{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:30:22Z","timestamp":1770823822012,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1007\/s00467-007-0466-6","type":"journal-article","created":{"date-parts":[[2007,4,20]],"date-time":"2007-04-20T11:01:58Z","timestamp":1177066918000},"page":"962-974","source":"Crossref","is-referenced-by-count":27,"title":["Expression profiles of congenital renal dysplasia reveal new insights into renal development and disease"],"prefix":"10.1007","volume":"22","author":[{"given":"Sanjay","family":"Jain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian A.","family":"Suarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"McGuire","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Liapis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,7,1]]},"reference":[{"key":"466_CR1","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1046\/j.1523-1755.2002.00188.x","volume":"61","author":"I Ichikawa","year":"2002","unstructured":"Ichikawa I, Kuwayama F, Pope JC 4th, Stephens FD, Miyazaki Y (2002) Paradigm shift from classic anatomic theories to contemporary cell biological views of CAKUT. Kidney Int 61:889\u2013898","journal-title":"Kidney Int"},{"key":"466_CR2","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1007\/s00467-003-1158-5","volume":"18","author":"MG Seikaly","year":"2003","unstructured":"Seikaly MG, Ho PL, Emmett L, Fine RN, Tejani A (2003) Chronic renal insufficiency in children: the 2001 Annual Report of the NAPRTCS. Pediatr Nephrol 18:796\u2013804","journal-title":"Pediatr Nephrol"},{"key":"466_CR3","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1002\/ajmg.1320260413","volume":"26","author":"E McPherson","year":"1987","unstructured":"McPherson E, Carey J, Kramer A, Hall JG, Pauli RM, Schimke RN, Tasin MH (1987) Dominantly inherited renal adysplasia. Am J Med Genet 26:863\u2013872","journal-title":"Am J Med Genet"},{"key":"466_CR4","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1016\/S0272-6386(12)80118-1","volume":"18","author":"B Murugasu","year":"1991","unstructured":"Murugasu B, Cole BR, Hawkins EP, Blanton SH, Conley SB, Portman RJ (1991) Familial renal adysplasia. Am J Kidney Dis 18:490\u2013494","journal-title":"Am J Kidney Dis"},{"key":"466_CR5","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3109\/15513819409024271","volume":"14","author":"P Moerman","year":"1994","unstructured":"Moerman P, Fryns JP, Sastrowijoto SH, Vandenberghe K, Lauweryns JM (1994) Hereditary renal adysplasia: new observations and hypotheses. Pediatr Pathol 14:405\u2013410","journal-title":"Pediatr Pathol"},{"key":"466_CR6","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1002\/ajmg.1320280532","volume":"3","author":"EC Squiers","year":"1987","unstructured":"Squiers EC, Morden RS, Bernstein J (1987) Renal multicystic dysplasia: an occasional manifestation of the hereditary renal adysplasia syndrome. Am J Med Genet Suppl 3:279\u2013284","journal-title":"Am J Med Genet Suppl"},{"key":"466_CR7","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1038\/ng0198-81","volume":"18","author":"J Kohlhase","year":"1998","unstructured":"Kohlhase J, Wischermann A, Reichenbach H, Froster U, Engel W (1998) Mutations in the SALL1 putative transcription factor gene cause Townes-Brocks syndrome. Nat Genet 18:81\u201383","journal-title":"Nat Genet"},{"key":"466_CR8","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/ng0396-241","volume":"12","author":"G Pilia","year":"1996","unstructured":"Pilia G, Hughes-Benzie RM, MacKenzie A, Baybayan P, Chen EY, Huber R, Neri G, Cao A, Forabosco A, Schlessinger D (1996) Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome. Nat Genet 12:241\u2013247","journal-title":"Nat Genet"},{"key":"466_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1097-2765(00)80169-0","volume":"3","author":"H Nishimura","year":"1999","unstructured":"Nishimura H, Yerkes E, Hohenfellner K, Miyazaki Y, Ma J, Hunley TE, Yoshida H, Ichiki T, Threadgill D, Phillips JA 3rd, Hogan BM, Fogo A, Brock JW 3rd, Inagami T, Ichikawa I (1999) Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. Mol Cell 3:1\u201310","journal-title":"Mol Cell"},{"key":"466_CR10","doi-asserted-by":"publisher","first-page":"2864","DOI":"10.1681\/ASN.2006030277","volume":"17","author":"S Weber","year":"2006","unstructured":"Weber S, Moriniere V, Knuppel T, Charbit M, Dusek J, Ghiggeri GM, Jankauskiene A, Mir S, Montini G, Peco-Antic A, Wuhl E, Zurowska AM, Mehls O, Antignac C, Schaefer F, Salomon R (2006) Prevalence of mutations in renal developmental genes in children with renal hypodysplasia: results of the ESCAPE study. J Am Soc Nephrol 17:2864\u20132870","journal-title":"J Am Soc Nephrol"},{"key":"466_CR11","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1053\/ajkd.1998.v31.pm9506676","volume":"31","author":"JH Lipschutz","year":"1998","unstructured":"Lipschutz JH (1998) Molecular development of the kidney: a review of the results of gene disruption studies. Am J Kidney Dis 31:383\u2013397","journal-title":"Am J Kidney Dis"},{"key":"466_CR12","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1101\/gad.1387206","volume":"20","author":"S Jain","year":"2006","unstructured":"Jain S, Encinas M, Johnson EM Jr, Milbrandt J (2006) Critical and distinct roles for key RET tyrosine docking sites in renal development. Genes Dev 20:321\u2013333","journal-title":"Genes Dev"},{"key":"466_CR13","doi-asserted-by":"publisher","first-page":"e87","DOI":"10.1159\/000069554","volume":"93","author":"H Liapis","year":"2003","unstructured":"Liapis H (2003) Biology of congenital obstructive nephropathy. Nephron Exp Nephrol 93:e87\u2013e91","journal-title":"Nephron Exp Nephrol"},{"key":"466_CR14","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1097\/01.ASN.0000113778.06598.6F","volume":"15","author":"AS Woolf","year":"2004","unstructured":"Woolf AS, Price KL, Scambler PJ, Winyard PJ (2004) Evolving concepts in human renal dysplasia. J Am Soc Nephrol 15:998\u20131007","journal-title":"J Am Soc Nephrol"},{"key":"466_CR15","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1016\/S0022-5347(05)64421-7","volume":"168","author":"H Liapis","year":"2002","unstructured":"Liapis H, Doshi RH, Watson MA, Liapis A, Steinhardt GF (2002) Reduced renin expression and altered gene transcript profiles in multicystic dysplastic kidneys. J Urol 168:1816\u20131820","journal-title":"J Urol"},{"key":"466_CR16","unstructured":"Wigglesworth JS, Singer DB (1991) In: Textbook of fetal and perinatal pathology. Blackwell Scientific, p 40"},{"key":"466_CR17","doi-asserted-by":"publisher","first-page":"1250","DOI":"10.1016\/S0046-8177(98)90253-2","volume":"29","author":"DG Tiniakos","year":"1998","unstructured":"Tiniakos DG, Yu H, Liapis H (1998) Osteopontin expression in ovarian carcinomas and tumors of low malignant potential (LMP). Hum Pathol 29:1250\u20131254","journal-title":"Hum Pathol"},{"key":"466_CR18","doi-asserted-by":"publisher","first-page":"3907","DOI":"10.1158\/0008-5472.CAN-03-3801","volume":"64","author":"S Jain","year":"2004","unstructured":"Jain S, Watson MA, DeBenedetti MK, Hiraki Y, Moley JF, Milbrandt J (2004) Expression profiles provide insights into early malignant potential and skeletal abnormalities in multiple endocrine neoplasia type 2B syndrome tumors. Cancer Res 64:3907\u20133913","journal-title":"Cancer Res"},{"key":"466_CR19","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1111\/j.1523-1755.2004.00641.x","volume":"65","author":"K Surendran","year":"2004","unstructured":"Surendran K, Simon TC, Liapis H, McGuire JK (2004) Matrilysin (MMP-7) expression in renal tubular damage: association with Wnt4. Kidney Int 65:2212\u20132222","journal-title":"Kidney Int"},{"key":"466_CR20","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1046\/j.1432-0436.2002.700602.x","volume":"70","author":"TD Piscione","year":"2002","unstructured":"Piscione TD, Rosenblum ND (2002) The molecular control of renal branching morphogenesis: current knowledge and emerging insights. Differentiation 70:227\u2013246","journal-title":"Differentiation"},{"key":"466_CR21","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.devcel.2004.12.004","volume":"8","author":"MA Basson","year":"2005","unstructured":"Basson MA, Akbulut S, Watson-Johnson J, Simon R, Carroll TJ, Shakya R, Gross I, Martin GR, Lufkin T, McMahon AP, Wilson PD, Costantini FD, Mason IJ, Licht JD (2005) Sprouty1 is a critical regulator of GDNF\/RET-mediated kidney induction. Dev Cell 8:229\u2013239","journal-title":"Dev Cell"},{"key":"466_CR22","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S1534-5807(04)00108-X","volume":"6","author":"U Grieshammer","year":"2004","unstructured":"Grieshammer U, Le M, Plump AS, Wang F, Tessier-Lavigne M, Martin GR (2004) SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell 6:709\u2013717","journal-title":"Dev Cell"},{"key":"466_CR23","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1016\/j.cub.2003.08.054","volume":"13","author":"H Zhang","year":"2003","unstructured":"Zhang H, Palmer R, Gao X, Kreidberg J, Gerald W, Hsiao L, Jensen RV, Gullans SR, Haber DA (2003) Transcriptional activation of placental growth factor by the forkhead\/winged helix transcription factor FoxD1. Curr Biol 13:1625\u20131629","journal-title":"Curr Biol"},{"key":"466_CR24","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s10024001-0141-z","volume":"5","author":"AS Woolf","year":"2002","unstructured":"Woolf AS, Winyard PJ (2002) Molecular mechanisms of human embryogenesis: developmental pathogenesis of renal tract malformations. Pediatr Dev Pathol 5:108\u2013129","journal-title":"Pediatr Dev Pathol"},{"key":"466_CR25","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1139\/o98-092","volume":"76","author":"H Sariola","year":"1998","unstructured":"Sariola H, Sainio K (1998) Cell lineages in the embryonic kidney: their inductive interactions and signalling molecules. Biochem Cell Biol 76:1009\u20131016","journal-title":"Biochem Cell Biol"},{"key":"466_CR26","doi-asserted-by":"crossref","unstructured":"Hruska KA, DePetris L, Li T, Wang S, Geurs T, Strebeck F, Chen Q, Liapis H (2006) The Prospect of a novel therapeutic, BMP7, in diabetic nephropathy. In: Cortes P, Mogensen CE (eds) Contemporary diabetes: the diabetic kidney. Humana Press","DOI":"10.1007\/978-1-59745-153-6_18"},{"key":"466_CR27","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1002\/1096-8628(20010801)102:2<161::AID-AJMG1453>3.0.CO;2-O","volume":"102","author":"M Li","year":"2001","unstructured":"Li M, Shuman C, Fei YL, Cutiongco E, Bender HA, Stevens C, Wilkins-Haug L, Day-Salvatore D, Yong SL, Geraghty MT, Squire J, Weksberg R (2001) GPC3 mutation analysis in a spectrum of patients with overgrowth expands the phenotype of Simpson-Golabi-Behmel syndrome. Am J Med Genet 102:161\u2013168","journal-title":"Am J Med Genet"},{"key":"466_CR28","doi-asserted-by":"publisher","first-page":"818A","DOI":"10.1097\/01.ASN.0000115399.80913.B1","volume":"15","author":"JK McGuire","year":"2004","unstructured":"McGuire JK, Liapis H, Suarez A, Hruska K (2004) Matrilysin (MMP7) is expressed in Renal Dysplasia and inhibits Bone Morphogenetic Protein 7 (BMP7) induced tubulogenesis. J Am Soc Nephrol 15:818A","journal-title":"J Am Soc Nephrol"},{"key":"466_CR29","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1083\/jcb.200302152","volume":"163","author":"B Cat De","year":"2003","unstructured":"De Cat B, Muyldermans SY, Coomans C, Degeest G, Vanderschueren B, Creemers J, Biemar F, Peers B, David G (2003) Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements. J Cell Biol 163:625\u2013635","journal-title":"J Cell Biol"},{"key":"466_CR30","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1681\/ASN.V9163","volume":"9","author":"V Reddi","year":"1998","unstructured":"Reddi V, Zaglul A, Pentz ES, Gomez RA (1998) Renin-expressing cells are associated with branching of the developing kidney vasculature. J Am Soc Nephrol 9:63\u201371","journal-title":"J Am Soc Nephrol"},{"key":"466_CR31","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1159\/000147926","volume":"158","author":"K Wu","year":"1997","unstructured":"Wu K, Setty S, Mauer SM, Killen P, Nagase H, Michael AF, Tsilibary EC (1997) Altered kidney matrix gene expression in early stages of experimental diabetes. Acta Anat (Basel) 158:155\u2013165","journal-title":"Acta Anat (Basel)"},{"key":"466_CR32","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1038\/ki.1996.421","volume":"50","author":"AA Eddy","year":"1996","unstructured":"Eddy AA (1996) Interstitial inflammation and fibrosis in rats with diet-induced hypercholesterolemia. Kidney Int 50:1139\u20131149","journal-title":"Kidney Int"},{"key":"466_CR33","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1042\/cs0850295","volume":"85","author":"T Nakamura","year":"1993","unstructured":"Nakamura T, Ebihara I, Osada S, Takahashi T, Yamamoto M, Tomino Y, Koide H (1993) Gene expression of metalloproteinases and their inhibitor in renal tissue of New Zealand black\/white F1 mice. Clin Sci (Lond) 85:295\u2013301","journal-title":"Clin Sci (Lond)"},{"key":"466_CR34","first-page":"754","volume":"125","author":"AK Sharma","year":"1995","unstructured":"Sharma AK, Mauer SM, Kim Y, Michael AF (1995) Altered expression of matrix metalloproteinase-2, TIMP, and TIMP-2 in obstructive nephropathy. J Lab Clin Med 125:754\u2013761","journal-title":"J Lab Clin Med"},{"key":"466_CR35","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1681\/ASN.V591675","volume":"5","author":"E Engelmyer","year":"1995","unstructured":"Engelmyer E, van Goor H, Edwards DR, Diamond JR (1995) Differential mRNA expression of renal cortical tissue inhibitor of metalloproteinase-1,-2, and -3 in experimental hydronephrosis. J Am Soc Nephrol 5:1675\u20131683","journal-title":"J Am Soc Nephrol"},{"key":"466_CR36","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/ki.1996.10","volume":"49","author":"L Schaefer","year":"1996","unstructured":"Schaefer L, Han X, Gretz N, Hafner C, Meier K, Matzkies F, Schaefer RM (1996) Tubular gelatinase A (MMP-2) and its tissue inhibitors in polycystic kidney disease in the Han:SPRD rat. Kidney Int 49:75\u201381","journal-title":"Kidney Int"},{"key":"466_CR37","first-page":"1381","volume":"141","author":"CL Jones","year":"1992","unstructured":"Jones CL, Buch S, Post M, McCulloch L, Liu E, Eddy AA (1992) Renal extracellular matrix accumulation in acute puromycin aminonucleoside nephrosis in rats. Am J Pathol 141:1381\u20131396","journal-title":"Am J Pathol"},{"key":"466_CR38","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1681\/ASN.V124736","volume":"12","author":"H Kim","year":"2001","unstructured":"Kim H, Oda T, Lopez-Guisa J, Wing D, Edwards DR, Soloway PD, Eddy AA (2001) TIMP-1 deficiency does not attenuate interstitial fibrosis in obstructive nephropathy. J Am Soc Nephrol 12:736\u2013748","journal-title":"J Am Soc Nephrol"},{"key":"466_CR39","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1111\/j.1523-1755.2004.00499.x","volume":"65","author":"A Henger","year":"2004","unstructured":"Henger A, Kretzler M, Doran P, Bonrouhi M, Schmid H, Kiss E, Cohen CD, Madden S, Porubsky S, Grone EF, Schlondorff D, Nelson PJ, Grone HJ (2004) Gene expression fingerprints in human tubulointerstitial inflammation and fibrosis as prognostic markers of disease progression. Kidney Int 65:904\u2013917","journal-title":"Kidney Int"},{"key":"466_CR40","unstructured":"Liapis H, Winyard JP (2006) Heptinstall\u2019s pathology of the kidney, cystic diseases of the kidney and developmental defects, chapter 22, 6th edn. Lippincott-Raven, pp 1287\u20131290"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-007-0466-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-007-0466-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-007-0466-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-007-0466-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T18:57:56Z","timestamp":1628794676000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-007-0466-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["466"],"URL":"https:\/\/doi.org\/10.1007\/s00467-007-0466-6","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}