{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:02:17Z","timestamp":1793361737979,"version":"4.5.0"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2011,9,27]],"date-time":"2011-09-27T00:00:00Z","timestamp":1317081600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2012,6]]},"DOI":"10.1007\/s00467-011-1992-9","type":"journal-article","created":{"date-parts":[[2011,9,26]],"date-time":"2011-09-26T07:04:30Z","timestamp":1317020670000},"page":"901-909","source":"Crossref","is-referenced-by-count":213,"title":["Tubulointerstitial injury and the progression of chronic kidney disease"],"prefix":"10.1007","volume":"27","author":[{"given":"Kavita S.","family":"Hodgkins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. William","family":"Schnaper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,9,27]]},"reference":[{"key":"1992_CR1","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1007\/s00467-010-1503-4","volume":"25","author":"HW Schnaper","year":"2010","unstructured":"Schnaper HW, Hubchak SC, Runyan CE, Browne JA, Finer G, Liu X, Hayashida T (2010) A conceptual framework for the molecular pathogenesis of progressive kidney disease. Pediatr Nephrol 25:2223\u20132230","journal-title":"Pediatr Nephrol"},{"key":"1992_CR2","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1523-1755.2005.67097.x","volume":"67","author":"W Kriz","year":"2005","unstructured":"Kriz W, LeHir M (2005) Pathways to nephron loss starting from glomerular diseases\u2014insights from animal models. Kidney Int 67:404\u2013419","journal-title":"Kidney Int"},{"key":"1992_CR3","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0046-8177(70)80061-2","volume":"1","author":"LI Schainuck","year":"1970","unstructured":"Schainuck LI, Striker GE, Cutler RE, Benditt EP (1970) Structural-functional correlations in renal diseases. Part II: the correlations. Hum Pathol 1:631\u2013641","journal-title":"Hum Pathol"},{"key":"1992_CR4","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0344-0338(11)81021-6","volume":"186","author":"A Bohle","year":"1990","unstructured":"Bohle A, Mackensen-Haen S, VonGise, Grund KE, Wehrmann M, Batz C, Bogen Schutz O, Schmitt H, Nagy J, Muller C (1990) The consequences of tubule-interstitial changes for renal function in glomerulopathies. A morphometric and cytological analysis. Pathol Res Pract 186:135\u2013144","journal-title":"Pathol Res Pract"},{"key":"1992_CR5","doi-asserted-by":"crossref","first-page":"c81","DOI":"10.1159\/000314656","volume":"116","author":"B Rodriguez-Iturbe","year":"2010","unstructured":"Rodriguez-Iturbe B, Garcia Garcia G (2010) The role of tubulointerstitial inflammation in the progression of chronic renal failure. Nephron Clin Pract 116:c81\u2013c88","journal-title":"Nephron Clin Pract"},{"key":"1992_CR6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/ki.1990.175","volume":"38","author":"A Fogo","year":"1990","unstructured":"Fogo A, Hawkins EP, Berry PL, Glick AD, Chiang ML, MacDonell RC Jr, Ichikawa I (1990) Glomerular hypertrophy in minimal change disease predicts subsequent progression to focal glomerular sclerosis. Kidney Int 38:115\u2013123","journal-title":"Kidney Int"},{"key":"1992_CR7","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1046\/j.1523-1755.2003.00782.x","volume":"63","author":"M LeHir","year":"2003","unstructured":"LeHir M, Besse-Eschmann V (2003) A novel mechanism of nephron loss in a murine model of crescentic glomerulonephritis. Kidney Int 63:591\u2013599","journal-title":"Kidney Int"},{"key":"1992_CR8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2169\/internalmedicine.43.9","volume":"43","author":"M Nangaku","year":"2004","unstructured":"Nangaku M (2004) Mechanisms of tubulointerstitial injury in the kidney: final common pathways to end-stage renal failure. Intern Med 43:9\u201317","journal-title":"Intern Med"},{"key":"1992_CR9","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/00041552-199911000-00001","volume":"8","author":"G Remuzzi","year":"1999","unstructured":"Remuzzi G (1999) Nephropathic nature of proteinuria. Curr Opin Nephrol Hypertens 8:655\u2013633","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"1992_CR10","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s00467-009-1381-9","volume":"25","author":"R Nielsen","year":"2010","unstructured":"Nielsen R, Christensen EI (2010) Proteinuria and events beyond the slit. Pediatr Nephrol 25:813\u2013822","journal-title":"Pediatr Nephrol"},{"key":"1992_CR11","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1038\/sj.ki.5000298","volume":"69","author":"D Biemesderfer","year":"2006","unstructured":"Biemesderfer D (2006) Regulated intramembrane proteolysis of megalin: linking urinary protein and gene regulation in proximal tubule? Kidney Int 69:1717\u20131721","journal-title":"Kidney Int"},{"key":"1992_CR12","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1681\/ASN.2010050492","volume":"21","author":"S Amsellem","year":"2010","unstructured":"Amsellem S, Gburek J, Hamard G, Nielsen R, Willnow TE, Devuyst O, Nexo E, Verroust PJ, Christensen EI, Kozyraki R (2010) Cubilin is essential for albumin reabsorption in the renal proximal tubule. J Am Soc Nephrol 21:1859\u20131867","journal-title":"J Am Soc Nephrol"},{"key":"1992_CR13","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1097\/01.ASN.0000069223.98703.8E","volume":"14","author":"H Shimizu","year":"2003","unstructured":"Shimizu H, Maruyama S, Yuzawa Y, Kato T, Miki Y, Suzuki S, Sato W, Morita Y, Maruyama H, Egashira K, Matsuo S (2003) Anti-monocyte chemoattractant protein-1 gene therapy attenuates renal injury induced by protein-overload proteinuria. J Am Soc Nephrol 14:1496\u20131505","journal-title":"J Am Soc Nephrol"},{"key":"1992_CR14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/sj.ki.5000053","volume":"69","author":"H-J Anders","year":"2006","unstructured":"Anders H-J, Ninichuk V, Schlondorff D (2006) Progression of kidney disease: blocking leukocyte recruitment with chemokine receptor CCR1 antagonist. Kidney Int 69:29\u201332","journal-title":"Kidney Int"},{"key":"1992_CR15","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1681\/ASN.2008050492","volume":"20","author":"Z Kassiri","year":"2009","unstructured":"Kassiri Z, Oudit GY, Kandalam V, Awad A, Wang X, Ziou X, Maeda N, Herzenberg AM, Scholey JW (2009) Loss of TIMP3 enhances interstitial nephritis and fibrosis. J Am Soc Nephrol 20:1223\u20131235","journal-title":"J Am Soc Nephrol"},{"key":"1992_CR16","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000098432","volume":"27","author":"AT Whaley-Connell","year":"2007","unstructured":"Whaley-Connell AT, Morris EM, Rehmer N, Yaghoubian JC, Wei Y, Hayden MR, Habib J, Stump CS, Sowers JR (2007) Albumin activation of NAD(P)H oxidase activity is mediated via Rac1 in proximal tubule cells. Am J Nephrol 27:15\u201323","journal-title":"Am J Nephrol"},{"key":"1992_CR17","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0272-6386(95)90014-4","volume":"25","author":"MA Cooper","year":"1995","unstructured":"Cooper MA, Buddington B, Miller NL, Alfrey AC (1995) Urinary iron speciation in nephrotic syndrome. Am J Kidney Dis 25:314\u2013319","journal-title":"Am J Kidney Dis"},{"key":"1992_CR18","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1046\/j.1523-1755.2002.00618.x","volume":"62","author":"A Kamijo","year":"2002","unstructured":"Kamijo A, Kimura K, Sugaya T, Yamanouchi M, Hase H, Kaneko T, Hirata Y, Goto A, Fujita T, Omata M (2002) Urinary free fatty acids bound to albumin aggravate tubulointerstitial damage. Kidney Int 62:1628\u20131637","journal-title":"Kidney Int"},{"key":"1992_CR19","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1093\/ndt\/gfh964","volume":"20","author":"MM Timmeren Van","year":"2005","unstructured":"Van Timmeren MM, Bakker SJL, Stegeman CA, Gans RO, van Goor H (2005) Addition of oleic acid to delipidated bovine serum albumin aggravates renal damage in experimental protein-overload nephrosis. Nephrol Dial Transplant 20:2349\u20132357","journal-title":"Nephrol Dial Transplant"},{"key":"1992_CR20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/01.ASN.0000042167.66685.EA","volume":"14","author":"M Arici","year":"2003","unstructured":"Arici M, Chana R, Lewington A, Brown J, Brunskill NJ (2003) Stimulation of proximal tubular cell apoptosis by albumin-bound fatty acids mediated by peroxisome proliferator activated receptor-\u03b3. J Am Soc Nephrol 14:17\u201327","journal-title":"J Am Soc Nephrol"},{"key":"1992_CR21","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1681\/ASN.2009111130","volume":"22","author":"T Souma","year":"2011","unstructured":"Souma T, Abe M, Moriguchi T, Takai J, Yanagisawa-Miyazawa N, Shibata E, Akiyama Y, Toyohara T, Suzuki T, Tanemoto M, Abe T, Sato H, Yamamoto M, Ito S (2011) Luminal alkalinization attenuates proteinuria-induced oxidative damage in proximal tubular cells. J Am Soc Nephrol 22:635\u2013648","journal-title":"J Am Soc Nephrol"},{"key":"1992_CR22","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1681\/ASN.V134928","volume":"13","author":"M Nangaku","year":"2002","unstructured":"Nangaku M, Pippin J, Couser W (2002) C6 mediates chronic progression of tubulointerstitial damage in rats with remnant kidneys. J Am Soc Nephrol 13:928\u2013936","journal-title":"J Am Soc Nephrol"},{"key":"1992_CR23","doi-asserted-by":"crossref","first-page":"5750","DOI":"10.4049\/jimmunol.174.9.5750","volume":"174","author":"C He","year":"2005","unstructured":"He C, Imai M, Song H, Quigg RJ, Tomlinson S (2005) Complement inhibitors targeted to the proximal tubule prevent injury in experimental nephritic syndrome and demonstrate a key role for C5b-9. J Immunol 174:5750\u20135757","journal-title":"J Immunol"},{"key":"1992_CR24","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1681\/ASN.2010060616","volume":"21","author":"M Zeisberg","year":"2010","unstructured":"Zeisberg M, Duffield JS (2010) Resolved: EMT produces fibroblasts in the kidney. J Am Soc Nephrol 21:1247\u20131253","journal-title":"J Am Soc Nephrol"},{"key":"1992_CR25","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.2353\/ajpath.2008.080433","volume":"173","author":"SL Lin","year":"2008","unstructured":"Lin SL, Kisseleva T, Brenner DA, Duffield JS (2008) Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am J Pathol 173:1617\u20131627","journal-title":"Am J Pathol"},{"key":"1992_CR26","doi-asserted-by":"crossref","first-page":"F721","DOI":"10.1152\/ajprenal.00546.2010","volume":"300","author":"DP Basile","year":"2011","unstructured":"Basile DP, Friedrich JL, Spahic J, Knipe N, Mang H, Leonard EC, Changizi-Ashtiyani S, Bacallao RL, Molitoris BA, Sutton TA (2011) Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury. Am J Physiol Renal Physiol 300:F721\u2013F733","journal-title":"Am J Physiol Renal Physiol"},{"key":"1992_CR27","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1681\/ASN.2008050513","volume":"19","author":"EM Zeisberg","year":"2008","unstructured":"Zeisberg EM, Potenta SE, Sugimoto H, Zeisberg M, Kalluri R (2008) Fibroblasts in kidney fibrosis emerge via endothelial-to-mesenchymal transition. J Am Soc Nephrol 19:2282\u20132287","journal-title":"J Am Soc Nephrol"},{"key":"1992_CR28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.ASN.0000106015.29070.E7","volume":"15","author":"Y Liu","year":"2004","unstructured":"Liu Y (2004) Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 15:1\u201312","journal-title":"J Am Soc Nephrol"},{"key":"1992_CR29","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1038\/ki.2010.88","volume":"77","author":"O Garc\u00eda-S\u00e1nchez","year":"2010","unstructured":"Garc\u00eda-S\u00e1nchez O, L\u00f3pez-Hern\u00e1ndez FJ, L\u00f3pez-Novoa JM (2010) An integrative view on the role of TGF-\u03b2 in the progressive tubular deletion associated with chronic kidney disease. Kidney Int 77:950\u2013955","journal-title":"Kidney Int"},{"key":"1992_CR30","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1159\/000262316","volume":"114","author":"MK Phanish","year":"2010","unstructured":"Phanish MK, Winn SK, Dockrell ME (2010) Connective tissue growth factor-(CTGF, CCN2)\u2014a marker, mediator, and therapeutic target for renal fibrosis. Nephron Exp Nephrol 114:e83\u2013e92","journal-title":"Nephron Exp Nephrol"},{"key":"1992_CR31","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1681\/ASN.2006050503","volume":"17","author":"AA Eddy","year":"2006","unstructured":"Eddy AA, Fogo AB (2006) Plasminogen activator inhibitor-1 in chronic kidney disease: evidence and mechanisms of action. J Am Soc Nephrol 17:2999\u20133012","journal-title":"J Am Soc Nephrol"},{"key":"1992_CR32","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1172\/JCI36150","volume":"118","author":"SD Ricardo","year":"2008","unstructured":"Ricardo SD, van Goor H, Eddy AA (2008) Macrophage diversity in renal injury and repair. J Clin Invest 118:3522\u20133530","journal-title":"J Clin Invest"},{"key":"1992_CR33","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1007\/s00467-003-1116-2","volume":"18","author":"B Lange-Sperandio","year":"2003","unstructured":"Lange-Sperandio B, Fulda S, Vandewalle A, Chevalier RL (2003) Macrophages induce apoptosis in proximal tubule cells. Pediatr Nephrol 18:335\u2013341","journal-title":"Pediatr Nephrol"},{"key":"1992_CR34","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1681\/ASN.2005070757","volume":"17","author":"M Nangaku","year":"2006","unstructured":"Nangaku M (2006) Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. J Am Soc Nephrol 17:17\u201375","journal-title":"J Am Soc Nephrol"},{"key":"1992_CR35","doi-asserted-by":"crossref","first-page":"520","DOI":"10.2215\/CJN.06711208","volume":"4","author":"MD Okusa","year":"2009","unstructured":"Okusa MD, Chertow GM, Portilla D (2009) The nexus of acute kidney injury, chronic kidney disease, and World Kidney Day 2009. Clin J Am Soc Nephrol 4:520\u2013522","journal-title":"Clin J Am Soc Nephrol"},{"key":"1992_CR36","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/ki.2008.350","volume":"74","author":"LG Fine","year":"2008","unstructured":"Fine LG, Norman JT (2008) Chronic hypoxia as a mechanism of progression of chronic kidney diseases: from hypothesis to novel therapeutics. Kidney Int 74:867\u2013872","journal-title":"Kidney Int"},{"key":"1992_CR37","doi-asserted-by":"crossref","first-page":"F995","DOI":"10.1152\/ajprenal.00092.2006","volume":"291","author":"H Xu","year":"2006","unstructured":"Xu H, Zeng L, Peng H, Chen S, Jones J, Chew TL, Sadeghi MM, Kanwar YS, Danesh FR (2006) HMG-CoA reductase inhibitor simvastatin mitigates VEGF-induced \u201cinside-out\u201d signaling to extracellular matrix by preventing RhoA activation. Am J Physiol Renal Physiol 291:F995\u2013F1004","journal-title":"Am J Physiol Renal Physiol"},{"key":"1992_CR38","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/ki.2010.326","volume":"79","author":"Z Wang","year":"2011","unstructured":"Wang Z, Tang L, Zhu Q, Yi F, Zhang F, Li PL, Li N (2011) Hypoxia-inducible factor-1\u03b1 contributes to the profibrotic action of angiotensin II in renal medullary interstitial cells. Kidney Int 79:300\u2013310","journal-title":"Kidney Int"},{"key":"1992_CR39","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/ki.2010.112","volume":"78","author":"VH Haase","year":"2010","unstructured":"Haase VH (2010) The sweet side of HIF. Kidney Int 78:10\u201313","journal-title":"Kidney Int"},{"key":"1992_CR40","doi-asserted-by":"crossref","first-page":"F898","DOI":"10.1152\/ajprenal.00335.2010","volume":"300","author":"RK Basu","year":"2011","unstructured":"Basu RK, Hubchak S, Hayashida T, Runyan CE, Schumacker PT, Schnaper HW (2011) Interdependence of HIF-1\u03b1 and TGF-\u03b2\/Smad3 signaling in normoxic and hypoxic renal epithelial cell collagen expression. Am J Physiol Renal Physiol 300:F898\u2013F905","journal-title":"Am J Physiol Renal Physiol"},{"key":"1992_CR41","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1007\/s00467-007-0524-0","volume":"22","author":"AB Fogo","year":"2007","unstructured":"Fogo AB (2007) Mechanisms of progression of chronic kidney disease. Pediatr Nephrol 22:2011\u20132022","journal-title":"Pediatr Nephrol"},{"key":"1992_CR42","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/01.mnh.0000165889.60254.98","volume":"14","author":"NJ Brown","year":"2005","unstructured":"Brown NJ (2005) Aldosterone and end-organ damage. Curr Opin Nephrol Hypertens 14:235\u2013241","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"1992_CR43","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/mc.20710","volume":"50","author":"N Queisser","year":"2011","unstructured":"Queisser N, Oteiza PI, Stopper H, Oli RG, Schupp N (2011) Aldosterone induces oxidative stress, oxidative DNA damage and NF-\u03baB-activation in kidney tubule cells. Mol Carcinog 50:123\u2013135","journal-title":"Mol Carcinog"},{"key":"1992_CR44","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrneph.2010.30","volume":"6","author":"M Briet","year":"2010","unstructured":"Briet M, Schiffrin EL (2010) Aldosterone: effects on the kidney and cardiovascular system. Nat Rev Nephrol 6:261\u2013273","journal-title":"Nat Rev Nephrol"},{"key":"1992_CR45","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1365-2362.2006.01689.x","volume":"3","author":"W Neuhofer","year":"2006","unstructured":"Neuhofer W, Pittrow D (2006) Role of endothelin and endothelin receptor antagonists in renal disease. Eur J Clin Invest Suppl 3:78\u201388","journal-title":"Eur J Clin Invest Suppl"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-011-1992-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-011-1992-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-011-1992-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T17:44:00Z","timestamp":1638899040000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-011-1992-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,27]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["1992"],"URL":"https:\/\/doi.org\/10.1007\/s00467-011-1992-9","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,27]]}}}