{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:38:05Z","timestamp":1783471085988,"version":"3.55.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2010,10,30]],"date-time":"2010-10-30T00:00:00Z","timestamp":1288396800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1007\/s00467-010-1676-x","type":"journal-article","created":{"date-parts":[[2010,11,3]],"date-time":"2010-11-03T17:18:03Z","timestamp":1288804683000},"page":"645-649","source":"Crossref","is-referenced-by-count":95,"title":["Minimal change disease: a \u201ctwo-hit\u201d podocyte immune disorder?"],"prefix":"10.1007","volume":"26","author":[{"given":"Michiko","family":"Shimada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Araya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Rivard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuji","family":"Ishimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard J.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo H.","family":"Garin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,10,30]]},"reference":[{"key":"1676_CR1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0140-6736(74)91880-7","volume":"2","author":"RJ Shalhoub","year":"1974","unstructured":"Shalhoub RJ (1974) Pathogenesis of lipoid nephrosis: a disorder of T-cell function. Lancet 2:556\u2013560","journal-title":"Lancet"},{"key":"1676_CR2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1681\/ASN.2007080836","volume":"20","author":"EH Garin","year":"2009","unstructured":"Garin EH, Diaz LN, Mu W, Wasserfall C, Araya C, Segal M, Johnson RJ (2009) Urinary CD80 excretion increases in idiopathic minimal-change disease. J Am Soc Nephrol 20:260\u2013266","journal-title":"J Am Soc Nephrol"},{"key":"1676_CR3","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1053\/j.ajkd.2009.03.019","volume":"54","author":"M Abdel-Hafez","year":"2009","unstructured":"Abdel-Hafez M, Shimada M, Lee PY, Johnson RJ, Garin EH (2009) Idiopathic nephrotic syndrome and atopy: is there a common link? Am J Kidney Dis 54:945\u2013953","journal-title":"Am J Kidney Dis"},{"key":"1676_CR4","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1097\/01.ASN.0000136312.46464.33","volume":"15","author":"J Reiser","year":"2004","unstructured":"Reiser J, Mundel P (2004) Danger signaling by glomerular podocytes defines a novel function of inducible B7-1 in the pathogenesis of nephrotic syndrome. J Am Soc Nephrol 15:2246\u20132248","journal-title":"J Am Soc Nephrol"},{"key":"1676_CR5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1126\/science.1160062","volume":"322","author":"K Wing","year":"2008","unstructured":"Wing K, Onishi Y, Prieto-Martin P, Yamaguchi T, Miyara M, Fehervari Z, Nomura T, Sakaguchi S (2008) CTLA-4 control over Foxp3+ regulatory T cell function. Science 322:271\u2013275","journal-title":"Science"},{"key":"1676_CR6","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1172\/JCI20402","volume":"113","author":"J Reiser","year":"2004","unstructured":"Reiser J, von Gersdorff G, Loos M, Oh J, Asanuma K, Giardino L, Rastaldi MP, Calvaresi N, Watanabe H, Schwarz K, Faul C, Kretzler M, Davidson A, Sugimoto H, Kalluri R, Sharpe AH, Kreidberg JA, Mundel P (2004) Induction of B7-1 in podocytes is associated with nephrotic syndrome. J Clin Invest 113:1390\u20131397","journal-title":"J Clin Invest"},{"key":"1676_CR7","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/ki.2010.143","volume":"78","author":"EH Garin","year":"2010","unstructured":"Garin EH, Mu W, Arthur JM, Rivard CJ, Araya CE, Shimada M, Johnson RJ (2010) Urinary CD80 excretion distinguishes minimal change disease from focal segmental glomerulosclerosis. Kidney Int 78:296\u2013302","journal-title":"Kidney Int"},{"key":"1676_CR8","first-page":"569A","volume":"20","author":"M Shimada","year":"2009","unstructured":"Shimada M, Lee PY, Wymer D, Rivard C, Roncal CA, Lanaspa MA, Mathieson PM, Saleem MA, Garin EH, Johnson RJ (2009) CD80 expression in podocytes: role of toll receptors. J Am Soc Nephrol 20:569A (Abstract FPO2010)","journal-title":"J Am Soc Nephrol"},{"key":"1676_CR9","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1001\/archpedi.1967.02090270087008","volume":"114","author":"MF Randolph","year":"1967","unstructured":"Randolph MF, Greenfield M (1967) Proteinuria. A six-year study of normal infants, preschool, and school-age populations previously screened for urinary tract disease. Am J Dis Child 114:631\u2013638","journal-title":"Am J Dis Child"},{"key":"1676_CR10","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1136\/adc.45.240.250","volume":"45","author":"MI Marks","year":"1970","unstructured":"Marks MI, McLaine PN, Drummond KN (1970) Proteinuria in children with febrile illnesses. Arch Dis Child 45:250\u2013253","journal-title":"Arch Dis Child"},{"key":"1676_CR11","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1440-1754.2004.00285.x","volume":"40","author":"RK Alwadhi","year":"2004","unstructured":"Alwadhi RK, Mathew JL, Rath B (2004) Clinical profile of children with nephrotic syndrome not on glucorticoid therapy, but presenting with infection. J Paediatr Child Health 40:28\u201332","journal-title":"J Paediatr Child Health"},{"key":"1676_CR12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1043-4666(03)00017-6","volume":"21","author":"YL Tain","year":"2003","unstructured":"Tain YL, Chen TY, Yang KD (2003) Implications of serum TNF-beta and IL-13 in the treatment response of childhood nephrotic syndrome. Cytokine 21:155\u2013159","journal-title":"Cytokine"},{"key":"1676_CR13","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1681\/ASN.V103529","volume":"10","author":"HK Yap","year":"1999","unstructured":"Yap HK, Cheung W, Murugasu B, Sim SK, Seah CC, Jordan SC (1999) Th1 and Th2 cytokine mRNA profiles in childhood nephrotic syndrome: evidence for increased IL-13 mRNA expression in relapse. J Am Soc Nephrol 10:529\u2013537","journal-title":"J Am Soc Nephrol"},{"key":"1676_CR14","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1681\/ASN.2006070710","volume":"18","author":"KW Lai","year":"2007","unstructured":"Lai KW, Wei CL, Tan LK, Tan PH, Chiang GS, Lee CG, Jordan SC, Yap HK (2007) Overexpression of interleukin-13 induces minimal-change-like nephropathy in rats. J Am Soc Nephrol 18:1476\u20131485","journal-title":"J Am Soc Nephrol"},{"key":"1676_CR15","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1038\/sj.ki.5000341","volume":"69","author":"V Audard","year":"2006","unstructured":"Audard V, Larousserie F, Grimbert P, Abtahi M, Sotto JJ, Delmer A, Boue F, Nochy D, Brousse N, Delarue R, Remy P, Ronco P, Sahali D, Lang P, Hermine O (2006) Minimal change nephrotic syndrome and classical Hodgkin's lymphoma: report of 21 cases and review of the literature. Kidney Int 69:2251\u20132260","journal-title":"Kidney Int"},{"key":"1676_CR16","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1080\/10428190290026259","volume":"43","author":"BF Skinnider","year":"2002","unstructured":"Skinnider BF, Kapp U, Mak TW (2002) The role of interleukin 13 in classical Hodgkin lymphoma. Leuk Lymphoma 43:1203\u20131210","journal-title":"Leuk Lymphoma"},{"key":"1676_CR17","first-page":"151","volume":"12","author":"G Lagrue","year":"1983","unstructured":"Lagrue G, Laurent J (1983) Allergy and lipoid nephrosis. Adv Nephrol Necker Hosp 12:151\u2013175","journal-title":"Adv Nephrol Necker Hosp"},{"key":"1676_CR18","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00467-004-1438-8","volume":"19","author":"W Cheung","year":"2004","unstructured":"Cheung W, Wei CL, Seah CC, Jordan SC, Yap HK (2004) Atopy, serum IgE, and interleukin-13 in steroid-responsive nephrotic syndrome. Pediatr Nephrol 19:627\u2013632","journal-title":"Pediatr Nephrol"},{"key":"1676_CR19","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1600-065X.2008.00706.x","volume":"226","author":"DM Mosser","year":"2008","unstructured":"Mosser DM, Zhang X (2008) Interleukin-10: new perspectives on an old cytokine. Immunol Rev 226:205\u2013218","journal-title":"Immunol Rev"},{"key":"1676_CR20","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1007\/s00467-009-1214-x","volume":"24","author":"C Araya","year":"2009","unstructured":"Araya C, Diaz L, Wasserfall C, Atkinson M, Mu W, Johnson R, Garin E (2009) T regulatory cell function in idiopathic minimal lesion nephrotic syndrome. Pediatr Nephrol 24:1691\u20131698","journal-title":"Pediatr Nephrol"},{"key":"1676_CR21","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00467-009-1119-8","volume":"24","author":"Y Hashimura","year":"2009","unstructured":"Hashimura Y, Nozu K, Kanegane H, Miyawaki T, Hayakawa A, Yoshikawa N, Nakanishi K, Takemoto M, Iijima K, Matsuo M (2009) Minimal change nephrotic syndrome associated with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Pediatr Nephrol 24:1181\u20131186","journal-title":"Pediatr Nephrol"},{"key":"1676_CR22","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/CJI.0b013e31818ac2f7","volume":"32","author":"SY Lee","year":"2009","unstructured":"Lee SY, Choi HK, Lee KJ, Jung JY, Hur GY, Jung KH, Kim JH, Shin C, Shim JJ, In KH, Kang KH, Yoo SH (2009) The immune tolerance of cancer is mediated by IDO that is inhibited by COX-2 inhibitors through regulatory T cells. J Immunother 32:22\u201328","journal-title":"J Immunother"},{"key":"1676_CR23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1681\/ASN.2007111244","volume":"20","author":"L Berre Le","year":"2009","unstructured":"Le Berre L, Bruneau S, Naulet J, Renaudin K, Buzelin F, Usal C, Smit H, Condamine T, Soulillou JP, Dantal J (2009) Induction of T regulatory cells attenuates idiopathic nephrotic syndrome. J Am Soc Nephrol 20:57\u201367","journal-title":"J Am Soc Nephrol"},{"key":"1676_CR24","doi-asserted-by":"crossref","first-page":"e4948","DOI":"10.1371\/journal.pone.0004948","volume":"4","author":"CI Sellin","year":"2009","unstructured":"Sellin CI, J\u00e9gou JF, Renneson J, Druelle J, Wild TF, Marie JC, Horvat B (2009) Interplay between virus-specific effector response and Foxp3 regulatory T cells in measles virus immunopathogenesis. PLoS One 4:e4948","journal-title":"PLoS One"},{"key":"1676_CR25","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1086\/344230","volume":"186","author":"WJ Moss","year":"2002","unstructured":"Moss WJ, Ryon JJ, Monze M, Griffin DE (2002) Differential regulation of interleukin (IL)-4, IL-5, and IL-10 during measles in Zambian children. J Infect Dis 186:879\u2013887","journal-title":"J Infect Dis"},{"key":"1676_CR26","doi-asserted-by":"crossref","first-page":"R83","DOI":"10.1186\/ar1954","volume":"8","author":"M Vigna-Perez","year":"2006","unstructured":"Vigna-Perez M, Hern\u00e1ndez-Castro B, Paredes-Saharopulos O, Portales-P\u00e9rez D, Baranda L, Abud-Mendoza C, Gonz\u00e1lez-Amaro R (2006) Clinical and immunological effects of Rituximab in patients with lupus nephritis refractory to conventional therapy: a pilot study. Arthritis Res Ther 8:R83","journal-title":"Arthritis Res Ther"},{"key":"1676_CR27","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1136\/ard.2006.057885","volume":"66","author":"M Tokunaga","year":"2007","unstructured":"Tokunaga M, Saito K, Kawabata D, Imura Y, Fujii T, Nakayamada S, Tsujimura S, Nawata M, Iwata S, Azuma T, Mimori T, Tanaka Y, Tokunaga M, Saito K, Kawabata D, Imura Y, Fujii T, Nakayamada S, Tsujimura S, Nawata M, Iwata S, Azuma T, Mimori T, Tanaka Y (2007) Efficacy of rituximab (anti-CD20) for refractory systemic lupus erythematosus involving the central nervous system. Ann Rheum Dis 66:470\u2013475","journal-title":"Ann Rheum Dis"},{"key":"1676_CR28","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1182\/blood-2007-12-129262","volume":"112","author":"R Stasi","year":"2008","unstructured":"Stasi R, Cooper N, Del Poeta G, Stipa E, Laura Evangelista M, Abruzzese E, Amadori S (2008) Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell-depleting therapy with rituximab. Blood 112:1147\u20131150","journal-title":"Blood"},{"key":"1676_CR29","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0272-6386(03)00801-1","volume":"42","author":"RJ Johnson","year":"2003","unstructured":"Johnson RJ, Hurtado A, Merszei J, Rodriguez-Iturbe B, Feng L (2003) Hypothesis: dysregulation of immunologic balance resulting from hygiene and socioeconomic factors may influence the epidemiology and cause of glomerulonephritis worldwide. Am J Kidney Dis 42:575\u2013581","journal-title":"Am J Kidney Dis"},{"key":"1676_CR30","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nm.1857","volume":"14","author":"C Faul","year":"2008","unstructured":"Faul C, Donnelly M, Merscher-Gomez S, Chang YH, Franz S, Delfgaauw J, Chang JM, Choi HY, Campbell KN, Kim K, Reiser J, Mundel P (2008) The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A. Nat Med 14:931\u2013938","journal-title":"Nat Med"},{"key":"1676_CR31","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1038\/sj.ki.5001655","volume":"70","author":"CY Xing","year":"2006","unstructured":"Xing CY, Saleem MA, Coward RJ, Ni L, Witherden IR, Mathieson PW (2006) Direct effects of dexamethasone on human podocytes. Kidney Int 70:1038\u20131045","journal-title":"Kidney Int"},{"key":"1676_CR32","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1084\/jem.20011629","volume":"195","author":"FJ Barrat","year":"2002","unstructured":"Barrat FJ, Cua DJ, Boonstra A, Richards DF, Crain C, Savelkoul HF, de Waal-Malefyt R, Coffman RL, Hawrylowicz CM, O'Garra A (2002) In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med 195:603\u2013616","journal-title":"J Exp Med"},{"key":"1676_CR33","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1681\/ASN.V133630","volume":"13","author":"MA Saleem","year":"2002","unstructured":"Saleem MA, O'Hare MJ, Reiser J, Coward RJ, Inward CD, Farren T, Xing CY, Ni L, Mathieson PW, Mundel P (2002) A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression. J Am Soc Nephrol 13:630\u2013638","journal-title":"J Am Soc Nephrol"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-010-1676-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-010-1676-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-010-1676-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,13]],"date-time":"2021-11-13T01:31:06Z","timestamp":1636767066000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-010-1676-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,30]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["1676"],"URL":"https:\/\/doi.org\/10.1007\/s00467-010-1676-x","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,30]]}}}