{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T16:36:33Z","timestamp":1770222993415,"version":"3.49.0"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T00:00:00Z","timestamp":1487203200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1007\/s00467-017-3615-6","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T08:18:53Z","timestamp":1487233133000},"page":"1089-1092","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Thrombotic microangiopathy caused by methionine synthase deficiency: diagnosis and treatment pitfalls"],"prefix":"10.1007","volume":"32","author":[{"given":"Maria Helena","family":"Vaisbich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andressa","family":"Braga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Gabrielle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarissa","family":"Bueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via","family":"Piazzon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Kok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,2,16]]},"reference":[{"key":"3615_CR1","doi-asserted-by":"publisher","first-page":"1401","DOI":"10.1007\/s00467-012-2152-6","volume":"27","author":"F Menni","year":"2012","unstructured":"Menni F, Testa S, Guez S, Chiarelli G, Alberti L, Esposito S (2012) Neonatal atypical hemolytic uremic syndrome due to methylmalonic aciduria and homocystinuria. Pediatr Nephrol 27:1401\u20131405","journal-title":"Pediatr Nephrol"},{"key":"3615_CR2","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.1007\/s00467-010-1609-8","volume":"25","author":"AH Bouts","year":"2010","unstructured":"Bouts AH, Roofthooft MTR, Salomons GS, Davin JC (2010) CD46-associated atypical hemolytic uremic syndrome with uncommon course caused by cblC deficiency. Pediatr Nephrol 25:2547\u20132548","journal-title":"Pediatr Nephrol"},{"issue":"1","key":"3615_CR3","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1007\/s00467-015-3076-8","volume":"31","author":"C Loirat","year":"2016","unstructured":"Loirat C, Fakhouri F, Ariceta G, Besbas N, Bitzan M, Anna Bjerre A, Coppo R, Emma F, Johnson S, Karpman D, Landau D, Langman CB, Lapeyraque AL, Licht C, Nester C, Pecoraro C, Riedl M, van de Kar NCAJ, Van de Walle J, Vivarelli M, Fr\u00e9meaux-Bacchi V, for HUS International (2016) An international consensus approach to the management of atypical hemolytic uremic syndrome in children. Pediatr Nephrol 31(1):15\u201339","journal-title":"Pediatr Nephrol"},{"issue":"4","key":"3615_CR4","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1007\/s00281-014-0416-x","volume":"36","author":"C Mele","year":"2014","unstructured":"Mele C, Remuzzi G, Noris M (2014) Hemolytic uremic syndrome. Semin Immunopathol 36(4):399\u2013420","journal-title":"Semin Immunopathol"},{"key":"3615_CR5","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.blre.2014.01.003","volume":"28","author":"SR Cataland","year":"2014","unstructured":"Cataland SR, Wu HM (2014) Diagnosis and management of complement mediated thrombotic microangiopathies. Blood Rev 28:67\u201374","journal-title":"Blood Rev"},{"issue":"1","key":"3615_CR6","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1053\/j.ajkd.2013.08.031","volume":"63","author":"E Cornec-Le Gall","year":"2014","unstructured":"Cornec-Le Gall E, Delmas Y, De Parscau L, Doucet L, Ogier H, Benoist JF, Fremeaux-Bacchi V, Le Meur Y (2014) Adult-onset eculizumab-resistant hemolytic uremic syndrome associated with cobalamin C deficiency. Am J Kidney Dis 63(1):119\u2013123","journal-title":"Am J Kidney Dis"},{"key":"3615_CR7","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1016\/S0140-6736(15)00076-8","volume":"386","author":"S Grang\u00e9","year":"2015","unstructured":"Grang\u00e9 S, Bekri S, Artaud-Macari E, Francois A, Girault C, Poitou AL, Benhamou Y, Vianey-Saban C, Benoist JF, Ch\u00e2telet V, Tamion F, Guerrot D (2015) Adult-onset renal thrombotic microangiopathy and pulmonary arterial hypertension in cobalamin C deficiency. Lancet 386:1011\u20131012","journal-title":"Lancet"},{"key":"3615_CR8","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1007\/s004310051190","volume":"158","author":"P Labrune","year":"1999","unstructured":"Labrune P, Zittoun J, Duvaltier I, Trioche P, Marquet J, Niaudet P, Odie \u00c1vre M (1999) Haemolytic uraemic syndrome and pulmonary hypertension in a patient with methionine synthase deficiency. Eur J Pediatr 158:734\u2013739","journal-title":"Eur J Pediatr"},{"issue":"6","key":"3615_CR9","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1007\/s00467-015-3078-6","volume":"30","author":"G Schalk","year":"2015","unstructured":"Schalk G, Kirschfink M, Wehling C, Gastoldi S, Bergmann C, Hoppe B, Weber LT (2015) A complicated case of atypical hemolytic uremic syndrome with frequent relapses under eculizumab. Pediatr Nephrol 30(6):1039\u20131042","journal-title":"Pediatr Nephrol"},{"key":"3615_CR10","first-page":"491","volume-title":"Hematology: basic principles and practice","author":"AC Antony","year":"2009","unstructured":"Antony AC (2009) Megaloblastic anemias. In: Hoffman R (ed) Hematology: basic principles and practice. Churchill Livingstone Elsevier, Philadelphia, pp 491\u2013524"},{"issue":"1","key":"3615_CR11","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s10545-011-9364-y","volume":"35","author":"N Carrillo-Carrasco","year":"2012","unstructured":"Carrillo-Carrasco N, Chandler RJ, Venditti CP (2012) Combined methylmalonic acidemia and homocystinuria, cblC type. I. Clinical presentations, diagnosis and management. J Inherit Metab Dis 35(1):91\u2013102","journal-title":"J Inherit Metab Dis"},{"key":"3615_CR12","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1086\/341354","volume":"71","author":"D Watkins","year":"2002","unstructured":"Watkins D, Ming Ru M, Hwang HY, Kim CD, Murray A, Philip NS, Kim W, Legakis H, Wai T, Hilton JF, Ge B, Dor\u00e9 C, Hosack A, Wilson A, Gravel RA, Shane B, Hudson TJ, Rosenblatt DS (2002) Hyperhomocysteinemia due to methionine synthase deficiency, cblG: structure of the MTR gene, genotype diversity, and recognition of a common mutation, P1173L. Am J Hum Genet 71:143\u2013153","journal-title":"Am J Hum Genet"},{"key":"3615_CR13","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1111\/j.1538-7836.2005.01364.x","volume":"3","author":"SR Lentz","year":"2005","unstructured":"Lentz SR (2005) Mechanisms of homocysteine-induced atherothrombosis. J Thromb Haemost 3:1646\u20131654","journal-title":"J Thromb Haemost"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-017-3615-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-017-3615-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-017-3615-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T12:10:14Z","timestamp":1492690214000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-017-3615-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,16]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["3615"],"URL":"https:\/\/doi.org\/10.1007\/s00467-017-3615-6","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,16]]}}}