{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T11:02:46Z","timestamp":1790938966560,"version":"4.1.0"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2013,2,7]],"date-time":"2013-02-07T00:00:00Z","timestamp":1360195200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1007\/s00467-013-2416-9","type":"journal-article","created":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T03:21:01Z","timestamp":1360120861000},"page":"827-830","source":"Crossref","is-referenced-by-count":58,"title":["Neurologic involvement in atypical hemolytic uremic syndrome and successful treatment with eculizumab"],"prefix":"10.1007","volume":"28","author":[{"given":"Kaan","family":"Gulleroglu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kibriya","family":"Fidan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veysel S.","family":"Han\u00e7er","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umut","family":"Bayrakci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Baskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oguz","family":"Soylemezoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,2,7]]},"reference":[{"key":"2416_CR1","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s00467-008-0964-1","volume":"24","author":"G Ariceta","year":"2009","unstructured":"Ariceta G, Besbas N, Johnson S, Karpman D, Landau D, Licht C, Loirat C, Pecoraro C, Taylor CM, Van de Kar N, Vandewalle J, Zimmerhackl LB, European Paediatric Study Group for HUS (2009) Guideline for the investigation and initial therapy of diarrhea-negative hemolytic uremic syndrome. Pediatr Nephrol 24:687\u2013696","journal-title":"Pediatr Nephrol"},{"key":"2416_CR2","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1056\/NEJMra0902814","volume":"361","author":"M Noris","year":"2009","unstructured":"Noris M, Remuzzi G (2009) Atypical hemolytic-uremic syndrome. N Engl J Med 361:1676\u20131687","journal-title":"N Engl J Med"},{"key":"2416_CR3","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1136\/adc.76.6.518","volume":"76","author":"TJ Neuhaus","year":"1997","unstructured":"Neuhaus TJ, Calonder S, Leumann EP (1997) Heterogeneity of atypical haemolyticuraemic syndromes. Arch Dis Child 76:518\u2013521","journal-title":"Arch Dis Child"},{"key":"2416_CR4","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1681\/ASN.2010030315","volume":"21","author":"MA Dragon-Durey","year":"2010","unstructured":"Dragon-Durey MA, Sethi SK, Bagga A, Blanc C, Blouin J, Ranchin B, Andr\u00e9 JL, Takagi N, Cheong HI, Hari P, Le Quintrec M, Niaudet P, Loirat C, Fridman WH, Fr\u00e9meaux-Bacchi V (2010) Clinical features of anti-factor H autoantibody-associated hemolytic uremic syndrome. J Am Soc Nephrol 21:2180\u20132187","journal-title":"J Am Soc Nephrol"},{"key":"2416_CR5","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1007\/s00467-010-1606-y","volume":"25","author":"B Koehl","year":"2010","unstructured":"Koehl B, Boyer O, Biebuyck-Goug\u00e9 N, Kossorotoff M, Fr\u00e9meaux-Bacchi V, Boddaert N, Niaudet P (2010) Neurological involvement in a child with atypical hemolytic uremic syndrome. Pediatr Nephrol 25:2539\u20132542","journal-title":"Pediatr Nephrol"},{"key":"2416_CR6","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1007\/s00467-011-1989-4","volume":"26","author":"S Tschumi","year":"2011","unstructured":"Tschumi S, Gugger M, Bucher BS, Riedl M, Simonetti GD (2011) Eculizumab in atypical hemolytic uremic syndrome: long-term clinical course and histological findings. Pediatr Nephrol 26:2085\u20132088","journal-title":"Pediatr Nephrol"},{"key":"2416_CR7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s00467-010-1556-4","volume":"26","author":"AM Waters","year":"2011","unstructured":"Waters AM, Licht C (2011) aHUS caused by complement dysregulation: new therapies on the horizon. Pediatr Nephrol 26:41\u201357","journal-title":"Pediatr Nephrol"},{"key":"2416_CR8","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/1750-1172-6-60","volume":"6","author":"C Loirat","year":"2011","unstructured":"Loirat C, Fr\u00e9meaux-Bacchi V (2011) Atypical hemolytic uremic syndrome. Orphanet J Rare Dis 6:60","journal-title":"Orphanet J Rare Dis"},{"key":"2416_CR9","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1182\/blood-2005-10-007252","volume":"108","author":"J Caprioli","year":"2006","unstructured":"Caprioli J, Noris M, Brioschi S, Pianetti G, Castelletti F, Bettinaglio P, Mele C, Bresin E, Cassis L, Gamba S, Porrati F, Bucchioni S, Monteferrante G, Fang CJ, Liszewski MK, Kavanagh D, Atkinson JP, Remuzzi G, International Registry of Recurrent and Familial HUS\/TTP (2006) Genetics of HUS: the impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome. Blood 108:1267\u20131279","journal-title":"Blood"},{"key":"2416_CR10","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nrneph.2012.214","volume":"8","author":"J Zuber","year":"2012","unstructured":"Zuber J, Fakhouri F, Roumenina LT, Loirat C, Fr\u00e9meaux-Bacchi V (2012) Use of eculizumab for atypical haemolyticuraemic syndrome and C3 glomerulopathies. Nat Rev Nephrol 8:643\u2013657","journal-title":"Nat Rev Nephrol"},{"key":"2416_CR11","first-page":"5","volume":"3","author":"M Ohanian","year":"2011","unstructured":"Ohanian M, Cable C, Halka K (2011) Eculizumab safely reverses neurologic impairment and eliminates need for dialysis in severe atypical hemolytic uremic syndrome. Clin Pharmacol 3:5\u201312","journal-title":"Clin Pharmacol"},{"key":"2416_CR12","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1056\/NEJMc0809959","volume":"360","author":"RA Gruppo","year":"2009","unstructured":"Gruppo RA, Rother RP (2009) Eculizumab for congenital atypical hemolytic-uremic syndrome. N Engl J Med 360:544\u2013546","journal-title":"N Engl J Med"},{"key":"2416_CR13","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s12017-009-8085-y","volume":"12","author":"TM Woodruff","year":"2010","unstructured":"Woodruff TM, Ager RR, Tenner AJ, Noakes PG, Taylor SM (2010) The role of the complement system and the activation fragment C5a in the central nervous system. Neuromolecular Med 12:179\u2013192","journal-title":"Neuromolecular Med"},{"key":"2416_CR14","doi-asserted-by":"crossref","first-page":"7227","DOI":"10.1073\/pnas.0501536102","volume":"102","author":"GS Hageman","year":"2005","unstructured":"Hageman GS, Anderson DH, Johnson LV, Hancox LS, Taiber AJ, Hardisty LI, Hageman JL, Stockman HA, Borchardt JD, Gehrs KM, Smith RJ, Silvestri G, Russell SR, Klaver CC, Barbazetto I, Chang S, Yannuzzi LA, Barile GR, Merriam JC, Smith RT, Olsh AK, Bergeron J, Zernant J, Merriam JE, Gold B, Dean M, Allikmets R (2005) A common haplotype in the complement regulatory gene factor H (HF1\/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci USA 102:7227\u20137232","journal-title":"Proc Natl Acad Sci USA"},{"key":"2416_CR15","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1007\/s00467-012-2276-8","volume":"27","author":"R Vilalta","year":"2012","unstructured":"Vilalta R, Lara E, Madrid A, Chocron S, Mu\u00f1oz M, Casquero A, Nieto J (2012) Long-term eculizumab improves clinical outcomes in atypical hemolytic uremic syndrome. Pediatr Nephrol 27:2323\u20132326","journal-title":"Pediatr Nephrol"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-013-2416-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-013-2416-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-013-2416-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T21:03:57Z","timestamp":1559077437000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-013-2416-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,7]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["2416"],"URL":"https:\/\/doi.org\/10.1007\/s00467-013-2416-9","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,7]]}}}