{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:14:11Z","timestamp":1761862451904},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2005,5,24]],"date-time":"2005-05-24T00:00:00Z","timestamp":1116892800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1007\/s00467-005-1863-3","type":"journal-article","created":{"date-parts":[[2005,5,23]],"date-time":"2005-05-23T12:36:30Z","timestamp":1116851790000},"page":"886-890","source":"Crossref","is-referenced-by-count":69,"title":["Mutational analysis of idiopathic renal hypouricemia in Korea"],"prefix":"10.1007","volume":"20","author":[{"given":"Hae Il","family":"Cheong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Hyung","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Hoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Il Soo","family":"Ha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suhnggwon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fusako","family":"Komoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Sekine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Igarashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2005,5,24]]},"reference":[{"key":"1863_CR1","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nature742","volume":"417","author":"Enomoto","year":"2002","unstructured":"Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH, Hosoyamada M, Takeda M, Sekine T, Igarashi T, Matsuo H, Kikuchi Y, Oda T, Ichida K, Hosoya T, Shimokata K, Niwa T, Kanai Y, Endou H (2002) Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature 417:447\u2013452","journal-title":"Nature"},{"key":"1863_CR2","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/0272-6386(95)90579-0","volume":"25","author":"Yeun","year":"1995","unstructured":"Yeun JY, Hasbargen JA (1995) Renal hypouricemia: prevention of exercise-induced acute renal failure and a review of the literature. Am J Kidney Dis 25:937\u2013946","journal-title":"Am J Kidney Dis"},{"key":"1863_CR3","doi-asserted-by":"crossref","first-page":"313","DOI":"10.5414\/CNP58313","volume":"58","author":"Ohta","year":"2002","unstructured":"Ohta T, Sakano T, Ogawa T, Kato J, Awaya Y, Kihara H, Kinoshita Y (2002) Exercise-induced acute renal failure with renal hypouricemia: a case report and a review of the literature. Clin Nephrol 58:313\u2013316","journal-title":"Clin Nephrol"},{"key":"1863_CR4","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2169\/internalmedicine.36.201","volume":"36","author":"Hirasaki","year":"1997","unstructured":"Hirasaki S, Koide N, Fujita K, Ogawa H, Tsuji T (1997) Two cases of renal hypouricemia with nephrolithiasis. Intern Med 36:201\u2013205","journal-title":"Intern Med"},{"key":"1863_CR5","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1159\/000187567","volume":"65","author":"Hisatome","year":"1993","unstructured":"Hisatome I, Tanaka Y, Kotake H, Kosaka H, Hirata N, Fujimoto Y, Yoshida A, Shigemasa C, Mashiba H, Sato R, Takeda A (1993) Renal hypouricemia due to enhanced tubular secretion of urate associated with urolithiasis: successful treatment of urolithiasis by alkalization of urine K+, Na(+)-citrate. Nephron 65:578\u2013582","journal-title":"Nephron"},{"key":"1863_CR6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.2169\/internalmedicine.37.40","volume":"37","author":"Hisatome","year":"1998","unstructured":"Hisatome I, Tanaka Y, Ogino K, Shimoyama M, Hiroe K, Tsuboi M, Yamamoto Y, Hamada N, Kato T, Manabe I, Kinugawa T, Ohtahara A, Yoshida A, Shigemasa C, Takeda A, Sato R (1998) Hematuria in patients with renal hypouricemia. Intern Med 37:40\u201346","journal-title":"Intern Med"},{"key":"1863_CR7","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1007\/s00467-004-1424-1","volume":"19","author":"Komoda","year":"2004","unstructured":"Komoda F, Sekine T, Inatomi J, Enomoto A, Endou H, Ota T, Matsuyama T, Ogata T, Ikeda M, Awazu M, Muroya K, Kamimaki I, Igarashi T (2004) The W258X mutation in SLC22A12 is the predominant cause of Japanese renal hypouricemia. Pediatr Nephrol 19:728\u2013733","journal-title":"Pediatr Nephrol"},{"key":"1863_CR8","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/S0272-6386(98)70067-8","volume":"32","author":"Maesaka","year":"1998","unstructured":"Maesaka JK, Fishbane S (1998) Regulation of renal urate excretion: a critical review. Am J Kidney Dis 32:917\u2013933","journal-title":"Am J Kidney Dis"},{"key":"1863_CR9","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S0272-6386(03)00355-X","volume":"41","author":"Bairaktari","year":"2003","unstructured":"Bairaktari ET, Kakafika AI, Pritsivelis N, Hatzidimou KG, Tsianos EV, Seferiadis KI, Elisaf MS (2003) Hypouricemia in individuals admitted to an inpatient hospital-based facility. Am J Kidney Dis 41:1225\u20131232","journal-title":"Am J Kidney Dis"},{"key":"1863_CR10","first-page":"76","volume":"22","author":"Ogino","year":"1991","unstructured":"Ogino K, Hisatome M, Saitoh J, Miyamoto J, Ishiko R, Hasegawa J, Kotake H, Mashiba H (1991) Clinical significance of hypouricemia in hospitalized patients. J Med 22:76\u201382","journal-title":"J Med"},{"key":"1863_CR11","doi-asserted-by":"crossref","first-page":"977","DOI":"10.7326\/0003-4819-78-6-977","volume":"78","author":"Van","year":"1973","unstructured":"Van Peenen HJ (1973) Causes of hypouricemia. Ann Intern Med 78:977\u2013978","journal-title":"Ann Intern Med"},{"key":"1863_CR12","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000185233","volume":"51","author":"Hisatome","year":"1989","unstructured":"Hisatome I, Ogino K, Kotake H, Ishiko R, Saito M, Hasegawa J, Mashiba H, Nakamoto S (1989) Cause of persistent hypouricemia in outpatients. Nephron 51:13\u201316","journal-title":"Nephron"},{"key":"1863_CR13","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/01.ASN.0000105320.04395.D0","volume":"15","author":"Ichida","year":"2004","unstructured":"Ichida K, Hosoyamada M, Hisatome I, Enomoto A, Hikita M, Endou H, Hosoya T (2004) Clinical and molecular analysis of patients with renal hypouricemia in Japan\u2014Influence of URAT1 gene on urinary urate excretion. J Am Soc Nephrol 15:164\u2013173","journal-title":"J Am Soc Nephrol"},{"key":"1863_CR14","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1053\/j.ajkd.2003.08.032","volume":"42","author":"Tanaka","year":"2003","unstructured":"Tanaka M, Itoh K, Matsushita K, Matsushita K, Wakita N, Adachi M, Nonoguchi H, Kitamura K, Hosoyamada M, Endou H, Tomita K (2003) Two male siblings with hereditary renal hypouricemia and exercise-Induced ARF. Am J Kidney Dis 42:1287\u20131292","journal-title":"Am J Kidney Dis"},{"key":"1863_CR15","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/j.1523-1755.2004.00839.x","volume":"66","author":"Iwai","year":"2004","unstructured":"Iwai N, MIno Y, Hosoyamada M, Tago N, Kokubo Y, Endou H (2004) A high prevalence of renal hypouricemia caused by inactive SLC22A12 in Japanese. Kidney Int 66:935\u2013944","journal-title":"Kidney Int"},{"key":"1863_CR16","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1172\/JCI107323","volume":"52","author":"Diamond","year":"1973","unstructured":"Diamond HS, Paolino JS (1973) Evidence for a postsecretory reabsorptive site for uric acid in man. J Clin Invest 52:1491\u20131499","journal-title":"J Clin Invest"},{"key":"1863_CR17","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1136\/ard.39.2.173","volume":"39","author":"Levinson","year":"1980","unstructured":"Levinson DJ, Sorensen LB (1980) Renal handling of uric acid in normal and gouty subject: evidence for a 4-component system. Ann Rheum Dis 39:173\u2013179","journal-title":"Ann Rheum Dis"},{"key":"1863_CR18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000421446","volume":"100","author":"Sperling","year":"1992","unstructured":"Sperling O (1992) Renal hypouricemia: classification, tubular defect and clinical consequences. Contrib Nephrol 100:1\u201314","journal-title":"Contrib Nephrol"},{"key":"1863_CR19","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1159\/000065013","volume":"91","author":"Ishikawa","year":"2002","unstructured":"Ishikawa I (2002) Acute renal failure with severe loin pain and patchy renal ischemia after anaerobic exercise in patients with or without renal hypouricemia. Nephron 91:559\u2013570","journal-title":"Nephron"},{"key":"1863_CR20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000185233","volume":"51","author":"Hisatome","year":"1989","unstructured":"Hisatome I, Ogino K, Kotake H, Ishiko R, Saito M, Hasegawa J, Mashiba H, Nakamoto S (1989) Cause of persistent hypouricemia in outpatients. Nephron 51:13\u201316","journal-title":"Nephron"},{"key":"1863_CR21","first-page":"75","volume":"30","author":"de","year":"1979","unstructured":"de Vries A, Sperling O (1979) Inborn hypouricemia due to isolated renal tubular defect. Biomedicine 30:75\u201380","journal-title":"Biomedicine"},{"key":"1863_CR22","first-page":"309","volume":"15","author":"Gafter","year":"1989","unstructured":"Gafter U, Zuta A, Frydman M, Lewinski UH, Levi J (1989) Hypouricemia due to familial isolated renal tubular uricosuria. Evaluation with the combined pyrazinamide\u2013probenecid test. Miner Electrolyte Metab 15:309\u2013314","journal-title":"Miner Electrolyte Metab"},{"key":"1863_CR23","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1073\/pnas.78.11.6858","volume":"78","author":"Ames","year":"1981","unstructured":"Ames BN, Cathcart R, Schwiers E, Hochstein P (1981) Uric acid provides an antioxidant defence in humans against oxidant- and radical-causing aging and cancer: a hypothesis. Proc Natl Acad Sci USA 78:6853\u20136862","journal-title":"Proc Natl Acad Sci USA"},{"key":"1863_CR24","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1042\/bj2350747","volume":"235","author":"Davies","year":"1986","unstructured":"Davies KJ, Sevanian A, Muakkassah-Kelly SF, Hochstein P (1986) Uric acid\u2013iron ion complexes: a new aspect of the anti-oxidant functions of uric acid. Biochem J 235:747\u2013754","journal-title":"Biochem J"},{"key":"1863_CR25","doi-asserted-by":"crossref","first-page":"5778","DOI":"10.1021\/ja00197a042","volume":"111","author":"Simie","year":"1989","unstructured":"Simie MG, Jovanovic SV (1989) Antioxidation mechanisms of uric acid. J Am Chem Soc 111:5778\u20135782","journal-title":"J Am Chem Soc"},{"key":"1863_CR26","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1161\/01.HYP.0000069700.62727.C5","volume":"41","author":"Johnson","year":"2003","unstructured":"Johnson RJ, Kang D-H, Feig D, Kivlighn S, Kanellis J, Watanabe S, Tuttle KR, Rodriguez-Iturbe B, Herrera-Acosta J, Mazzali M (2003) Is There a pathogenetic role for uric acid in hypertension and cardiovascular and renal disease? Hypertension 41:1183\u20131190","journal-title":"Hypertension"},{"key":"1863_CR27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1159\/000180580","volume":"16","author":"Cockcroft","year":"1976","unstructured":"Cockcroft DW, Gault MH (1976) Prediction of creatinine clearance from serum creatinine. Nephron 16:31\u201341","journal-title":"Nephron"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-005-1863-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-005-1863-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-005-1863-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T00:39:28Z","timestamp":1559090368000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-005-1863-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,24]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["1863"],"URL":"https:\/\/doi.org\/10.1007\/s00467-005-1863-3","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5,24]]}}}