{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T23:15:30Z","timestamp":1793834130582,"version":"4.6.1"},"reference-count":80,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T00:00:00Z","timestamp":1479168000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000384","name":"Higher Education Funding Council for England","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000384","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1007\/s00467-016-3533-z","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T00:07:28Z","timestamp":1479168448000},"page":"2015-2025","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":133,"title":["Aminoglycoside-induced nephrotoxicity in children"],"prefix":"10.1007","volume":"32","author":[{"given":"Stephen J","family":"McWilliam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J","family":"Antoine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalind L","family":"Smyth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munir","family":"Pirmohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,11,15]]},"reference":[{"key":"3533_CR1","first-page":"597","volume":"39","author":"EJ Begg","year":"1995","unstructured":"Begg EJ, Barclay ML (1995) Aminoglycosides\u201450 years on. Br J Clin Pharmacol 39:597\u2013603","journal-title":"Br J Clin Pharmacol"},{"key":"3533_CR2","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1128\/AAC.43.5.1003","volume":"43","author":"MP Mingeot-Leclercq","year":"1999","unstructured":"Mingeot-Leclercq MP, Tulkens PM (1999) Aminoglycosides: Nephrotoxicity. Antimicrob Agents Chemother 43:1003\u20131012","journal-title":"Antimicrob Agents Chemother"},{"key":"3533_CR3","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1074\/jbc.M109959200","volume":"277","author":"C Schmitz","year":"2002","unstructured":"Schmitz C, Hilpert J, Jacobsen C, Boensch C, Christensen EI, Luft FC, Willnow TE (2002) Megalin deficiency offers protection from renal aminoglycoside accumulation. J Biol Chem 277:618\u2013622","journal-title":"J Biol Chem"},{"key":"3533_CR4","doi-asserted-by":"crossref","first-page":"F562","DOI":"10.1152\/ajprenal.2001.280.4.F562","volume":"280","author":"EI Christensen","year":"2001","unstructured":"Christensen EI, Birn H (2001) Megalin and cubilin: synergistic endocytic receptors in renal proximal tubule. Am J Physiol Renal Physiol 280:F562\u2013F573","journal-title":"Am J Physiol Renal Physiol"},{"key":"3533_CR5","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.bcp.2009.09.021","volume":"79","author":"DJ Antoine","year":"2010","unstructured":"Antoine DJ, Srivastava A, Pirmohamed M, Park BK (2010) Statins inhibit aminoglycoside accumulation and cytotoxicity to renal proximal tubule cells. Biochem Pharmacol 79:647\u2013654","journal-title":"Biochem Pharmacol"},{"key":"3533_CR6","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1517\/14740330802410462","volume":"7","author":"SS Taber","year":"2008","unstructured":"Taber SS, Pasko DA (2008) The epidemiology of drug-induced disorders: The kidney. Expert Opin Drug Saf 7:679\u2013690","journal-title":"Expert Opin Drug Saf"},{"key":"3533_CR7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/ki.1979.45","volume":"15","author":"FJ Silverblatt","year":"1979","unstructured":"Silverblatt FJ, Kuehn C (1979) Autoradiography of gentamicin uptake by the rat proximal tubule cell. Kidney Int 15:335\u2013345","journal-title":"Kidney Int"},{"key":"3533_CR8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/ki.2010.337","volume":"79","author":"JM Lopez-Novoa","year":"2011","unstructured":"Lopez-Novoa JM, Quiros Y, Vicente L, Morales AI, Lopez-Hernandez FJ (2011) New insights into the mechanism of aminoglycoside nephrotoxicity: an integrative point of view. Kidney Int 79:33\u201345","journal-title":"Kidney Int"},{"key":"3533_CR9","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1016\/0006-2952(89)90098-1","volume":"38","author":"AL Regec","year":"1989","unstructured":"Regec AL, Trump BF, Trifilis AL (1989) Effect of gentamicin on the lysosomal system of cultured human proximal tubular cells. Endocytotic activity, lysosomal pH and membrane fragility. Biochem Pharmacol 38:2527\u20132534","journal-title":"Biochem Pharmacol"},{"key":"3533_CR10","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.taap.2004.11.024","volume":"206","author":"H Servais","year":"2005","unstructured":"Servais H, Van Der Smissen P, Thirion G, Van der Essen G, Van BF, Tulkens PM, Mingeot-Leclercq MP (2005) Gentamicin-induced apoptosis in LLC-PK1 cells: involvement of lysosomes and mitochondria. Toxicol Appl Pharmacol 206:321\u2013333","journal-title":"Toxicol Appl Pharmacol"},{"key":"3533_CR11","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s10495-006-3486-y","volume":"11","author":"CE Chwieralski","year":"2006","unstructured":"Chwieralski CE, Welte T, B\u00fchling F (2006) Cathepsin-regulated apoptosis. Apoptosis 11:143\u2013149","journal-title":"Apoptosis"},{"key":"3533_CR12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.tibs.2006.11.001","volume":"32","author":"P Golstein","year":"2007","unstructured":"Golstein P, Kroemer G (2007) Cell death by necrosis: towards a molecular definition. Trends Biochem Sci 32:37\u201343","journal-title":"Trends Biochem Sci"},{"key":"3533_CR13","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1093\/toxsci\/kfm152","volume":"99","author":"M Peyrou","year":"2007","unstructured":"Peyrou M, Hanna PE, Cribb AE (2007) Cisplatin, gentamicin, and p-aminophenol induce markers of endoplasmic reticulum stress in the rat kidneys. Toxicol Sci 99:346\u2013353","journal-title":"Toxicol Sci"},{"key":"3533_CR14","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0021-9924(98)00014-8","volume":"31","author":"SI Usami","year":"1998","unstructured":"Usami SI, Abe S, Shinkawa H, Kimberling WJ (1998) Sensorineural hearing loss caused by mitochondrial dna mutations: Special reference to the A1555G mutation. J Commun Disord 31:423\u2013435","journal-title":"J Commun Disord"},{"key":"3533_CR15","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1007\/s00424-011-1026-2","volume":"462","author":"C Raggi","year":"2011","unstructured":"Raggi C, Fujiwara K, Leal T, Jouret F, Devuyst O, Terryn S (2011) Decreased renal accumulation of aminoglycoside reflects defective receptor-mediated endocytosis in cystic fibrosis and Dent\u2019s disease. Pflugers Arch 462:851\u2013860","journal-title":"Pflugers Arch"},{"key":"3533_CR16","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/sj.ki.5002231","volume":"71","author":"A Akcan-Arikan","year":"2007","unstructured":"Akcan-Arikan A, Zappitelli M, Loftis LL, Washburn KK, Jefferson LS, Goldstein SL (2007) Modified RIFLE criteria in critically ill children with acute kidney injury. Kidney Int 71:1028\u20131035","journal-title":"Kidney Int"},{"key":"3533_CR17","doi-asserted-by":"crossref","first-page":"856","DOI":"10.2215\/CJN.08110910","volume":"6","author":"BS Moffett","year":"2011","unstructured":"Moffett BS, Goldstein SL (2011) Acute kidney injury and increasing nephrotoxic-medication exposure in noncritically-ill children. Clin J Am Soc Nephrol 6:856\u2013863","journal-title":"Clin J Am Soc Nephrol"},{"key":"3533_CR18","doi-asserted-by":"crossref","first-page":"R31","DOI":"10.1186\/cc5713","volume":"11","author":"RL Mehta","year":"2007","unstructured":"Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Levin A (2007) Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury. Crit Care 11:R31","journal-title":"Crit Care"},{"key":"3533_CR19","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/ndt\/gfq375","volume":"26","author":"M Zappitelli","year":"2011","unstructured":"Zappitelli M, Moffett BS, Hyder A, Goldstein SL (2011) Acute kidney injury in non-critically ill children treated with aminoglycoside antibiotics in a tertiary healthcare centre: a retrospective cohort study. Nephrol Dial Transplant 26:144\u2013150","journal-title":"Nephrol Dial Transplant"},{"key":"3533_CR20","doi-asserted-by":"crossref","first-page":"948","DOI":"10.2215\/CJN.05431207","volume":"3","author":"M Zappitelli","year":"2008","unstructured":"Zappitelli M, Parikh CR, Akcan-Arikan A, Washburn KK, Moffett BS, Goldstein SL (2008) Ascertainment and epidemiology of acute kidney injury varies with definition interpretation. Clin J Am Soc Nephrol 3:948\u2013954","journal-title":"Clin J Am Soc Nephrol"},{"key":"3533_CR21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/kisup.2012.1","volume":"2","author":"JA Kellum","year":"2012","unstructured":"Kellum JA, Lameire N, Aspelin P, Barsoum RS, Burdmann EA, Goldstein SL, Herzog CA, Joannidis M, Kribben A, Levey AS, MacLeod AM, Mehta RL, Murray PT, Naicker S, Opal SM, Schaefer F, Schetz M, Uchino S (2012) Kidney disease: Improving global outcomes (KDIGO) acute kidney injury work group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl 2:1\u2013138","journal-title":"Kidney Int Suppl"},{"key":"3533_CR22","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/ki.2015.115","volume":"88","author":"RL Mehta","year":"2015","unstructured":"Mehta RL, Awdishu L, Davenport A, Murray PT, Macedo E, Cerda J, Chakaravarthi R, Holden AL, Goldstein SL (2015) Phenotype standardization for drug-induced kidney disease. Kidney Int 88:226\u2013234","journal-title":"Kidney Int"},{"key":"3533_CR23","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1038\/clpt.2011.30","volume":"89","author":"M Pirmohamed","year":"2011","unstructured":"Pirmohamed M, Aithal GP, Behr E, Daly A, Roden D (2011) The phenotype standardization project: Improving pharmacogenetic studies of serious adverse drug reactions. Clin Pharmacol Ther 89:784\u2013785","journal-title":"Clin Pharmacol Ther"},{"key":"3533_CR24","doi-asserted-by":"crossref","first-page":"e28096","DOI":"10.1371\/journal.pone.0028096","volume":"6","author":"RM Gallagher","year":"2011","unstructured":"Gallagher RM, Kirkham JJ, Mason JR, Bird KA, Williamson PR, Nunn AJ, Turner MA, Smyth RL, Pirmohamed M (2011) Development and inter-rater reliability of the Liverpool adverse drug reaction causality assessment tool. PLoS ONE 6:e28096","journal-title":"PLoS ONE"},{"key":"3533_CR25","doi-asserted-by":"crossref","first-page":"e756","DOI":"10.1542\/peds.2013-0794","volume":"132","author":"SL Goldstein","year":"2013","unstructured":"Goldstein SL, Kirkendall E, Nguyen H, Schaffzin JK, Bucuvalas J, Bracke T, Seid M, Ashby M, Foertmeyer N, Brunner L, Lesko A, Barclay C, Lannon C, Muething S (2013) Electronic health record identification of nephrotoxin exposure and associated acute kidney injury. Pediatrics 132:e756\u2013e767","journal-title":"Pediatrics"},{"key":"3533_CR26","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1471-2431-9-50","volume":"9","author":"MA Turner","year":"2009","unstructured":"Turner MA, Lewis S, Hawcutt DB, Field D (2009) Prioritising neonatal medicines research: UK Medicines for Children Research Network scoping survey. BMC Pediatr 9:50","journal-title":"BMC Pediatr"},{"key":"3533_CR27","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1542\/peds.2005-1707","volume":"117","author":"RH Clark","year":"2006","unstructured":"Clark RH, Bloom BT, Spitzer AR, Gerstmann DR (2006) Reported medication use in the neonatal intensive care unit: Data from a large national data set. Pediatrics 117:1979\u20131987","journal-title":"Pediatrics"},{"key":"3533_CR28","unstructured":"National Institute of Health and Care Excellence (2012) Antibiotics for early onset neonatal infection. CG149. National Institute for Health and Care Excellence, London. https:\/\/guidance.nice.org.uk\/cg149 . Accessed 28 Sept 2016"},{"key":"3533_CR29","doi-asserted-by":"crossref","first-page":"F294","DOI":"10.1136\/adc.2004.056317","volume":"90","author":"E Nestaas","year":"2005","unstructured":"Nestaas E, Bangstad HJ, Sandvik L, Wathne KO (2005) Aminoglycoside extended interval dosing in neonates is safe and effective: a meta-analysis. Arch Dis Child Fetal Neonatal Ed 90:F294\u2013F300","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"3533_CR30","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.3109\/14767058.2013.860522","volume":"27","author":"ET Rhone","year":"2014","unstructured":"Rhone ET, Carmody JB, Swanson JR, Charlton JR (2014) Nephrotoxic medication exposure in very low birth weight infants. J Matern Fetal Neonatal Med 27:1485\u20131490","journal-title":"J Matern Fetal Neonatal Med"},{"key":"3533_CR31","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1586\/14787210.2014.878648","volume":"12","author":"A Kent","year":"2014","unstructured":"Kent A, Turner MA, Sharland M, Heath PT (2014) Aminoglycoside toxicity in neonates: Something to worry about? Expert Rev Anti Infect Ther 12:319\u2013331","journal-title":"Expert Rev Anti Infect Ther"},{"key":"3533_CR32","doi-asserted-by":"crossref","first-page":"2400","DOI":"10.1016\/j.clinthera.2011.01.013","volume":"32","author":"J Mart\u00ednkov\u00e1","year":"2010","unstructured":"Mart\u00ednkov\u00e1 J, Pokorn\u00e1 P, Z\u00e1hora J, Chl\u00e1dek J, Vobruba V, Selke-Krulichov\u00e1 I, Chl\u00e1dkov\u00e1 J (2010) Tolerability and outcomes of kinetically guided therapy with gentamicin in critically ill neonates during the first week of life: an open-label, prospective study. Clin Ther 32:2400\u20132414","journal-title":"Clin Ther"},{"key":"3533_CR33","unstructured":"Cystic Fibrosis Trust (2011) UK CF Registry Annual Data Report 2009. Cystic Fibrosis Trust, Bromley Kent"},{"key":"3533_CR34","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1136\/thx.2006.067595","volume":"62","author":"C Bertenshaw","year":"2007","unstructured":"Bertenshaw C, Watson AR, Lewis S, Smyth A (2007) Survey of acute renal failure in patients with cystic fibrosis in the UK. Thorax 62:541\u2013545","journal-title":"Thorax"},{"key":"3533_CR35","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1136\/thx.2007.088757","volume":"63","author":"A Smyth","year":"2008","unstructured":"Smyth A, Lewis S, Bertenshaw C, Choonara I, McGaw J, Watson A (2008) Case-control study of acute renal failure in patients with cystic fibrosis in the UK. Thorax 63:532\u2013535","journal-title":"Thorax"},{"key":"3533_CR36","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jcf.2014.03.005","volume":"13","author":"KJ Downes","year":"2014","unstructured":"Downes KJ, Rao MB, Kahill L, Nguyen H, Clancy JP, Goldstein SL (2014) Daily serum creatinine monitoring promotes earlier detection of acute kidney injury in children and adolescents with cystic fibrosis. J Cyst Fibros 13:435\u2013441","journal-title":"J Cyst Fibros"},{"key":"3533_CR37","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1007\/s00467-015-3097-3","volume":"30","author":"KJ Downes","year":"2015","unstructured":"Downes KJ, Patil NR, Rao MB, Koralkar R, Harris WT, Clancy JP, Goldstein SL, Askenazi DJ (2015) Risk factors for acute kidney injury during aminoglycoside therapy in patients with cystic fibrosis. Pediatr Nephrol 30:1879\u20131888","journal-title":"Pediatr Nephrol"},{"key":"3533_CR38","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.jpeds.2014.04.058","volume":"165","author":"S Menon","year":"2014","unstructured":"Menon S, Kirkendall ES, Nguyen H, Goldstein SL (2014) Acute kidney injury associated with high nephrotoxic medication exposure leads to chronic kidney disease after 6 months. J Pediatr 165:522\u2013527","journal-title":"J Pediatr"},{"key":"3533_CR39","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/ppul.20138","volume":"39","author":"M Al-Aloul","year":"2005","unstructured":"Al-Aloul M, Miller H, Alapati S, Stockton PA, Ledson MJ, Walshaw MJ (2005) Renal impairment in cystic fibrosis patients due to repeated intravenous aminoglycoside use. Pediatr Pulmonol 39:15\u201320","journal-title":"Pediatr Pulmonol"},{"key":"3533_CR40","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1128\/AAC.31.4.594","volume":"31","author":"SS Pedersen","year":"1987","unstructured":"Pedersen SS, Jensen T, Osterhammel D, Osterhammel P (1987) Cumulative and acute toxicity of repeated high-dose tobramycin treatment in cystic fibrosis. Antimicrob Agents Chemother 31:594\u2013599","journal-title":"Antimicrob Agents Chemother"},{"key":"3533_CR41","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00467-008-1060-2","volume":"24","author":"DJ Askenazi","year":"2009","unstructured":"Askenazi DJ, Ambalavanan N, Goldstein SL (2009) Acute kidney injury in critically ill newborns: what do we know? What do we need to learn? Pediatr Nephrol 24:265\u2013274","journal-title":"Pediatr Nephrol"},{"key":"3533_CR42","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1681\/ASN.2008070669","volume":"20","author":"SS Waikar","year":"2009","unstructured":"Waikar SS, Bonventre JV (2009) Creatinine kinetics and the definition of acute kidney injury. J Am Soc Nephrol 20:672\u2013679","journal-title":"J Am Soc Nephrol"},{"key":"3533_CR43","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nbt.1625","volume":"28","author":"F Dieterle","year":"2010","unstructured":"Dieterle F, Sistare F, Goodsaid F, Papaluca M, Ozer JS, Webb CP, Baer W, Senagore A, Schipper MJ, Vonderscher J, Sultana S, Gerhold DL, Phillips JA, Maurer G, Carl K, Laurie D, Harpur E, Sonee M, Ennulat D, Holder D, Andrews-cleavenger D, Y-z G, Thompson KL, Goering PL, J-m V, Abadie E, Maciulaitis R, Jacobson-kram D, Defelice AF, Hausner EA, Blank M, Thompson A, Harlow P, Throckmorton D, Xiao S, Xu N, Taylor W, Vamvakas S, Flamion B, Lima BS, Kasper P, Pasanen M, Prasad K, Troth S, Bounous D, Robinson-gravatt D, Betton G, Davis MA, Akunda J, McDuffie JE, Suter L, Obert L, Guffroy M, Pinches M, Jayadev S, Blomme EA, Beushausen SA, Barlow VG, Collins N, Waring J, Honor D, Snook S, Lee J, Rossi P, Walker E, Mattes W (2010) Renal biomarker qualification submission: a dialog between the FDA\u2013EMEA and Predictive Safety Testing Consortium. Nat Biotechnol 28:455\u2013462","journal-title":"Nat Biotechnol"},{"key":"3533_CR44","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nbt0510-436","volume":"28","author":"JV Bonventre","year":"2010","unstructured":"Bonventre JV, Vaidya VS, Schmouder R, Feig P, Dieterle F (2010) Next-generation biomarkers for detecting kidney toxicity. Nat Biotechnol 28:436\u2013440","journal-title":"Nat Biotechnol"},{"key":"3533_CR45","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/nbt.1624","volume":"28","author":"Y Yu","year":"2010","unstructured":"Yu Y, Jin H, Holder D, Ozer JS, Villarreal S, Shughrue P, Shi S, Figueroa DJ, Clouse H, Su M, Muniappa N, Troth SP, Bailey W, Seng J, Aslamkhan AG, Thudium D, Sistare FD, Gerhold DL (2010) Urinary biomarkers trefoil factor 3 and albumin enable early detection of kidney tubular injury. Nat Biotechnol 28:470\u2013477","journal-title":"Nat Biotechnol"},{"key":"3533_CR46","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nbt.1623","volume":"28","author":"VS Vaidya","year":"2010","unstructured":"Vaidya VS, Ozer JS, Dieterle F, Collings FB, Ramirez V, Troth S, Muniappa N, Thudium D, Gerhold D, Holder DJ, Bobadilla NA, Marrer E, Perentes E, Cordier A, Vonderscher J, Maurer G, Goering PL, Sistare FD, Bonventre JV (2010) Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies. Nat Biotechnol 28:478\u2013485","journal-title":"Nat Biotechnol"},{"key":"3533_CR47","doi-asserted-by":"crossref","first-page":"e43809","DOI":"10.1371\/journal.pone.0043809","volume":"7","author":"SJ McWilliam","year":"2012","unstructured":"McWilliam SJ, Antoine DJ, Sabbisetti V, Turner MA, Farragher T, Bonventre JV, Park BK, Smyth RL, Pirmohamed M (2012) Mechanism-based urinary biomarkers to identify the potential for aminoglycoside-induced nephrotoxicity in premature neonates: A proof-of-concept study. PLoS ONE 7:e43809","journal-title":"PLoS ONE"},{"key":"3533_CR48","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/ppul.22795","volume":"49","author":"T Lahiri","year":"2014","unstructured":"Lahiri T, Guillet A, Diehl S, Ferguson M (2014) High-dose ibuprofen is not associated with increased biomarkers of kidney injury in patients with cystic fibrosis. Pediatr Pulmonol 49:148\u2013153","journal-title":"Pediatr Pulmonol"},{"key":"3533_CR49","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1016\/S1569-1993(14)60202-2","volume":"13","author":"SJ McWilliam","year":"2014","unstructured":"McWilliam SJ, Antoine DJ, Smyth RL, Pirmohamed M (2014) 66 Association of urinary kidney injury molecule-1 with aminoglycoside exposure in children with cystic fibrosis. J Cyst Fibros 13:S63","journal-title":"J Cyst Fibros"},{"key":"3533_CR50","first-page":"A278","volume":"45","author":"AZ Uluer","year":"2010","unstructured":"Uluer AZ, Casey A, Jawaid N, Fowler R, Demars N, Vaidya V, Waikar S, Bonventre JV, Ferguson M (2010) Urinary biomarkers for early detection of nephrotoxicity in cystic fibrosis. Pediatr Pulmonol 45:A278","journal-title":"Pediatr Pulmonol"},{"key":"3533_CR51","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1093\/clinids\/10.5.951","volume":"10","author":"JE Buring","year":"1988","unstructured":"Buring JE, Evans DA, Mayrent SL, Rosner B, Colton T, Hennekens CH (1988) Randomized trials of aminoglycoside antibiotics: quantitative overview. Rev Infect Dis 10:951\u2013957","journal-title":"Rev Infect Dis"},{"key":"3533_CR52","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1136\/thorax.58.9.794","volume":"58","author":"TL Pitt","year":"2003","unstructured":"Pitt TL, Sparrow M, Warner M, Stefanidou M (2003) Survey of resistance of Pseudomonas aeruginosa from UK patients with cystic fibrosis to six commonly prescribed antimicrobial agents. Thorax 58:794\u2013796","journal-title":"Thorax"},{"key":"3533_CR53","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00467-008-1036-2","volume":"24","author":"D Bockenhauer","year":"2009","unstructured":"Bockenhauer D, Hug MJ, Kleta R (2009) Cystic fibrosis, aminoglycoside treatment and acute renal failure: The not so gentle micin. Pediatr Nephrol 24:925\u2013928","journal-title":"Pediatr Nephrol"},{"key":"3533_CR54","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0140-6736(05)17906-9","volume":"365","author":"A Smyth","year":"2005","unstructured":"Smyth A, Tan KHV, Hyman-Taylor P, Mulheran M, Lewis S, Stableforth D, Knox A (2005) Once versus three-times daily regimens of tobramycin treatment for pulmonary exacerbations of cystic fibrosis\u2014the TOPIC study: a randomised controlled trial. Lancet 365:573\u2013578","journal-title":"Lancet"},{"key":"3533_CR55","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s40272-014-0093-1","volume":"16","author":"CA Knoderer","year":"2014","unstructured":"Knoderer CA, Nichols KR, Cox EG (2014) Optimized antimicrobial dosing strategies: a survey of pediatric hospitals. Pediatr Drugs 16:523\u2013529","journal-title":"Pediatr Drugs"},{"key":"3533_CR56","doi-asserted-by":"crossref","first-page":"e111","DOI":"10.1542\/peds.114.1.e111","volume":"114","author":"DG Contopoulos-Ioannidis","year":"2004","unstructured":"Contopoulos-Ioannidis DG, Giotis ND, Baliatsa DV, Ioannidis JP (2004) Extended-interval aminoglycoside administration for children: a meta-analysis. Pediatrics 114:e111\u2013118","journal-title":"Pediatrics"},{"key":"3533_CR57","unstructured":"UK CF Trust Antibiotic Working Group (2009) Antibiotic treatment for cystic fibrosis. Cystic Fibrosis Trust. Bromley Kent. https:\/\/www.cysticfibrosis.org.uk\/~\/media\/documents\/the-work-we-do\/care\/consensus-documents\/antibiotic-treatment-cystic-fibrosis-may-09.ashx?la=en . Accessed 28 Sept 2016"},{"key":"3533_CR58","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1164\/rccm.200812-1845PP","volume":"180","author":"PA Flume","year":"2009","unstructured":"Flume PA, Mogayzel PJ Jr, Robinson KA, Goss CH, Rosenblatt RL, Kuhn RJ, Marshall BC, Bujan J, Downs A, Finder J, Goss C, Gutierrez H, Hazle L, Lester M, Quittell L, Sabadosa K, Vender RL, White TB, Willey-Courand DB, Saldanha I, Oyegunle M, Shankar MB, McKoy N, Sengupta S, Odelola OA, Waybright S (2009) Cystic fibrosis pulmonary guidelines: Treatment of pulmonary exacerbations. Am J Respir Crit Care Med 180:802\u2013808","journal-title":"Am J Respir Crit Care Med"},{"key":"3533_CR59","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jcf.2006.05.015","volume":"6","author":"KP Coulthard","year":"2007","unstructured":"Coulthard KP, Peckham DG, Conway SP, Smith CA, Bell J, Turnidge J (2007) Therapeutic drug monitoring of once daily tobramycin in cystic fibrosis\u2014caution with trough concentrations. J Cyst Fibros 6:125\u2013130","journal-title":"J Cyst Fibros"},{"key":"3533_CR60","first-page":"CD001021","volume":"3","author":"G Ryan","year":"2011","unstructured":"Ryan G, Singh M, Dwan K (2011) Inhaled antibiotics for long-term therapy in cystic fibrosis. Cochrane Database Syst Rev 3:CD001021","journal-title":"Cochrane Database Syst Rev"},{"key":"3533_CR61","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jcf.2014.01.014","volume":"13","author":"S Hennig","year":"2014","unstructured":"Hennig S, McKay K, Vidmar S, O\u2019Brien K, Stacey S, Cheney J, Wainwright CE (2014) Safety of inhaled (Tobi\u00ae) and intravenous tobramycin in young children with cystic fibrosis. J Cyst Fibros 13:428\u2013434","journal-title":"J Cyst Fibros"},{"key":"3533_CR62","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/ppul.10185","volume":"34","author":"IM Hoffmann","year":"2002","unstructured":"Hoffmann IM, Rubin BK, Iskandar SS, Schechter MS, Nagaraj SK, Bitzan MM (2002) Acute renal failure in cystic fibrosis: association with inhaled tobramycin therapy. Pediatr Pulmonol 34:375\u2013377","journal-title":"Pediatr Pulmonol"},{"key":"3533_CR63","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.kint.2016.03.031","volume":"90","author":"SL Goldstein","year":"2016","unstructured":"Goldstein SL, Mottes T, Simpson K, Barclay C, Muething S, Haslam DB, Kirkendall ES (2016) A sustained quality improvement program reduces nephrotoxic medication-associated acute kidney injury. Kidney Int 90:212\u2013221","journal-title":"Kidney Int"},{"key":"3533_CR64","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jcf.2015.07.012","volume":"15","author":"AP Prayle","year":"2016","unstructured":"Prayle AP, Jain K, Touw DJ, Koch BCP, Knox AJ, Watson A, Smyth AR (2016) The pharmacokinetics and toxicity of morning vs. evening tobramycin dosing for pulmonary exacerbations of cystic fibrosis: A randomised comparison. J Cyst Fibros 15:510\u2013517","journal-title":"J Cyst Fibros"},{"key":"3533_CR65","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.phrs.2010.04.004","volume":"62","author":"P Balakumar","year":"2010","unstructured":"Balakumar P, Rohilla A, Thangathirupathi A (2010) Gentamicin-induced nephrotoxicity: Do we have a promising therapeutic approach to blunt it? Pharmacol Res 62:179\u2013186","journal-title":"Pharmacol Res"},{"key":"3533_CR66","first-page":"417","volume":"41","author":"J Vla\u0161i\u00e6-Matas","year":"2000","unstructured":"Vla\u0161i\u00e6-Matas J, Rumboldt Z, Karelovi\u00e6 D (2000) Renoprotective role of nifedipine during gentamicin therapy: Randomized controlled trial. Croat Med J 41:417\u2013422","journal-title":"Croat Med J"},{"key":"3533_CR67","doi-asserted-by":"crossref","first-page":"P121","DOI":"10.1136\/thx.2003.014258","volume":"59","author":"M Al-Aloul","year":"2004","unstructured":"Al-Aloul M, Miller H, Ledson MJ, Walshaw MJ (2004) Renoprotective effect of fosfomycin in the treatment of multiresistant Pseugomonas aeruginosa in CF. Thorax 59:P121","journal-title":"Thorax"},{"key":"3533_CR68","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jconrel.2003.12.005","volume":"95","author":"A Watanabe","year":"2004","unstructured":"Watanabe A, Nagai J, Adachi Y, Katsube T, Kitahara Y, Murakami T, Takano M (2004) Targeted prevention of renal accumulation and toxicity of gentamicin by aminoglycoside binding receptor antagonists. J Control Release 95:423\u2013433","journal-title":"J Control Release"},{"key":"3533_CR69","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1097\/01.ASN.0000136778.32499.05","volume":"15","author":"A Verhulst","year":"2004","unstructured":"Verhulst A, D\u2019Haese PC, De Broe ME (2004) Inhibitors of HMG-CoA reductase reduce receptor-mediated endocytosis in human kidney proximal tubular cells. J Am Soc Nephrol 15:2249\u20132257","journal-title":"J Am Soc Nephrol"},{"key":"3533_CR70","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1097\/01.ASN.0000138236.82706.EE","volume":"15","author":"JE Sidaway","year":"2004","unstructured":"Sidaway JE, Davidson RG, McTaggart F, Orton TC, Scott RC, Smith GJ, Brunskill NJ (2004) Inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase reduce receptor-mediated endocytosis in opossum kidney cells. J Am Soc Nephrol 15:2258\u20132265","journal-title":"J Am Soc Nephrol"},{"key":"3533_CR71","first-page":"36","volume":"5","author":"V Chinnapa Reddy","year":"2012","unstructured":"Chinnapa Reddy V, Amulya V, Anusha Lakshmi C, Bala Praveen Kumar Reddy D, Pratima D, Thanga Thirupathi A, Pavan Kumar K, Sengottuvelu S (2012) Effect of simvastatin in gentamicin induced nephrotoxicity in albino rats. Asian J Pharm Clin Res 5:36\u201340","journal-title":"Asian J Pharm Clin Res"},{"key":"3533_CR72","first-page":"1181","volume":"22","author":"M Jabbari","year":"2011","unstructured":"Jabbari M, Rostami Z, Jenabi A, Bahrami A, Mooraki A (2011) Simvastatin ameliorates gentamicin-induced renal injury in rats. Saudi J Kidney Dis Transpl 22:1181\u20131186","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"3533_CR73","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1177\/0192623308315832","volume":"36","author":"J Zhang","year":"2008","unstructured":"Zhang J, Brown RP, Shaw M, Vaidya VS, Zhou Y, Espandiari P, Sadrieh N, Stratmeyer M, Keenan J, Kilty CG, Bonventre JV, Goering PL (2008) Immunolocalization of Kim-1, RPA-1, and RPA-2 in kidney of gentamicin-, mercury-, or chromium-treated rats: relationship to renal distributions of iNOS and nitrotyrosine. Toxicol Pathol 36:397\u2013409","journal-title":"Toxicol Pathol"},{"key":"3533_CR74","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1172\/JCI34487","volume":"118","author":"T Ichimura","year":"2008","unstructured":"Ichimura T, Asseldonk EJPV, Humphreys BD, Gunaratnam L, Duffield JS, Bonventre JV (2008) Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells. J Clin Invest 118:1657\u20131668","journal-title":"J Clin Invest"},{"key":"3533_CR75","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/sj.ki.5002729","volume":"73","author":"SG Coca","year":"2008","unstructured":"Coca SG, Yalavarthy R, Concato J, Parikh CR (2008) Biomarkers for the diagnosis and risk stratification of acute kidney injury: a systematic review. Kidney Int 73:1008\u20131016","journal-title":"Kidney Int"},{"key":"3533_CR76","doi-asserted-by":"crossref","first-page":"10425","DOI":"10.1016\/S0021-9258(18)82217-7","volume":"268","author":"L Kjeldsen","year":"1993","unstructured":"Kjeldsen L, Johnsen AH, Sengelov H, Borregaard N (1993) Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem 268:10425\u201310432","journal-title":"J Biol Chem"},{"key":"3533_CR77","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1159\/000078452","volume":"24","author":"J Mishra","year":"2004","unstructured":"Mishra J, Mori K, Ma Q, Kelly C, Barasch J, Devarajan P (2004) Neutrophil gelatinase-associated lipocalin: A novel early urinary biomarker for cisplatin nephrotoxicity. Am J Nephrol 24:307\u2013315","journal-title":"Am J Nephrol"},{"key":"3533_CR78","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3109\/0886022X.2014.996109","volume":"37","author":"A Suchojad","year":"2015","unstructured":"Suchojad A, Tarko A, Smertka M, Majcherczyk M, Brzozowska A, Wroblewska J, Maruniak-Chudek I (2015) Factors limiting usefulness of serum and urinary NGAL as a marker of acute kidney injury in preterm newborns. Ren Fail 37:439\u2013445","journal-title":"Ren Fail"},{"key":"3533_CR79","doi-asserted-by":"crossref","first-page":"75","DOI":"10.14712\/18059694.2018.35","volume":"48","author":"S Sk\u00e1lov\u00e1","year":"2005","unstructured":"Sk\u00e1lov\u00e1 S (2005) The diagnostic role of urinary N-acetyl-beta-D-glucosaminidase (NAG) activity in the detection of renal tubular impairment. Acta Med (Hradec Kralove) 48:75\u201380","journal-title":"Acta Med (Hradec Kralove)"},{"key":"3533_CR80","first-page":"S14","volume":"38","author":"RG Price","year":"1992","unstructured":"Price RG (1992) The role of NAG (N-acetyl-\u03b2-D-glucosaminidase) in the diagnosis of kidney disease including the monitoring of nephrotoxicity. Clin Nephrol 38:S14\u2013S19","journal-title":"Clin Nephrol"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-016-3533-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-016-3533-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-016-3533-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T10:39:34Z","timestamp":1657708774000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-016-3533-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,15]]},"references-count":80,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["3533"],"URL":"https:\/\/doi.org\/10.1007\/s00467-016-3533-z","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,15]]}}}