{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:59:04Z","timestamp":1793383144985,"version":"4.5.0"},"reference-count":108,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2012,8,18]],"date-time":"2012-08-18T00:00:00Z","timestamp":1345248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1007\/s00467-012-2272-z","type":"journal-article","created":{"date-parts":[[2012,8,17]],"date-time":"2012-08-17T14:01:26Z","timestamp":1345212086000},"page":"1025-1036","source":"Crossref","is-referenced-by-count":36,"title":["An update on the pathomechanisms and future therapies of Alport syndrome"],"prefix":"10.1007","volume":"28","author":[{"given":"Damien","family":"Noone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Licht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,8,18]]},"reference":[{"key":"2272_CR1","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1056\/NEJMra022296","volume":"348","author":"BG Hudson","year":"2003","unstructured":"Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG (2003) Alport\u2019s syndrome, Goodpasture\u2019s syndrome, and type IV collagen. N Engl J Med 348:2543\u20132556","journal-title":"N Engl J Med"},{"key":"2272_CR2","doi-asserted-by":"crossref","first-page":"c82","DOI":"10.1159\/000101802","volume":"106","author":"PS Thorner","year":"2007","unstructured":"Thorner PS (2007) Alport syndrome and thin basement membrane nephropathy. Nephron Clin Pract 106:c82\u2013c88","journal-title":"Nephron Clin Pract"},{"key":"2272_CR3","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1681\/ASN.2009070784","volume":"21","author":"MR Bekheirnia","year":"2010","unstructured":"Bekheirnia MR, Reed B, Gregory MC, McFann K, Shamshirsaz AA, Masoumi A, Schrier RW (2010) Genotype-phenotype correlation in X-linked Alport syndrome. J Am Soc Nephrol 21:876\u2013883","journal-title":"J Am Soc Nephrol"},{"key":"2272_CR4","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1056\/NEJMra052131","volume":"354","author":"K Tryggvason","year":"2006","unstructured":"Tryggvason K, Patrakka J, Wartiovaara J (2006) Hereditary proteinuria syndromes and mechanisms of proteinuria. N Engl J Med 354:1387\u20131401","journal-title":"N Engl J Med"},{"key":"2272_CR5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s00441-009-0866-y","volume":"339","author":"T Agtmael Van","year":"2010","unstructured":"Van Agtmael T, Bruckner-Tuderman L (2010) Basement membranes and human disease. Cell Tissue Res 339:167\u2013188","journal-title":"Cell Tissue Res"},{"key":"2272_CR6","doi-asserted-by":"crossref","unstructured":"Miglio G, Rosa AC, Rattazzi L, Grange C, Camussi G, Fantozzi R (2012) Protective effects of peroxisome proliferator-activated receptor agonists on human podocytes: proposed mechanisms of action. Br J Pharmacol. doi: 10.1111\/j.1476-5381.2012.02026.x","DOI":"10.1111\/j.1476-5381.2012.02026.x"},{"key":"2272_CR7","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1681\/ASN.2008101086","volume":"20","author":"DR Abrahamson","year":"2009","unstructured":"Abrahamson DR, Hudson BG, Stroganova L, Borza DB, St John PL (2009) Cellular origins of type IV collagen networks in developing glomeruli. J Am Soc Nephrol 20:1471\u20131479","journal-title":"J Am Soc Nephrol"},{"key":"2272_CR8","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1681\/ASN.2007030328","volume":"18","author":"DR Abrahamson","year":"2007","unstructured":"Abrahamson DR, Isom K, Roach E, Stroganova L, Zelenchuk A, Miner JH, St John PL (2007) Laminin compensation in collagen alpha3(IV) knockout (Alport) glomeruli contributes to permeability defects. J Am Soc Nephrol 18:2465\u20132472","journal-title":"J Am Soc Nephrol"},{"key":"2272_CR9","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00467-011-1868-z","volume":"27","author":"D Cosgrove","year":"2011","unstructured":"Cosgrove D (2011) Glomerular pathology in Alport syndrome: a molecular perspective. Pediatr Nephrol 27:885\u2013890","journal-title":"Pediatr Nephrol"},{"key":"2272_CR10","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1046\/j.1523-1755.1999.00744.x","volume":"56","author":"R Sayers","year":"1999","unstructured":"Sayers R, Kalluri R, Rodgers KD, Shield CF, Meehan DT, Cosgrove D (1999) Role for transforming growth factor-beta1 in Alport renal disease progression. Kidney Int 56:1662\u20131673","journal-title":"Kidney Int"},{"key":"2272_CR11","doi-asserted-by":"crossref","first-page":"e100","DOI":"10.1371\/journal.pmed.0030100","volume":"3","author":"M Zeisberg","year":"2006","unstructured":"Zeisberg M, Khurana M, Rao VH, Cosgrove D, Rougier JP, Werner MC, Shield CF 3rd, Werb Z, Kalluri R (2006) Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. PLoS Med 3:e100","journal-title":"PLoS Med"},{"key":"2272_CR12","doi-asserted-by":"crossref","first-page":"32","DOI":"10.2353\/ajpath.2006.050896","volume":"169","author":"VH Rao","year":"2006","unstructured":"Rao VH, Meehan DT, Delimont D, Nakajima M, Wada T, Gratton MA, Cosgrove D (2006) Role for macrophage metalloelastase in glomerular basement membrane damage associated with Alport syndrome. Am J Pathol 169:32\u201346","journal-title":"Am J Pathol"},{"key":"2272_CR13","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1046\/j.1523-1755.2003.00871.x","volume":"63","author":"KD Rodgers","year":"2003","unstructured":"Rodgers KD, Rao V, Meehan DT, Fager N, Gotwals P, Ryan ST, Koteliansky V, Nemori R, Cosgrove D (2003) Monocytes may promote myofibroblast accumulation and apoptosis in Alport renal fibrosis. Kidney Int 63:1338\u20131355","journal-title":"Kidney Int"},{"key":"2272_CR14","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1046\/j.1523-1755.2003.00939.x","volume":"63","author":"VH Rao","year":"2003","unstructured":"Rao VH, Lees GE, Kashtan CE, Nemori R, Singh RK, Meehan DT, Rodgers K, Berridge BR, Bhattacharya G, Cosgrove D (2003) Increased expression of MMP-2, MMP-9 (type IV collagenases\/gelatinases), and MT1-MMP in canine X-linked Alport syndrome (XLAS). Kidney Int 63:1736\u20131748","journal-title":"Kidney Int"},{"key":"2272_CR15","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1007\/s00467-004-1805-5","volume":"20","author":"VH Rao","year":"2005","unstructured":"Rao VH, Lees GE, Kashtan CE, Delimont DC, Singh R, Meehan DT, Bhattacharya G, Berridge BR, Cosgrove D (2005) Dysregulation of renal MMP-3 and MMP-7 in canine X-linked Alport syndrome. Pediatr Nephrol 20:732\u2013739","journal-title":"Pediatr Nephrol"},{"key":"2272_CR16","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/ki.2009.324","volume":"76","author":"DT Meehan","year":"2009","unstructured":"Meehan DT, Delimont D, Cheung L, Zallocchi M, Sansom SC, Holzclaw JD, Rao V, Cosgrove D (2009) Biomechanical strain causes maladaptive gene regulation, contributing to Alport glomerular disease. Kidney Int 76:968\u2013976","journal-title":"Kidney Int"},{"key":"2272_CR17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S1097-2765(00)80003-9","volume":"1","author":"W Vogel","year":"1997","unstructured":"Vogel W, Gish GD, Alves F, Pawson T (1997) The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell 1:13\u201323","journal-title":"Mol Cell"},{"key":"2272_CR18","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1097\/01.ASN.0000032419.13208.0C","volume":"13","author":"CA Curat","year":"2002","unstructured":"Curat CA, Vogel WF (2002) Discoidin domain receptor 1 controls growth and adhesion of mesangial cells. J Am Soc Nephrol 13:2648\u20132656","journal-title":"J Am Soc Nephrol"},{"key":"2272_CR19","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.matbio.2010.03.002","volume":"29","author":"O Gross","year":"2010","unstructured":"Gross O, Girgert R, Beirowski B, Kretzler M, Kang HG, Kruegel J, Miosge N, Busse AC, Segerer S, Vogel WF, Muller GA, Weber M (2010) Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease. Matrix Biol 29:346\u2013356","journal-title":"Matrix Biol"},{"key":"2272_CR20","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00441-009-0834-6","volume":"339","author":"M Barczyk","year":"2010","unstructured":"Barczyk M, Carracedo S, Gullberg D (2010) Integrins. Cell Tissue Res 339:269\u2013280","journal-title":"Cell Tissue Res"},{"key":"2272_CR21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1755-1536-3-19","volume":"3","author":"R Girgert","year":"2010","unstructured":"Girgert R, Martin M, Kruegel J, Miosge N, Temme J, Eckes B, Muller GA, Gross O (2010) Integrin alpha2-deficient mice provide insights into specific functions of collagen receptors in the kidney. Fibrogenesis Tissue Repair 3:19","journal-title":"Fibrogenesis Tissue Repair"},{"key":"2272_CR22","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1681\/ASN.2011040367","volume":"23","author":"CM Borza","year":"2012","unstructured":"Borza CM, Su Y, Chen X, Yu L, Mont S, Chetyrkin S, Voziyan P, Hudson BG, Billings PC, Jo H, Bennett JS, Degrado WF, Eckes B, Zent R, Pozzi A (2012) Inhibition of integrin alpha2beta1 ameliorates glomerular injury. J Am Soc Nephrol 23:1027\u20131038","journal-title":"J Am Soc Nephrol"},{"key":"2272_CR23","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1101\/gad.10.23.2981","volume":"10","author":"D Cosgrove","year":"1996","unstructured":"Cosgrove D, Meehan DT, Grunkemeyer JA, Kornak JM, Sayers R, Hunter WJ, Samuelson GC (1996) Collagen COL4A3 knockout: a mouse model for autosomal Alport syndrome. Genes Dev 10:2981\u20132992","journal-title":"Genes Dev"},{"key":"2272_CR24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/01913123.2011.620731","volume":"36","author":"J Hicks","year":"2012","unstructured":"Hicks J, Mierau G, Wartchow E, Eldin K (2012) Renal diseases associated with hematuria in children and adolescents: a brief tutorial. Ultrastruct Pathol 36:1\u201318","journal-title":"Ultrastruct Pathol"},{"key":"2272_CR25","doi-asserted-by":"crossref","unstructured":"Ryu M, Migliorini A, Miosge N, Gross O, Shankland S, Brinkkoetter PT, Hagmann H, Romagnani P, Liapis H, Anders HJ (2012) Plasma leakage through glomerular basement membrane ruptures triggers the proliferation of parietal epithelial cells and crescent formation in non-inflammatory glomerular injury. J Pathol. doi: 10.1002\/path.4046","DOI":"10.1002\/path.4046"},{"key":"2272_CR26","doi-asserted-by":"crossref","first-page":"2974","DOI":"10.1681\/ASN.2006040377","volume":"17","author":"M Abbate","year":"2006","unstructured":"Abbate M, Zoja C, Remuzzi G (2006) How does proteinuria cause progressive renal damage? J Am Soc Nephrol 17:2974\u20132984","journal-title":"J Am Soc Nephrol"},{"key":"2272_CR27","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.4049\/jimmunol.173.6.4190","volume":"173","author":"MC Braun","year":"2004","unstructured":"Braun MC, Reins RY, Li TB, Hollmann TJ, Dutta R, Rick WA, Teng BB, Ke B (2004) Renal expression of the C3a receptor and functional responses of primary human proximal tubular epithelial cells. J Immunol 173:4190\u20134196","journal-title":"J Immunol"},{"key":"2272_CR28","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1053\/ajkd.2001.20593","volume":"37","author":"S Tang","year":"2001","unstructured":"Tang S, Lai KN, Chan TM, Lan HY, Ho SK, Sacks SH (2001) Transferrin but not albumin mediates stimulation of complement C3 biosynthesis in human proximal tubular epithelial cells. Am J Kidney Dis 37:94\u2013103","journal-title":"Am J Kidney Dis"},{"key":"2272_CR29","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nrneph.2010.174","volume":"7","author":"RJ Baines","year":"2011","unstructured":"Baines RJ, Brunskill NJ (2011) Tubular toxicity of proteinuria. Nat Rev Nephrol 7:177\u2013180","journal-title":"Nat Rev Nephrol"},{"key":"2272_CR30","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1681\/ASN.2011070645","volume":"23","author":"J Chen","year":"2012","unstructured":"Chen J, Chen JK, Nagai K, Plieth D, Tan M, Lee TC, Threadgill DW, Neilson EG, Harris RC (2012) EGFR signaling promotes TGFbeta-dependent renal fibrosis. J Am Soc Nephrol 23:215\u2013224","journal-title":"J Am Soc Nephrol"},{"key":"2272_CR31","doi-asserted-by":"crossref","first-page":"7200","DOI":"10.1016\/S0021-9258(18)32352-4","volume":"258","author":"FJ Chiu","year":"1983","unstructured":"Chiu FJ, Atkin CL (1983) Catabolites of the third component of complement in urines of hereditary nephritis patients. J Biol Chem 258:7200\u20137207","journal-title":"J Biol Chem"},{"key":"2272_CR32","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1681\/ASN.V104804","volume":"10","author":"M Abbate","year":"1999","unstructured":"Abbate M, Zoja C, Rottoli D, Corna D, Perico N, Bertani T, Remuzzi G (1999) Antiproteinuric therapy while preventing the abnormal protein traffic in proximal tubule abrogates protein- and complement-dependent interstitial inflammation in experimental renal disease. J Am Soc Nephrol 10:804\u2013813","journal-title":"J Am Soc Nephrol"},{"key":"2272_CR33","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/ki.1994.247","volume":"46","author":"S Ichida","year":"1994","unstructured":"Ichida S, Yuzawa Y, Okada H, Yoshioka K, Matsuo S (1994) Localization of the complement regulatory proteins in the normal human kidney. Kidney Int 46:89\u201396","journal-title":"Kidney Int"},{"key":"2272_CR34","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/ki.1994.59","volume":"45","author":"L Biancone","year":"1994","unstructured":"Biancone L, David S, Della Pietra V, Montrucchio G, Cambi V, Camussi G (1994) Alternative pathway activation of complement by cultured human proximal tubular epithelial cells. Kidney Int 45:451\u2013460","journal-title":"Kidney Int"},{"key":"2272_CR35","first-page":"315","volume":"16","author":"EC Clark","year":"1990","unstructured":"Clark EC, Nath KA, Hostetter MK, Hostetter TH (1990) Role of ammonia in tubulointerstitial injury. Miner Electrolyte Metab 16:315\u2013321","journal-title":"Miner Electrolyte Metab"},{"key":"2272_CR36","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.4049\/jimmunol.162.7.4336","volume":"162","author":"S Tang","year":"1999","unstructured":"Tang S, Zhou W, Sheerin NS, Vaughan RW, Sacks SH (1999) Contribution of renal secreted complement C3 to the circulating pool in humans. J Immunol 162:4336\u20134341","journal-title":"J Immunol"},{"key":"2272_CR37","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1681\/ASN.V10169","volume":"10","author":"S Tang","year":"1999","unstructured":"Tang S, Sheerin NS, Zhou W, Brown Z, Sacks SH (1999) Apical proteins stimulate complement synthesis by cultured human proximal tubular epithelial cells. J Am Soc Nephrol 10:69\u201376","journal-title":"J Am Soc Nephrol"},{"key":"2272_CR38","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1681\/ASN.2008040434","volume":"20","author":"Z Tang","year":"2009","unstructured":"Tang Z, Lu B, Hatch E, Sacks SH, Sheerin NS (2009) C3a mediates epithelial-to-mesenchymal transition in proteinuric nephropathy. J Am Soc Nephrol 20:593\u2013603","journal-title":"J Am Soc Nephrol"},{"key":"2272_CR39","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1111\/j.1523-1755.2004.00957.x","volume":"66","author":"GK Rangan","year":"2004","unstructured":"Rangan GK, Pippin JW, Couser WG (2004) C5b-9 regulates peritubular myofibroblast accumulation in experimental focal segmental glomerulosclerosis. Kidney Int 66:1838\u20131848","journal-title":"Kidney Int"},{"key":"2272_CR40","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1681\/ASN.V10112323","volume":"10","author":"M Nangaku","year":"1999","unstructured":"Nangaku M, Pippin J, Couser WG (1999) Complement membrane attack complex (C5b-9) mediates interstitial disease in experimental nephrotic syndrome. J Am Soc Nephrol 10:2323\u20132331","journal-title":"J Am Soc Nephrol"},{"key":"2272_CR41","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1681\/ASN.V134928","volume":"13","author":"M Nangaku","year":"2002","unstructured":"Nangaku M, Pippin J, Couser WG (2002) C6 mediates chronic progression of tubulointerstitial damage in rats with remnant kidneys. J Am Soc Nephrol 13:928\u2013936","journal-title":"J Am Soc Nephrol"},{"key":"2272_CR42","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/ki.2011.102","volume":"80","author":"SG Sayyed","year":"2011","unstructured":"Sayyed SG, Ryu M, Kulkarni OP, Schmid H, Lichtnekert J, Gruner S, Green L, Mattei P, Hartmann G, Anders HJ (2011) An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes. Kidney Int 80:68\u201378","journal-title":"Kidney Int"},{"key":"2272_CR43","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1681\/ASN.2010050510","volume":"22","author":"AC Chung","year":"2011","unstructured":"Chung AC, Lan HY (2011) Chemokines in renal injury. J Am Soc Nephrol 22:802\u2013809","journal-title":"J Am Soc Nephrol"},{"key":"2272_CR44","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s00467-005-1955-0","volume":"20","author":"RH White","year":"2005","unstructured":"White RH, Raafat F, Milford DV, Komianou F, Moghal NE (2005) The Alport nephropathy: clinicopathological correlations. Pediatr Nephrol 20:897\u2013903","journal-title":"Pediatr Nephrol"},{"key":"2272_CR45","first-page":"89","volume":"10","author":"J Churg","year":"1974","unstructured":"Churg J, Strauss L, Sherman RL (1974) Electron microscopic studies in hereditary nephritis. Birth Defects Orig Artic Ser 10:89\u201392","journal-title":"Birth Defects Orig Artic Ser"},{"key":"2272_CR46","first-page":"109","volume":"10","author":"GS Spear","year":"1974","unstructured":"Spear GS (1974) The pathology of the kidney in the Alport syndrome. Birth Defects Orig Artic Ser 10:109\u2013113","journal-title":"Birth Defects Orig Artic Ser"},{"key":"2272_CR47","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/ki.2010.373","volume":"79","author":"M Ryu","year":"2011","unstructured":"Ryu M, Kulkarni OP, Radomska E, Miosge N, Gross O, Anders HJ (2011) Bacterial CpG-DNA accelerates Alport glomerulosclerosis by inducing an M1 macrophage phenotype and tumor necrosis factor-alpha-mediated podocyte loss. Kidney Int 79:189\u2013198","journal-title":"Kidney Int"},{"key":"2272_CR48","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1681\/ASN.2004100871","volume":"16","author":"V Ninichuk","year":"2005","unstructured":"Ninichuk V, Gross O, Reichel C, Khandoga A, Pawar RD, Ciubar R, Segerer S, Belemezova E, Radomska E, Luckow B, Perez de Lema G, Murphy PM, Gao JL, Henger A, Kretzler M, Horuk R, Weber M, Krombach F, Schlondorff D, Anders HJ (2005) Delayed chemokine receptor 1 blockade prolongs survival in collagen 4A3-deficient mice with Alport disease. J Am Soc Nephrol 16:977\u2013985","journal-title":"J Am Soc Nephrol"},{"key":"2272_CR49","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/path.2505","volume":"218","author":"S Clauss","year":"2009","unstructured":"Clauss S, Gross O, Kulkarni O, Avila-Ferrufino A, Radomska E, Segerer S, Eulberg D, Klussmann S, Anders HJ (2009) Ccl2\/Mcp-1 blockade reduces glomerular and interstitial macrophages but does not ameliorate renal pathology in collagen4A3-deficient mice with autosomal recessive Alport nephropathy. J Pathol 218:40\u201347","journal-title":"J Pathol"},{"key":"2272_CR50","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.humpath.2009.08.024","volume":"41","author":"J Jedlicka","year":"2010","unstructured":"Jedlicka J, Soleiman A, Draganovici D, Mandelbaum J, Ziegler U, Regele H, Wuthrich RP, Gross O, Anders HJ, Segerer S (2010) Interstitial inflammation in Alport syndrome. Hum Pathol 41:582\u2013593","journal-title":"Hum Pathol"},{"key":"2272_CR51","first-page":"120","volume":"336","author":"M Ryu","year":"2011","unstructured":"Ryu M, Mulay SR, Miosge N, Gross O, Anders HJ (2011) Tumour necrosis factor-alpha drives Alport glomerulosclerosis in mice by promoting podocyte apoptosis. J Pathol 336:120\u2013131","journal-title":"J Pathol"},{"key":"2272_CR52","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/S0002-9440(10)64802-X","volume":"157","author":"D Cosgrove","year":"2000","unstructured":"Cosgrove D, Rodgers K, Meehan D, Miller C, Bovard K, Gilroy A, Gardner H, Kotelianski V, Gotwals P, Amatucci A, Kalluri R (2000) Integrin alpha1beta1 and transforming growth factor-beta1 play distinct roles in Alport glomerular pathogenesis and serve as dual targets for metabolic therapy. Am J Pathol 157:1649\u20131659","journal-title":"Am J Pathol"},{"key":"2272_CR53","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1146\/annurev-cellbio-092910-154036","volume":"27","author":"MA Nieto","year":"2011","unstructured":"Nieto MA (2011) The ins and outs of the epithelial-to-mesenchymal transition in health and disease. Annu Rev Cell Dev Biol 27:347\u2013376","journal-title":"Annu Rev Cell Dev Biol"},{"key":"2272_CR54","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1172\/JCI39104","volume":"119","author":"R Kalluri","year":"2009","unstructured":"Kalluri R, Weinberg RA (2009) The basics of epithelial-mesenchymal transition. J Clin Invest 119:1420\u20131428","journal-title":"J Clin Invest"},{"key":"2272_CR55","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/S0002-9440(10)64327-1","volume":"162","author":"S Cheng","year":"2003","unstructured":"Cheng S, Lovett DH (2003) Gelatinase A (MMP-2) is necessary and sufficient for renal tubular cell epithelial-mesenchymal transformation. Am J Pathol 162:1937\u20131949","journal-title":"Am J Pathol"},{"key":"2272_CR56","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1096\/fj.06-5898fje","volume":"20","author":"S Cheng","year":"2006","unstructured":"Cheng S, Pollock AS, Mahimkar R, Olson JL, Lovett DH (2006) Matrix metalloproteinase 2 and basement membrane integrity: a unifying mechanism for progressive renal injury. FASEB J 20:1898\u20131900","journal-title":"FASEB J"},{"key":"2272_CR57","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1046\/j.1523-1755.1999.0550031051.x","volume":"55","author":"L Callis","year":"1999","unstructured":"Callis L, Vila A, Carrera M, Nieto J (1999) Long-term effects of cyclosporine A in Alport\u2019s syndrome. Kidney Int 55:1051\u20131056","journal-title":"Kidney Int"},{"key":"2272_CR58","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1080\/00365590600830417","volume":"40","author":"TS Sigmundsson","year":"2006","unstructured":"Sigmundsson TS, Palsson R, Hardarson S, Edvardsson V (2006) Resolution of proteinuria in a patient with X-linked Alport syndrome treated with cyclosporine. Scand J Urol Nephrol 40:522\u2013525","journal-title":"Scand J Urol Nephrol"},{"key":"2272_CR59","doi-asserted-by":"crossref","unstructured":"Kashtan CE, Ding J, Gregory M, Gross O, Heidet L, Knebelmann B, Rheault M, Licht C (2012) Clinical practice recommendations for the treatment of Alport syndrome: a statement of the Alport Syndrome Research Collaborative. Pediatr Nephrol. doi: 10.1007\/s00467-012-2138-4","DOI":"10.1007\/s00467-012-2138-4"},{"key":"2272_CR60","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.1093\/ndt\/gfq797","volume":"26","author":"NJ Webb","year":"2011","unstructured":"Webb NJ, Lam C, Shahinfar S, Strehlau J, Wells TG, Gleim GW, Le Bailly De Tilleghem C (2011) Efficacy and safety of losartan in children with Alport syndrome-results from a subgroup analysis of a prospective, randomized, placebo- or amlodipine-controlled trial. Nephrol Dial Transplant 26:2521\u20132526","journal-title":"Nephrol Dial Transplant"},{"key":"2272_CR61","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/ki.2011.407","volume":"81","author":"O Gross","year":"2012","unstructured":"Gross O, Licht C, Anders HJ, Hoppe B, Beck B, Tonshoff B, Hocker B, Wygoda S, Ehrich JH, Pape L, Konrad M, Rascher W, Dotsch J, Muller-Wiefel DE, Hoyer P, Knebelmann B, Pirson Y, Grunfeld JP, Niaudet P, Cochat P, Heidet L, Lebbah S, Torra R, Friede T, Lange K, Muller GA, Weber M (2012) Early angiotensin-converting enzyme inhibition in Alport syndrome delays renal failure and improves life expectancy. Kidney Int 81:494\u2013501","journal-title":"Kidney Int"},{"key":"2272_CR62","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1751-7176.2007.tb00091.x","volume":"9","author":"S Ubaid-Girioli","year":"2007","unstructured":"Ubaid-Girioli S, Ferreira-Melo SE, Souza LA, Nogueira EA, Yugar-Toledo JC, Coca A, Moreno H Jr (2007) Aldosterone escape with diuretic or angiotensin-converting enzyme inhibitor\/angiotensin II receptor blocker combination therapy in patients with mild to moderate hypertension. J Clin Hypertens (Greenwich) 9:770\u2013774","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"2272_CR63","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1161\/01.HYP.0000044937.95080.E9","volume":"41","author":"A Sato","year":"2003","unstructured":"Sato A, Hayashi K, Naruse M, Saruta T (2003) Effectiveness of aldosterone blockade in patients with diabetic nephropathy. Hypertension 41:64\u201368","journal-title":"Hypertension"},{"key":"2272_CR64","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.amjhyper.2004.06.029","volume":"18","author":"A Sato","year":"2005","unstructured":"Sato A, Hayashi K, Saruta T (2005) Antiproteinuric effects of mineralocorticoid receptor blockade in patients with chronic renal disease. Am J Hypertens 18:44\u201349","journal-title":"Am J Hypertens"},{"key":"2272_CR65","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1038\/sj.ki.5001854","volume":"70","author":"S Bianchi","year":"2006","unstructured":"Bianchi S, Bigazzi R, Campese VM (2006) Long-term effects of spironolactone on proteinuria and kidney function in patients with chronic kidney disease. Kidney Int 70:2116\u20132123","journal-title":"Kidney Int"},{"key":"2272_CR66","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1053\/j.ajkd.2007.10.040","volume":"51","author":"AS Bomback","year":"2008","unstructured":"Bomback AS, Kshirsagar AV, Amamoo MA, Klemmer PJ (2008) Change in proteinuria after adding aldosterone blockers to ACE inhibitors or angiotensin receptor blockers in CKD: a systematic review. Am J Kidney Dis 51:199\u2013211","journal-title":"Am J Kidney Dis"},{"key":"2272_CR67","doi-asserted-by":"crossref","first-page":"542","DOI":"10.2215\/CJN.04750908","volume":"4","author":"SD Navaneethan","year":"2009","unstructured":"Navaneethan SD, Nigwekar SU, Sehgal AR, Strippoli GF (2009) Aldosterone antagonists for preventing the progression of chronic kidney disease: a systematic review and meta-analysis. Clin J Am Soc Nephrol 4:542\u2013551","journal-title":"Clin J Am Soc Nephrol"},{"key":"2272_CR68","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1007\/s00467-006-0270-8","volume":"21","author":"H Kaito","year":"2006","unstructured":"Kaito H, Nozu K, Iijima K, Nakanishi K, Yoshiya K, Kanda K, Przybyslaw Krol R, Yoshikawa N, Matsuo M (2006) The effect of aldosterone blockade in patients with Alport syndrome. Pediatr Nephrol 21:1824\u20131829","journal-title":"Pediatr Nephrol"},{"key":"2272_CR69","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1345\/aph.1E618","volume":"39","author":"ML Buck","year":"2005","unstructured":"Buck ML (2005) Clinical experience with spironolactone in pediatrics. Ann Pharmacother 39:823\u2013828","journal-title":"Ann Pharmacother"},{"key":"2272_CR70","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1007\/s00467-009-1176-z","volume":"24","author":"E Ku","year":"2009","unstructured":"Ku E, Campese VM (2009) Role of aldosterone in the progression of chronic kidney disease and potential use of aldosterone blockade in children. Pediatr Nephrol 24:2301\u20132307","journal-title":"Pediatr Nephrol"},{"key":"2272_CR71","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s00467-010-1469-2","volume":"25","author":"A Bensman","year":"2010","unstructured":"Bensman A, Niaudet P (2010) Non-immunologic mechanisms of calcineurin inhibitors explain its antiproteinuric effects in genetic glomerulopathies. Pediatr Nephrol 25:1197\u20131199","journal-title":"Pediatr Nephrol"},{"key":"2272_CR72","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00467-006-0227-y","volume":"22","author":"M Charbit","year":"2007","unstructured":"Charbit M, Gubler MC, Dechaux M, Gagnadoux MF, Grunfeld JP, Niaudet P (2007) Cyclosporin therapy in patients with Alport syndrome. Pediatr Nephrol 22:57\u201363","journal-title":"Pediatr Nephrol"},{"key":"2272_CR73","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1007\/s00467-010-1484-3","volume":"25","author":"L Massella","year":"2010","unstructured":"Massella L, Muda AO, Legato A, Di Zazzo G, Giannakakis K, Emma F (2010) Cyclosporine A treatment in patients with Alport syndrome: a single-center experience. Pediatr Nephrol 25:1269\u20131275","journal-title":"Pediatr Nephrol"},{"key":"2272_CR74","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1096\/fj.07-8719com","volume":"22","author":"NS Sheerin","year":"2008","unstructured":"Sheerin NS, Risley P, Abe K, Tang Z, Wong W, Lin T, Sacks SH (2008) Synthesis of complement protein C3 in the kidney is an important mediator of local tissue injury. FASEB J 22:1065\u20131072","journal-title":"FASEB J"},{"key":"2272_CR75","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1681\/ASN.2007060686","volume":"19","author":"M Abbate","year":"2008","unstructured":"Abbate M, Zoja C, Corna D, Rottoli D, Zanchi C, Azzollini N, Tomasoni S, Berlingeri S, Noris M, Morigi M, Remuzzi G (2008) Complement-mediated dysfunction of glomerular filtration barrier accelerates progressive renal injury. J Am Soc Nephrol 19:1158\u20131167","journal-title":"J Am Soc Nephrol"},{"key":"2272_CR76","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1046\/j.1523-1755.2003.00305.x","volume":"64","author":"AM Saran","year":"2003","unstructured":"Saran AM, Yuan H, Takeuchi E, McLaughlin M, Salant DJ (2003) Complement mediates nephrin redistribution and actin dissociation in experimental membranous nephropathy. Kidney Int 64:2072\u20132078","journal-title":"Kidney Int"},{"key":"2272_CR77","doi-asserted-by":"crossref","first-page":"5750","DOI":"10.4049\/jimmunol.174.9.5750","volume":"174","author":"C He","year":"2005","unstructured":"He C, Imai M, Song H, Quigg RJ, Tomlinson S (2005) Complement inhibitors targeted to the proximal tubule prevent injury in experimental nephrotic syndrome and demonstrate a key role for C5b-9. J Immunol 174:5750\u20135757","journal-title":"J Immunol"},{"key":"2272_CR78","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1681\/ASN.V114700","volume":"11","author":"Y Morita","year":"2000","unstructured":"Morita Y, Ikeguchi H, Nakamura J, Hotta N, Yuzawa Y, Matsuo S (2000) Complement activation products in the urine from proteinuric patients. J Am Soc Nephrol 11:700\u2013707","journal-title":"J Am Soc Nephrol"},{"key":"2272_CR79","doi-asserted-by":"crossref","first-page":"F19","DOI":"10.1152\/ajprenal.2001.280.1.F19","volume":"280","author":"TD Piscione","year":"2001","unstructured":"Piscione TD, Phan T, Rosenblum ND (2001) BMP7 controls collecting tubule cell proliferation and apoptosis via Smad1-dependent and -independent pathways. Am J Physiol Ren Physiol 280:F19\u2013F33","journal-title":"Am J Physiol Ren Physiol"},{"key":"2272_CR80","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1093\/ndt\/gfk010","volume":"21","author":"M Zeisberg","year":"2006","unstructured":"Zeisberg M (2006) Bone morphogenic protein-7 and the kidney: current concepts and open questions. Nephrol Dial Transplant 21:568\u2013573","journal-title":"Nephrol Dial Transplant"},{"key":"2272_CR81","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1681\/ASN.V981456","volume":"9","author":"MM Almanzar","year":"1998","unstructured":"Almanzar MM, Frazier KS, Dube PH, Piqueras AI, Jones WK, Charette MF, Paredes AL (1998) Osteogenic protein-1 mRNA expression is selectively modulated after acute ischemic renal injury. J Am Soc Nephrol 9:1456\u20131463","journal-title":"J Am Soc Nephrol"},{"issue":"Suppl 1","key":"2272_CR82","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1681\/ASN.V13suppl_1s14","volume":"13","author":"J Morrissey","year":"2002","unstructured":"Morrissey J, Hruska K, Guo G, Wang S, Chen Q, Klahr S (2002) Bone morphogenetic protein-7 improves renal fibrosis and accelerates the return of renal function. J Am Soc Nephrol 13(Suppl 1):S14\u2013S21","journal-title":"J Am Soc Nephrol"},{"key":"2272_CR83","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1038\/nm888","volume":"9","author":"M Zeisberg","year":"2003","unstructured":"Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, Kalluri R (2003) BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 9:964\u2013968","journal-title":"Nat Med"},{"key":"2272_CR84","doi-asserted-by":"crossref","first-page":"F1641","DOI":"10.1152\/ajprenal.00179.2007","volume":"293","author":"GM Mitu","year":"2007","unstructured":"Mitu GM, Wang S, Hirschberg R (2007) BMP7 is a podocyte survival factor and rescues podocytes from diabetic injury. Am J Physiol Ren Physiol 293:F1641\u2013F1648","journal-title":"Am J Physiol Ren Physiol"},{"key":"2272_CR85","doi-asserted-by":"crossref","first-page":"F1060","DOI":"10.1152\/ajprenal.00191.2002","volume":"285","author":"M Zeisberg","year":"2003","unstructured":"Zeisberg M, Bottiglio C, Kumar N, Maeshima Y, Strutz F, Muller GA, Kalluri R (2003) Bone morphogenic protein-7 inhibits progression of chronic renal fibrosis associated with two genetic mouse models. Am J Physiol Ren Physiol 285:F1060\u2013F1067","journal-title":"Am J Physiol Ren Physiol"},{"key":"2272_CR86","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1172\/JCI39569","volume":"120","author":"M Tanaka","year":"2010","unstructured":"Tanaka M, Asada M, Higashi AY, Nakamura J, Oguchi A, Tomita M, Yamada S, Asada N, Takase M, Okuda T, Kawachi H, Economides AN, Robertson E, Takahashi S, Sakurai T, Goldschmeding R, Muso E, Fukatsu A, Kita T, Yanagita M (2010) Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome. J Clin Invest 120:768\u2013777","journal-title":"J Clin Invest"},{"key":"2272_CR87","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/sj.ki.5001731","volume":"70","author":"M Yanagita","year":"2006","unstructured":"Yanagita M (2006) Modulator of bone morphogenetic protein activity in the progression of kidney diseases. Kidney Int 70:989\u2013993","journal-title":"Kidney Int"},{"key":"2272_CR88","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1097\/01.TP.0000151644.85832.B5","volume":"79","author":"J Lutz","year":"2005","unstructured":"Lutz J, Yao Y, Song E, Antus B, Hamar P, Liu S, Heemann U (2005) Inhibition of matrix metalloproteinases during chronic allograft nephropathy in rats. Transplantation 79:655\u2013661","journal-title":"Transplantation"},{"key":"2272_CR89","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1159\/000101726","volume":"27","author":"AE Naini","year":"2007","unstructured":"Naini AE, Harandi AA, Moghtaderi J, Bastani B, Amiran A (2007) Doxycycline: a pilot study to reduce diabetic proteinuria. Am J Nephrol 27:269\u2013273","journal-title":"Am J Nephrol"},{"key":"2272_CR90","doi-asserted-by":"crossref","first-page":"941","DOI":"10.3109\/0886022X.2010.502606","volume":"32","author":"HK Aggarwal","year":"2010","unstructured":"Aggarwal HK, Jain D, Talapatra P, Yadav RK, Gupta T, Kathuria KL (2010) Evaluation of role of doxycycline (a matrix metalloproteinase inhibitor) on renal functions in patients of diabetic nephropathy. Ren Fail 32:941\u2013946","journal-title":"Ren Fail"},{"key":"2272_CR91","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ajpath.2011.03.023","volume":"179","author":"D Guerrot","year":"2011","unstructured":"Guerrot D, Kerroch M, Placier S, Vandermeersch S, Trivin C, Mael-Ainin M, Chatziantoniou C, Dussaule JC (2011) Discoidin domain receptor 1 is a major mediator of inflammation and fibrosis in obstructive nephropathy. Am J Pathol 179:83\u201391","journal-title":"Am J Pathol"},{"key":"2272_CR92","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1385\/IR:31:3:219","volume":"31","author":"T Yoshimura","year":"2005","unstructured":"Yoshimura T, Matsuyama W, Kamohara H (2005) Discoidin domain receptor 1: a new class of receptor regulating leukocyte-collagen interaction. Immunol Res 31:219\u2013230","journal-title":"Immunol Res"},{"key":"2272_CR93","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1681\/ASN.2006060677","volume":"17","author":"M Flamant","year":"2006","unstructured":"Flamant M, Placier S, Rodenas A, Curat CA, Vogel WF, Chatziantoniou C, Dussaule JC (2006) Discoidin domain receptor 1 null mice are protected against hypertension-induced renal disease. J Am Soc Nephrol 17:3374\u20133381","journal-title":"J Am Soc Nephrol"},{"key":"2272_CR94","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.molimm.2010.02.023","volume":"47","author":"LN Hachehouche","year":"2010","unstructured":"Hachehouche LN, Chetoui N, Aoudjit F (2010) Implication of discoidin domain receptor 1 in T cell migration in three-dimensional collagen. Mol Immunol 47:1866\u20131869","journal-title":"Mol Immunol"},{"key":"2272_CR95","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/sj.ki.5001521","volume":"70","author":"V Ninichuk","year":"2006","unstructured":"Ninichuk V, Gross O, Segerer S, Hoffmann R, Radomska E, Buchstaller A, Huss R, Akis N, Schlondorff D, Anders HJ (2006) Multipotent mesenchymal stem cells reduce interstitial fibrosis but do not delay progression of chronic kidney disease in collagen4A3-deficient mice. Kidney Int 70:121\u2013129","journal-title":"Kidney Int"},{"key":"2272_CR96","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1093\/ndt\/gfl367","volume":"21","author":"J Floege","year":"2006","unstructured":"Floege J, Kunter U, Weber M, Gross O (2006) Bone marrow transplantation rescues Alport mice. Nephrol Dial Transplant 21:2721\u20132723","journal-title":"Nephrol Dial Transplant"},{"key":"2272_CR97","unstructured":"Sedrakyan S, Da Sacco S, Milanesi A, Shiri L, Petrosyan A, Varimezova R, Warburton D, Lemley KV, De Filippo RE, Perin L (2012) Injection of amniotic fluid stem cells delays progression of renal fibrosis. J Am Soc Nephrol. doi: 10.1007\/s00467-012-2138-4O"},{"key":"2272_CR98","doi-asserted-by":"crossref","first-page":"7321","DOI":"10.1073\/pnas.0601436103","volume":"103","author":"H Sugimoto","year":"2006","unstructured":"Sugimoto H, Mundel TM, Sund M, Xie L, Cosgrove D, Kalluri R (2006) Bone-marrow-derived stem cells repair basement membrane collagen defects and reverse genetic kidney disease. Proc Natl Acad Sci USA 103:7321\u20137326","journal-title":"Proc Natl Acad Sci USA"},{"key":"2272_CR99","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1634\/stemcells.2006-0201","volume":"24","author":"EI Prodromidi","year":"2006","unstructured":"Prodromidi EI, Poulsom R, Jeffery R, Roufosse CA, Pollard PJ, Pusey CD, Cook HT (2006) Bone marrow-derived cells contribute to podocyte regeneration and amelioration of renal disease in a mouse model of Alport syndrome. Stem Cells 24:2448\u20132455","journal-title":"Stem Cells"},{"key":"2272_CR100","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1681\/ASN.2007070829","volume":"19","author":"K Katayama","year":"2008","unstructured":"Katayama K, Kawano M, Naito I, Ishikawa H, Sado Y, Asakawa N, Murata T, Oosugi K, Kiyohara M, Ishikawa E, Ito M, Nomura S (2008) Irradiation prolongs survival of Alport mice. J Am Soc Nephrol 19:1692\u20131700","journal-title":"J Am Soc Nephrol"},{"key":"2272_CR101","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1681\/ASN.2009010123","volume":"20","author":"V LeBleu","year":"2009","unstructured":"LeBleu V, Sugimoto H, Mundel TM, Gerami-Naini B, Finan E, Miller CA, Gattone VH 2nd, Lu L, Shield CF 3rd, Folkman J, Kalluri R (2009) Stem cell therapies benefit Alport syndrome. J Am Soc Nephrol 20:2359\u20132370","journal-title":"J Am Soc Nephrol"},{"key":"2272_CR102","doi-asserted-by":"crossref","first-page":"E1366","DOI":"10.1152\/ajpendo.00478.2009","volume":"297","author":"C Zhang","year":"2009","unstructured":"Zhang C, Tan Y, Guo W, Li C, Ji S, Li X, Cai L (2009) Attenuation of diabetes-induced renal dysfunction by multiple exposures to low-dose radiation is associated with the suppression of systemic and renal inflammation. Am J Physiol Endocrinol Metab 297:E1366\u2013E1377","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2272_CR103","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1681\/ASN.2008050482","volume":"20","author":"RR Wenzel","year":"2009","unstructured":"Wenzel RR, Littke T, Kuranoff S, Jurgens C, Bruck H, Ritz E, Philipp T, Mitchell A (2009) Avosentan reduces albumin excretion in diabetics with macroalbuminuria. J Am Soc Nephrol 20:655\u2013664","journal-title":"J Am Soc Nephrol"},{"key":"2272_CR104","doi-asserted-by":"crossref","first-page":"550","DOI":"10.5301\/jn.5000024","volume":"24","author":"VM Campese","year":"2011","unstructured":"Campese VM, Ku E, Bigazzi R, Bianchi S (2011) Do HMG-CoA reductase inhibitors improve kidney function? The saga continues. J Nephrol 24:550\u2013553","journal-title":"J Nephrol"},{"key":"2272_CR105","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1523-1755.2005.00423.x","volume":"68","author":"O Gross","year":"2005","unstructured":"Gross O, Koepke ML, Beirowski B, Schulze-Lohoff E, Segerer S, Weber M (2005) Nephroprotection by antifibrotic and anti-inflammatory effects of the vasopeptidase inhibitor AVE7688. Kidney Int 68:456\u2013463","journal-title":"Kidney Int"},{"key":"2272_CR106","doi-asserted-by":"crossref","unstructured":"Shroff R, Wan M, Rees L (2011) Can vitamin D slow down the progression of chronic kidney disease? Pediatr Nephrol. doi: 10.1007\/s00467-011-2071-y","DOI":"10.1007\/s00467-011-2071-y"},{"key":"2272_CR107","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/ajh.2010.231","volume":"24","author":"O Gross","year":"2011","unstructured":"Gross O, Girgert R, Rubel D, Temme J, Theissen S, Muller GA (2011) Renal protective effects of aliskiren beyond its antihypertensive property in a mouse model of progressive fibrosis. Am J Hypertens 24:355\u2013361","journal-title":"Am J Hypertens"},{"key":"2272_CR108","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1093\/ndt\/gfl810","volume":"22","author":"ML Koepke","year":"2007","unstructured":"Koepke ML, Weber M, Schulze-Lohoff E, Beirowski B, Segerer S, Gross O (2007) Nephroprotective effect of the HMG-CoA-reductase inhibitor cerivastatin in a mouse model of progressive renal fibrosis in Alport syndrome. Nephrol Dial Transplant 22:1062\u20131069","journal-title":"Nephrol Dial Transplant"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-012-2272-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-012-2272-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-012-2272-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T13:31:51Z","timestamp":1714311111000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-012-2272-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,18]]},"references-count":108,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["2272"],"URL":"https:\/\/doi.org\/10.1007\/s00467-012-2272-z","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,18]]}}}