesterol esterification: a new pathway for the cholecystokinin 2 receptor involved in cell growth and invasion. J Lipid Res 50:2203\u20132211","journal-title":"J Lipid Res"},{"key":"12521_CR26","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.gene.2019.04.029","volume":"704","author":"E Tang","year":"2019","unstructured":"Tang E, Wang Y, Liu T, Yan B (2019) Gastrin promotes angiogenesis by activating HIF-1\u03b1\/\u03b2-catenin\/VEGF signaling in gastric cancer. Gene 704:42\u201348","journal-title":"Gene"},{"key":"12521_CR27","first-page":"128","volume":"239","author":"JA Schuurkes","year":"1979","unstructured":"Schuurkes JA, Charbon GA (1979) Pentagastrin stimulates tonic and phasic contractile activity of the canine stomach. Arch Int Pharmacodyn Ther 239:128\u2013137","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"12521_CR28","doi-asserted-by":"publisher","first-page":"662","DOI":"10.3390\/nu16050662","volume":"16","author":"L Taylor","year":"2024","unstructured":"Taylor L, McCaddon A, Wolffenbuttel BHR (2024) Creating a framework for treating autoimmune gastritis\u2014the case for replacing lost acid. Nutrients 16:662","journal-title":"Nutrients"},{"key":"12521_CR29","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.52773","author":"MS Bhatnagar","year":"2024","unstructured":"Bhatnagar MS, Choudhari S, Pawar D, Sharma A (2024) Long-term use of proton-pump inhibitors: unravelling the safety puzzle. Cureus. https:\/\/doi.org\/10.7759\/cureus.52773","journal-title":"Cureus"},{"key":"12521_CR30","doi-asserted-by":"publisher","first-page":"3383","DOI":"10.1016\/j.celrep.2018.08.054","volume":"24","author":"MA Nishiguchi","year":"2018","unstructured":"Nishiguchi MA, Spencer CA, Leung DH, Leung TH (2018) Aging suppresses skin-derived circulating SDF1 to promote full-thickness tissue regeneration. Cell Rep 24:3383-3392.e5","journal-title":"Cell Rep"},{"key":"12521_CR31","doi-asserted-by":"publisher","first-page":"e70068","DOI":"10.1111\/hel.70068","volume":"30","author":"Y-I Kim","year":"2025","unstructured":"Kim Y-I, Lee JY, Kim CG, Choi IJ (2025) Helicobacter pylori infection and metachronous gastric cancer in elderly patients with gastric cancer aged \u2265 75 years who underwent endoscopic submucosal dissection. Helicobacter 30:e70068","journal-title":"Helicobacter"},{"key":"12521_CR32","doi-asserted-by":"publisher","first-page":"e12518","DOI":"10.1111\/hel.12518","volume":"23","author":"M Venerito","year":"2018","unstructured":"Venerito M, Vasapolli R, Rokkas T, Malfertheiner P (2018) Gastric cancer: epidemiology, prevention, and therapy. Helicobacter 23:e12518","journal-title":"Helicobacter"},{"key":"12521_CR33","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1055\/s-2006-944780","volume":"38","author":"S Oka","year":"2006","unstructured":"Oka S, Tanaka S, Kaneko I, Mouri R, Hirata M, Kanao H, Kawamura T, Yoshida S, Yoshihara M, Chayama K (2006) Endoscopic submucosal dissection for residual\/local recurrence of early gastric cancer after endoscopic mucosal resection. Endoscopy 38:996\u20131000","journal-title":"Endoscopy"},{"key":"12521_CR34","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1002\/bjs.7274","volume":"98","author":"H Jung","year":"2011","unstructured":"Jung H, Bae JM, Choi MG, Noh JH, Sohn TS, Kim S (2011) Surgical outcome after incomplete endoscopic submucosal dissection of gastric cancer. J Br Surg 98:73\u201378","journal-title":"J Br Surg"},{"key":"12521_CR35","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/S0016-5085(00)70412-4","volume":"118","author":"TC Wang","year":"2000","unstructured":"Wang TC, Dangler CA, Chen D et al (2000) Synergistic interaction between hypergastrinemia and helicobacter infection in a mouse model of gastric cancer. Gastroenterology 118:36\u201347","journal-title":"Gastroenterology"},{"key":"12521_CR36","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1016\/S0016-5085(03)00406-2","volume":"124","author":"JG Fox","year":"2003","unstructured":"Fox JG, Wang TC, Rogers AB et al (2003) Host and microbial constituents influence helicobacter pylori-induced cancer in a murine model of hypergastrinemia. Gastroenterology 124:1879\u20131890","journal-title":"Gastroenterology"},{"key":"12521_CR37","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1053\/gast.2002.34231","volume":"123","author":"PL Peghini","year":"2002","unstructured":"Peghini PL, Annibale B, Azzoni C, Milione M, Corleto VD, Gibril F, Venzon DJ, Delle Fave G, Bordi C, Jensen RT (2002) Effect of chronic hypergastrinemia on human enterochromaffin-like cells: insights from patients with sporadic gastrinomas. Gastroenterology 123:68\u201385","journal-title":"Gastroenterology"},{"key":"12521_CR38","doi-asserted-by":"publisher","first-page":"e70070","DOI":"10.1002\/deo2.70070","volume":"5","author":"K Takahashi","year":"2025","unstructured":"Takahashi K, Nosaka T, Murata Y et al (2025) Influence of antiplatelet drugs on gastric ulcer healing after endoscopic submucosal dissection in patients with early gastric cancer. DEN Open 5:e70070","journal-title":"DEN Open"}],"container-title":["Surgical Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-025-12521-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00464-025-12521-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-025-12521-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T19:35:24Z","timestamp":1773084924000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00464-025-12521-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,5]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["12521"],"URL":"https:\/\/doi.org\/10.1007\/s00464-025-12521-7","relation":{},"ISSN":["0930-2794","1432-2218"],"issn-type":[{"value":"0930-2794","type":"print"},{"value":"1432-2218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,5]]},"assertion":[{"value":"3 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 January 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Drs. Shiyun Mai, Xiaochu Zhao, Xiaoting Feng, Yiting Shi, Zhongyuan Liu, and Huijing Zhang have no conflicts of interest or financial ties to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosures"}}]}}