{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:48:21Z","timestamp":1790704101810,"version":"4.1.0"},"reference-count":96,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1007\/s00467-008-1072-y","type":"journal-article","created":{"date-parts":[[2008,12,15]],"date-time":"2008-12-15T15:46:00Z","timestamp":1229355960000},"page":"1621-1632","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Genetic and developmental basis for urinary tract obstruction"],"prefix":"10.1007","volume":"24","author":[{"given":"Feng","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,9,1]]},"reference":[{"key":"1072_CR1","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1007\/s00467-003-1074-8","volume":"18","author":"RL Chevalier","year":"2003","unstructured":"Chevalier RL, Peters CA (2003) Congenital urinary tract obstruction: Proceedings of the State-Of-The-Art Strategic Planning Workshop\u2014National Institutes of Health, Bethesda, Maryland, USA, 11\u201312 March 2002. Pediatr Nephrol 18:576\u2013606","journal-title":"Pediatr Nephrol"},{"key":"1072_CR2","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1007\/s004670050756","volume":"13","author":"RL Chevalier","year":"1999","unstructured":"Chevalier RL (1999) Molecular and cellular pathophysiology of obstructive nephropathy. Pediatr Nephrol 13:612\u2013619","journal-title":"Pediatr Nephrol"},{"key":"1072_CR3","first-page":"585","volume":"18","author":"RL Chevalier","year":"1998","unstructured":"Chevalier RL (1998) Pathophysiology of obstructive nephropathy in the newborn. Semin Nephrol 18:585\u2013593","journal-title":"Semin Nephrol"},{"key":"1072_CR4","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1172\/JCI20049","volume":"113","author":"CP Chang","year":"2004","unstructured":"Chang CP, McDill BW, Neilson JR, Joist HE, Epstein JA, Crabtree GR, Chen F (2004) Calcineurin is required in urinary tract mesenchyme for the development of the pyeloureteral peristaltic machinery. J Clin Invest 113:1051\u20131058","journal-title":"J Clin Invest"},{"key":"1072_CR5","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1172\/JCI21402","volume":"113","author":"C Mendelsohn","year":"2004","unstructured":"Mendelsohn C (2004) Functional obstruction: the renal pelvis rules. J Clin Invest 113:957\u2013959","journal-title":"J Clin Invest"},{"key":"1072_CR6","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/j.1523-1755.2005.00486.x","volume":"68","author":"JL Bascands","year":"2005","unstructured":"Bascands JL, Schanstra JP (2005) Obstructive nephropathy: insights from genetically engineered animals. Kidney Int 68:925\u2013937","journal-title":"Kidney Int"},{"key":"1072_CR7","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1111\/j.1523-1755.2004.00984.x","volume":"66","author":"RL Chevalier","year":"2004","unstructured":"Chevalier RL (2004) Promise for gene therapy in obstructive nephropathy. Kidney Int 66:1709\u20131710","journal-title":"Kidney Int"},{"key":"1072_CR8","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1523-1755.2005.00124.x","volume":"67","author":"CA Peters","year":"2005","unstructured":"Peters CA (2005) Congenital obstructive nephropathy: is the fog lifting? Kidney Int 67:371\u2013372","journal-title":"Kidney Int"},{"key":"1072_CR9","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1159\/000069554","volume":"93","author":"H Liapis","year":"2003","unstructured":"Liapis H (2003) Biology of congenital obstructive nephropathy. Nephron Exp Nephrol 93:e87\u2013e91","journal-title":"Nephron Exp Nephrol"},{"key":"1072_CR10","doi-asserted-by":"crossref","first-page":"F861","DOI":"10.1152\/ajprenal.00362.2001","volume":"283","author":"S Klahr","year":"2002","unstructured":"Klahr S, Morrissey J (2002) Obstructive nephropathy and renal fibrosis. Am J Physiol Renal Physiol 283:F861\u2013F875","journal-title":"Am J Physiol Renal Physiol"},{"key":"1072_CR11","first-page":"95","volume":"24","author":"RL Chevalier","year":"2002","unstructured":"Chevalier RL (2002) Obstructive uropathy: state of the art. Pediatr Med Chir 24:95\u201397","journal-title":"Pediatr Med Chir"},{"key":"1072_CR12","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/BF01958768","volume":"150","author":"RB Kenda","year":"1991","unstructured":"Kenda RB, Kenig T, Budihna N (1991) Detecting vesico-ureteral reflux in asymptomatic siblings of children with reflux by direct radionuclide cystography. Eur J Pediatr 150:735\u2013737","journal-title":"Eur J Pediatr"},{"key":"1072_CR13","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1086\/302864","volume":"66","author":"SA Feather","year":"2000","unstructured":"Feather SA, Malcolm S, Woolf AS, Wright V, Blayton D, Reid CJ, Flinter FA, Proesmans W, Devriendt K, Carter J, Warwicker P, Goodship TH, Goodship JA (2000) Primary, nonsyndromic vesicoureteric reflux and its nephropathy is genetically heterogeneous, with a locus on chromosome 1. Am J Hum Genet 66:1420\u20131425","journal-title":"Am J Hum Genet"},{"key":"1072_CR14","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00404-001-0265-4","volume":"266","author":"A Queisser-Luft","year":"2002","unstructured":"Queisser-Luft A, Stolz G, Wiesel A, Schlaefer K, Spranger J (2002) Malformations in newborn: results based on 30,940 infants and fetuses from the Mainz congenital birth defect monitoring system (1990\u20131998). Arch Gynecol Obstet 266:163\u2013167","journal-title":"Arch Gynecol Obstet"},{"key":"1072_CR15","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nrg2205","volume":"8","author":"A Schedl","year":"2007","unstructured":"Schedl A (2007) Renal abnormalities and their developmental origin. Nat Rev Genet 8:791\u2013802","journal-title":"Nat Rev Genet"},{"key":"1072_CR16","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1146\/annurev.cellbio.22.010305.104340","volume":"22","author":"GR Dressler","year":"2006","unstructured":"Dressler GR (2006) The cellular basis of kidney development. Annu Rev Cell Dev Biol 22:509\u2013529","journal-title":"Annu Rev Cell Dev Biol"},{"key":"1072_CR17","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/0092-8674(93)90515-R","volume":"74","author":"JA Kreidberg","year":"1993","unstructured":"Kreidberg JA, Sariola H, Loring JM, Maeda M, Pelletier J, Housman D, Jaenisch R (1993) WT-1 is required for early kidney development. Cell 74:679\u2013691","journal-title":"Cell"},{"key":"1072_CR18","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/12722","volume":"23","author":"PX Xu","year":"1999","unstructured":"Xu PX, Adams J, Peters H, Brown MC, Heaney S, Maas R (1999) Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat Genet 23:113\u2013117","journal-title":"Nat Genet"},{"key":"1072_CR19","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1101\/gad.993302","volume":"16","author":"DM Wellik","year":"2002","unstructured":"Wellik DM, Hawkes PJ, Capecchi MR (2002) Hox11 paralogous genes are essential for metanephric kidney induction. Genes Dev 16:1423\u20131432","journal-title":"Genes Dev"},{"key":"1072_CR20","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1242\/dev.00536","volume":"130","author":"PX Xu","year":"2003","unstructured":"Xu PX, Zheng W, Huang L, Marie P, Laclef DL (2003) Six1 is required for the early organogenesis of mammalian kidney. Development 130:3085\u20133094","journal-title":"Development"},{"key":"1072_CR21","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1242\/dev.128.16.3105","volume":"128","author":"R Nishinakamura","year":"2001","unstructured":"Nishinakamura R, Matsumoto Y, Nakao K, Nakamura K, Sato A, Copeland NG, Gilbert DJ, Jenkins NA, Scully S, Lacey DL, Katsuki M, Asashima M, Yokota T (2001) Murine homolog of SALL1 is essential for ureteric bud invasion in kidney development. Development 128:3105\u20133115","journal-title":"Development"},{"key":"1072_CR22","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ydbio.2005.05.029","volume":"284","author":"G Sajithlal","year":"2005","unstructured":"Sajithlal G, Zou D, Silvius D, Xu PX (2005) Eya 1 acts as a critical regulator for specifying the metanephric mesenchyme. Dev Biol 284:323\u2013336","journal-title":"Dev Biol"},{"key":"1072_CR23","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.ydbio.2004.03.034","volume":"271","author":"B Wilm","year":"2004","unstructured":"Wilm B, James RG, Schultheiss TM, Hogan BL (2004) The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate. Dev Biol 271:176\u2013189","journal-title":"Dev Biol"},{"key":"1072_CR24","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/S1534-5807(04)00108-X","volume":"6","author":"U Grieshammer","year":"2004","unstructured":"Grieshammer U, Le M, Plump AS, Wang F (2004) SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. Dev Cell 6:709\u2013717","journal-title":"Dev Cell"},{"key":"1072_CR25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.ydbio.2005.04.008","volume":"283","author":"R Shakya","year":"2005","unstructured":"Shakya R, Jho EH, Kotka P, Wu Z, Kholodilv N, Burke R, D\u2019Agati V, Constantini F (2005) The role of GDNF in patterning the excretory system. Dev Biol 283:70\u201384","journal-title":"Dev Biol"},{"key":"1072_CR26","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1681\/ASN.2007060642","volume":"18","author":"A Maeshima","year":"2007","unstructured":"Maeshima A, Sakurai H, Choi Y, Kitamura S, Vaughn DA, Tee JB, Nigam SK (2007) Glial cell-derived neurotrophic factor independent ureteric bud outgrowth from the Wolffian duct. J Am Soc Nephrol 18:3147\u20133155","journal-title":"J Am Soc Nephrol"},{"key":"1072_CR27","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00467-006-0239-7","volume":"22","author":"CM Bates","year":"2007","unstructured":"Bates CM (2007) Role of fibroblast growth factor receptor signaling in kidney development. Pediatr Nephrol 22:343\u2013349","journal-title":"Pediatr Nephrol"},{"key":"1072_CR28","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1203\/PDR.0b013e318187cc12","volume":"64","author":"D Hains","year":"2008","unstructured":"Hains D, Sims-Lucas S, Kish K, Saha M, McHugh K, Bates CM (2008) Role of fibroblast growth factor receptor 2 in kidney mesenchyme. Pediatr Res 64:592\u2013598","journal-title":"Pediatr Res"},{"key":"1072_CR29","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1101\/gad.1387206","volume":"20","author":"S Jain","year":"2006","unstructured":"Jain S, Encinas M, Johnson EM Jr, Milbrandt J (2006) Critical and distinct roles for key RET tyrosine docking sites in renal development. Genes Dev 20:321\u2013333","journal-title":"Genes Dev"},{"key":"1072_CR30","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/bies.20357","volume":"28","author":"F Costantini","year":"2006","unstructured":"Costantini F, Shakya R (2006) GDNF\/Ret signaling and the development of the kidney. Bioessays 28:117\u2013127","journal-title":"Bioessays"},{"key":"1072_CR31","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.devcel.2004.12.004","volume":"8","author":"MA Basson","year":"2005","unstructured":"Basson MA, Akbulut S, Watson-Johnson J, Simon R, Carroll TJ, Shakya R, Gross I, Martin GR, Lufkin T, McMahon AP, Wilson PD, Costantini FD, Mason IJ, Licht JD (2005) Sprouty1 is a critical regulator of GDNF\/RET-mediated kidney induction. Dev Cell 8:229\u2013239","journal-title":"Dev Cell"},{"key":"1072_CR32","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.ydbio.2006.08.051","volume":"299","author":"MA Basson","year":"2006","unstructured":"Basson MA, Watson-Johnson J, Shakya R, Akbulut S, Hyink D, Constantini FD, Wilson PD, Mason IJ, Licht JD (2006) Branching morphogenesis of the ureteric epithelium during kidney development is coordinated by the opposing functions of GDNF and Sprouty1. Dev Biol 299:466\u2013477","journal-title":"Dev Biol"},{"key":"1072_CR33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1006\/dbio.1997.8664","volume":"188","author":"NR Dunn","year":"1997","unstructured":"Dunn NR, Winnier GE, Hargett LK, Schrick JJ, Fogo AB, Hogan BL (1997) Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. Dev Biol 188:235\u2013247","journal-title":"Dev Biol"},{"key":"1072_CR34","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1172\/JCI8256","volume":"105","author":"Y Miyazaki","year":"2000","unstructured":"Miyazaki Y, Oshima K, Fogo A, Hogan BL, Ichikawa I (2000) Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter. J Clin Invest 105:863\u2013873","journal-title":"J Clin Invest"},{"key":"1072_CR35","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1242\/dev.01251","volume":"131","author":"O Michos","year":"2004","unstructured":"Michos O, Panman L, Vintersten K, Beier K, Zeller R, Zuniga A (2004) Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesis. Development 131:3401\u20133410","journal-title":"Development"},{"key":"1072_CR36","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/ng952","volume":"32","author":"E Batourina","year":"2002","unstructured":"Batourina E, Choi C, Paragas N, Bello N, Hensle T, Constantini FD, Schuchardt A, Bacallao RL, Mendelsohn CL (2002) Distal ureter morphogenesis depends on epithelial cell remodeling mediated by vitamin A and Ret. Nat Genet 32:109\u2013115","journal-title":"Nat Genet"},{"key":"1072_CR37","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.ydbio.2007.11.016","volume":"314","author":"TD Marose","year":"2008","unstructured":"Marose TD, Merkel CE, McMahon AP, Carroll TJ (2008) Beta-catenin is necessary to keep cells of ureteric bud\/Wolffian duct epithelium in a precursor state. Dev Biol 314:112\u2013126","journal-title":"Dev Biol"},{"key":"1072_CR38","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1007\/s00467-006-0390-1","volume":"22","author":"L Murer","year":"2007","unstructured":"Murer L, Benetti E, Artifoni L (2007) Embryology and genetics of primary vesico-ureteric reflux and associated renal dysplasia. Pediatr Nephrol 22:788\u2013797","journal-title":"Pediatr Nephrol"},{"key":"1072_CR39","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1038\/ng1645","volume":"37","author":"E Batourina","year":"2005","unstructured":"Batourina E, Tsai S, Lambert S, Sprenkle P, Viana R, Dutta S, Hensle T, Wang F, Niederreither K, McMahon AP, Carroll TJ, Mendelsohn CL (2005) Apoptosis induced by vitamin A signaling is crucial for connecting the ureters to the bladder. Nat Genet 37:1082\u20131089","journal-title":"Nat Genet"},{"key":"1072_CR40","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1242\/dev.004234","volume":"134","author":"A Brenner-Anantharam","year":"2007","unstructured":"Brenner-Anantharam A, Cebrian C, Guillaume R, Hurtado R, Sunn TT, Herzlinger D (2007) Tailbud-derived mesenchyme promotes urinary tract segmentation via BMP4 signaling. Development 134:1967\u20131975","journal-title":"Development"},{"key":"1072_CR41","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1242\/dev.011270","volume":"134","author":"R Viana","year":"2007","unstructured":"Viana R, Batourina E, Huang H, Dressler GR, Kobayashi A, Behringer RR, Shapiro E, Hensle T, Lambert S, Mendelsohn C (2007) The development of the bladder trigone, the center of the anti-reflux mechanism. Development 134:3763\u20133769","journal-title":"Development"},{"key":"1072_CR42","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1172\/JCI26027","volume":"116","author":"R Airik","year":"2006","unstructured":"Airik R, Bussen M, Singh MK, Petry M, Kispert A (2006) Tbx18 regulates the development of the ureteral mesenchyme. J Clin Invest 116:663\u2013674","journal-title":"J Clin Invest"},{"key":"1072_CR43","doi-asserted-by":"crossref","first-page":"19872","DOI":"10.1073\/pnas.0609326103","volume":"103","author":"ZX Mahoney","year":"2006","unstructured":"Mahoney ZX, Sammut B, Xavier RJ, Cunningham J, Go G, Brim KL, Stappenbeck TS, Miner JH, Swat W (2006) Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter. Proc Natl Acad Sci USA 103:19872\u201319877","journal-title":"Proc Natl Acad Sci USA"},{"key":"1072_CR44","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1242\/dev.02830","volume":"134","author":"A Iizuka-Kogo","year":"2007","unstructured":"Iizuka-Kogo A, Ishidao T, Akiyama T, Senda T (2007) Abnormal development of urogenital organs in Dlgh1-deficient mice. Development 134:1799\u20131807","journal-title":"Development"},{"key":"1072_CR45","doi-asserted-by":"crossref","first-page":"F1736","DOI":"10.1152\/ajprenal.00221.2007","volume":"293","author":"IJ Murawski","year":"2007","unstructured":"Murawski IJ, Myburgh DB, Favor J, Gupta IR (2007) Vesico-ureteric reflux and urinary tract development in the Pax2 1Neu+\/- mouse. Am J Physiol Renal Physiol 293:F1736\u2013F1745","journal-title":"Am J Physiol Renal Physiol"},{"key":"1072_CR46","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1399-0004.2005.00562.x","volume":"69","author":"IJ Murawski","year":"2006","unstructured":"Murawski IJ, Gupta IR (2006) Vesicoureteric reflux and renal malformations: a developmental problem. Clin Genet 69:105\u2013117","journal-title":"Clin Genet"},{"key":"1072_CR47","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1371\/journal.pgen.0030080","volume":"3","author":"W Lu","year":"2007","unstructured":"Lu W, Quintero-Rivera F, Fan Y, Alkuraya FS, Donovan DJ, Xi Q, Turbe-Doan A, Li QG, Campbell CG, Shanske AL, Sherr EH, Ahmad A, Peters R, Rilliet B, Parvex P, Bassuk AG, Harris DJ, Ferguson H, Kelly C, Walsh CA, Gronostajski RM, Devriendt K, Higgins A, Ligon AH, Quade BJ, Morton CC, Gusella JF, Maas RL (2007) NFIA haploinsufficiency is associated with a CNS malformation syndrome and urinary tract defects. PLoS Genet 3:e80","journal-title":"PLoS Genet"},{"key":"1072_CR48","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S0022-5347(17)38354-4","volume":"145","author":"A Alcaraz","year":"1991","unstructured":"Alcaraz A, Vinaixa F, Tejedo-Mateu A, Fores MM, Gotzens V, Mestres CA, Oliveira J, Carretero P (1991) Obstruction and recanalization of the ureter during embryonic development. J Urol 145:410\u2013416","journal-title":"J Urol"},{"key":"1072_CR49","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0031-6997(24)01384-X","volume":"50","author":"P Santicioli","year":"1998","unstructured":"Santicioli P, Maggi CA (1998) Myogenic and neurogenic factors in the control of pyeloureteral motility and ureteral peristalsis. Pharmacol Rev 50:683\u2013721","journal-title":"Pharmacol Rev"},{"key":"1072_CR50","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1152\/physrev.1997.77.1.75","volume":"77","author":"GF DiBona","year":"1997","unstructured":"DiBona GF, Kopp UC (1997) Neural control of renal function. Physiol Rev 77:75\u2013197","journal-title":"Physiol Rev"},{"key":"1072_CR51","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1172\/JCI27985","volume":"116","author":"C Mendelsohn","year":"2006","unstructured":"Mendelsohn C (2006) Going in circles: conserved mechanisms control radial patterning in the urinary and digestive tracts. J Clin Invest 116:635\u2013637","journal-title":"J Clin Invest"},{"key":"1072_CR52","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.1242\/dev.129.22.5301","volume":"129","author":"J Yu","year":"2002","unstructured":"Yu J, Carroll TJ, McMahon AP (2002) Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney. Development 129:5301\u20135312","journal-title":"Development"},{"key":"1072_CR53","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1242\/dev.022442","volume":"135","author":"X Caubit","year":"2008","unstructured":"Caubit X, Lye CM, Martin E, Cor\u00e9 N, Long DA, Vola C, Jenkins D, Garratt AN, Skaer H, Woolf AS, Fasano L (2008) Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4. Development 135:3301\u20133310","journal-title":"Development"},{"key":"1072_CR54","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1111\/j.1523-1755.2000.00374.x","volume":"58","author":"H Fujinaka","year":"2000","unstructured":"Fujinaka H, Miyazaki Y, Matsusaka T, Yoshida H, Fogo AB, Inagami T, Ichikawa I (2000) Salutary role for angiotensin in partial urinary tract obstruction. Kidney Int 58:2018\u20132027","journal-title":"Kidney Int"},{"key":"1072_CR55","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1007\/s00467-005-1944-3","volume":"20","author":"IV Yosypiv","year":"2005","unstructured":"Yosypiv IV, El-Dahr SS (2005) Role of the renin-angiotensin system in the development of the ureteric bud and renal collecting system. Pediatr Nephrol 20:1219\u20131229","journal-title":"Pediatr Nephrol"},{"key":"1072_CR56","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/S0022-5347(05)65703-5","volume":"166","author":"K Oshima","year":"2001","unstructured":"Oshima K, Miyazaki Y, Brock JW 3rd, Adams MC, Ichikawa I, Pope JC (2001) Angiotensin type II receptor expression and ureteral budding. J Urol 166:1848\u20131852","journal-title":"J Urol"},{"key":"1072_CR57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1097-2765(00)80169-0","volume":"3","author":"H Nishimura","year":"1999","unstructured":"Nishimura H, Yerkes E, Hohenfellner K, Miyazaki Y, Ma J, Hunley TE, Yoshida H, Ichiki T, Threadgill D, Phillips JA 3rd, Hogan BM, Fogo A, Brock JW 3rd, Inagami T, Ichikawa I (1999) Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. Mol Cell 3:1\u201310","journal-title":"Mol Cell"},{"key":"1072_CR58","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1172\/JCI4401","volume":"102","author":"Y Miyazaki","year":"1998","unstructured":"Miyazaki Y, Tsuchida S, Nishimura H, Pope JC, Harris RC, McKanna JM, Inagami T, Hogan BL, Fogo A, Ichikawa I (1998) Angiotensin induces the urinary peristaltic machinery during the perinatal period. J Clin Invest 102:1489\u20131497","journal-title":"J Clin Invest"},{"key":"1072_CR59","doi-asserted-by":"crossref","first-page":"15496","DOI":"10.1073\/pnas.95.26.15496","volume":"95","author":"MI Oliverio","year":"1998","unstructured":"Oliverio MI, Kim HS, Ito M, Le T, Audoly L, Best CF, Hiller S, Kluckman K, Maeda N, Smithies O, Coffman TM (1998) Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. Proc Natl Acad Sci USA 95:15496\u201315501","journal-title":"Proc Natl Acad Sci USA"},{"key":"1072_CR60","first-page":"953","volume":"74","author":"CR Esther Jr","year":"1996","unstructured":"Esther CR Jr, Howard TE, Marino EM, Goddard JM, Capecchi MR, Bernstein KE (1996) Mice lacking angiotensin-converting enzyme have low blood pressure, renal pathology, and reduced male fertility. Lab Invest 74:953\u2013965","journal-title":"Lab Invest"},{"key":"1072_CR61","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1172\/JCI118366","volume":"96","author":"F Niimura","year":"1995","unstructured":"Niimura F, Labosky PA, Kakuchi J, Okubo S, Yoshida H, Oikawa T, Ichiki T, Naftilan AJ, Fogo A, Inagami T (1995) Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. J Clin Invest 96:2947\u20132954","journal-title":"J Clin Invest"},{"key":"1072_CR62","first-page":"745","volume":"75","author":"M Nagata","year":"1996","unstructured":"Nagata M, Tanimoto K, Fukamizu A, Kon Y, Sugiyama F, Yagami K, Murakami K, Watanable T (1996) Nephrogenesis and renovascular development in angiotensinogen-deficient mice. Lab Invest 75:745\u2013753","journal-title":"Lab Invest"},{"key":"1072_CR63","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1083\/jcb.200406025","volume":"167","author":"XT Kong","year":"2004","unstructured":"Kong XT, Deng FM, Hu P, Liang FX, Zhou G, Auerbach AB, Genieser N, Nelson PK, Robbins ES, Shapiro E, Kachar B, Sun TT (2004) Roles of uroplakins in plaque formation, umbrella cell enlargement, and urinary tract diseases. J Cell Biol 167:1195\u20131204","journal-title":"J Cell Biol"},{"key":"1072_CR64","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1083\/jcb.151.5.961","volume":"151","author":"P Hu","year":"2000","unstructured":"Hu P, Deng FM, Liang FX, Hu CM, Auerbach AB, Shapiro E, Wu XR, Kachar B, Sun TT (2000) Ablation of uroplakin III gene results in small urothelial plaques, urothelial leakage, and vesicoureteral reflux. J Cell Biol 151:961\u2013972","journal-title":"J Cell Biol"},{"key":"1072_CR65","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/tera.1420350307","volume":"35","author":"BD Abbott","year":"1987","unstructured":"Abbott BD, Birnbaum LS, Pratt RM (1987) TCDD-induced hyperplasia of the ureteral epithelium produces hydronephrosis in murine fetuses. Teratology 35:329\u2013334","journal-title":"Teratology"},{"key":"1072_CR66","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1084\/jem.20051984","volume":"202","author":"T Okazaki","year":"2005","unstructured":"Okazaki T, Otaka Y, Wang J, Hiai H, Takai T, Ravetch JV, Honjo T (2005) Hydronephrosis associated with antiurothelial and antinuclear autoantibodies in BALB\/c-Fcgr2b\u2212\/\u2212Pdcd1\u2212\/\u2212 mice. J Exp Med 202:1643\u20131648","journal-title":"J Exp Med"},{"key":"1072_CR67","doi-asserted-by":"crossref","first-page":"113","DOI":"10.4049\/jimmunol.173.1.113","volume":"173","author":"AJ Lauder","year":"2004","unstructured":"Lauder AJ, Jolin HE, Smith P, van den Berg JG, Jones A, Wisden W, Smith KG, Dasvarma A, Fallon PG, McKenzie AN (2004) Lymphomagenesis, hydronephrosis, and autoantibodies result from dysregulation of IL-9 and are differentially dependent on Th2 cytokines. J Immunol 173:113\u2013122","journal-title":"J Immunol"},{"key":"1072_CR68","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/BF00219184","volume":"89","author":"L Izquierdo","year":"1992","unstructured":"Izquierdo L, Porteous M, Paramo PG, Connor JM (1992) Evidence for genetic heterogeneity in hereditary hydronephrosis caused by pelvi-ureteric junction obstruction, with one locus assigned to chromosome 6p. Hum Genet 89:557\u2013560","journal-title":"Hum Genet"},{"key":"1072_CR69","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1399-0039.1989.tb01735.x","volume":"34","author":"P Mackintosh","year":"1989","unstructured":"Mackintosh P, Almarhoos G, Heath DA (1989) HLA linkage with familial vesicoureteral reflux and familial pelvi-ureteric junction obstruction. Tissue Antigens 34:185\u2013189","journal-title":"Tissue Antigens"},{"key":"1072_CR70","doi-asserted-by":"crossref","first-page":"6952","DOI":"10.1073\/pnas.0602087103","volume":"103","author":"BW McDill","year":"2006","unstructured":"McDill BW, Li SZ, Kovach PA, Ding L, Chen F (2006) Congenital progressive hydronephrosis (cph) is caused by an S256L mutation in aquaporin-2 that affects its phosphorylation and apical membrane accumulation. Proc Natl Acad Sci USA 103:6952\u20136957","journal-title":"Proc Natl Acad Sci USA"},{"key":"1072_CR71","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1093\/hmg\/ddg228","volume":"12","author":"L Feliubadalo","year":"2003","unstructured":"Feliubadalo L, Arbones ML, Manas S, Chillaron J, Visa J, Rodes M, Rousaud F, Zorzano A, Palacin M, Nunes V (2003) Slc7a9-deficient mice develop cystinuria non-I and cystine urolithiasis. Hum Mol Genet 12:2097\u20132108","journal-title":"Hum Mol Genet"},{"key":"1072_CR72","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1172\/JCI8635","volume":"105","author":"T Shindo","year":"2000","unstructured":"Shindo T, Kurihara H, Kuno K, Yokoyama H, Wada T, Kurihara Y, Imai T, Wang Y, Ogata M, Nishimatsu H, Moriyama N, Oh-hashi Y, Morita H, Ishikawa T, Nagai R, Yazaki Y, Matsushima K (2000) ADAMTS-1: a metalloproteinase-disintegrin essential for normal growth, fertility, and organ morphology and function. J Clin Invest 105:1345\u20131352","journal-title":"J Clin Invest"},{"key":"1072_CR73","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1074\/jbc.M008216200","volume":"276","author":"B Yang","year":"2001","unstructured":"Yang B, Gillespie A, Carlson EJ, Epstein CJ, Verkman AS (2001) Neonatal mortality in an aquaporin-2 knock-in mouse model of recessive nephrogenic diabetes insipidus. J Biol Chem 276:2775\u20132779","journal-title":"J Biol Chem"},{"key":"1072_CR74","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1371\/journal.pgen.0010020","volume":"1","author":"DJ Lloyd","year":"2005","unstructured":"Lloyd DJ, Hall FW, Tarantino LM, Gekakis N (2005) Diabetes insipidus in mice with a mutation in aquaporin-2. PLoS Genet 1:e20","journal-title":"PLoS Genet"},{"key":"1072_CR75","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jmor.1050880102","volume":"88","author":"M Green","year":"1951","unstructured":"Green M (1951) Further morphological effects of the short ear gene in the house mouse. J Morphol 88:1\u201322","journal-title":"J Morphol"},{"key":"1072_CR76","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1006\/dbio.1994.1300","volume":"166","author":"JA King","year":"1994","unstructured":"King JA, Marker PC, Seung KJ, Kinglesy DM (1994) BMP5 and the molecular, skeletal, and soft-tissue alterations in short ear mice. Dev Biol 166:112\u2013122","journal-title":"Dev Biol"},{"key":"1072_CR77","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1242\/dev.127.7.1387","volume":"127","author":"T Kume","year":"2000","unstructured":"Kume T, Deng K, Hogan BL (2000) Murine forkhead\/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract. Development 127:1387\u20131395","journal-title":"Development"},{"key":"1072_CR78","doi-asserted-by":"crossref","first-page":"6689","DOI":"10.1093\/emboj\/17.22.6689","volume":"17","author":"Y Zhou","year":"1998","unstructured":"Zhou Y, Lim KC, Onodera K, Takahashi S, Ohta J, Minegishi N, Tsai FY, Orkin SH, Yamamoto M, Engel JD (1998) Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development. EMBO J 17:6689\u20136700","journal-title":"EMBO J"},{"key":"1072_CR79","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.1242\/dev.124.23.4781","volume":"124","author":"X Warot","year":"1997","unstructured":"Warot X, Fromental-Ramain C, Fraulob V, Chambon P, Dolle P (1997) Gene dosage-dependent effects of the Hoxa-13 and Hoxd-13 mutations on morphogenesis of the terminal parts of the digestive and urogenital tracts. Development 124:4781\u20134791","journal-title":"Development"},{"key":"1072_CR80","doi-asserted-by":"crossref","first-page":"8099","DOI":"10.1128\/MCB.01332-06","volume":"26","author":"T Held","year":"2006","unstructured":"Held T, Paprotta I, Khulan J, Hemmerlein B, Binder L, Wolf S, Schubert S, Meinhardt A, Engel W, Adham IM (2006) Hspa4l-deficient mice display increased incidence of male infertility and hydronephrosis development. Mol Cell Biol 26:8099\u20138108","journal-title":"Mol Cell Biol"},{"key":"1072_CR81","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1111\/j.1365-2443.2004.00805.x","volume":"9","author":"Y Aoki","year":"2004","unstructured":"Aoki Y, Mori S, Kitajima K, Yokoyama O, Kanamaru H, Okada K, Yokota Y (2004) Id2 haploinsufficiency in mice leads to congenital hydronephrosis resembling that in humans. Genes Cells 9:1287\u20131296","journal-title":"Genes Cells"},{"issue":"Suppl 9","key":"1072_CR82","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/ndt\/17.suppl_9.42","volume":"17","author":"H Debiec","year":"2002","unstructured":"Debiec H, Kutsche M, Schachner M, Ronco M (2002) Abnormal renal phenotype in L1 knockout mice: a novel cause of CAKUT. Nephrol Dial Transplant 17 [Suppl 9]:42\u201344","journal-title":"Nephrol Dial Transplant"},{"key":"1072_CR83","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/hmg\/ddg062","volume":"12","author":"AC Gamp","year":"2003","unstructured":"Gamp AC, Tanaka Y, Lullmann-Rauch R, Wittke D, D\u2019Hooge R, De Deyn PP, Moser T, Maier H, Hartmann D, Reiss K, Illert AL, von Figura K, Saftig P (2003) LIMP-2\/LGP85 deficiency causes ureteric pelvic junction obstruction, deafness and peripheral neuropathy in mice. Hum Mol Genet 12:631\u2013646","journal-title":"Hum Mol Genet"},{"key":"1072_CR84","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/BF02982937","volume":"51","author":"T Carter","year":"1953","unstructured":"Carter T (1953) The genetics of luxate mice III. Horseshoe kidney, hydronephrosis and lumbar reduction. J Genet 51:441\u2013457","journal-title":"J Genet"},{"key":"1072_CR85","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1681\/ASN.2006040405","volume":"18","author":"S Singh","year":"2007","unstructured":"Singh S, Robinson M, Nahi F, Coley B, Robinson ML, Bates CM, Kornacker K, McHugh KM (2007) Identification of a unique transgenic mouse line that develops megabladder, obstructive uropathy, and renal dysfunction. J Am Soc Nephrol 18:461\u2013471","journal-title":"J Am Soc Nephrol"},{"key":"1072_CR86","doi-asserted-by":"crossref","first-page":"5434","DOI":"10.1073\/pnas.090091297","volume":"97","author":"N Takahashi","year":"2000","unstructured":"Takahashi N, Chernavvsky DR, Gomez RA, Igarashi P, Gitelman HJ, Smithies O (2000) Uncompensated polyuria in a mouse model of Bartter\u2019s syndrome. Proc Natl Acad Sci USA 97:5434\u20135439","journal-title":"Proc Natl Acad Sci USA"},{"key":"1072_CR87","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1681\/ASN.2004060490","volume":"16","author":"N Takahashi","year":"2005","unstructured":"Takahashi N, Lopez ML, Cowhig JE Jr, Taylor MA, Hatada T, Riggs E, Lee G, Gomez RA, Kim HS, Smithies O (2005) Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type. J Am Soc Nephrol 16:125\u2013132","journal-title":"J Am Soc Nephrol"},{"key":"1072_CR88","doi-asserted-by":"crossref","first-page":"10657","DOI":"10.1073\/pnas.93.20.10657","volume":"93","author":"QC Vega","year":"1996","unstructured":"Vega QC, Worby CA, Lechner MS, Dixon JE, Dressler GR (1996) Glial cell line-derived neurotrophic factor activates the receptor tyrosine kinase RET and promotes kidney morphogenesis. Proc Natl Acad Sci USA 93:10657\u201310661","journal-title":"Proc Natl Acad Sci USA"},{"key":"1072_CR89","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.1242\/dev.124.20.4077","volume":"124","author":"K Sainio","year":"1997","unstructured":"Sainio K, Suvanto P, Davies J, Wartiovaara J, Wartiovaara K, Saarma M, Arum\u00e4e U, Meng X, Lindahl M, Pachnis V, Sariola H (1997) Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium. Development 124:4077\u20134087","journal-title":"Development"},{"key":"1072_CR90","doi-asserted-by":"crossref","first-page":"F1123","DOI":"10.1152\/ajprenal.00444.2003","volume":"287","author":"OH Yu","year":"2004","unstructured":"Yu OH, Murawski IJ, Myburgh DB, Gupta IR (2004) Overexpression of RET leads to vesicoureteric reflux in mice. Am J Physiol Renal Physiol 287:F1123\u2013F1130","journal-title":"Am J Physiol Renal Physiol"},{"key":"1072_CR91","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1086\/512735","volume":"80","author":"W Lu","year":"2007","unstructured":"Lu W, van Eerde AM, Fan X, Quintero-Rivera F, Kulkarni S, Ferguson H, Kim HG, Fan Y, Xi Q, Li QG, Sanlaville D, Andrews W, Sundaresan V, Bi W, Yan J, Giltay JC, Wijmenga C, de Jong TP, Feather SA, Woolf AS, Rao Y, Lupski JR, Eccles MR, Quade BJ, Gusella JF, Morton CC, Maas RL (2007) Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux. Am J Hum Genet 80:616\u2013632","journal-title":"Am J Hum Genet"},{"key":"1072_CR92","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1681\/ASN.2007060692","volume":"19","author":"AM Bertoli-Avella","year":"2008","unstructured":"Bertoli-Avella AM, Conte ML, Punzo F, de Graaf BM, Lama G, La Manna A, Polito C, Grassia C, Nobili B, Rambaldi PF, Oostra BA, Perrotta S (2008) ROBO2 gene variants are associated with familial vesicoureteral reflux. J Am Soc Nephrol 19:825\u2013831","journal-title":"J Am Soc Nephrol"},{"key":"1072_CR93","doi-asserted-by":"crossref","first-page":"37871","DOI":"10.1074\/jbc.M205627200","volume":"277","author":"JN Lorenz","year":"2002","unstructured":"Lorenz JN, Baird NR, Judd LM, Noonan WT, Andringa A, Doetschman T, Manning PA, Liu LH, Miller ML, Schull GE (2002) Impaired renal NaCl absorption in mice lacking the ROMK potassium channel, a model for type II Bartter\u2019s syndrome. J Biol Chem 277:37871\u201337880","journal-title":"J Biol Chem"},{"key":"1072_CR94","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1242\/dev.01324","volume":"131","author":"L Oxburgh","year":"2004","unstructured":"Oxburgh L, Chu GC, Michael SK, Robertson EJ (2004) TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development 131:4593\u20134605","journal-title":"Development"},{"key":"1072_CR95","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1242\/dev.01200","volume":"131","author":"L Chi","year":"2004","unstructured":"Chi L, Zhang S, Lin Y, Prunskaite-Hyyrylainen R, Vuolteenaho R, Itaranta P, Vainio S (2004) Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development. Development 131:3345\u20133356","journal-title":"Development"},{"key":"1072_CR96","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1083\/jcb.136.6.1349","volume":"136","author":"SH Lo","year":"1997","unstructured":"Lo SH, Yu QC, Degenstein L, Chen LB, Fuchs E (1997) Progressive kidney degeneration in mice lacking tensin. J Cell Biol 136:1349\u20131361","journal-title":"J Cell Biol"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-008-1072-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-008-1072-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-008-1072-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-008-1072-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T05:26:30Z","timestamp":1738819590000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-008-1072-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":96,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["1072"],"URL":"https:\/\/doi.org\/10.1007\/s00467-008-1072-y","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9]]},"assertion":[{"value":"23 October 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 November 2008","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 November 2008","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 September 2009","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}