{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T18:03:50Z","timestamp":1773425030298,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2013,3,16]],"date-time":"2013-03-16T00:00:00Z","timestamp":1363392000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1007\/s00467-013-2439-2","type":"journal-article","created":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T08:51:41Z","timestamp":1363337501000},"page":"1227-1234","source":"Crossref","is-referenced-by-count":43,"title":["Remission of nephrotic syndrome diminishes urinary plasmin content and abolishes activation of ENaC"],"prefix":"10.1007","volume":"28","author":[{"given":"Ren\u00e9 F.","family":"Andersen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian B.","family":"Buhl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boye L.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per","family":"Svenningsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla G.","family":"Friis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bente","family":"Jespersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f8ren","family":"Rittig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,3,16]]},"reference":[{"key":"2439_CR1","first-page":"47","volume":"104","author":"MH Humphreys","year":"1993","unstructured":"Humphreys MH, Valentin JP, Qiu C, Ying WZ, Muldowney WP, Gardner DG (1993) Underfill and overflow revisited: mechanisms of nephrotic edema. Trans Am Clin Climatol Assoc 104:47\u201359","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"2439_CR2","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/S0140-6736(82)90102-7","volume":"2","author":"EA Brown","year":"1982","unstructured":"Brown EA, Markandu ND, Sagnella GA, Squires M, Jones BE, MacGregor GA (1982) Evidence that some mechanism other than the renin system causes sodium retention in nephrotic syndrome. Lancet 2:1237\u20131240","journal-title":"Lancet"},{"key":"2439_CR3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1159\/000183206","volume":"37","author":"EA Brown","year":"1984","unstructured":"Brown EA, Markandu ND, Sagnella GA, Jones BE, MacGregor GA (1984) Lack of effect of captopril on the sodium retention of the nephrotic syndrome. Nephron 37:43\u201348","journal-title":"Nephron"},{"key":"2439_CR4","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0140-6736(95)91210-X","volume":"346","author":"JG Vande Walle","year":"1995","unstructured":"Vande Walle JG, Donckerwolcke RA, van Isselt JW, Derkx FH, Joles JA, Koomans HA (1995) Volume regulation in children with early relapse of minimal-change nephrosis with or without hypovolaemic symptoms. Lancet 346:148\u2013152","journal-title":"Lancet"},{"key":"2439_CR5","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1038\/ki.1996.207","volume":"49","author":"WJ Vande","year":"1996","unstructured":"Vande WJ, Donckerwolcke R, Boer P, van Isselt HW, Koomans HA, Joles JA (1996) Blood volume, colloid osmotic pressure and F-cell ratio in children with the nephrotic syndrome. Kidney Int 49:1471\u20131477","journal-title":"Kidney Int"},{"key":"2439_CR6","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1681\/ASN.V102323","volume":"10","author":"JG Vande Walle","year":"1999","unstructured":"Vande Walle JG, Donckerwolcke RA, Koomans HA (1999) Pathophysiology of edema formation in children with nephrotic syndrome not due to minimal change disease. J Am Soc Nephrol 10:323\u2013331","journal-title":"J Am Soc Nephrol"},{"key":"2439_CR7","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/ki.1994.33","volume":"45","author":"MH Humphreys","year":"1994","unstructured":"Humphreys MH (1994) Mechanisms and management of nephrotic edema. Kidney Int 45:266\u2013281","journal-title":"Kidney Int"},{"key":"2439_CR8","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1172\/JCI110756","volume":"71","author":"I Ichikawa","year":"1983","unstructured":"Ichikawa I, Rennke HG, Hoyer JR, Badr KF, Schor N, Troy JL, Lechene CP, Brenner BM (1983) Role for intrarenal mechanisms in the impaired salt excretion of experimental nephrotic syndrome. J Clin Invest 71:91\u2013103","journal-title":"J Clin Invest"},{"key":"2439_CR9","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1681\/ASN.V123598","volume":"12","author":"G Deschenes","year":"2001","unstructured":"Deschenes G, Wittner M, Stefano A, Jounier S, Doucet A (2001) Collecting duct is a site of sodium retention in PAN nephrosis: a rationale for amiloride therapy. J Am Soc Nephrol 12:598\u2013601","journal-title":"J Am Soc Nephrol"},{"key":"2439_CR10","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1681\/ASN.2008040364","volume":"20","author":"P Svenningsen","year":"2009","unstructured":"Svenningsen P, Bistrup C, Friis UG, Bertog M, Haerteis S, Krueger B, Stubbe J, Jensen ON, Thiesson HC, Uhrenholt TR, Jespersen B, Jensen BL, Korbmacher C, Skott O (2009) Plasmin in nephrotic urine activates the epithelial sodium channel. J Am Soc Nephrol 20:299\u2013310","journal-title":"J Am Soc Nephrol"},{"key":"2439_CR11","doi-asserted-by":"crossref","first-page":"36586","DOI":"10.1074\/jbc.M805676200","volume":"283","author":"CJ Passero","year":"2008","unstructured":"Passero CJ, Mueller GM, Rondon-Berrios H, Tofovic SP, Hughey RP, Kleyman TR (2008) Plasmin activates epithelial Na+ channels by cleaving the gamma subunit. J Biol Chem 283:36586\u201336591","journal-title":"J Biol Chem"},{"key":"2439_CR12","doi-asserted-by":"crossref","first-page":"20447","DOI":"10.1074\/jbc.R800083200","volume":"284","author":"TR Kleyman","year":"2009","unstructured":"Kleyman TR, Carattino MD, Hughey RP (2009) ENaC at the cutting edge: regulation of epithelial sodium channels by proteases. J Biol Chem 284:20447\u201320451","journal-title":"J Biol Chem"},{"key":"2439_CR13","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/39329","volume":"389","author":"V Vallet","year":"1997","unstructured":"Vallet V, Chraibi A, Gaeggeler HP, Horisberger JD, Rossier BC (1997) An epithelial serine protease activates the amiloride-sensitive sodium channel. Nature 389:607\u2013610","journal-title":"Nature"},{"key":"2439_CR14","doi-asserted-by":"crossref","first-page":"F1249","DOI":"10.1152\/ajprenal.00401.2009","volume":"297","author":"G Frindt","year":"2009","unstructured":"Frindt G, Palmer LG (2009) Surface expression of sodium channels and transporters in rat kidney: effects of dietary sodium. Am J Physiol Ren Physiol 297:F1249\u2013F1255","journal-title":"Am J Physiol Ren Physiol"},{"key":"2439_CR15","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1681\/ASN.2008030287","volume":"20","author":"GJ Schwartz","year":"2009","unstructured":"Schwartz GJ, Munoz A, Schneider MF, Mak RH, Kaskel F, Warady BA, Furth SL (2009) New equations to estimate GFR in children with CKD. J Am Soc Nephrol 20:629\u2013637","journal-title":"J Am Soc Nephrol"},{"key":"2439_CR16","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1111\/apha.12047","volume":"207","author":"P Svenningsen","year":"2012","unstructured":"Svenningsen P, Friis UG, Versland JB, Buhl KB, Moller FB, Andersen H, Zachar RM, Bistrup C, Skott O, Jorgensen JS, Andersen RF, Jensen BL (2012) Mechanisms of renal NaCl retention in proteinuric disease. Acta Physiol (Oxf) 207:536\u2013545","journal-title":"Acta Physiol (Oxf)"},{"key":"2439_CR17","first-page":"118","volume":"124","author":"ND Vaziri","year":"1994","unstructured":"Vaziri ND, Gonzales EC, Shayestehfar B, Barton CH (1994) Plasma levels and urinary excretion of fibrinolytic and protease inhibitory proteins in nephrotic syndrome. J Lab Clin Med 124:118\u2013124","journal-title":"J Lab Clin Med"},{"key":"2439_CR18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/BF01450878","volume":"105","author":"SN Wagner","year":"1996","unstructured":"Wagner SN, Atkinson MJ, Wagner C, Hofler H, Schmitt M, Wilhelm O (1996) Sites of urokinase-type plasminogen activator expression and distribution of its receptor in the normal human kidney. Histochem Cell Biol 105:53\u201360","journal-title":"Histochem Cell Biol"},{"key":"2439_CR19","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1182\/blood-2008-11-188938","volume":"115","author":"NM Andronicos","year":"2010","unstructured":"Andronicos NM, Chen EI, Baik N, Bai H, Parmer CM, Kiosses WB, Kamps MP, Yates JR III, Parmer RJ, Miles LA (2010) Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation. Blood 115:1319\u20131330","journal-title":"Blood"},{"key":"2439_CR20","doi-asserted-by":"crossref","first-page":"R1733","DOI":"10.1152\/ajpregu.00321.2009","volume":"297","author":"P Svenningsen","year":"2009","unstructured":"Svenningsen P, Uhrenholt TR, Palarasah Y, Skjodt K, Jensen BL, Skott O (2009) Prostasin-dependent activation of epithelial Na+ channels by low plasmin concentrations. Am J Physiol Regul Integr Comp Physiol 297:R1733\u2013R1741","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2439_CR21","doi-asserted-by":"crossref","first-page":"907","DOI":"10.2215\/CJN.04390808","volume":"4","author":"G Kapur","year":"2009","unstructured":"Kapur G, Valentini RP, Imam AA, Mattoo TK (2009) Treatment of severe edema in children with nephrotic syndrome with diuretics alone\u2013a prospective study. Clin J Am Soc Nephrol 4:907\u2013913","journal-title":"Clin J Am Soc Nephrol"},{"key":"2439_CR22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1442-200X.2010.03192.x","volume":"53","author":"MK Gurgoze","year":"2011","unstructured":"Gurgoze MK, Gunduz Z, Poyrazoglu MH, Dursun I, Uzum K, Dusunsel R (2011) Role of sodium during formation of edema in children with nephrotic syndrome. Pediatr Int 53:50\u201356","journal-title":"Pediatr Int"},{"key":"2439_CR23","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1177\/0009922810361366","volume":"50","author":"SD Theuns-Valks","year":"2011","unstructured":"Theuns-Valks SD, van Wijk JA, van Heerde M, Dolman KM, Bokenkamp A (2011) Abdominal pain and vomiting in a boy with nephrotic syndrome. Clin Pediatr (Phila) 50:470\u2013473","journal-title":"Clin Pediatr (Phila)"},{"key":"2439_CR24","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/ki.2012.180","volume":"82","author":"EJ Siddall","year":"2012","unstructured":"Siddall EJ, Radhakrishnan J (2012) The pathophysiology of edema formation in the nephrotic syndrome. Kidney Int 82:635\u2013642","journal-title":"Kidney Int"},{"issue":"Suppl 3","key":"2439_CR25","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2165\/00003495-199100413-00004","volume":"41","author":"DC Brater","year":"1991","unstructured":"Brater DC (1991) Clinical pharmacology of loop diuretics. Drugs 41[Suppl 3]:14\u201322","journal-title":"Drugs"},{"key":"2439_CR26","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1056\/NEJM199808063390607","volume":"339","author":"DC Brater","year":"1998","unstructured":"Brater DC (1998) Diuretic therapy. N Engl J Med 339:387\u2013395","journal-title":"N Engl J Med"},{"key":"2439_CR27","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.2215\/CJN.05691108","volume":"4","author":"HA Kyrieleis","year":"2009","unstructured":"Kyrieleis HA, Lowik MM, Pronk I, Cruysberg HR, Kremer JA, Oyen WJ, van den Heuvel BL, Wetzels JF, Levtchenko EN (2009) Long-term outcome of biopsy-proven, frequently relapsing minimal-change nephrotic syndrome in children. Clin J Am Soc Nephrol 4:1593\u20131600","journal-title":"Clin J Am Soc Nephrol"},{"key":"2439_CR28","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1681\/ASN.V1161100","volume":"11","author":"R Agarwal","year":"2000","unstructured":"Agarwal R, Gorski JC, Sundblad K, Brater DC (2000) Urinary protein binding does not affect response to furosemide in patients with nephrotic syndrome. J Am Soc Nephrol 11:1100\u20131105","journal-title":"J Am Soc Nephrol"},{"key":"2439_CR29","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1152\/physrev.1997.77.2.359","volume":"77","author":"H Garty","year":"1997","unstructured":"Garty H, Palmer LG (1997) Epithelial sodium channels: function, structure, and regulation. Physiol Rev 77:359\u2013396","journal-title":"Physiol Rev"},{"key":"2439_CR30","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0014-5793(87)80039-X","volume":"214","author":"JD Vassalli","year":"1987","unstructured":"Vassalli JD, Belin D (1987) Amiloride selectively inhibits the urokinase-type plasminogen activator. FEBS Lett 214:187\u2013191","journal-title":"FEBS Lett"},{"key":"2439_CR31","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.arcped.2004.03.029","volume":"11","author":"G Deschenes","year":"2004","unstructured":"Deschenes G, Guigonis V, Doucet A (2004) Molecular mechanism of edema formation in nephrotic syndrome. Arch Pediatr 11:1084\u20131094","journal-title":"Arch Pediatr"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-013-2439-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-013-2439-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-013-2439-2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T14:18:56Z","timestamp":1644589136000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-013-2439-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,16]]},"references-count":31,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["2439"],"URL":"https:\/\/doi.org\/10.1007\/s00467-013-2439-2","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,16]]}}}