{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T22:35:31Z","timestamp":1793399731419,"version":"4.5.0"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T00:00:00Z","timestamp":1373328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1007\/s00467-013-2553-1","type":"journal-article","created":{"date-parts":[[2013,7,8]],"date-time":"2013-07-08T00:48:40Z","timestamp":1373244520000},"page":"2235-2238","source":"Crossref","is-referenced-by-count":15,"title":["Uncertainty in management of childhood-onset idiopathic nephrotic syndrome: is the long-term prognosis really favorable?"],"prefix":"10.1007","volume":"28","author":[{"given":"Shuichiro","family":"Fujinaga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amane","family":"Endo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Ohtomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Ohtsuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiaki","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,9]]},"reference":[{"key":"2553_CR1","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/BF01956754","volume":"152","author":"JH Ehrich","year":"1993","unstructured":"Ehrich JH, Brodehl J (1993) Long versus standard prednisone therapy for initial treatment of idiopathic nephrotic syndrome in children. Arbeitsgemeinschaft fur Padiatrische Nephrologie. Eur J Pediatr 152:357\u2013361","journal-title":"Eur J Pediatr"},{"key":"2553_CR2","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0022-3476(88)80136-7","volume":"112","author":"N Ueda","year":"1988","unstructured":"Ueda N, Chihara M, Kawaguchi S, Niinomi Y, Nonoda T, Matsumoto J, Ohnishi M, Yasaki T (1988) Intermittent versus long-term tapering prednisolone for initial therapy in children with idiopathic nephrotic syndrome. J Pediatr 112:122\u2013126","journal-title":"J Pediatr"},{"key":"2553_CR3","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0272-6386(03)00346-9","volume":"41","author":"M Hiraoka","year":"2003","unstructured":"Hiraoka M, Tsukahara H, Matsubara K, Tsurusawa M, Takeda N, Haruki S, Hayashi S, Ohta K, Motoi T, Ohshima Y, Suganuma N, Mayumi M (2003) A randomized study of two long-course prednisolone regimens for nephrotic syndrome in children. Am J Kidney Dis 41:1155\u20131162","journal-title":"Am J Kidney Dis"},{"key":"2553_CR4","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0140-6736(85)91387-X","volume":"16","author":"RS Trompeter","year":"1985","unstructured":"Trompeter RS, Lloyd BW, Hicks J, White RH, Cameron JS (1985) Long-term outcome for children with minimal-change nephrotic syndrome. Lancet 16:368\u2013370","journal-title":"Lancet"},{"key":"2553_CR5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0140-6736(89)91266-X","volume":"4","author":"MA Lewis","year":"1989","unstructured":"Lewis MA, Baildom EM, Davis N, Houston IB, Postlethwaite RJ (1989) Nephrotic syndrome: from toddlers to twenties. Lancet 4:255\u2013259","journal-title":"Lancet"},{"key":"2553_CR6","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1053\/ajkd.2003.50116","volume":"41","author":"F Fakhouri","year":"2003","unstructured":"Fakhouri F, Bocquet N, Taupin P, Presne C, Gagnadoux MF, Landais P, Lesavre P, Chauveau D, Knebelmann B, Broyer M, Gr\u00fcnfeld JP, Niaudet P (2003) Steroid-sensitive nephrotic syndrome: from childhood to adulthood. Am J Kidney Dis 41:550\u2013557","journal-title":"Am J Kidney Dis"},{"key":"2553_CR7","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.jpeds.2005.03.050","volume":"147","author":"EM R\u00fcth","year":"2005","unstructured":"R\u00fcth EM, Kemper MJ, Leumann EP, Laube GF, Neuhaus TJ (2005) Children with steroid-sensitive nephrotic syndrome come of age: long-term outcome. J Pediatr 147:202\u2013207","journal-title":"J Pediatr"},{"key":"2553_CR8","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/kisup.2012.16","volume":"2","author":"Kidney Disease Improving Global Outcomes (KDIGO)","year":"2012","unstructured":"Kidney Disease Improving Global Outcomes (KDIGO), Glomerulonephritis Work Group (2012) KDIGO clinical practice guideline for glomerulonephritis: steroid-sensitive nephrotic syndrome in children. Kidney Int Suppl 2:163\u2013171","journal-title":"Kidney Int Suppl"},{"key":"2553_CR9","doi-asserted-by":"crossref","unstructured":"Samuel S, Morgan CJ, Bitzan M, Mammen C, Dart AB MD, Manns BJ, Alexander RT, Erickson RL, Grisaru S, Wade AW MD, Blydt-Hansen T, Feber J, Arora S, Licht C, Zappitelli M (2013) Substantial practice variation exists in the management of childhood nephrotic syndrome. Pediatr Nephrol. doi: 10.1007\/s00467-013-2546-0","DOI":"10.1007\/s00467-013-2546-0"},{"key":"2553_CR10","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0031-3955(16)32565-2","volume":"18","author":"GC Arneil","year":"1971","unstructured":"Arneil GC (1971) The nephrotic syndrome. Pediatr Clin North Am 18:547\u2013559","journal-title":"Pediatr Clin North Am"},{"key":"2553_CR11","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1542\/peds.2008-1559","volume":"124","author":"DS Gipson","year":"2009","unstructured":"Gipson DS, Massengill SF, Yao L, Nagaraj S, Smoyer WE, Mahan JD, Wigfall D, Miles P, Powell L, Lin JJ, Trachtman H, Greenbaum LA (2009) Management of childhood onset nephrotic syndrome. Pediatrics 124:747\u2013757","journal-title":"Pediatrics"},{"key":"2553_CR12","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1681\/ASN.V85769","volume":"8","author":"P Tarshish","year":"1997","unstructured":"Tarshish P, Tobin JN, Bernstein J, Edelmann CM Jr (1997) Prognostic significance of the early course of minimal change nephrotic syndrome: report of the International Study of Kidney Disease in Children. J Am Soc Nephrol 8:769\u2013776","journal-title":"J Am Soc Nephrol"},{"key":"2553_CR13","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00467-010-1642-7","volume":"26","author":"S Fujinaga","year":"2011","unstructured":"Fujinaga S, Hirano D, Nishizaki N (2011) Early identification of steroid dependency in Japanese children with steroid-sensitive nephrotic syndrome undergoing short-term initial steroid therapy. Pediatr Nephrol 26:485\u2013486","journal-title":"Pediatr Nephrol"},{"key":"2553_CR14","doi-asserted-by":"crossref","first-page":"756","DOI":"10.2215\/CJN.09010912","volume":"8","author":"K Nakanishi","year":"2013","unstructured":"Nakanishi K, Iijima K, Ishikura K, Hataya H, Nakazato H, Sasaki S, Honda M, Yoshikawa N, Japanese Study Group of Renal Disease in Children (2013) Two-year outcome of the ISKDC regimen and frequent-relapsing risk in children with idiopathic nephrotic syndrome. Clin J Am Soc Nephrol 8:756\u2013762","journal-title":"Clin J Am Soc Nephrol"},{"key":"2553_CR15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1681\/ASN.2012070646","volume":"24","author":"N Teeninga","year":"2013","unstructured":"Teeninga N, Kist-van Holthe JE, van Rijswijk N, de Mos NI, Hop WC, Wetzels JF, van der Heijden AJ, Nauta J (2013) Extending prednisolone treatment does not reduce relapses in childhood nephrotic syndrome. J Am Soc Nephrol 24:149\u2013159","journal-title":"J Am Soc Nephrol"},{"key":"2553_CR16","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1007\/s00467-009-1282-y","volume":"24","author":"N MacHardy","year":"2009","unstructured":"MacHardy N, Miles PV, Massengill SF, Smoyer WE, Mahan JD, Greenbaum L, Massie S, Yao L, Nagaraj S, Lin JJ, Wigfall D, Trachtman H, Hu Y, Gipson DS (2009) Management patterns of childhood-onset nephrotic syndrome. Pediatr Nephrol 24:2193\u20132201","journal-title":"Pediatr Nephrol"},{"key":"2553_CR17","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1136\/adc.2005.080960","volume":"91","author":"S Fujinaga","year":"2006","unstructured":"Fujinaga S, Kaneko K, Muto T, Ohtomo Y, Murakami H, Yamashiro Y (2006) Independent risk factors for chronic cyclosporine induced nephropathy in children with nephrotic syndrome. Arch Dis Child 91:666\u2013670","journal-title":"Arch Dis Child"},{"key":"2553_CR18","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1093\/ndt\/gfh066","volume":"19","author":"MJ Kemper","year":"2004","unstructured":"Kemper MJ, Kuwertz-Broeking E, Bulla M, Mueller-Wiefel DE, Neuhaus TJ (2004) Recurrence of severe steroid dependency in cyclosporin A-treated childhood idiopathic nephrotic syndrome. Nephrol Dial Transplant 19:1136\u20131141","journal-title":"Nephrol Dial Transplant"},{"key":"2553_CR19","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1007\/s00467-011-1948-0","volume":"26","author":"S Ito","year":"2011","unstructured":"Ito S, Ikeda H, Harada T, Kamei K, Takahashi E (2011) Cyclophosphamide followed by mizoribine as maintenance therapy against refractory steroiddependent nephrotic syndrome. Pediatr Nephrol 26:1921\u20131922","journal-title":"Pediatr Nephrol"},{"key":"2553_CR20","doi-asserted-by":"crossref","first-page":"251","DOI":"10.5414\/CN107500","volume":"78","author":"S Fujinaga","year":"2012","unstructured":"Fujinaga S, Endo A, Watanabe T, Hirano D, Ohtomo Y, Shimizu T, Kaneko K (2012) Maintenance therapy with single-daily, high-dose mizoribine after cyclophosphamide therapy for prepubertal boys with severe steroid-dependent nephrotic syndrome. Clin Nephrol 78:251\u2013252","journal-title":"Clin Nephrol"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-013-2553-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-013-2553-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-013-2553-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,27]],"date-time":"2022-02-27T16:07:00Z","timestamp":1645978020000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-013-2553-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,9]]},"references-count":20,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["2553"],"URL":"https:\/\/doi.org\/10.1007\/s00467-013-2553-1","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,9]]}}}