{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:15:26Z","timestamp":1790774126924,"version":"4.1.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1007\/s00467-006-0376-z","type":"journal-article","created":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T12:04:53Z","timestamp":1164974693000},"page":"621-625","source":"Crossref","is-referenced-by-count":22,"title":["Diagnosis of Alport syndrome without biopsy?"],"prefix":"10.1007","volume":"22","author":[{"given":"Marie Claire","family":"Gubler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,5,1]]},"reference":[{"key":"376_CR1","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1038\/ki.1985.63","volume":"27","author":"J Feingold","year":"1985","unstructured":"Feingold J, Bois E, Chompret A, Broyer M, Gubler MC, Gr\u00fcnfeld JP (1985) Genetic heterogenerity of Alport syndrome. Kidney Int 27:672\u2013677","journal-title":"Kidney Int"},{"key":"376_CR2","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1056\/NEJMra022296","volume":"348","author":"BG Hudson","year":"2003","unstructured":"Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG (2003) Alport\u2019s syndrome, Goodpasture\u2019s syndrome, and type IV collagen. New Engl J Med 348:2543\u20132556","journal-title":"New Engl J Med"},{"key":"376_CR3","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1681\/ASN.V114649","volume":"11","author":"JP Jais","year":"2000","unstructured":"Jais JP, Knebelmann B, Giatras I, De Marchi M, Rizzoni G, Renieri A, Weber M, Gross O, Netzer KO, Flinter F, Pirson Y, Verelen C, Wieslander J, Persson U, Tryggvason K, Martin P, Hertz JM, Schr\u00f6der C, Sanak M, Krejcova S, Carvalho MF, Saus J, Antignac C, Smeets H, Gubler MC (2000) X-linked Alport syndrome. Natural history in 195 families and genotype-phenotype correlations in males. J Am Soc Nephrol 11:649\u2013657","journal-title":"J Am Soc Nephrol"},{"key":"376_CR4","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1016\/S0140-6736(88)90753-2","volume":"2","author":"FA Flinter","year":"1988","unstructured":"Flinter FA, Cameron JS, Chantler C, Houston I, Bobrow M (1988) Genetics of classic Alport\u2019s syndrome. Lancet 2:1005\u20131007","journal-title":"Lancet"},{"key":"376_CR5","doi-asserted-by":"publisher","first-page":"760","DOI":"10.1046\/j.1523-1755.1999.00601.x","volume":"56","author":"Y Pirson","year":"1999","unstructured":"Pirson Y (1999) Making the diagnosis of Alport syndrome. Kidney Int 56:760\u2013773","journal-title":"Kidney Int"},{"key":"376_CR6","doi-asserted-by":"publisher","first-page":"1260","DOI":"10.1007\/s00467-005-1975-9","volume":"20","author":"M Slajpah","year":"2005","unstructured":"Slajpah M, Meglic A, Furlan P, Glavac D (2005) The importance of non-invasive genetic analysis in the initial dignostics of Alport syndrome in young patients. Pediatr Nephrol 20:1260\u20131264","journal-title":"Pediatr Nephrol"},{"key":"376_CR7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1681\/ASN.V12197","volume":"12","author":"L Heidet","year":"2001","unstructured":"Heidet L, Arrondel C, Cohen-Solal L, Forestier L, Mollet G, Guttierez B, Stavrou C, Gubler MC, Antignac MC (2001) Structure of the human type IV collagen gene COL4A3 and mutations in autosomal Alport syndrome. J Am Soc Nephrol 12:97\u2013106","journal-title":"J Am Soc Nephrol"},{"key":"376_CR8","doi-asserted-by":"publisher","first-page":"2429","DOI":"10.1093\/ndt\/gfh435","volume":"19","author":"R Torra","year":"2004","unstructured":"Torra R, Tazon-Vega B, Ars E, Ballarin J, (2004) Collagen type IV (\u03b13\u2013\u03b14) nephropathy from isolated haematuria to renal failure. Nephrol Dial Transplant 19:2429\u20132432","journal-title":"Nephrol Dial Transplant"},{"key":"376_CR9","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1159\/000424811","volume":"117","author":"CE Kashtan","year":"1996","unstructured":"Kashtan CE, Kleppel MM, Gubler MC (1996) Immunohistologic findings in Alport syndrome. in Molecular Pathology and Genetics of Alport Syndrome. Contr Nephrol Basel, Karger 117:142\u2013153","journal-title":"Contr Nephrol Basel, Karger"},{"key":"376_CR10","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/S0272-6386(99)70042-9","volume":"34","author":"Y Inoue","year":"1999","unstructured":"Inoue Y, Nishio H, Shirakawa T, Nekanishi K, Nakamura H, Sumino K, Nishiyama K, Iijima K, Yoshikawa N (1999) Detection of mutations in the COL4A5 gene in over 90% of patients with X-linked Alport\u2019s syndrome by RT-PCR and direct sequencing. Am J Kidney Dis 34:854\u2013862","journal-title":"Am J Kidney Dis"},{"key":"376_CR11","doi-asserted-by":"publisher","first-page":"1268","DOI":"10.1111\/j.1523-1755.2005.00204.x","volume":"67","author":"F Wang","year":"2005","unstructured":"Wang F, Wang YF, Ding J, Yang JY (2005) Detection of mutations in the COL4A5 gene by analyzing cDNA of skin fibroblasts. Kidney Int 67:1268\u20131274","journal-title":"Kidney Int"},{"key":"376_CR12","unstructured":"Torra R (2006) Alport syndrome and collagen IV nephropathy in Fourth Course on Genetics and renal Diseases. June 8\u201310, 2006, Genoa. Book of Abstracts pp 61\u201364"},{"key":"376_CR13","first-page":"584","volume":"110","author":"J Ding","year":"1997","unstructured":"Ding J, Yang J, Liu J, Yu L (1997) Immunofluorescence study of type IV collagen alpha chains in epidermal basement membrane: application in diagnosis of X-linked Alport syndrome. Chin Med J 110:584","journal-title":"Chin Med J"},{"key":"376_CR14","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1046\/j.1523-1755.1999.00357.x","volume":"55","author":"FT Loop Van der","year":"1999","unstructured":"Van der Loop FT, Monnens LA, Schr\u00f6der CH, Lemmink HH, Breuning MH, Timmer ED, Smeets HJ (1999) Identification of COL4A5 defects in Alport\u2019s syndrome by immunohistochemistry of skin. Kidney Int 55:1217\u20131224","journal-title":"Kidney Int"},{"key":"376_CR15","first-page":"211","volume":"42","author":"M Levy","year":"1994","unstructured":"Levy M, Pirson Y, Simon P, Boudailliez B, Nivet H, Rance N, Moynot A, Broyer M, Gr\u00fcnfeld JP (1994) Evaluation in patients with Alport syndrome of knowledge of the disease and attitudes toward prenatal diagnosis. Clin Nephrol 42:211\u2013220","journal-title":"Clin Nephrol"},{"key":"376_CR16","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1007\/s00467-005-0003-4","volume":"21","author":"L Copelovitch","year":"2006","unstructured":"Copelovitch L, Kaplan BS (2006) Is genetic testing of healthy pre-symptomatic children with possible Alport syndrome ethical? Pediatr Nephrol 21:455\u2013456","journal-title":"Pediatr Nephrol"},{"key":"376_CR17","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s00467-003-1366-z","volume":"19","author":"W Proesmans","year":"2004","unstructured":"Proesmans W, VanDyck M (2004) Enalapril in children with Alport syndrome. Pediatr Nephrol 19:271\u2013275","journal-title":"Pediatr Nephrol"},{"key":"376_CR18","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1046\/j.1523-1755.1999.0550031051.x","volume":"55","author":"L Callis","year":"1999","unstructured":"Callis L, Vila A, Carrera M, Nieto J (1999) Long-term effects of cyclosporine A in Alport\u2019s syndrome. Kidney Int 55:1051\u20131056","journal-title":"Kidney Int"},{"key":"376_CR19","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1097\/01.ASN.0000046964.15831.16","volume":"14","author":"D Chen","year":"2003","unstructured":"Chen D, Jefferson B, Harvey SJ, Zheng K, Gartley CJ, Jacobs RM, Thorner PS (2003) Cyclosporine A slows the progressive renal disease of Alpoer syndrome (X-linked hereditary nephritis): Results from a canin model. J Am Soc Nephrol 14:690\u2013698","journal-title":"J Am Soc Nephrol"},{"key":"376_CR20","doi-asserted-by":"crossref","unstructured":"Charbit M, Gubler MC, Dechaux M, Gagnadoux MF, Gr\u00fcnfeld JP, Niaudet P (2006) Cyclosporin therapy in patients with Alport syndrome. Pediatr Nephrol DOI https:\/\/doi.org\/10.1007\/s00467-006-0227-y","DOI":"10.1007\/s00467-006-0227-y"},{"key":"376_CR21","first-page":"1510","volume":"21","author":"A Legato","year":"2006","unstructured":"Legato A, Emma F, Massella L (2006) Cyclosporine A treatment in pediatric patients with X-linked Alport syndrome : a single centre experience. Pediatr Nephrol 21:1510 (abstract COD OP 14)","journal-title":"Pediatr Nephrol"},{"key":"376_CR22","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1016\/S0002-9440(10)63520-1","volume":"163","author":"L Heidet","year":"2003","unstructured":"Heidet L, Borza DB, Jouin M, Sich M, Mattei G, Sado Y, Hudson BG, Hastie N, Antignac C, Gubler MC (2003). A human-mouse chimera of the \u03b13\u03b14 \u03b15(IV) collagen protomer rescues the renal phenotype in Col4a3-\/- mice. Am J Pathol 163:1633\u20131644","journal-title":"Am J Pathol"},{"key":"376_CR23","doi-asserted-by":"publisher","first-page":"e100","DOI":"10.1371\/journal.pmed.0030100","volume":"3","author":"M Zeisberg","year":"2006","unstructured":"Zeisberg M, Khurana M, Rao VH, Cosgrove D, Rougoer JP, Werner MC, Shield CF, Werb Z, Kalluri R (2006) Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. PLoS Med 3:e100","journal-title":"PloS Med"},{"key":"376_CR24","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1681\/ASN.2004100871","volume":"16","author":"V Ninichuk","year":"2005","unstructured":"Ninichuk V, Gross O, Reichel C, Khandoga A, Pawar RD, Ciubar R, Segerer S, Belemezova E, Radomska E, Luckow B, de Lema GP, Murphy PM, Gao JL, Henger A, Kretzler M, Horuk R, Weber M, Krombach F, Schlondorff D, Anders HJ (2005) Delayed chemokine receptor 1 blockade prolongs survival in collagen 4A3-deficient mice with Alport disease. J Am Soc Nephrol 16:977\u2013985","journal-title":"J Am Soc Nephrol"},{"key":"376_CR25","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1111\/j.1523-1755.2005.00423.x","volume":"68","author":"O Gross","year":"2005","unstructured":"Gross O, Koepke ML, Beirowski B, Schulze-Lohoff E, Segerer S, Weber M (2005) Nephroprotection by antifibrotic and anti-inflammatory effects of the vasopeptidase inhibitor AVE7688. Kidney Int 68:456\u2013463","journal-title":"Kidney Int"},{"key":"376_CR26","doi-asserted-by":"publisher","first-page":"7321","DOI":"10.1073\/pnas.0601436103","volume":"103","author":"H Sugimoto","year":"2006","unstructured":"Sugimoto H, Mundel TM, Sund M, Xie L, Cosgrove D, Falluri R (2006) Bone-marrow-derived stem cells repair basement membrane collagen defects and reverse genetic kidney disease. Proc Natl Acad Sci USA 103:7321\u20137326","journal-title":"Proc Natl Acad Sci USA"},{"key":"376_CR27","doi-asserted-by":"publisher","first-page":"2448","DOI":"10.1634\/stemcells.2006-0201","volume":"24","author":"EI Prodromidi","year":"2006","unstructured":"Prodromidi EI, Poulsom R, Jeffery R, Roufosse CA, Pollard PJ, Pusey CD, Cook HT (2006) Bone marrow derived-cells contribute to podocyte regeneration and amelioration of renal disease in a mouse model of Alport syndrome. Stem Cells (24:2448\u20132455)","journal-title":"Stem Cells"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-006-0376-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-006-0376-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-006-0376-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-006-0376-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T09:36:13Z","timestamp":1628156173000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-006-0376-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["376"],"URL":"https:\/\/doi.org\/10.1007\/s00467-006-0376-z","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}