{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:47:07Z","timestamp":1790192827588,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2014,11,22]],"date-time":"2014-11-22T00:00:00Z","timestamp":1416614400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2014,11,22]],"date-time":"2014-11-22T00:00:00Z","timestamp":1416614400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1007\/s00467-014-2990-5","type":"journal-article","created":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T15:24:58Z","timestamp":1417447498000},"page":"775-781","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Eculizumab hepatotoxicity in pediatric aHUS"],"prefix":"10.1007","volume":"30","author":[{"given":"Wesley","family":"Hayes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibylle","family":"Tschumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon C.","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janusz","family":"Feber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kirschfink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Licht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,11,22]]},"reference":[{"key":"2990_CR1","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1056\/NEJMoa031688","volume":"350","author":"P Hillmen","year":"2004","unstructured":"Hillmen P, Hall C, Marsh JC, Elebute M, Bombara MP, Petro BE, Cullen MJ, Richards SJ, Rollins SA, Mojcik CF, Rother RP (2004) Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria. N Engl J Med 350:552\u2013559","journal-title":"N Engl J Med"},{"key":"2990_CR2","doi-asserted-by":"publisher","first-page":"1840","DOI":"10.1182\/blood-2007-06-094136","volume":"111","author":"RA Brodsky","year":"2008","unstructured":"Brodsky RA, Young NS, Antonioli E, Risitano AM, Schrezenmeier H, Schubert J, Gaya A, Coyle L, de Castro C, Fu CL, Maciejewski JP, Bessler M, Kroon HA, Rother RP, Hillmen P (2008) Multicenter phase 3 study of the complement inhibitor eculizumab for the treatment of patients with paroxysmal nocturnal hemoglobinuria. Blood 111:1840\u20131847","journal-title":"Blood"},{"key":"2990_CR3","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1056\/NEJMoa061648","volume":"355","author":"P Hillmen","year":"2006","unstructured":"Hillmen P, Young NS, Schubert J, Brodsky RA, Socie G, Muus P, Roth A, Szer J, Elebute MO, Nakamura R, Browne P, Risitano AM, Hill A, Schrezenmeier H, Fu CL, Maciejewski J, Rollins SA, Mojcik CF, Rother RP, Luzzatto L (2006) The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria. N Engl J Med 355:1233\u20131243","journal-title":"N Engl J Med"},{"key":"2990_CR4","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1053\/j.ajkd.2012.07.028","volume":"61","author":"J Schmidtko","year":"2013","unstructured":"Schmidtko J, Peine S, El-Housseini Y, Pascual M, Meier P (2013) Treatment of atypical hemolytic uremic syndrome and thrombotic microangiopathies: a focus on eculizumab. Am J Kidney Dis 61:289\u2013299","journal-title":"Am J Kidney Dis"},{"key":"2990_CR5","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1159\/000337954","volume":"35","author":"KS Hodgkins","year":"2012","unstructured":"Hodgkins KS, Bobrowski AE, Lane JC, Langman CB (2012) Clinical grand rounds: atypical hemolytic uremic syndrome. Am J Nephrol 35:394\u2013400","journal-title":"Am J Nephrol"},{"key":"2990_CR6","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1056\/NEJMc0809959","volume":"360","author":"RA Gruppo","year":"2009","unstructured":"Gruppo RA, Rother RP (2009) Eculizumab for congenital atypical hemolytic-uremic syndrome. N Engl J Med 360:544\u2013546","journal-title":"N Engl J Med"},{"key":"2990_CR7","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1056\/NEJMc0808527","volume":"360","author":"J Nurnberger","year":"2009","unstructured":"Nurnberger J, Philipp T, Witzke O, Opazo Saez A, Vester U, Baba HA, Kribben A, Zimmerhackl LB, Janecke AR, Nagel M, Kirschfink M (2009) Eculizumab for atypical hemolytic-uremic syndrome. N Engl J Med 360:542\u2013544","journal-title":"N Engl J Med"},{"key":"2990_CR8","doi-asserted-by":"publisher","first-page":"2169","DOI":"10.1056\/NEJMoa1208981","volume":"368","author":"CM Legendre","year":"2013","unstructured":"Legendre CM, Licht C, Muus P, Greenbaum LA, Babu S, Bedrosian C, Bingham C, Cohen DJ, Delmas Y, Douglas K, Eitner F, Feldkamp T, Fouque D, Furman RR, Gaber O, Herthelius M, Hourmant M, Karpman D, Lebranchu Y, Mariat C, Menne J, Moulin B, Nurnberger J, Ogawa M, Remuzzi G, Richard T, Sberro-Soussan R, Severino B, Sheerin NS, Trivelli A, Zimmerhackl LB, Goodship T, Loirat C (2013) Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome. N Engl J Med 368:2169\u20132181","journal-title":"N Engl J Med"},{"key":"2990_CR9","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1097\/INF.0b013e3182503849","volume":"31","author":"J Gleesing","year":"2012","unstructured":"Gleesing J, Chiwane S, Rongkavilit C (2012) Gonococcal septic shock associated with eculizumab treatment. Pediatr Infect Dis J 31:543","journal-title":"Pediatr Infect Dis J"},{"key":"2990_CR10","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/ajh.21672","volume":"85","author":"Y Balagula","year":"2010","unstructured":"Balagula Y, Newman SB, Lacouture ME (2010) Photodermatosis associated with eculizumab (Soliris): a novel monoclonal antibody directed against the complement protein C5. Am J Hematol 85:392\u2013393","journal-title":"Am J Hematol"},{"key":"2990_CR11","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s00277-011-1229-9","volume":"91","author":"AM Manganoni","year":"2012","unstructured":"Manganoni AM, Pavoni L, Facchetti F, Farisoglio C, Sereni E, Calzavara-Pinton P (2012) Melanoma in a patient in treatment with eculizumab. Ann Hematol 91:135\u2013136","journal-title":"Ann Hematol"},{"key":"2990_CR12","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1002\/ajh.21265","volume":"83","author":"BM Knoll","year":"2008","unstructured":"Knoll BM, Letendre L, Steensma DP (2008) Life-threatening desquamating rash and hyperammonemia following administration of eculizumab for paroxysmal nocturnal hemoglobinuria. Am J Hematol 83:881\u2013883","journal-title":"Am J Hematol"},{"key":"2990_CR13","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1038\/clpt.2011.58","volume":"89","author":"GP Aithal","year":"2011","unstructured":"Aithal GP, Watkins PB, Andrade RJ, Larrey D, Molokhia M, Takikawa H, Hunt CM, Wilke RA, Avigan M, Kaplowitz N, Bjornsson E, Daly AK (2011) Case definition and phenotype standardization in drug-induced liver injury. Clin Pharmacol Ther 89:806\u2013815","journal-title":"Clin Pharmacol Ther"},{"key":"2990_CR14","doi-asserted-by":"publisher","first-page":"1720","DOI":"10.1002\/acr.21750","volume":"64","author":"S Unizony","year":"2012","unstructured":"Unizony S, Arias-Urdaneta L, Miloslavsky E, Arvikar S, Khosroshahi A, Keroack B, Stone JR, Stone JH (2012) Tocilizumab for the treatment of large-vessel vasculitis (giant cell arteritis, Takayasu arteritis) and polymyalgia rheumatica. Arthritis Care Res 64:1720\u20131729","journal-title":"Arthritis Care Res"},{"key":"2990_CR15","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.clinthera.2012.02.014","volume":"34","author":"I Navarro-Millan","year":"2012","unstructured":"Navarro-Millan I, Singh JA, Curtis JR (2012) Systematic review of tocilizumab for rheumatoid arthritis: a new biologic agent targeting the interleukin-6 receptor. Clin Ther 34:788\u2013802","journal-title":"Clin Ther"},{"key":"2990_CR16","doi-asserted-by":"publisher","first-page":"6132","DOI":"10.1158\/1078-0432.CCR-10-2275","volume":"16","author":"R Hassan","year":"2010","unstructured":"Hassan R, Cohen SJ, Phillips M, Pastan I, Sharon E, Kelly RJ, Schweizer C, Weil S, Laheru D (2010) Phase I clinical trial of the chimeric anti-mesothelin monoclonal antibody MORAb-009 in patients with mesothelin-expressing cancers. Clin Cancer Res 16:6132\u20136138","journal-title":"Clin Cancer Res"},{"key":"2990_CR17","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1593\/neo.91864","volume":"12","author":"MH Langenberg","year":"2010","unstructured":"Langenberg MH, Witteveen PO, Lankheet NA, Roodhart JM, Rosing H, van den Heuvel IJ, Beijnen JH, Voest EE (2010) Phase 1 study of combination treatment with PTK 787\/ZK 222584 and cetuximab for patients with advanced solid tumors: safety, pharmacokinetics, pharmacodynamics analysis. Neoplasia 12:206\u2013213","journal-title":"Neoplasia"},{"key":"2990_CR18","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/sj.bjc.6605507","volume":"102","author":"T Trarbach","year":"2010","unstructured":"Trarbach T, Moehler M, Heinemann V, Kohne CH, Przyborek M, Schulz C, Sneller V, Gallant G, Kanzler S (2010) Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer. Br J Cancer 102:506\u2013512","journal-title":"Br J Cancer"},{"key":"2990_CR19","doi-asserted-by":"publisher","first-page":"673","DOI":"10.2165\/00044011-200626110-00008","volume":"26","author":"E Ierardi","year":"2006","unstructured":"Ierardi E, Valle ND, Nacchiero MC, De Francesco V, Stoppino G, Panella C (2006) Onset of liver damage after a single administration of infliximab in a patient with refractory ulcerative colitis. Clin Drug Invest 26:673\u2013676","journal-title":"Clin Drug Invest"},{"key":"2990_CR20","doi-asserted-by":"publisher","first-page":"84","DOI":"10.4065\/76.1.84","volume":"76","author":"VV Menghini","year":"2001","unstructured":"Menghini VV, Arora AS (2001) Infliximab-associated reversible cholestatic liver disease. Mayo Clin Proc 76:84\u201386","journal-title":"Mayo Clin Proc"},{"key":"2990_CR21","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1002\/1529-0131(200108)44:8<1966::AID-ART339>3.0.CO;2-3","volume":"44","author":"G Saleem","year":"2001","unstructured":"Saleem G, Li SC, MacPherson BR, Cooper SM (2001) Hepatitis with interface inflammation and IgG, IgM, and IgA anti-double-stranded DNA antibodies following infliximab therapy: comment on the article by Charles et al. Arthritis Rheum 44:1966\u20131968","journal-title":"Arthritis Rheum"},{"key":"2990_CR22","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1136\/ard.2004.032821","volume":"64","author":"V Germano","year":"2005","unstructured":"Germano V, Picchianti Diamanti A, Baccano G, Natale E, Onetti Muda A, Priori R, Valesini G (2005) Autoimmune hepatitis associated with infliximab in a patient with psoriatic arthritis. Ann Rheum Dis 64:1519\u20131520","journal-title":"Ann Rheum Dis"},{"key":"2990_CR23","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1007\/s10067-005-0169-y","volume":"26","author":"GJ Tobon","year":"2007","unstructured":"Tobon GJ, Canas C, Jaller JJ, Restrepo JC, Anaya JM (2007) Serious liver disease induced by infliximab. Clin Rheumatol 26:578\u2013581","journal-title":"Clin Rheumatol"},{"key":"2990_CR24","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1157\/13087475","volume":"29","author":"S Soto-Fernandez","year":"2006","unstructured":"Soto-Fernandez S, Gonzalez-Carro P, De Pedro-Esteban A, Legaz-Huidobro ML, Perez-Roldan F, Roncero Garcia-Escribano O, Valbuena-Gonzalez M, Ruiz-Carrillo F (2006) Infliximab-induced hepatitis in a patient with Crohn\u2019s disease. Gastroenterol Hepatol 29:321\u2013322","journal-title":"Gastroenterol Hepatol"},{"key":"2990_CR25","doi-asserted-by":"crossref","first-page":"524","DOI":"10.5694\/j.1326-5377.2007.tb01396.x","volume":"187","author":"G Ozorio","year":"2007","unstructured":"Ozorio G, McGarity B, Bak H, Jordan AS, Lau H, Marshall C (2007) Autoimmune hepatitis following infliximab therapy for ankylosing spondylitis. Med J Aust 187:524\u2013526","journal-title":"Med J Aust"},{"key":"2990_CR26","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1038\/nbt1344","volume":"25","author":"RP Rother","year":"2007","unstructured":"Rother RP, Rollins SA, Mojcik CF, Brodsky RA, Bell L (2007) Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria. Nat Biotechnol 25:1256\u20131264","journal-title":"Nat Biotechnol"},{"key":"2990_CR27","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/2162-3619-1-26","volume":"1","author":"A Brodsky","year":"2012","unstructured":"Brodsky A, Mazzocchi O, Sanchez F, Khursigara G, Malhotra S, Volpacchio M (2012) Eculizumab in paroxysmal nocturnal hemoglobinuria with Budd-Chiari syndrome progressing despite anticoagulation. Exp Hematol Oncol 1:26","journal-title":"Exp Hematol Oncol"},{"key":"2990_CR28","doi-asserted-by":"publisher","first-page":"2180","DOI":"10.1681\/ASN.2010030315","volume":"21","author":"MA Dragon-Durey","year":"2010","unstructured":"Dragon-Durey MA, Sethi SK, Bagga A, Blanc C, Blouin J, Ranchin B, Andre JL, Takagi N, Cheong HI, Hari P, Le Quintrec M, Niaudet P, Loirat C, Fridman WH, Fremeaux-Bacchi V (2010) Clinical features of anti-factor H autoantibody-associated hemolytic uremic syndrome. J Am Soc Nephrol 21:2180\u20132187","journal-title":"J Am Soc Nephrol"},{"key":"2990_CR29","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1038\/ncponc1087","volume":"5","author":"Y Loriot","year":"2008","unstructured":"Loriot Y, Perlemuter G, Malka D, Penault-Llorca F, Boige V, Deutsch E, Massard C, Armand JP, Soria JC (2008) Drug insight: gastrointestinal and hepatic adverse effects of molecular-targeted agents in cancer therapy. Nat Clin Pract Oncol 5:268\u2013278","journal-title":"Nat Clin Pract Oncol"},{"key":"2990_CR30","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.leukres.2006.07.005","volume":"31","author":"JM McKoy","year":"2007","unstructured":"McKoy JM, Angelotta C, Bennett CL, Tallman MS, Wadleigh M, Evens AM, Kuzel TM, Trifilio SM, Raisch DW, Kell J, DeAngelo DJ, Giles FJ (2007) Gemtuzumab ozogamicin-associated sinusoidal obstructive syndrome (SOS): an overview from the research on adverse drug events and reports (RADAR) project. Leuk Res 31:599\u2013604","journal-title":"Leuk Res"},{"key":"2990_CR31","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1182\/blood-2007-09-114165","volume":"112","author":"MB Maniecki","year":"2008","unstructured":"Maniecki MB, Hasle H, Friis-Hansen L, Lausen B, Nielsen OJ, Bendix K, Moestrup SK, Moller HJ (2008) Impaired CD163-mediated hemoglobin-scavenging and severe toxic symptoms in patients treated with gemtuzumab ozogamicin. Blood 112:1510\u20131514","journal-title":"Blood"},{"key":"2990_CR32","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.4049\/jimmunol.166.4.2479","volume":"166","author":"D Mastellos","year":"2001","unstructured":"Mastellos D, Papadimitriou JC, Franchini S, Tsonis PA, Lambris JD (2001) A novel role of complement: mice deficient in the fifth component of complement (C5) exhibit impaired liver regeneration. J Immunol 166:2479\u20132486","journal-title":"J Immunol"},{"key":"2990_CR33","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S1567-5769(00)00038-2","volume":"1","author":"HL Schieferdecker","year":"2001","unstructured":"Schieferdecker HL, Schlaf G, Jungermann K, Gotze O (2001) Functions of anaphylatoxin C5a in rat liver: direct and indirect actions on nonparenchymal and parenchymal cells. Int Immunopharmacol 1:469\u2013481","journal-title":"Int Immunopharmacol"},{"key":"2990_CR34","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1158\/1535-7163.MCT-11-0519","volume":"11","author":"Y Cao","year":"2012","unstructured":"Cao Y, Marks JD, Huang Q, Rudnick SI, Xiong C, Hittelman WN, Wen X, Marks JW, Cheung LH, Boland K, Li C, Adams GP, Rosenblum MG (2012) Single-chain antibody-based immunotoxins targeting Her2\/neu: design optimization and impact of affinity on antitumor efficacy and off-target toxicity. Mol Cancer Ther 11:143\u2013153","journal-title":"Mol Cancer Ther"},{"key":"2990_CR35","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1681\/ASN.2011121186","volume":"23","author":"LC Herlitz","year":"2012","unstructured":"Herlitz LC, Bomback AS, Markowitz GS, Stokes MB, Smith RN, Colvin RB, Appel GB, D\u2019Agati VD (2012) Pathology after eculizumab in dense deposit disease and C3 GN. J Am Soc Nephrol 23:1229\u20131237","journal-title":"J Am Soc Nephrol"},{"key":"2990_CR36","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/ng1599","volume":"37","author":"S Hillebrandt","year":"2005","unstructured":"Hillebrandt S, Wasmuth HE, Weiskirchen R, Hellerbrand C, Keppeler H, Werth A, Schirin-Sokhan R, Wilkens G, Geier A, Lorenzen J, Kohl J, Gressner AM, Matern S, Lammert F (2005) Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Nat Genet 37:835\u2013843","journal-title":"Nat Genet"},{"key":"2990_CR37","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1002\/hep.21424","volume":"44","author":"RJ Andrade","year":"2006","unstructured":"Andrade RJ, Lucena MI, Kaplowitz N, Garcia-Munoz B, Borraz Y, Pachkoria K, Garcia-Cortes M, Fernandez MC, Pelaez G, Rodrigo L, Duran JA, Costa J, Planas R, Barriocanal A, Guarner C, Romero-Gomez M, Munoz-Yague T, Salmeron J, Hidalgo R (2006) Outcome of acute idiosyncratic drug-induced liver injury: Long-term follow-up in a hepatotoxicity registry. Hepatology 44:1581\u20131588","journal-title":"Hepatology"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-014-2990-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-014-2990-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-014-2990-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-014-2990-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T13:12:52Z","timestamp":1717593172000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-014-2990-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,22]]},"references-count":37,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["2990"],"URL":"https:\/\/doi.org\/10.1007\/s00467-014-2990-5","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,22]]},"assertion":[{"value":"26 June 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 August 2014","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 October 2014","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2014","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}