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All five authors participated in editing the drafts of this manuscript. PM, GC, and DF assisted JL in the design and analysis of the manuscript and serve as primary mentors for JL\u2019s K23 award and TH serves as an advisory panel member.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Authorship statement"}},{"value":"GRC discloses the following: (1) participation in Data and Safety Monitoring Boards, as follows: Apotek, Biogen-Idec, Cleveland Clinic (Vivus), Glaxo Smith Klein Pharmaceuticals, Gilead Pharmaceuticals, Modigenetech\/Prolor, Merck\/Ono Pharmaceuticals, Merck, Merck\/Pfizer, Neuren, Sanofi-Aventis, Teva, Washington University, NHLBI (Protocol Review Committee), NINDS, NICHD (OPRU oversight committee); (2) participation on Consulting or Advisory Boards, as follows: Consortium of MS Centers (grant), D3 (Drug Discovery and Development), Genzyme, Jannsen Pharmaceuticals, Klein-Buendel Incorporated, Medimmune, Novartis, Opexa Therapeutics, Receptos, Roche, EMD Serono, Teva pharmaceuticals, Transparency Life Sciences. GRC is employed by the University of Alabama at Birmingham and President of Pythagoras, Inc. a private consulting company located in Birmingham, Alabama.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest statement"}}]}}