{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:23:59Z","timestamp":1785414239264,"version":"3.56.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T00:00:00Z","timestamp":1395705600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1007\/s00467-014-2803-x","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T04:29:54Z","timestamp":1395721794000},"page":"1607-1615","source":"Crossref","is-referenced-by-count":34,"title":["Neurological involvement in children with E. coli O104:H4-induced hemolytic uremic syndrome"],"prefix":"10.1007","volume":"29","author":[{"given":"Angela","family":"Bauer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Loos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Wehrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Horstmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Donnerstag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Lemke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Hillebrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"L\u00f6bel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Pape","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Haffner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carola","family":"Bindt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thurid","family":"Ahlenstiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anette","family":"Melk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Lehnhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus J.","family":"Kemper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,25]]},"reference":[{"key":"2803_CR1","first-page":"1073","volume":"365","author":"PI Tarr","year":"2005","unstructured":"Tarr PI, Gordon CA, Chandler WL (2005) Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome. Lancet 365:1073\u20131086","journal-title":"Lancet"},{"key":"2803_CR2","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/S0140-6736(10)60963-4","volume":"376","author":"H Pennington","year":"2010","unstructured":"Pennington H (2010) Escherichia coli O157. Lancet 376:1428\u20131435","journal-title":"Lancet"},{"key":"2803_CR3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00431-009-1039-4","volume":"169","author":"J Scheiring","year":"2010","unstructured":"Scheiring J, Rosales A, Zimmerhackl LB (2010) Clinical practice. Today's understanding of the haemolytic uraemic syndrome. Eur J Pediatr 169:7\u201313","journal-title":"Eur J Pediatr"},{"key":"2803_CR4","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/nrneph.2012.196","volume":"8","author":"H Trachtman","year":"2012","unstructured":"Trachtman H, Austin C, Lewinski M, Stahl RA (2012) Renal and neurological involvement in typical Shiga toxin-associated HUS. Nat Rev Nephrol 8:658\u2013669","journal-title":"Nat Rev Nephrol"},{"key":"2803_CR5","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/ana.23814","volume":"73","author":"SG Meuth","year":"2013","unstructured":"Meuth SG, Gobel K, Kanyshkova T, Ehling P, Ritter MA, Schwindt W, Bielaszewska M, Lebiedz P, Coulon P, Herrmann AM, Storck W, Kohmann D, Muthing J, Pavenstadt H, Kuhlmann T, Karch H, Peters G, Budde T, Wiendl H, Pape HC (2013) Thalamic involvement in patients with neurologic impairment due to Shiga toxin 2. Ann Neurol 73:419\u2013429","journal-title":"Ann Neurol"},{"key":"2803_CR6","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1136\/adc.84.5.434","volume":"84","author":"KJ Eriksson","year":"2001","unstructured":"Eriksson KJ, Boyd SG, Tasker RC (2001) Acute neurology and neurophysiology of haemolytic-uraemic syndrome. Arch Dis Child 84:434\u2013435","journal-title":"Arch Dis Child"},{"key":"2803_CR7","first-page":"694","volume":"21","author":"H Otukesh","year":"2008","unstructured":"Otukesh H, Hoseini R, Golnari P, Fereshtehnejad SM, Zamanfar D, Hooman N, Tabarroki A (2008) Short-term and long-term outcome of hemolytic uremic syndrome in Iranian children. J Nephrol 21:694\u2013703","journal-title":"J Nephrol"},{"key":"2803_CR8","first-page":"67","volume":"8","author":"JC Rooney","year":"1971","unstructured":"Rooney JC, Anderson RM, Hopkins IJ (1971) Clinical and pathologic aspects of central nervous system involvement in the haemolytic uraemic syndrome. Proc Aust Assoc Neurol 8:67\u201375","journal-title":"Proc Aust Assoc Neurol"},{"key":"2803_CR9","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/ana.410190120","volume":"19","author":"KJ Sheth","year":"1986","unstructured":"Sheth KJ, Swick HM, Haworth N (1986) Neurological involvement in hemolytic-uremic syndrome. Ann Neurol 19:90\u201393","journal-title":"Ann Neurol"},{"key":"2803_CR10","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1177\/088307388900400206","volume":"4","author":"JS Hahn","year":"1989","unstructured":"Hahn JS, Havens PL, Higgins JJ, O'Rourke PP, Estroff JA, Strand R (1989) Neurological complications of hemolytic-uremic syndrome. J Child Neurol 4:108\u2013113","journal-title":"J Child Neurol"},{"key":"2803_CR11","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.2215\/CJN.08921209","volume":"5","author":"S Nathanson","year":"2010","unstructured":"Nathanson S, Kwon T, Elmaleh M, Charbit M, Launay EA, Harambat J, Brun M, Ranchin B, Bandin F, Cloarec S, Bourdat-Michel G, Pietrement C, Champion G, Ulinski T, Deschenes G (2010) Acute neurological involvement in diarrhea-associated hemolytic uremic syndrome. Clin J Am Soc Nephrol 5:1218\u20131228","journal-title":"Clin J Am Soc Nephrol"},{"key":"2803_CR12","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1136\/adc.80.3.214","volume":"80","author":"A Schlieper","year":"1999","unstructured":"Schlieper A, Orrbine E, Wells GA, Clulow M, McLaine PN, Rowe PC (1999) Neuropsychological sequelae of haemolytic uraemic syndrome. Investigators of the HUS Cognitive Study. Arch Dis Child 80:214\u2013220","journal-title":"Arch Dis Child"},{"key":"2803_CR13","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1111\/dmcn.12161","volume":"55","author":"C Gitiaux","year":"2013","unstructured":"Gitiaux C, Krug P, Grevent D, Kossorotoff M, Poncet S, Eisermann M, Oualha M, Boddaert N, Salomon R, Desguerre I (2013) Brain magnetic resonance imaging pattern and outcome in children with haemolytic-uraemic syndrome and neurological impairment treated with eculizumab. Dev Med Child Neurol 55:758\u2013765","journal-title":"Dev Med Child Neurol"},{"key":"2803_CR14","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1093\/cid\/cis531","volume":"55","author":"S Loos","year":"2012","unstructured":"Loos S, Ahlenstiel T, Kranz B, Staude H, Pape L, Hartel C, Vester U, Buchtala L, Benz K, Hoppe B, Beringer O, Krause M, Muller D, Pohl M, Lemke J, Hillebrand G, Kreuzer M, Konig J, Wigger M, Konrad M, Haffner D, Oh J, Kemper MJ (2012) An outbreak of Shiga toxin-producing Escherichia coli O104:H4 hemolytic uremic syndrome in Germany: Presentation and short-term outcome in children. Clin Infect Dis 55:753\u2013759","journal-title":"Clin Infect Dis"},{"key":"2803_CR15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s00467-011-2067-7","volume":"27","author":"MJ Kemper","year":"2012","unstructured":"Kemper MJ (2012) Outbreak of hemolytic uremic syndrome caused by E. coli O104:H4 in Germany: a pediatric perspective. Pediatr Nephrol 27:161\u2013164","journal-title":"Pediatr Nephrol"},{"key":"2803_CR16","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0140-6736(11)61217-8","volume":"378","author":"P Ruggenenti","year":"2011","unstructured":"Ruggenenti P, Remuzzi G (2011) A German outbreak of haemolytic uraemic syndrome. Lancet 378:1057\u20131058","journal-title":"Lancet"},{"key":"2803_CR17","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1056\/NEJMoa1106483","volume":"365","author":"C Frank","year":"2011","unstructured":"Frank C, Werber D, Cramer JP, Askar M, Faber M, van der Heiden M, Bernard H, Fruth A, Prager R, Spode A, Wadl M, Zoufaly A, Jordan S, Kemper MJ, Follin P, Muller L, King LA, Rosner B, Buchholz U, Stark K, Krause G (2011) Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany. N Engl J Med 365:1771\u20131780","journal-title":"N Engl J Med"},{"key":"2803_CR18","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S1473-3099(11)70165-7","volume":"11","author":"M Bielaszewska","year":"2011","unstructured":"Bielaszewska M, Mellmann A, Zhang W, Kock R, Fruth A, Bauwens A, Peters G, Karch H (2011) Characterisation of the Escherichia coli strain associated with an outbreak of haemolytic uraemic syndrome in Germany, 2011: a microbiological study. Lancet Infect Dis 11:671\u2013676","journal-title":"Lancet Infect Dis"},{"key":"2803_CR19","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/emmm.201201662","volume":"4","author":"H Karch","year":"2012","unstructured":"Karch H, Denamur E, Dobrindt U, Finlay BB, Hengge R, Johannes L, Ron EZ, Tonjum T, Sansonetti PJ, Vicente M (2012) The enemy within us: lessons from the 2011 European Escherichia coli O104:H4 outbreak. EMBO Mol Med 4:841\u2013848","journal-title":"EMBO Mol Med"},{"key":"2803_CR20","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1093\/brain\/aws090","volume":"135","author":"T Magnus","year":"2012","unstructured":"Magnus T, Rother J, Simova O, Meier-Cillien M, Repenthin J, Moller F, Gbadamosi J, Panzer U, Wengenroth M, Hagel C, Kluge S, Stahl RK, Wegscheider K, Urban P, Eckert B, Glatzel M, Fiehler J, Gerloff C (2012) The neurological syndrome in adults during the 2011 northern German E. coli serotype O104:H4 outbreak. Brain 135:1850\u20131859","journal-title":"Brain"},{"key":"2803_CR21","unstructured":"International Federation of Clinical Neurophysiology (1999) Recommendations for the practice of clinical neurophysiology: guidelines of the International Federation of Clinical Neurophysiology. Electroencephalogr Clin Neurophysiol Suppl 52:1\u2013304"},{"key":"2803_CR22","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1007\/s00330-011-2286-0","volume":"22","author":"F Donnerstag","year":"2012","unstructured":"Donnerstag F, Ding X, Pape L, Bultmann E, Lucke T, Zajaczek J, Hoy L, Das AM, Lanfermann H, Ehrich J, Hartmann H (2012) Patterns in early diffusion-weighted MRI in children with haemolytic uraemic syndrome and CNS involvement. Eur Radiol 22:506\u2013513","journal-title":"Eur Radiol"},{"key":"2803_CR23","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF00858990","volume":"9","author":"EG Gallo","year":"1995","unstructured":"Gallo EG, Gianantonio CA (1995) Extrarenal involvement in diarrhoea-associated haemolytic-uraemic syndrome. Pediatr Nephrol 9:117\u2013119","journal-title":"Pediatr Nephrol"},{"key":"2803_CR24","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1309\/UMW9-D06Q-M94Q-JGH2","volume":"118","author":"F Gunzer","year":"2002","unstructured":"Gunzer F, Hennig-Pauka I, Waldmann KH, Sandhoff R, Grone HJ, Kreipe HH, Matussek A, Mengel M (2002) Gnotobiotic piglets develop thrombotic microangiopathy after oral infection with enterohemorrhagic Escherichia coli. Am J Clin Pathol 118:364\u2013375","journal-title":"Am J Clin Pathol"},{"key":"2803_CR25","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1001\/archpedi.1980.02130210053014","volume":"134","author":"JF Bale Jr","year":"1980","unstructured":"Bale JF Jr, Brasher C, Siegler RL (1980) CNS manifestations of the hemolytic-uremic syndrome. Relationship to metabolic alterations and prognosis. Am J Dis Child 134:869\u2013872","journal-title":"Am J Dis Child"},{"key":"2803_CR26","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1542\/peds.90.4.616","volume":"90","author":"N Cimolai","year":"1992","unstructured":"Cimolai N, Morrison BJ, Carter JE (1992) Risk factors for the central nervous system manifestations of gastroenteritis-associated hemolytic-uremic syndrome. Pediatrics 90:616\u2013621","journal-title":"Pediatrics"},{"key":"2803_CR27","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1086\/341940","volume":"186","author":"A Gerber","year":"2002","unstructured":"Gerber A, Karch H, Allerberger F, Verweyen HM, Zimmerhackl LB (2002) Clinical course and the role of shiga toxin-producing Escherichia coli infection in the hemolytic-uremic syndrome in pediatric patients, 1997\u20132000, in Germany and Austria: a prospective study. J Infect Dis 186:493\u2013500","journal-title":"J Infect Dis"},{"key":"2803_CR28","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1007\/s00467-008-0935-6","volume":"23","author":"J Scheiring","year":"2008","unstructured":"Scheiring J, Andreoli SP, Zimmerhackl LB (2008) Treatment and outcome of Shiga-toxin-associated hemolytic uremic syndrome (HUS). Pediatr Nephrol 23:1749\u20131760","journal-title":"Pediatr Nephrol"},{"key":"2803_CR29","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1212\/WNL.0b013e31826d5f26","volume":"79","author":"K Weissenborn","year":"2012","unstructured":"Weissenborn K, Donnerstag F, Kielstein JT, Heeren M, Worthmann H, Hecker H, Schmitt R, Schiffer M, Pasedag T, Schuppner R, Tryc AB, Raab P, Hartmann H, Ding XQ, Hafer C, Menne J, Schmidt BM, Bultmann E, Haller H, Dengler R, Lanfermann H, Giesemann AM (2012) Neurologic manifestations of E. coli infection-induced hemolytic-uremic syndrome in adults. Neurology 79:1466\u20131473","journal-title":"Neurology"},{"key":"2803_CR30","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1136\/adc.67.7.930","volume":"67","author":"A Schlieper","year":"1992","unstructured":"Schlieper A, Rowe PC, Orrbine E, Zoubek M, Clark W, Wolfish N, McLaine PN (1992) Sequelae of haemolytic uraemic syndrome. Arch Dis Child 67:930\u2013934","journal-title":"Arch Dis Child"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-014-2803-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-014-2803-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-014-2803-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,25]],"date-time":"2024-05-25T09:35:46Z","timestamp":1716629746000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-014-2803-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,25]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["2803"],"URL":"https:\/\/doi.org\/10.1007\/s00467-014-2803-x","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,25]]}}}