{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:54:46Z","timestamp":1790956486606,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Surg Endosc"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1007\/s00464-026-13215-4","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:35:08Z","timestamp":1785425708000},"page":"8981-8988","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["One PPI may not fit all\u2014prevalence of CYP2C19 phenotypes in patients with Barrett\u2019s esophagus"],"prefix":"10.1007","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0884-6612","authenticated-orcid":false,"given":"Keouna","family":"Pather","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel-Rahman","family":"Naser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M.","family":"Mobley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefania","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethar","family":"Elsheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J.","family":"Cicali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Crisp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larisa H.","family":"Cavallari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana M.","family":"Sacco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchir","family":"Puri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"13215_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.gtc.2013.11.006","volume":"43","author":"JH Rubenstein","year":"2014","unstructured":"Rubenstein JH, Chen JW (2014) Epidemiology of gastroesophageal reflux disease. Gastroenterol Clin North Am 43:1\u201314","journal-title":"Gastroenterol Clin North Am"},{"key":"13215_CR2","first-page":"175","volume":"63","author":"E Savarino","year":"2017","unstructured":"Savarino E, Marabotto E, Bodini G, Pellegatta G, Coppo C, Giambruno E, Brunacci M, Zentilin P, Savarino V (2017) Epidemiology and natural history of gastroesophageal reflux disease. Minerva Gastroenterol Dietol 63:175\u2013183","journal-title":"Minerva Gastroenterol Dietol"},{"key":"13215_CR3","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1136\/gutjnl-2023-330616","volume":"73","author":"CP Gyawali","year":"2024","unstructured":"Gyawali CP, Yadlapati R, Fass R, Katzka D, Pandolfino J, Savarino E, Sifrim D, Spechler S, Zerbib F, Fox MR (2024) Updates to the modern diagnosis of GERD: Lyon consensus 2.0. Gut 73:361\u2013371","journal-title":"Gut"},{"key":"13215_CR4","first-page":"81","volume":"72","author":"A Sonnenberg","year":"1999","unstructured":"Sonnenberg A, El-Serag HB (1999) Clinical epidemiology and natural history of gastroesophageal reflux disease. Yale J Biol Med 72:81","journal-title":"Yale J Biol Med"},{"key":"13215_CR5","doi-asserted-by":"publisher","first-page":"559","DOI":"10.14309\/ajg.0000000000001680","volume":"117","author":"NJ Shaheen","year":"2022","unstructured":"Shaheen NJ, Falk GW, Iyer PG, Souza RF, Yadlapati RH, Sauer BG, Wani S (2022) Diagnosis and management of Barrett\u2019s esophagus: an updated ACG guideline. Am J Gastroenterol 117:559\u2013587","journal-title":"Am J Gastroenterol"},{"key":"13215_CR6","first-page":"7","volume":"69","author":"RL Siegel","year":"2019","unstructured":"Siegel RL, Miller KD, Jemal A (2019) Cancer statistics, 2019. CA Cancer J Clin 69:7\u201334","journal-title":"CA Cancer J Clin"},{"key":"13215_CR7","doi-asserted-by":"publisher","first-page":"267","DOI":"10.5009\/gnl.2011.5.3.267","volume":"5","author":"JJ Hyun","year":"2011","unstructured":"Hyun JJ, Bak Y-T (2011) Clinical significance of hiatal hernia. Gut Liver 5:267","journal-title":"Gut Liver"},{"key":"13215_CR8","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1136\/gut.2007.145177","volume":"57","author":"RM Zagari","year":"2008","unstructured":"Zagari RM, Fuccio L, Wallander M-A, Johansson S, Fiocca R, Casanova S, Farahmand BY, Winchester CC, Roda E, Bazzoli F (2008) Gastro-oesophageal reflux symptoms, oesophagitis and Barrett\u2019s oesophagus in the general population: the Loiano-Monghidoro study. Gut 57:1354\u20131359","journal-title":"Gut"},{"key":"13215_CR9","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9270(99)00333-0","author":"AJ Cameron","year":"1999","unstructured":"Cameron AJ (1999) Barrett\u2019s esophagus: prevalence and size of hiatal hernia. Am J Gastroenterol. https:\/\/doi.org\/10.1016\/s0002-9270(99)00333-0","journal-title":"Am J Gastroenterol"},{"key":"13215_CR10","doi-asserted-by":"publisher","first-page":"518","DOI":"10.3390\/medicina60030518","volume":"60","author":"J Lee","year":"2024","unstructured":"Lee J, Lee I, Oh Y, Kim JW, Kwon Y, Alromi A, Eledreesi M, Khalid A, Aljarbou W, Park S (2024) Current status of anti-reflux surgery as a treatment for GERD. Medicina B Aires 60:518","journal-title":"Medicina B Aires"},{"key":"13215_CR11","doi-asserted-by":"publisher","DOI":"10.21037\/aoe-21-63","author":"G Nesheiwat","year":"2022","unstructured":"Nesheiwat G, Carr R, Molena D, Tang L (2022) Treatment of Barrett\u2019s esophagus: a narrative review. Annals Esophagus. https:\/\/doi.org\/10.21037\/aoe-21-63","journal-title":"Annals Esophagus"},{"key":"13215_CR12","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/S0003-4975(03)01352-3","volume":"77","author":"AE Abbas","year":"2004","unstructured":"Abbas AE, Deschamps C, Cassivi SD, Allen MS, Nichols IIIFC, Miller DL, Pairolero PC (2004) Barrett\u2019s esophagus: the role of laparoscopic fundoplication. Ann Thorac Surg 77:393\u2013396","journal-title":"Ann Thorac Surg"},{"key":"13215_CR13","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.bpg.2013.06.005","volume":"27","author":"PJ Kahrilas","year":"2013","unstructured":"Kahrilas PJ, Boeckxstaens G, Smout AJ (2013) Management of the patient with incomplete response to PPI therapy. Best Pract Res Clin Gastroenterol 27:401\u2013414","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"13215_CR14","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1080\/17425255.2018.1461835","volume":"14","author":"N El Rouby","year":"2018","unstructured":"El Rouby N, Lima JJ, Johnson JA (2018) Proton pump inhibitors: from CYP2C19 pharmacogenetics to precision medicine. Expert Opin Drug Metab Toxicol 14:447\u2013460","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"13215_CR15","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1111\/j.1365-2036.2006.02943.x","volume":"23","author":"G Sachs","year":"2006","unstructured":"Sachs G, Shin J, Howden C (2006) The clinical pharmacology of proton pump inhibitors. Aliment Pharmacol Ther 23:2\u20138","journal-title":"Aliment Pharmacol Ther"},{"key":"13215_CR16","doi-asserted-by":"publisher","first-page":"873","DOI":"10.2217\/pgs.11.4","volume":"12","author":"K Hagym\u00e1si","year":"2011","unstructured":"Hagym\u00e1si K, M\u00fcllner K, Hersz\u00e9nyi L, Tulassay Z (2011) Update on the pharmacogenomics of proton pump inhibitors. Pharmacogenomics 12:873\u2013888","journal-title":"Pharmacogenomics"},{"key":"13215_CR17","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1007\/s00228-012-1252-3","volume":"68","author":"B Gawro\u0144ska-Szklarz","year":"2012","unstructured":"Gawro\u0144ska-Szklarz B, Adamiak-Giera U, Wyska E, Kurzawski M, Gornik W, Kaldonska M, Drozdzik M (2012) CYP2C19 polymorphism affects single-dose pharmacokinetics of oral pantoprazole in healthy volunteers. Eur J Clin Pharmacol 68:1267\u20131274","journal-title":"Eur J Clin Pharmacol"},{"key":"13215_CR18","doi-asserted-by":"publisher","first-page":"153","DOI":"10.2133\/dmpk.20.153","volume":"20","author":"T Furuta","year":"2005","unstructured":"Furuta T, Shirai N, Sugimoto M, Nakamura A, Hishida A, Ishizaki T (2005) Influence of CYP2C19 pharmacogenetic polymorphism on proton pump inhibitor-based therapies. Drug Metab Pharmacokinet 20:153\u2013167","journal-title":"Drug Metab Pharmacokinet"},{"key":"13215_CR19","unstructured":"Dean L, Kane M (2012) Omeprazole therapy and CYP2C19 genotype. National Center for Biotechnology Information (US), Bethesda, MD"},{"key":"13215_CR20","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1002\/cpt.2015","volume":"109","author":"JJ Lima","year":"2021","unstructured":"Lima JJ, Thomas CD, Barbarino J, Desta Z, Van Driest SL, El Rouby N, Johnson JA, Cavallari LH, Shakhnovich V, Thacker DL (2021) Clinical pharmacogenetics implementation consortium (CPIC) guideline for CYP2C19 and proton pump inhibitor dosing. Clin Pharmacol Ther 109:1417\u20131423","journal-title":"Clin Pharmacol Ther"},{"key":"13215_CR21","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1186\/s12967-018-1469-8","volume":"16","author":"LH Cavallari","year":"2018","unstructured":"Cavallari LH, Franchi F, Rollini F, Been L, Rivas A, Agarwal M, Smith DM, Newsom K, Gong Y, Elsey AR (2018) Clinical implementation of rapid CYP2C19 genotyping to guide antiplatelet therapy after percutaneous coronary intervention. J Transl Med 16:92","journal-title":"J Transl Med"},{"key":"13215_CR22","doi-asserted-by":"publisher","first-page":"1249003","DOI":"10.3389\/fgene.2023.1249003","volume":"14","author":"M Norris","year":"2023","unstructured":"Norris M, Dalton R, Alam B, Eddy E, Nguyen KA, Cavallari LH, Sumfest J, Wiisanen K, Cicali EJ (2023) Lessons from clinical implementation of a preemptive pharmacogenetic panel as part of a testing pilot program with an employer-sponsored medical plan. Front Genet 14:1249003","journal-title":"Front Genet"},{"key":"13215_CR23","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1161\/ATVBAHA.118.311963","volume":"39","author":"MD Klein","year":"2019","unstructured":"Klein MD, Williams AK, Lee CR, Stouffer GA (2019) Clinical utility of CYP2C19 genotyping to guide antiplatelet therapy in patients with an acute coronary syndrome or undergoing percutaneous coronary intervention. Arterioscler Thromb Vasc Biol 39:647\u2013652","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"13215_CR24","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/j.1365-2125.2007.03057.x","volume":"65","author":"K Sugimoto","year":"2008","unstructured":"Sugimoto K, Uno T, Yamazaki H, Tateishi T (2008) Limited frequency of the CYP2C19* 17 allele and its minor role in a Japanese population. Br J Clin Pharmacol 65:437\u2013439","journal-title":"Br J Clin Pharmacol"},{"key":"13215_CR25","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1136\/gut.2009.178061","volume":"59","author":"H Beaumont","year":"2010","unstructured":"Beaumont H, Bennink RJ, de Jong J, Boeckxstaens GE (2010) The position of the acid pocket as a major risk factor for acidic reflux in healthy subjects and patients with GORD. Gut 59:441\u2013451","journal-title":"Gut"},{"issue":"12","key":"13215_CR26","doi-asserted-by":"publisher","first-page":"2133","DOI":"10.14309\/ajg.0000000000002411","volume":"118","author":"M Zamani","year":"2022","unstructured":"Zamani M, Alizadeh-Tabari S, Chan WW, Talley NJ (2022) Association between anxiety\/depression and gastro-esophageal reflux: A systematic review and meta-analysis. Am J Gastroenterol 118(12):2133\u20132143","journal-title":"Am J Gastroenterol"},{"key":"13215_CR27","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1177\/000313481808400651","volume":"84","author":"F Schlottmann","year":"2018","unstructured":"Schlottmann F, Andolfi C, Herbella FA, Rebecchi F, Allaix ME, Patti MG (2018) GERD: presence and size of hiatal hernia influence clinical presentation, esophageal function, reflux profile, and degree of mucosal injury. Am Surg 84:978\u2013982","journal-title":"Am Surg"},{"key":"13215_CR28","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b2576","author":"D Epstein","year":"2009","unstructured":"Epstein D, Bojke L, Sculpher MJ (2009) Laparoscopic fundoplication compared with medical management for gastro-oesophageal reflux disease: cost effectiveness study. BMJ. https:\/\/doi.org\/10.1136\/bmj.b2576","journal-title":"BMJ"},{"key":"13215_CR29","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.1111\/j.1572-0241.2003.08702.x","volume":"98","author":"KE Corey","year":"2003","unstructured":"Corey KE, Schmitz SM, Shaheen NJ (2003) Does a surgical antireflux procedure decrease the incidence of esophageal adenocarcinoma in Barrett\u2019s esophagus? A meta-analysis. Am J Gastroenterol 98:2390\u20132394","journal-title":"Am J Gastroenterol"},{"key":"13215_CR30","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1007\/s10620-013-2763-1","volume":"58","author":"JT Watson","year":"2013","unstructured":"Watson JT, Moawad FJ, Veerappan GR, Bassett JT, Maydonovitch CL, Horwhat JD, Wong RK (2013) The dose of omeprazole required to achieve adequate intraesophageal acid suppression in patients with gastroesophageal junction specialized intestinal metaplasia and Barrett\u2019s esophagus. Dig Dis Sci 58:2253\u20132260","journal-title":"Dig Dis Sci"},{"key":"13215_CR31","doi-asserted-by":"publisher","DOI":"10.1177\/10600280251392989","author":"YJ Lee","year":"2025","unstructured":"Lee YJ, Je NK (2025) Comparison of the effect of proton pump inhibitors versus histamine-2 receptor antagonists on cardiovascular outcomes on clopidogrel-based dual antiplatelet therapy: a nationwide cohort study. Ann Pharmacother. https:\/\/doi.org\/10.1177\/10600280251392989","journal-title":"Ann Pharmacother"},{"key":"13215_CR32","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-024-03549-y","volume":"22","author":"JH Kim","year":"2024","unstructured":"Kim JH, Hong SJ, Cha J-J, Lim S, Joo HJ, Park JH, Yu CW, Ahn TH, Jeong Y-H, Kim B-K (2024) Impact of proton pump inhibitor use on clinical outcomes in East Asian patients receiving clopidogrel following drug-eluting stent implantation. BMC Med 22:335","journal-title":"BMC Med"},{"key":"13215_CR33","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1002\/cpt.1361","volume":"106","author":"M Kim","year":"2019","unstructured":"Kim M, Song HJ, Lee J, Yang BR, Choi N, Park B (2019) Effectiveness and safety of clopidogrel co-administered with statins and proton pump inhibitors: a Korean National Health Insurance Database Study. Clin Pharmacol Ther 106:182\u2013194","journal-title":"Clin Pharmacol Ther"}],"container-title":["Surgical Endoscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-026-13215-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00464-026-13215-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00464-026-13215-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:13:10Z","timestamp":1790953990000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00464-026-13215-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["13215"],"URL":"https:\/\/doi.org\/10.1007\/s00464-026-13215-4","relation":{},"ISSN":["0930-2794","1432-2218"],"issn-type":[{"value":"0930-2794","type":"print"},{"value":"1432-2218","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,30]]},"assertion":[{"value":"31 March 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Keouna Pather, Abdel-Rahman Naser, Erin M. Mobley, Estefania Garcia, Ethar Elsheikh, Emily J. Cicali, Amy Crisp, Larisa H. Cavallari, Jana M. Sacco, and Ruchir Puri have no conflict of interest or financial ties to disclose.","order":1,"name":"Ethics","label":"Disclosures","group":{"name":"EthicsHeading","label":"Declarations"}}]}}