{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T02:07:27Z","timestamp":1774490847342,"version":"3.50.1"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2011,11,1]],"date-time":"2011-11-01T00:00:00Z","timestamp":1320105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1007\/s00467-011-1989-4","type":"journal-article","created":{"date-parts":[[2011,8,29]],"date-time":"2011-08-29T09:38:57Z","timestamp":1314610737000},"page":"2085-2088","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Eculizumab in atypical hemolytic uremic syndrome: long-term clinical course and histological findings"],"prefix":"10.1007","volume":"26","author":[{"given":"Sibylle","family":"Tschumi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Gugger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara S.","family":"Bucher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Riedl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomo D.","family":"Simonetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,11,1]]},"reference":[{"key":"1989_CR1","first-page":"905","volume":"85","author":"C Gasser","year":"1955","unstructured":"Gasser C, Gautier E, Steck A, Siebenmann RE, Oechslin R (1955) hemolytic-uremic syndrome: Bilateral necrosis of the renal cortex in acute acquired hemolytic anemia. Schweiz Med Wochenschr 85:905\u2013909","journal-title":"Schweiz Med Wochenschr"},{"key":"1989_CR2","doi-asserted-by":"publisher","first-page":"2431","DOI":"10.1007\/s00467-010-1555-5","volume":"25","author":"D Kavanagh","year":"2010","unstructured":"Kavanagh D, Goodship T (2010) Genetics and complement in atypical hus. Pediatr Nephrol 25:2431\u20132442","journal-title":"Pediatr Nephrol"},{"key":"1989_CR3","doi-asserted-by":"publisher","first-page":"1957","DOI":"10.1007\/s00467-008-0872-4","volume":"23","author":"C Loirat","year":"2008","unstructured":"Loirat C, Noris M, Fremeaux-Bacchi V (2008) Complement and the atypical hemolytic uremic syndrome in children. Pediatr Nephrol 23:1957\u20131972","journal-title":"Pediatr Nephrol"},{"key":"1989_CR4","doi-asserted-by":"publisher","first-page":"2392","DOI":"10.1681\/ASN.2006080811","volume":"18","author":"AL Sellier-Leclerc","year":"2007","unstructured":"Sellier-Leclerc AL, Fremeaux-Bacchi V, Dragon-Durey MA, Macher MA, Niaudet P, Guest G, Boudailliez B, Bouissou F, Deschenes G, Gie S, Tsimaratos M, Fischbach M, Morin D, Nivet H, Alberti C, Loirat C (2007) Differential impact of complement mutations on clinical characteristics in atypical hemolytic uremic syndrome. J Am Soc Nephrol 18:2392\u20132400","journal-title":"J Am Soc Nephrol"},{"key":"1989_CR5","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1007\/s00467-008-0964-1","volume":"24","author":"G Ariceta","year":"2009","unstructured":"Ariceta G, Besbas N, Johnson S, Karpman D, Landau D, Licht C, Loirat C, Pecoraro C, Taylor CM, Van de Kar N, Vandewalle J, Zimmerhackl LB (2009) Guideline for the investigation and initial therapy of diarrhea-negative hemolytic uremic syndrome. Pediatr Nephrol 24:687\u2013696","journal-title":"Pediatr Nephrol"},{"key":"1989_CR6","doi-asserted-by":"publisher","first-page":"6786","DOI":"10.1182\/blood-2011-02-333997","volume":"117","author":"RJ Kelly","year":"2011","unstructured":"Kelly RJ, Hill A, Arnold LM, Brooksbank GL, Richards SJ, Cullen M, Mitchell LD, Cohen DR, Gregory WM, Hillmen P (2011) Long-term treatment with eculizumab in paroxysmal nocturnal hemoglobinuria: Sustained efficacy and improved survival. Blood 117:6786\u20136792","journal-title":"Blood"},{"key":"1989_CR7","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1007\/s00467-010-1708-6","volume":"26","author":"SI Al-Akash","year":"2011","unstructured":"Al-Akash SI, Almond PS, Savell VH Jr, Gharaybeh SI, Hogue C (2011) Eculizumab induces long-term remission in recurrent post-transplant hus associated with c3 gene mutation. Pediatr Nephrol 26:613\u2013619","journal-title":"Pediatr Nephrol"},{"key":"1989_CR8","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1056\/NEJMc0809959","volume":"360","author":"RA Gruppo","year":"2009","unstructured":"Gruppo RA, Rother RP (2009) Eculizumab for congenital atypical hemolytic-uremic syndrome. N Engl J Med 360:544\u2013546","journal-title":"N Engl J Med"},{"key":"1989_CR9","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.2215\/CJN.01090209","volume":"4","author":"CJ Mache","year":"2009","unstructured":"Mache CJ, Acham-Roschitz B, Fremeaux-Bacchi V, Kirschfink M, Zipfel PF, Roedl S, Vester U, Ring E (2009) Complement inhibitor eculizumab in atypical hemolytic uremic syndrome. Clin J Am Soc Nephrol 4:1312\u20131316","journal-title":"Clin J Am Soc Nephrol"},{"key":"1989_CR10","doi-asserted-by":"publisher","first-page":"1488","DOI":"10.2215\/CJN.10181110","volume":"6","author":"C Nester","year":"2011","unstructured":"Nester C, Stewart Z, Myers D, Jetton J, Nair R, Reed A, Thomas C, Smith R, Brophy P (2011) Pre-emptive eculizumab and plasmapheresis for renal transplant in atypical hemolytic uremic syndrome. Clin J Am Soc Nephrol 6:1488\u20131494","journal-title":"Clin J Am Soc Nephrol"},{"key":"1989_CR11","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1056\/NEJMc0808527","volume":"360","author":"J Nurnberger","year":"2009","unstructured":"Nurnberger J, Philipp T, Witzke O, Opazo Saez A, Vester U, Baba HA, Kribben A, Zimmerhackl LB, Janecke AR, Nagel M, Kirschfink M (2009) Eculizumab for atypical hemolytic-uremic syndrome. N Engl J Med 360:542\u2013544","journal-title":"N Engl J Med"},{"key":"1989_CR12","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1007\/s00467-010-1719-3","volume":"26","author":"AL Lapeyraque","year":"2011","unstructured":"Lapeyraque AL, Fremeaux-Bacchi V, Robitaille P (2011) Efficacy of eculizumab in a patient with factor-H-associated atypical hemolytic uremic syndrome. Pediatr Nephrol 26:621\u2013624","journal-title":"Pediatr Nephrol"},{"key":"1989_CR13","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1007\/s00467-011-1879-9","volume":"26","author":"M Weitz","year":"2011","unstructured":"Weitz M, Amon O, Bassler D, Koenigsrainer A, Nadalin S (2011) Prophylactic eculizumab prior to kidney transplantation for atypical hemolytic uremic syndrome. Pediatr Nephrol 26:1325\u20131329","journal-title":"Pediatr Nephrol"},{"issue":"18","key":"1989_CR14","doi-asserted-by":"publisher","first-page":"1746","DOI":"10.1056\/NEJMc1001060","volume":"362","author":"LB Zimmerhackl","year":"2010","unstructured":"Zimmerhackl LB, Hofer J, Cortina G, Mark W, W\u00fcrzner R, Jungraithmayr TC, Khursigara G, Kliche KO, Radauer W (2010) Prophylactic eculizumab after renal transplantation in atypical hemolytic-uremic syndrome. N Engl J Med 362(18):1746\u20131748","journal-title":"N Engl J Med"},{"key":"1989_CR15","doi-asserted-by":"publisher","unstructured":"Bouts A, Monnens L, Davin JC, Struijk G, Spanjaard L (2011) Insufficient protection by Neisseria meningitidis vaccination alone during eculizumab therapy. Pediatr Nephrol. doi:https:\/\/doi.org\/10.1007\/s00477-011-1929-3","DOI":"10.1007\/s00477-011-1929-3"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-011-1989-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-011-1989-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-011-1989-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-011-1989-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T17:04:54Z","timestamp":1610816694000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-011-1989-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["1989"],"URL":"https:\/\/doi.org\/10.1007\/s00467-011-1989-4","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11]]},"assertion":[{"value":"10 July 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2011","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 July 2011","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2011","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}