{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:13:10Z","timestamp":1790874790622,"version":"4.1.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2008,6,1]],"date-time":"2008-06-01T00:00:00Z","timestamp":1212278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1007\/s00467-008-0747-8","type":"journal-article","created":{"date-parts":[[2008,2,12]],"date-time":"2008-02-12T12:53:57Z","timestamp":1202820837000},"page":"847-850","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["NPHS3: new clues for understanding idiopathic nephrotic syndrome"],"prefix":"10.1007","volume":"23","author":[{"given":"Bernward G.","family":"Hinkes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,6,1]]},"reference":[{"key":"747_CR1","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1172\/JCI0215094","volume":"109","author":"C Antignac","year":"2002","unstructured":"Antignac C (2002) Genetic models: clues for understanding the pathogenesis of idiopathic nephrotic syndrome. J Clin Invest 109:447\u2013449","journal-title":"J Clin Invest"},{"key":"747_CR2","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1159\/000186702","volume":"60","author":"R Tanaka","year":"1992","unstructured":"Tanaka R, Yoshikawa N, Nakamura H, Ito H (1992) Infusion of peripheral blood mononuclear cell products from nephrotic children increases albuminuria in rats. Nephron 60:35\u201341","journal-title":"Nephron"},{"key":"747_CR3","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/S1097-2765(00)80057-X","volume":"4","author":"M Kestila","year":"1998","unstructured":"Kestila M, Lenkkeri U, Mannikko M, Lamerdin J, McCready P, Putaala H, Ruotsalainen V, Morita T, Nissinen M, Herva R, Kashtan CE, Peltonen L, Holmberg C, Olsen A, Tryggvason K (1998) Positionally cloned gene for a novel glomerular protein - nephrin - is mutated in congenital nephrotic syndrome. Mol Cell 4:575\u2013582","journal-title":"Mol Cell"},{"key":"747_CR4","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/74166","volume":"24","author":"N Boute","year":"2000","unstructured":"Boute N, Gribouval O, Roselli S, Benessy F, Lee H, Fuchshuber A, Dahan K, Gubler MC, Niaudet P, Antignac C (2000) NPHS2, encoding the glomerular protein podocin, is mutated in autosomal recessive steroid-resistant nephrotic syndrome. Nat Genet 24:349\u2013354","journal-title":"Nat Genet"},{"key":"747_CR5","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/353431a0","volume":"353","author":"J Pelletier","year":"1991","unstructured":"Pelletier J, Bruening W, Li FP, Haber DA, Housman DE (1991) WT1 mutations contribute to abnormal genital system development and hereditary Wilms\u2019 tumour. Nature 353:431\u2013434","journal-title":"Nature"},{"key":"747_CR6","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.1093\/hmg\/ddh284","volume":"13","author":"M Zenker","year":"2004","unstructured":"Zenker M, Aigner T, Wendler O, Tralau T, Muntefering H, Fenski R, Pitz S, Schumacher V, Royer-Pokora B, Wuhl E, Cochat P, Bouvier R, Kraus C, Mark K, Dotsch J, Rascher W, Maruniak-Chudek I, Lennert T, Neumann LM, Reis A (2004) Human laminin beta2 deficiency causes congenital nephrosis with mesangial sclerosis and distinct eye abnormalities. Hum Mol Genet 13:2625\u20132632","journal-title":"Hum Mol Genet"},{"key":"747_CR7","doi-asserted-by":"publisher","first-page":"e907","DOI":"10.1542\/peds.2006-2164","volume":"119","author":"BG Hinkes","year":"2007","unstructured":"Hinkes BG, Mucha B, Vlangos CN, Gbadegesin R, Liu J, Hasselbacher K, Hangan D, Ozaltin F, Zenker M, Hildebrandt F, Members of the APN Study Group (2007) Nephrotic syndrome in the first year of life: two thirds of cases are caused by mutations in 4 genes (NPHS1, NPHS2, WT1, LAMB2). Pediatrics 119:e907\u2013e910","journal-title":"Pediatrics"},{"key":"747_CR8","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1038\/ng1918","volume":"38","author":"B Hinkes","year":"2006","unstructured":"Hinkes B, Wiggins RC, Gbadegesin R, Vlangos CN, Seelow D, Nurnberg G, Garg P, Verma R, Chaib H, Hoskins B, Ashraf S, Becker C, Hennies HC, Goyal M, Wharram B, Schachter A, Mudumana S, Drummond I, Kerjaschki D, Waldherr R, Dietrich A, Ozaltin F, Bakkaloglu A, Cleper R, Basel-Vanagaite L, Pohl M, Griebel A, Tsygin A, Soylu A, Muller D, Sorli C, Bunney T, Katan M, Liu J, Attanasio M, O\u2019Toole J, Hasselbacher K, Mucha B, Otto E, Airik R, Kispert A, Kelley G, Smrcka A, Gudermann T, Holzman L, Nurnberg P, Hildebrandt F (2006) Positional cloning uncovers mutation in PLCE1 responsible for a nephrotic syndrome variant that may be reversible. Nat Genet 38:1397\u2013405","journal-title":"Nat Genet"},{"key":"747_CR9","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1038\/sj.ki.5001679","volume":"70","author":"K Hasselbacher","year":"2006","unstructured":"Hasselbacher K, Wiggins RC, Matejas V, Hinkes B, Mucha B, Hoskins BE, Ozaltin F, N\u00fcrnberg G, Becker C, Hangan D, Pohl M, Kuwertz-Br\u00f6cking E, Griebel M, Schumacher V, Royer-Pokora B, Bakkaloglu A, Nurnberg P, Zenker M, Hildebrandt F (2006) Recessive missense mutations in LAMB2 expand the clinical spectrum of LAMB2-associated disorders. Kidney Int 70:1008\u20131012","journal-title":"Kidney Int"},{"key":"747_CR10","doi-asserted-by":"publisher","unstructured":"Hinkes B, Vlangos CN, Heeringa S, Mucha B, Gbadegesin R, Liu J, Hasselbacher K, Ozaltin F, Hildebrandt F, Members of the APN Study Group (2008) Specific podocin mutations correlate with age of onset in steroid-resistant nephrotic syndrome (SRNS). J Am Soc Nephrol (in press). DOI https:\/\/doi.org\/10.1681\/ASN.2007-040452","DOI":"10.1681\/ASN.2007-040452"},{"key":"747_CR11","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1046\/j.1523-1755.1999.00503.x","volume":"56","author":"K Yan","year":"1999","unstructured":"Yan K, Kudo A, Hirano H, Watanabe T, Tasaka T, Kataoka S, Nakajima N, Nishibori Y, Shibata T, Kohsaka T, Higashihara E, Tanaka H, Watanabe H, Nagasawa T, Awa S (1999) Subcellular localization of glucocorticoid receptor protein in the human kidney glomerulus. Kidney Int 56:65\u201373","journal-title":"Kidney Int"},{"key":"747_CR12","doi-asserted-by":"publisher","first-page":"3775","DOI":"10.1073\/pnas.89.9.3775","volume":"89","author":"F Castellino","year":"1992","unstructured":"Castellino F, Heuser J, Marchetti S, Bruno B, Luini A (1992) Glucocoticoid stabilization of actin filaments: a possible mechanism for inhibition of corticotrophin release. Proc Natl Acad Science U S A 89:3775\u20133779","journal-title":"Proc Natl Acad Science U S A"},{"key":"747_CR13","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1002\/(SICI)1097-4644(19970615)65:4<492::AID-JCB5>3.0.CO;2-J","volume":"65","author":"SB Koukouritaki","year":"1997","unstructured":"Koukouritaki SB, Margioris AN, Gravanis A, Stournaras C (1997) Dexamethasone induces rapid actin assembly in human endometrial cells without affecting its synthesis. J Cell Bichem 65:492\u2013500","journal-title":"J Cell Bichem"},{"key":"747_CR14","doi-asserted-by":"publisher","first-page":"2473","DOI":"10.1111\/j.1523-1755.2005.00723.x","volume":"68","author":"R Ranson","year":"2005","unstructured":"Ranson R, Lam NG, Hallett MA, Atkinson SJ, Smoyer WE (2005) Glucocorticoids protect and enhance recovery of cultured murine podocytes via actin filament stabilization. Kidney Int 68:2473\u20132483","journal-title":"Kidney Int"},{"key":"747_CR15","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1111\/j.1523-1755.2005.00205.x","volume":"67","author":"R Ranson","year":"2005","unstructured":"Ranson R, Vega-Warner V, Smoyer WE, Klein J (2005) Differential proteomic analysis of proteins induced by glucocorticoids in cultured murine podocytes. Kidney Int 67:1275\u20131285","journal-title":"Kidney Int"},{"key":"747_CR16","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1038\/sj.ki.5001625","volume":"70","author":"K Yamauchi","year":"2006","unstructured":"Yamauchi K, Takano Y, Kasai A, Hayakawa K, Hiramatsu N, Enomoto N, Yao J, Kitamura M (2006) Screening and identification of substances that regulate nephrin gene expression using engineered reporter podocyte. Kidney Int 70:892\u2013900","journal-title":"Kidney Int"},{"key":"747_CR17","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1038\/sj.ki.5001655","volume":"70","author":"CY Xing","year":"2006","unstructured":"Xing CY, Saleem MA, Coward RJ, Ni L, Witherden IR, Mathieson PW (2006) Direct effects of dexamethasone on human podocyte. Kidney Int 70:1038\u20131045","journal-title":"Kidney Int"},{"key":"747_CR18","doi-asserted-by":"publisher","first-page":"F1573","DOI":"10.1152\/ajprenal.00423.2006","volume":"292","author":"Y Takano","year":"2007","unstructured":"Takano Y, Yamauchi K, Hiramatsu N, Kasai A, Hayakawa M, Yokouchi M, Yao J, Kitamura M (2007) Recovery and maintenance of nephrin expression in cultured podocytes and identification of HGF as a repressor of nephrin. Am J Physiol Renal Physiol 292:F1573\u2013F1582","journal-title":"Am J Physiol Renal Physiol"},{"key":"747_CR19","doi-asserted-by":"publisher","first-page":"2615","DOI":"10.1681\/ASN.2005020142","volume":"16","author":"T Wada","year":"2005","unstructured":"Wada T, Pippin JW, Marshall CB, Griffin SV, Shankland SJ (2005) Dexamethasone prevents apoptosis induced by puromycin aminonucleoside: role of P53 and BCL-2-related family proteins. J Am Soc Nephrol 16:2615\u20132625","journal-title":"J Am Soc Nephrol"},{"key":"747_CR20","doi-asserted-by":"publisher","first-page":"F722","DOI":"10.1152\/ajprenal.00433.2005","volume":"291","author":"A Bjornson Granquist","year":"2006","unstructured":"Bjornson Granquist A, Ebefors K, Saleem MA, Mathieson PW, Haraldsson B, Nystrom JS (2006) Podocyte proteoglycane synthesis is involved in the development of nephrotic syndrome. Am J Physiol Renal Physiol 291:F722\u2013F730","journal-title":"Am J Physiol Renal Physiol"},{"key":"747_CR21","doi-asserted-by":"publisher","unstructured":"Gbadegesin R, Hinkes BG, Hoskins B, Vlangos CN, Heeringa S, Liu J, Albalwi M, Ozaltin F, Hashmi S, Ulmer F, Cleper R, Ettenger R, Antignac C, Wiggins RC, Zenker M, Hildebrandt F (2007) Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (IDMS). Nephrol Dial Transplant DOI https:\/\/doi.org\/10.1093\/ndt\/gfm759","DOI":"10.1093\/ndt\/gfm759"},{"key":"747_CR22","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1097\/01.ASN.0000113552.59155.72","volume":"15","author":"RG Ruf","year":"2004","unstructured":"Ruf RG, Lichtenberger A, Karle SM, Haas JP, Anacleto FE, Schultheiss M, Zalewski I, Imm A, Ruf EM, Mucha B, Bagga A, Neuhaus T, Fuchshuber A, Bakkaloglu A, Hildebrandt F, Members of the APN Study Group (2004) Patients with mutations in NPHS2 (Podocin) do not respond to standard steroid treatment of nephrotic syndrome. J Am Soc Nephrol 15:722\u2013732","journal-title":"J Am Soc Nephrol"},{"key":"747_CR23","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1111\/j.1523-1755.2004.00776.x","volume":"66","author":"S Weber","year":"2004","unstructured":"Weber S, Gribouval O, Esquivel EL, Moriniere V, Tete MJ, Legendre C, Niaudet P, Antignac C (2004) NPHS2 mutation analysis shows genetic heterogeneity of steroid-resistant nephrotic syndrome and low post-transplant recurrence. Kidney Int 66:571\u2013579","journal-title":"Kidney Int"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-008-0747-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-008-0747-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-008-0747-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-008-0747-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T17:10:22Z","timestamp":1610817022000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-008-0747-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["747"],"URL":"https:\/\/doi.org\/10.1007\/s00467-008-0747-8","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]},"assertion":[{"value":"23 October 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 November 2007","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2007","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2008","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}