{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:57:10Z","timestamp":1789952230064,"version":"4.0.1"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1007\/s00467-012-2248-z","type":"journal-article","created":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T09:15:19Z","timestamp":1343812519000},"page":"2233-2241","source":"Crossref","is-referenced-by-count":17,"title":["DNA methylation changes between relapse and remission of minimal change nephrotic syndrome"],"prefix":"10.1007","volume":"27","author":[{"given":"Yasuko","family":"Kobayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Aizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Takizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikage","family":"Yoshizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Horiguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Ikeuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Kakegawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izuho","family":"Hatada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirokazu","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,8,2]]},"reference":[{"key":"2248_CR1","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/1439-7633(20020402)3:4<274::AID-CBIC274>3.0.CO;2-S","volume":"3","author":"A Jeltsch","year":"2002","unstructured":"Jeltsch A (2002) Beyond Watson and Crick: DNA methylation and molecular enzymology of DNA methyltransferases. ChemBioChem 3:274\u2013293","journal-title":"ChemBioChem"},{"key":"2248_CR2","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0092-8674(92)90611-F","volume":"69","author":"E Li","year":"1992","unstructured":"Li E, Bestor TH, Jaenisch R (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69:915\u2013926","journal-title":"Cell"},{"key":"2248_CR3","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/366362a0","volume":"366","author":"E Li","year":"1993","unstructured":"Li E, Beard C, Jaenisch R (1993) Role for DNA methylation in genomic imprinting. Nature 366:362\u2013365","journal-title":"Nature"},{"key":"2248_CR4","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1146\/annurev.genet.31.1.571","volume":"31","author":"E Heard","year":"1997","unstructured":"Heard E, Clerc P, Avner P (1997) X-chromosome inactivation in mammals. Annu Rev Genet 31:571\u2013610","journal-title":"Annu Rev Genet"},{"key":"2248_CR5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature02625","volume":"429","author":"G Egger","year":"2004","unstructured":"Egger G, Liang G, Aparicio A, Jones PA (2004) Epigenetics in human disease and prospects for epigenetic therapy. Nature 429:457\u2013463","journal-title":"Nature"},{"key":"2248_CR6","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0140-6736(74)91880-7","volume":"2","author":"RJ Shalhoub","year":"1974","unstructured":"Shalhoub RJ (1974) Pathogenesis of lipoid nephrosis: a disorder of T-cell function. Lancet 2:556\u2013559","journal-title":"Lancet"},{"key":"2248_CR7","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000183664","volume":"42","author":"JM Heslan","year":"1986","unstructured":"Heslan JM, Branellec A, Laurent J, Lagrue G (1986) The vascular permeability factor is a T lymphocyte product. Nephron 42:187\u2013188","journal-title":"Nephron"},{"key":"2248_CR8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000185246","volume":"51","author":"K Maruyama","year":"1989","unstructured":"Maruyama K, Tomizawa S, Shimabukuro N, Fukuda T, Johshita T, Kuroume T (1989) Studies of vascular permeability factor and inhibitory effect of supernatants derived from T lymphocytes culture in minimal change nephrotic syndrome on rat kidney capillaries. Nephron 51:73\u201376","journal-title":"Nephron"},{"key":"2248_CR9","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/ki.1991.232","volume":"40","author":"A Koyama","year":"1991","unstructured":"Koyama A, Fujisaki M, Kobayashi M, Igarashi M, Narita M (1991) A glomerular permeability factor produced by human T cell hybridomas. Kidney Int 40:453\u2013460","journal-title":"Kidney Int"},{"key":"2248_CR10","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/ki.1978.23","volume":"13","author":"International Study of Kidney Disease in Children","year":"1978","unstructured":"International Study of Kidney Disease in Children (1978) Nephrotic syndrome in children: prediction of histopathology from clinical and laboratory characteristics at time of diagnosis. Kidney Int 13:159-165","journal-title":"Kidney Int"},{"key":"2248_CR11","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1681\/ASN.V85769","volume":"8","author":"P Tarshish","year":"1997","unstructured":"Tarshish P, Tobin JN, Bernstein J, Edelmann CM Jr (1997) Prognostic significance of the early course of minimal change nephrotic syndrome: report of the International Study of Kidney Disease in Children. J Am Soc Nephrol 8:769\u2013776","journal-title":"J Am Soc Nephrol"},{"key":"2248_CR12","doi-asserted-by":"crossref","first-page":"e30523","DOI":"10.1371\/journal.pone.0030523","volume":"7","author":"V Audard","year":"2012","unstructured":"Audard V, Pawlak A, Candelier M, Lang P, Sahali D (2012) Upregulation of Nuclear Factor-Related Kappa B Suggests a Disorder of Transcriptional Regulation in Minimal Change Nephrotic Syndrome. PLoS One 7:e30523","journal-title":"PLoS One"},{"key":"2248_CR13","author":"V Elie","year":"2011","unstructured":"Elie V, Fakhoury M, Deschenes G, Jacqz-Aigrain E (2011) Physiopathology of idiopathic nephrotic syndrome: lessons from glucocorticoids and epigenetic perspectives. Pediatr Nephrol. doi: 10.1007\/s00467-011-1947-1","journal-title":"Pediatr Nephrol"},{"key":"2248_CR14","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1159\/000243811","volume":"30","author":"L Zhang","year":"2009","unstructured":"Zhang L, Dai Y, Peng W, Lu J, Zhang Y, Wang L (2009) Genome-wide analysis of histone H3 lysine 4 trimethylation in peripheral blood mononuclear cells of minimal change nephrotic syndrome patients. Am J Nephrol 30:505\u2013513","journal-title":"Am J Nephrol"},{"key":"2248_CR15","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/S0022-3476(81)80760-3","volume":"98","author":"International Study of Kidney Disease in Children","year":"1981","unstructured":"International Study of Kidney Disease in Children (1981) The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. J Pediatr 98:561-564","journal-title":"J Pediatr"},{"key":"2248_CR16","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0272-6386(03)00652-8","volume":"42","author":"Y Kobayashi","year":"2003","unstructured":"Kobayashi Y, Arakawa H, Suzuki M, Takizawa T, Tokuyama T, Morikawa A (2003) Polymorphisms of interleukin-4-related genes in Japanese children with minimal change nephrotic syndrome. Am J Kidney Dis 42:271\u2013276","journal-title":"Am J Kidney Dis"},{"key":"2248_CR17","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1038\/sj.onc.1209331","volume":"25","author":"I Hatada","year":"2006","unstructured":"Hatada I, Fukasawa M, Kimura M, Morita S, Yamada K, Yoshikawa T, Yamanaka S, Endo C, Sakurada A, Sato M, Kondo T, Horii A, Ushijima T, Sasaki H (2006) Genome-wide profiling of promoter methylation in human. Oncogene 25:3059\u20133064","journal-title":"Oncogene"},{"key":"2248_CR18","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s10038-007-0228-0","volume":"53","author":"I Hatada","year":"2008","unstructured":"Hatada I, Morita S, Kimura M, Horii T, Yamashita R, Nakai K (2008) Genome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells. J Hum Genet 53:185\u2013191","journal-title":"J Hum Genet"},{"key":"2248_CR19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nm.2261","volume":"17","author":"LC Clement","year":"2011","unstructured":"Clement LC, Avila-Casado C, Mace C, Soria E, Bakker WW, Kersten S, Chugh SS (2011) Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome. Nat Med 17:117\u2013122","journal-title":"Nat Med"},{"key":"2248_CR20","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1681\/ASN.2006070710","volume":"18","author":"KW Lai","year":"2007","unstructured":"Lai KW, Wei CL, Tan LK, Tan PH, Chiang GS, Lee CG, Jordan SC, Yap HK (2007) Overexpression of interleukin-13 induces minimal-change-like nephropathy in rats. J Am Soc Nephrol 18:1476\u20131485","journal-title":"J Am Soc Nephrol"},{"key":"2248_CR21","doi-asserted-by":"crossref","first-page":"F26","DOI":"10.1152\/ajprenal.0102.2001","volume":"282","author":"JG Berg Van Den","year":"2002","unstructured":"Van Den Berg JG, Aten J, Annink C, Ravesloot JH, Weber E, Weening JJ (2002) Interleukin-4 and -13 promote basolateral secretion of H(+) and cathepsin L by glomerular epithelial cells. Am J Physiol Renal Physiol 282:F26\u2013F33","journal-title":"Am J Physiol Renal Physiol"},{"key":"2248_CR22","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s10157-009-0162-x","volume":"13","author":"H Kawachi","year":"2009","unstructured":"Kawachi H, Suzuki K, Miyauchi N, Hashimoto T, Otaki Y, Shimizu F (2009) Slit diaphragm dysfunction in proteinuric states: identification of novel therapeutic targets for nephrotic syndrome. Clin Exp Nephrol 13:275\u2013280","journal-title":"Clin Exp Nephrol"},{"key":"2248_CR23","doi-asserted-by":"crossref","first-page":"8951","DOI":"10.1074\/jbc.M806851200","volume":"284","author":"Y Harita","year":"2009","unstructured":"Harita Y, Kurihara H, Kosako H, Tezuka T, Sekine T, Igarashi T, Ohsawa I, Ohta S, Hattori S (2009) Phosphorylation of nephrin triggers Ca2+ signaling by recruitment and activation of phospholipase C-{gamma}1. J Biol Chem 284:8951\u20138962","journal-title":"J Biol Chem"},{"key":"2248_CR24","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1046\/j.1523-1755.2001.059002601.x","volume":"59","author":"S Chugh","year":"2001","unstructured":"Chugh S, Yuan H, Topham PS, Haydar SA, Mittal V, Taylor GA, Kalluri R, Salant DJ (2001) Aminopeptidase A: a nephritogenic target antigen of nephrotoxic serum. Kidney Int 59:601\u2013613","journal-title":"Kidney Int"},{"key":"2248_CR25","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1681\/ASN.2007080836","volume":"20","author":"EH Garin","year":"2009","unstructured":"Garin EH, Diaz LN, Mu W, Wasserfall C, Araya C, Segal M, Johnson RJ (2009) Urinary CD80 excretion increases in idiopathic minimal-change disease. J Am Soc Nephrol 20:260\u2013266","journal-title":"J Am Soc Nephrol"},{"key":"2248_CR26","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1681\/ASN.2006121346","volume":"18","author":"AL Sellier-Leclerc","year":"2007","unstructured":"Sellier-Leclerc AL, Duval A, Riveron S, Macher MA, Deschenes G, Loirat C, Verpont MC, Peuchmaur M, Ronco P, Monteiro RC, Haddad E (2007) A humanized mouse model of idiopathic nephrotic syndrome suggests a pathogenic role for immature cells. J Am Soc Nephrol 18:2732\u20132739","journal-title":"J Am Soc Nephrol"},{"key":"2248_CR27","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s00467-008-1003-y","volume":"24","author":"Y Ikeuchi","year":"2009","unstructured":"Ikeuchi Y, Kobayashi Y, Arakawa H, Suzuki M, Tamura K, Morikawa A (2009) Polymorphisms in interleukin-4-related genes in patients with minimal change nephrotic syndrome. Pediatr Nephrol 24:489\u2013495","journal-title":"Pediatr Nephrol"},{"key":"2248_CR28","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.4049\/jimmunol.169.4.1893","volume":"169","author":"S Santangelo","year":"2002","unstructured":"Santangelo S, Cousins DJ, Winkelmann NE, Staynov DZ (2002) DNA methylation changes at human Th2 cytokine genes coincide with DNase I hypersensitive site formation during CD4(+) T cell differentiation. J Immunol 169:1893\u20131903","journal-title":"J Immunol"},{"key":"2248_CR29","doi-asserted-by":"crossref","first-page":"42399","DOI":"10.1074\/jbc.M205876200","volume":"277","author":"M Yamashita","year":"2002","unstructured":"Yamashita M, Ukai-Tadenuma M, Kimura M, Omori M, Inami M, Taniguchi M, Nakayama T (2002) Identification of a conserved GATA3 response element upstream proximal from the interleukin-13 gene locus. J Biol Chem 277:42399\u201342408","journal-title":"J Biol Chem"},{"key":"2248_CR30","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1681\/ASN.V103529","volume":"10","author":"HK Yap","year":"1999","unstructured":"Yap HK, Cheung W, Murugasu B, Sim SK, Seah CC, Jordan SC (1999) Th1 and Th2 cytokine mRNA profiles in childhood nephrotic syndrome: evidence for increased IL-13 mRNA expression in relapse. J Am Soc Nephrol 10:529\u2013537","journal-title":"J Am Soc Nephrol"},{"key":"2248_CR31","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s004670050592","volume":"13","author":"BS Cho","year":"1999","unstructured":"Cho BS, Yoon SR, Jang JY, Pyun KH, Lee CE (1999) Up-regulation of interleukin-4 and CD23\/FcepsilonRII in minimal change nephrotic syndrome. Pediatr Nephrol 13:199\u2013204","journal-title":"Pediatr Nephrol"},{"key":"2248_CR32","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1681\/ASN.V1351238","volume":"13","author":"D Sahali","year":"2002","unstructured":"Sahali D, Pawlak A, Valanciute A, Grimbert P, Lang P, Remy P, Bensman A, Guellaen G (2002) A novel approach to investigation of the pathogenesis of active minimal-change nephrotic syndrome using subtracted cDNA library screening. J Am Soc Nephrol 13:1238\u20131247","journal-title":"J Am Soc Nephrol"},{"key":"2248_CR33","doi-asserted-by":"crossref","first-page":"608","DOI":"10.5414\/CNP71608","volume":"71","author":"A Komatsuda","year":"2009","unstructured":"Komatsuda A, Wakui H, Iwamoto K, Togashi M, Masai R, Maki N, Sawada K (2009) GATA-3 is upregulated in peripheral blood mononuclear cells from patients with minimal change nephrotic syndrome. Clin Nephrol 71:608\u2013616","journal-title":"Clin Nephrol"},{"key":"2248_CR34","doi-asserted-by":"crossref","first-page":"10604","DOI":"10.1073\/pnas.0500398102","volume":"102","author":"MF Fraga","year":"2005","unstructured":"Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suner D, Cigudosa JC, Urioste M, Benitez J, Boix-Chornet M, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector TD, Wu YZ, Plass C, Esteller M (2005) Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci USA 102:10604\u201310609","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1007\/s00467-012-2248-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,25]],"date-time":"2022-01-25T02:10:48Z","timestamp":1643076648000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-012-2248-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,2]]},"references-count":34,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["2248"],"URL":"https:\/\/doi.org\/10.1007\/s00467-012-2248-z","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,2]]}}}