{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T13:32:15Z","timestamp":1789824735911,"version":"4.0.1"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T00:00:00Z","timestamp":1402012800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1007\/s00467-014-2856-x","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T21:52:05Z","timestamp":1402005125000},"page":"2173-2180","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Clinico-pathological correlations of congenital and infantile nephrotic syndrome over twenty years"],"prefix":"10.1007","volume":"29","author":[{"given":"Jameela A.","family":"Kari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Montini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef","family":"Bockenhauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"Rees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Trompeter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell","family":"Tullus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"van\u2019t Hoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoife","family":"Waters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Ashton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Lench","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil J.","family":"Sebire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Marks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,6,6]]},"reference":[{"key":"2856_CR1","first-page":"105","volume":"22","author":"A Rivera","year":"2003","unstructured":"Rivera A, Meleg-Smith S, Yosipiv I, El-Dahr S, Boineau F (2003) Diagnosis of congenital nephrotic syndrome: a clinical and a pathologic challenge, Pediatr Pathol. Mol Med 22:105\u2013116","journal-title":"Mol Med"},{"key":"2856_CR2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/BF00857534","volume":"7","author":"R Habib","year":"1993","unstructured":"Habib R (1993) Nephrotic syndrome in the 1st year of life. Pediatr Nephrol 7:347\u2013353","journal-title":"Pediatr Nephrol"},{"key":"2856_CR3","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1046\/j.1523-1755.2000.00254.x","volume":"58","author":"J Patrakka","year":"2000","unstructured":"Patrakka J, Kestila M, Wartiovaara J, Ruotsalainen V, Tissari P, Lenkkeri U, Mannikko M, Visapaa I, Holmberg C, Rapola J, Tryggvason K, Jalanko H (2000) Congenital nephrotic syndrome (NPHS1): features resulting from different mutations in Finnish patients. Kidney Int 58:972\u2013980","journal-title":"Kidney Int"},{"key":"2856_CR4","first-page":"73","volume":"37","author":"R Habib","year":"1990","unstructured":"Habib R, Gubler MC, Antignac C, Loirat C, Gangnadoux MF (1990) Congenital or childhood nephrotic syndrome with diffuse mesangial sclerosis. Ann Pediatr (Paris) 37:73\u201377","journal-title":"Ann Pediatr (Paris)"},{"key":"2856_CR5","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1159\/000188856","volume":"72","author":"S Ozen","year":"1996","unstructured":"Ozen S, Tinaztepe K (1996) Diffuse mesangial sclerosis: a unique type of congenital and infantile nephrotic syndrome. Nephron 72:288\u2013291","journal-title":"Nephron"},{"key":"2856_CR6","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1159\/000045079","volume":"79","author":"K Kaneko","year":"1998","unstructured":"Kaneko K, Suzuki Y, Kiya K, Matsubara T, Fukuda Y, Yabuta K (1998) Minimal change lesion in congenital nephrotic syndrome. Two case reports and a review of the literature. Nephron 79:379\u2013380","journal-title":"Nephron"},{"key":"2856_CR7","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1681\/ASN.2009121309","volume":"21","author":"E Machuca","year":"2010","unstructured":"Machuca E, Benoit G, Nevo F, Tete MJ, Gribouval O, Pawtowski A, Brandstrom P, Loirat C, Niaudet P, Gubler MC, Antignac C (2010) Genotype-phenotype correlations in non-Finnish congenital nephrotic syndrome. J Am Soc Nephrol 21:1209\u20131217","journal-title":"J Am Soc Nephrol"},{"key":"2856_CR8","doi-asserted-by":"crossref","first-page":"2970","DOI":"10.1093\/ndt\/gfq088","volume":"25","author":"DS Schoeb","year":"2010","unstructured":"Schoeb DS, Chernin G, Heeringa SF, Matejas V, Held S, Vega-Warner V, Bockenhauer D, Vlangos CN, Moorani KN, Neuhaus TJ, Kari JA, MacDonald J, Saisawat P, Ashraf S, Ovunc B, Zenker M, Hildebrandt F (2010) Nineteen novel NPHS1 mutations in a worldwide cohort of patients with congenital nephrotic syndrome (CNS). Nephrol Dial Transplant 25:2970\u20132976","journal-title":"Nephrol Dial Transplant"},{"key":"2856_CR9","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1046\/j.1523-1755.1998.00948.x","volume":"53","author":"V Schumacher","year":"1998","unstructured":"Schumacher V, Scharer K, Wuhl E, Altrogge H, Bonzel KE, Guschmann M, Neuhaus TJ, Pollastro RM, Kuwertz-Broking E, Bulla M, Tondera AM, Mundel P, Helmchen U, Waldherr R, Weirich A, Royer-Pokora B (1998) Spectrum of early onset nephrotic syndrome associated with WT1 missense mutations. Kidney Int 53:1594\u20131600","journal-title":"Kidney Int"},{"key":"2856_CR10","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1093\/ndt\/gfm759","volume":"23","author":"R Gbadegesin","year":"2008","unstructured":"Gbadegesin R, Hinkes BG, Hoskins BE, Vlangos CN, Heeringa SF, Liu J, Loirat C, Ozaltin F, Hashmi S, Ulmer F, Cleper R, Ettenger R, Antignac C, Wiggins RC, Zenker M, Hildebrandt F (2008) Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (IDMS). Nephrol Dial Transplant 23:1291\u20131297","journal-title":"Nephrol Dial Transplant"},{"key":"2856_CR11","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1681\/ASN.2010060632","volume":"22","author":"YM Chen","year":"2011","unstructured":"Chen YM, Kikkawa Y, Miner JH (2011) A missense LAMB2 mutation causes congenital nephrotic syndrome by impairing laminin secretion. J Am Soc Nephrol 22:849\u2013858","journal-title":"J Am Soc Nephrol"},{"key":"2856_CR12","doi-asserted-by":"crossref","first-page":"e907","DOI":"10.1542\/peds.2006-2164","volume":"119","author":"BG Hinkes","year":"2007","unstructured":"Hinkes BG, Mucha B, Vlangos CN, Gbadegesin R, Liu J, Hasselbacher K, Hangan D, Ozaltin F, Zenker M, Hildebrandt F (2007) Nephrotic syndrome in the first year of life: two thirds of cases are caused by mutations in 4 genes (NPHS1, NPHS2, WT1, and LAMB2). Pediatrics 119:e907\u2013e919","journal-title":"Pediatrics"},{"key":"2856_CR13","first-page":"795","volume":"44","author":"B Roussel","year":"1987","unstructured":"Roussel B, Pinon JM, Birembaut P, Rullier J, Pennaforte F (1987) Congenital nephrotic syndrome associated with congenital toxoplasmosis. Arch Fr Pediatr 44:795\u2013797","journal-title":"Arch Fr Pediatr"},{"key":"2856_CR14","first-page":"210","volume":"17","author":"H Rahman","year":"2008","unstructured":"Rahman H, Begum A, Jahan S, Muinuddin G, Hossain MM (2008) Congenital nephrotic syndrome, an uncommon presentation of cytomegalovirus infection. Mymensingh Med J 17:210\u2013213","journal-title":"Mymensingh Med J"},{"key":"2856_CR15","first-page":"911","volume":"43","author":"HJ Xiao","year":"2011","unstructured":"Xiao HJ, Liu JC, Zhong XH (2011) Congenital syphillis presenting congenital nephrotic syndrome in two children and related data review. Beijing Da Xue Xue Bao 43:911\u2013913","journal-title":"Beijing Da Xue Xue Bao"},{"key":"2856_CR16","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/S0140-6736(04)17142-0","volume":"364","author":"H Debiec","year":"2004","unstructured":"Debiec H, Nauta J, Coulet F, van der Burg M, Guigonis V, de Heer E, Soubrier F, Janssen F, Ronco P (2004) Role of truncating mutations in MME gene in fetomaternal alloimmunisation and antenatal glomerulopathies. Lancet 364:1252\u20131259","journal-title":"Lancet"},{"key":"2856_CR17","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1007\/s00467-005-1918-5","volume":"20","author":"R Sreedharan","year":"2005","unstructured":"Sreedharan R, Bockenhauer D (2005) Congenital nephrotic syndrome responsive to angiotensin-converting enzyme inhibition. Pediatr Nephrol 20:1340\u20131342","journal-title":"Pediatr Nephrol"},{"key":"2856_CR18","doi-asserted-by":"crossref","first-page":"c10","DOI":"10.1159\/000112466","volume":"108","author":"D Bockenhauer","year":"2008","unstructured":"Bockenhauer D, Debiec H, Sebire N, Barratt M, Warwicker P, Ronco P, Kleta R (2008) Familial membranous nephropathy: an X-linked genetic susceptibility? Nephron Clin Pract 108:c10\u2013c15","journal-title":"Nephron Clin Pract"},{"key":"2856_CR19","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/BF00858984","volume":"9","author":"C Holmberg","year":"1995","unstructured":"Holmberg C, Antikainen M, Ronnholm K, Ala HM, Jalanko H (1995) Management of congenital nephrotic syndrome of the Finnish type. Pediatr Nephrol 9:87\u201393","journal-title":"Pediatr Nephrol"},{"key":"2856_CR20","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1056\/NEJMoa1110813","volume":"366","author":"C Has","year":"2012","unstructured":"Has C, Sparta G, Kiritsi D, Weibel L, Moeller A, Vega-Warner V, Waters A, He Y, Anikster Y, Esser P, Straub BK, Hausser I, Bockenhauer D, Dekel B, Hildebrandt F, Bruckner-Tuderman L, Laube GF (2012) Integrin alpha3 mutations with kidney, lung, and skin disease. N Engl J Med 366:1508\u20131514","journal-title":"N Engl J Med"},{"key":"2856_CR21","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1097\/01.ASN.0000129826.28932.FD","volume":"15","author":"XL Liu","year":"2004","unstructured":"Liu XL, Done SC, Yan K, Kilpelainen P, Pikkarainen T, Tryggvason K (2004) Defective trafficking of nephrin missense mutants rescued by a chemical chaperone. J Am Soc Nephrol 15:1731\u20131738","journal-title":"J Am Soc Nephrol"},{"key":"2856_CR22","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1007\/s00467-011-1911-0","volume":"26","author":"JJ Kim","year":"2011","unstructured":"Kim JJ, Clothier J, Sebire NJ, Milford DV, Moghal N, Trompeter RS (2011) Nephrotic syndrome in infancy can spontaneously resolve. Pediatr Nephrol 26:1897\u20131901","journal-title":"Pediatr Nephrol"},{"key":"2856_CR23","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.2215\/CJN.05260610","volume":"6","author":"S Santin","year":"2011","unstructured":"Santin S, Bullich G, Tazon-Vega B, Garcia-Maset R, Gimenez I, Silva I, Ruiz P, Ballarin J, Torra R, Ars E (2011) Clinical utility of genetic testing in children and adults with steroid-resistant nephrotic syndrome. Clin J Am Soc Nephrol 6:1139\u20131148","journal-title":"Clin J Am Soc Nephrol"},{"key":"2856_CR24","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1136\/jmg.2009.076166","volume":"47","author":"O Boyer","year":"2010","unstructured":"Boyer O, Benoit G, Gribouval O, Nevo F, Pawtowski A, Bilge I, Bircan Z, Deschenes G, Guay-Woodford LM, Hall M, Macher MA, Soulami K, Stefanidis CJ, Weiss R, Loirat C, Gubler MC, Antignac C (2010) Mutational analysis of the PLCE1 gene in steroid resistant nephrotic syndrome. J Med Genet 47:445\u2013452","journal-title":"J Med Genet"},{"key":"2856_CR25","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.2215\/CJN.01190210","volume":"5","author":"AK Buscher","year":"2010","unstructured":"Buscher AK, Kranz B, Buscher R, Hildebrandt F, Dworniczak B, Pennekamp P, Kuwertz-Broking E, Wingen AM, John U, Kemper M, Monnens L, Hoyer PF, Weber S, Konrad M (2010) Immunosuppression and renal outcome in congenital and pediatric steroid-resistant nephrotic syndrome. Clin J Am Soc Nephrol 5:2075\u20132084","journal-title":"Clin J Am Soc Nephrol"},{"key":"2856_CR26","doi-asserted-by":"crossref","first-page":"533","DOI":"10.5144\/0256-4947.2013.533","volume":"33","author":"JA Kari","year":"2013","unstructured":"Kari JA, El-Desoky SM, Gari M, Malik K, Vega-Warner V, Lovric S, Bockenhauer D (2013) Steroid-resistant nephrotic syndrome: impact of genetic testing. Ann Saudi Med 33:533\u2013538","journal-title":"Ann Saudi Med"},{"key":"2856_CR27","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/BF01478612","volume":"41","author":"R Kluthe","year":"1963","unstructured":"Kluthe R, Liem HH, Nussle D, Barandun S (1963) Intestinal plasma protein loss (protein diarrhea) in the nephrotic syndrome. Klin Wochenschr 41:15\u201318","journal-title":"Klin Wochenschr"},{"key":"2856_CR28","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1159\/000063305","volume":"92","author":"SK Ma","year":"2002","unstructured":"Ma SK, Kim SW, Kim NH, Choi KC (2002) Renal vein and inferior vena cava thrombosis associated with acute pancreatitis. Nephron 92:475\u2013477","journal-title":"Nephron"},{"key":"2856_CR29","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1038\/ki.1994.184","volume":"45","author":"AH Cohen","year":"1994","unstructured":"Cohen AH, Turner MC (1994) Kidney in Galloway-Mowat syndrome: clinical spectrum with description of pathology. Kidney Int 45:1407\u20131415","journal-title":"Kidney Int"},{"key":"2856_CR30","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1093\/ndt\/gfh484","volume":"19","author":"JC Cansick","year":"2004","unstructured":"Cansick JC, Lennon R, Cummins CL, Howie AJ, McGraw ME, Saleem MA, Tizard EJ, Hulton SA, Milford DV, Taylor CM (2004) Prognosis, treatment and outcome of childhood mesangiocapillary (membranoproliferative) glomerulonephritis. Nephrol Dial Transplant 19:2769\u20132777","journal-title":"Nephrol Dial Transplant"},{"key":"2856_CR31","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1007\/s00467-011-2059-7","volume":"27","author":"DF Lu","year":"2012","unstructured":"Lu DF, Moon M, Lanning LD, McCarthy AM, Smith RJ (2012) Clinical features and outcomes of 98 children and adults with dense deposit disease. Pediatr Nephrol 27:773\u2013781","journal-title":"Pediatr Nephrol"},{"key":"2856_CR32","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1007\/s004670100669","volume":"16","author":"JA Kari","year":"2001","unstructured":"Kari JA, Bamashmous H, Lingawi S, Al-Sabban E, Akhtar M (2001) Infantile nephrotic syndrome and congenital glaucoma. Pediatr Nephrol 16:894\u2013897","journal-title":"Pediatr Nephrol"},{"key":"2856_CR33","doi-asserted-by":"crossref","first-page":"723","DOI":"10.2215\/CJN.01211005","volume":"1","author":"M Obana","year":"2006","unstructured":"Obana M, Nakanishi K, Sako M, Yata N, Nozu K, Tanaka R, Iijima K, Yoshikawa N (2006) Segmental membranous glomerulonephritis in children: comparison with global membranous glomerulonephritis. Clin J Am Soc Nephrol 1:723\u2013729","journal-title":"Clin J Am Soc Nephrol"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-014-2856-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-014-2856-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-014-2856-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,11]],"date-time":"2019-08-11T09:02:42Z","timestamp":1565514162000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-014-2856-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,6]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["2856"],"URL":"https:\/\/doi.org\/10.1007\/s00467-014-2856-x","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,6]]}}}