{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:45:58Z","timestamp":1761237958173},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2012,12,20]],"date-time":"2012-12-20T00:00:00Z","timestamp":1355961600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1007\/s00467-012-2374-7","type":"journal-article","created":{"date-parts":[[2012,12,19]],"date-time":"2012-12-19T01:07:34Z","timestamp":1355879254000},"page":"745-750","source":"Crossref","is-referenced-by-count":18,"title":["Additive antiproteinuric effect of enalapril and losartan in children with hemolytic uremic syndrome"],"prefix":"10.1007","volume":"28","author":[{"given":"Mar\u00eda Gracia","family":"Caletti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Balestracci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mabel","family":"Missoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarisa","family":"Vezzani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,12,20]]},"reference":[{"key":"2374_CR1","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1046\/j.1523-1755.1998.00874.x","volume":"53","author":"P Ruggenenti","year":"1998","unstructured":"Ruggenenti P, Perna A, Mosconi L, Pisoni R, Remuzzi G (1998) Urinary protein excretion rate is the best independent predictor of ESRF in non-diabetic proteinuric chronic nephropathies. \u201cGruppo Italiano di Studi Epidemiologici in Nefrologia\u201d (GISEN). Kidney Int 53:1209\u20131216","journal-title":"Kidney Int"},{"key":"2374_CR2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0022-3476(05)80481-0","volume":"118","author":"D Milford","year":"1991","unstructured":"Milford D, White R, Taylor C (1991) Prognostic significance of proteinuria one year after onset of diarrhea-associated hemolytic uremic syndrome. J Pediatr 118:191\u2013194","journal-title":"J Pediatr"},{"key":"2374_CR3","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/ki.1994.113","volume":"45","author":"RT Gansevoort","year":"1994","unstructured":"Gansevoort RT, De Zeeuw Z, De Jong PE (1994) Is the antiproteinuric effect of ACE inhibition mediated by interference in the renin-angiotensin system? Kidney Int 45:861\u2013867","journal-title":"Kidney Int"},{"key":"2374_CR4","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1007\/s00467-008-0789-y","volume":"23","author":"E W\u00fchl","year":"2008","unstructured":"W\u00fchl E, Schaefer F (2008) Therapeutic strategies to slow chronic kidney disease progression. Pediatr Nephrol 23:705\u2013716","journal-title":"Pediatr Nephrol"},{"key":"2374_CR5","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1172\/JCI112528","volume":"77","author":"S Anderson","year":"1986","unstructured":"Anderson S, Rennke HG, Brenner BM (1986) Therapeutic advantage of converting enzyme inhibitors in arresting progressive renal disease associated with systemic hypertension in rat. J Clin Invest 77:1993\u20132000","journal-title":"J Clin Invest"},{"key":"2374_CR6","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1046\/j.1523-1755.2000.00031.x","volume":"57","author":"MW Taal","year":"2000","unstructured":"Taal MW, Brenner BM (2000) Renoprotective benefits of RAS inhibition: from ACEI to angiotensin II antagonists. Kidney Int 57:1803\u20131817","journal-title":"Kidney Int"},{"key":"2374_CR7","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0140-6736(98)10363-X","volume":"354","author":"P Ruggenenti","year":"1999","unstructured":"Ruggenenti P, Perna A, Gherardi G, Garini G, Zoccali C, Salvadori M, Scolari F, Schena FP, Remuzzi G (1999) Renoprotective properties of ACE inhibition in non-diabetic nephropathies with non-nephrotic proteinuria. Lancet 354:359\u2013364","journal-title":"Lancet"},{"key":"2374_CR8","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1007\/s00467-004-1516-y","volume":"19","author":"MG Caletti","year":"2004","unstructured":"Caletti MG, Lejarraga H, Kelmansky D, Missoni M (2004) Two different therapeutic regimes in patients with sequelae of hemolytic-uremic syndrome. Pediatr Nephrol 19:1148\u20131152","journal-title":"Pediatr Nephrol"},{"key":"2374_CR9","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1007\/s00467-004-1451-y","volume":"19","author":"M Dyck Van","year":"2004","unstructured":"Van Dyck M, Proesmans W (2004) Renoprotection by ACE inhibitors after severe hemolytic uremic syndrome. Pediatr Nephrol 19:688\u2013690","journal-title":"Pediatr Nephrol"},{"key":"2374_CR10","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1007\/s00467-011-1867-0","volume":"26","author":"MG Caletti","year":"2011","unstructured":"Caletti MG, Missoni M, Vezzani C, Grignoli M, Piantanida JJ, Repetto HA, Exeni R, Rasse SM (2011) Effect of diet, enalapril, or losartan in post-diarrheal hemolytic uremic syndrome nephropathy. Pediatr Nephrol 26:1247\u20131254","journal-title":"Pediatr Nephrol"},{"key":"2374_CR11","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1046\/j.1523-1755.2002.00536.x","volume":"62","author":"GD Laverman","year":"1991","unstructured":"Laverman GD, Navis G, Henning RH, de Jong PE, de Zeeuw D (1991) Dual renin-angiotensin system blockade at optimal doses for proteinuria. Kidney Int 62:1020\u20131025","journal-title":"Kidney Int"},{"key":"2374_CR12","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1007\/s004670050166","volume":"10","author":"W Proesmans","year":"1996","unstructured":"Proesmans W, Wambecke IV, Dyck MV (1996) Long-term therapy with enalapril in patients with nephrotic-range proteinuria. Ped Nephrol 10:587\u2013589","journal-title":"Ped Nephrol"},{"key":"2374_CR13","doi-asserted-by":"crossref","first-page":"S250","DOI":"10.1681\/ASN.2006080922","volume":"17","author":"G Fernandez-Ju\u00e1rez","year":"2006","unstructured":"Fernandez-Ju\u00e1rez G, Barrio V, de Vinuesa SG, Goicoechea M, Praga M, Lu\u00f1o J (2006) Dual blockade of the renin-angiotensin system in the progression of renal disease: the need for more clinical trials. J Am Soc Nephrol 17:S250\u2013S254","journal-title":"J Am Soc Nephrol"},{"key":"2374_CR14","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1053\/ajkd.2001.25176","volume":"38","author":"D Russo","year":"2001","unstructured":"Russo D, Minutolo R, Pisani A, Esposito R, Signoriello G, Andreucci M, Balletta MM (2001) Coadministration of losartan and enalapril exerts additive antiproteinuric effect in IgA nephropathy. Am J Kidney Dis 38:18\u201325","journal-title":"Am J Kidney Dis"},{"key":"2374_CR15","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1046\/j.1523-1755.62.s82.10.x","volume":"82","author":"J Luno","year":"2002","unstructured":"Luno J, Barrio V, Goicoechea M, Gonz\u00e1lez C, Garcia de Vinuesa S, Gomez F, Bernis C, Espinosa M, Ahijado F, Gomez J, Escalada P (2002) Effects of dual blockade of the renin\u2013angiotensin system in primary proteinuric nephropathies. Kidney Int 82:S47\u2013S52","journal-title":"Kidney Int"},{"key":"2374_CR16","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0140-6736(03)12229-5","volume":"361","author":"N Nakao","year":"2003","unstructured":"Nakao N, Yoshimura A, Morita H, Takada M, Kayano T, Ideura T (2003) Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial. Lancet 361:117\u2013124","journal-title":"Lancet"},{"key":"2374_CR17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0022-3476(03)00279-8","volume":"143","author":"D Ellis","year":"2003","unstructured":"Ellis D, Vats A, Moritz ML, Reitz S, Grosso MJ, Janosky JE (2003) Long-term antiproteinuric and renoprotective efficacy and safety of losartan in children with proteinuria. J Pediatr 143:89\u201397","journal-title":"J Pediatr"},{"key":"2374_CR18","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1007\/s00467-006-0223-2","volume":"21","author":"M Litwin","year":"2006","unstructured":"Litwin M, Grenda R, Sladowska J, Antoniewicz J (2006) Add-on therapy with angiotensin II receptor 1 blocker in children with chronic kidney disease already treated with angiotensin converting enzyme inhibitors. Pediatr Nephrol 21:1716\u20131722","journal-title":"Pediatr Nephrol"},{"key":"2374_CR19","volume-title":"Recommended dietary allowances","author":"Committee on Dietary Allowances","year":"1989","unstructured":"Committee on Dietary Allowances (1989) Recommended dietary allowances. National Academy of Science, Washington, DC"},{"key":"2374_CR20","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1159\/000180229","volume":"11","author":"CA Gianantonio","year":"1973","unstructured":"Gianantonio CA, Vitacco M, Mendilaharzu F, Gallo G, Sojo E (1973) The hemolytic uremic syndrome. Nephron 11:174\u2013192","journal-title":"Nephron"},{"key":"2374_CR21","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1007\/s00467-004-1554-5","volume":"19","author":"KF Hilgers","year":"2004","unstructured":"Hilgers KF, D\u00f6tsch J, Rascher W, Mann JF (2004) Treatment strategies in patients with chronic renal disease: ACE inhibitors, angiotensin receptor antagonists, or both? Pediatr Nephrol 19:956\u2013961","journal-title":"Pediatr Nephrol"},{"key":"2374_CR22","unstructured":"Joint National Committee (JNC) on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (2003) The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure (JNC7). Available at http:\/\/www.nhlbi.nih.gov\/guidelines\/hypertension\/"},{"key":"2374_CR23","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1542\/peds.58.2.259","volume":"58","author":"GJ Schwartz","year":"1976","unstructured":"Schwartz GJ, Haycock GB, Edelmann CM Jr, Spitzer A (1976) A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 58:259\u2013263","journal-title":"Pediatrics"},{"key":"2374_CR24","first-page":"438","volume":"14","author":"M Pennesi","year":"2000","unstructured":"Pennesi M, Torre G (2000) Angiotensin-converting enzyme inhibition in non diabetic nephropathy with non-nephrotic proteinuria. Pediatr Nephrol 14:438","journal-title":"Pediatr Nephrol"},{"key":"2374_CR25","first-page":"40","volume":"1","author":"N Delgado","year":"1994","unstructured":"Delgado N, Briones L, Pe\u00f1aloza J, Turconi A (1994) Acci\u00f3n del enalapril sobre la enfermedad renal secuela del s\u00edndrome ur\u00e9mico-hemol\u00edtico. Medicina Infantil 1:40\u201345","journal-title":"Medicina Infantil"},{"key":"2374_CR26","first-page":"528","volume":"65","author":"MG Caletti","year":"2005","unstructured":"Caletti MG, Gallo G (2005) Hemolytic uremic syndrome. Treatment of secondary glomerulopathy. Medicina (Buenos Aires) 65:528\u2013532","journal-title":"Medicina (Buenos Aires)"},{"key":"2374_CR27","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1172\/JCI116325","volume":"91","author":"H Urata","year":"1993","unstructured":"Urata H, Bohem KD, Philip A, Kinoshita A, Gabrovsek J, Bumpus M, Huasain A (1993) Cellular localization and regional distribution of an angiotensin II-forming chymase in the heart. J Clin Invest 91:1269\u20131281","journal-title":"J Clin Invest"},{"key":"2374_CR28","doi-asserted-by":"crossref","first-page":"3A","DOI":"10.1016\/S0002-9149(01)02321-9","volume":"89","author":"T Unger","year":"2002","unstructured":"Unger T (2002) The role of the renin-angiotensin system in the development of cardiovascular disease. Am J Cardiol 89:3A\u20139A","journal-title":"Am J Cardiol"},{"key":"2374_CR29","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s00467-009-1346-z","volume":"25","author":"SD Herder","year":"2010","unstructured":"Herder SD, Weber E, Winkemann A, Herder C, Morck H (2010) Efficacy and safety of angiotensin II receptor type 1 antagonist in children and adolescents. Pediatr Nephrol 25:801\u2013811","journal-title":"Pediatr Nephrol"},{"key":"2374_CR30","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1007\/s00467-003-1190-5","volume":"18","author":"CT White","year":"2003","unstructured":"White CT, Macpherson CF, Hurley RM, Matsell DG (2003) Antiproteinuric effects of enalapril and losartan: a pilot study. Pediatr Nephrol 18:1038\u20131043","journal-title":"Pediatr Nephrol"},{"key":"2374_CR31","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1056\/NEJMoa042274","volume":"351","author":"AH Barnett","year":"2004","unstructured":"Barnett AH, Bain SC, Bouter P, Karlberg B, Madsbad S, Jervell J, Mustonen J, the Diabetics Exposed to Telmisartan and Enalapril Study Group (2004) Angiotensin-receptor blockade versus converting-enzyme inhibition in type 2 diabetes and nephropathy. N Engl J Med 351:1952\u20131961","journal-title":"N Engl J Med"},{"key":"2374_CR32","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1681\/ASN.V1341100","volume":"13","author":"KF Hilgers","year":"2002","unstructured":"Hilgers KF, Mann JF (2002) ACE inhibitors versus AT (1) receptor antagonists in patients with chronic renal disease. J Am Soc Nephrol 13:1100\u20131108","journal-title":"J Am Soc Nephrol"},{"key":"2374_CR33","doi-asserted-by":"crossref","first-page":"S269","DOI":"10.1097\/00004872-198506000-00012","volume":"3","author":"J Nussberger","year":"1985","unstructured":"Nussberger J, Brunner DB, Waeber B, Brunner HR (1985) Plasma angiotensins under sustained converting enzyme inhibition with enalapril in normal humans. J Hypertens 3:S269\u2013S270","journal-title":"J Hypertens"},{"key":"2374_CR34","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s001250051199","volume":"42","author":"S Rudberg","year":"1999","unstructured":"Rudberg S, Osterby R, Bangstad HJ, Dahlquist G, Persson B (1999) Effect of converting enzyme inhibitor or beta blocker on glomerular structural changes in young microalbuminuria patients with Type 1 (insulin-dependent) diabetes mellitus. Diabetologia 42:589\u2013595","journal-title":"Diabetologia"},{"key":"2374_CR35","first-page":"F83","volume":"241","author":"TH Hostetter","year":"1981","unstructured":"Hostetter TH, Olson JL, Rennke HG, Venkatachalam MA, Brenner BM (1981) Hyperfiltration in remnant nephrons: a potentially adverse response in renal ablation. Am J Physiol 241:F83\u2013F93","journal-title":"Am J Physiol"},{"key":"2374_CR36","first-page":"F13","volume":"233","author":"MP Bohrer","year":"1977","unstructured":"Bohrer MP, Deen WM, Robertson CR, Brenner BM (1977) Mechanism of angiotensin II induced proteinuria in the rat. Am J Physiol 233:F13\u2013F21","journal-title":"Am J Physiol"},{"key":"2374_CR37","first-page":"S93","volume":"1","author":"D Zeeuw de","year":"1983","unstructured":"de Zeeuw D, Navis GJ, Donker AJ, de Jong PE (1983) The angiotensin converting enzyme inhibitor enalapril and its effects on renal function. J Hypertens 1:S93\u2013S97","journal-title":"J Hypertens"},{"key":"2374_CR38","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s00467-002-0829-y","volume":"17","author":"R Bhattacharjee","year":"2002","unstructured":"Bhattacharjee R, Filler G (2002) Additive antiproteinuric effect of ACE inhibitor and losartan in IgA nephropathy. Pediatr Nephrol 17:302\u2013304","journal-title":"Pediatr Nephrol"},{"key":"2374_CR39","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s004670050189","volume":"10","author":"MG Caletti","year":"1996","unstructured":"Caletti MG, Gallo GE, Gianantonio CA (1996) Development of focal segmental sclerosis and hyalinosis in hemolytic uremic syndrome. Pediatr Neprhol 10:687\u2013692","journal-title":"Pediatr Neprhol"},{"key":"2374_CR40","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/ki.1993.284","volume":"44","author":"RT Gansevoort","year":"1993","unstructured":"Gansevoort RT, de Zeeuw D, de Jong PE (1993) Dissociation between the courses of the hemodynamic and antiproteinuric effects of angiotensin I converting enzyme inhibition. Kidney Int 44:579\u2013584","journal-title":"Kidney Int"},{"key":"2374_CR41","unstructured":"British National Formulary for Children 2011-2012 (2011) BMJ Publishing Group, London, pp 102-103"},{"key":"2374_CR42","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1159\/000065227","volume":"22","author":"L Tylicki","year":"2002","unstructured":"Tylicki L, Rutkowski P, Renke M, Rutkowski B (2002) Renoprotective effect of small doses of losartan and enalapril in patients with primary glomerulonephritis. Short-term observation. Am J Nephrol 22:356\u2013362","journal-title":"Am J Nephrol"},{"key":"2374_CR43","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1053\/j.ajkd.2003.10.032","volume":"43","author":"P Rutkowski","year":"2004","unstructured":"Rutkowski P, Tylicki L, Renke M, Korejwo G, Zdrojewski Z, Rutkowski B (2004) Low-dose dual blockade of the renin-angiotensin system in patients with primary glomerulonephritis. Am J Kidney Dis 43:260\u2013268","journal-title":"Am J Kidney Dis"},{"key":"2374_CR44","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1053\/j.ajkd.2006.04.077","volume":"48","author":"M MacKinnon","year":"2006","unstructured":"MacKinnon M, Shurraw S, Akbari A, Knoll GA, Jaffey J, Clark HD (2006) Combination therapy with an angiotensin receptor blocker and an ACE inhibitor in proteinuric renal disease: a systematic review of the efficacy and safety data. Am J Kidney Dis 48:8\u201320","journal-title":"Am J Kidney Dis"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-012-2374-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-012-2374-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-012-2374-7","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T19:50:46Z","timestamp":1643917846000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-012-2374-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,20]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["2374"],"URL":"https:\/\/doi.org\/10.1007\/s00467-012-2374-7","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,20]]}}}