{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:17:11Z","timestamp":1773127031188,"version":"3.50.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T00:00:00Z","timestamp":1504656000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s00467-017-3780-7","type":"journal-article","created":{"date-parts":[[2017,9,6]],"date-time":"2017-09-06T22:53:00Z","timestamp":1504738380000},"page":"1641-1649","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Difficult-to-treat idiopathic nephrotic syndrome: established drugs, open questions and future options"],"prefix":"10.1007","volume":"33","author":[{"given":"Markus J.","family":"Kemper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Valentin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"van Husen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,9,6]]},"reference":[{"key":"3780_CR1","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1681\/ASN.2014050489","volume":"26","author":"CE Sadowski","year":"2015","unstructured":"Sadowski CE, Lovric S, Ashraf S, Pabst WL, Gee HY, Kohl S, Engelmann S, Vega-Warner V, Fang H, Halbritter J, Somers MJ, Tan W, Shril S, Fessi I, Lifton RP, Bockenhauer D, El-Desoky S, Kari JA, Zenker M, Kemper MJ, Mueller D, Fathy HM, Soliman NA, SNRS Study Group, Hildebrandt F (2015) A single-gene cause in 29.5% of cases of steroid-resistant nephrotic syndrome. J Am Soc Nephrol 26:1279\u20131289","journal-title":"J Am Soc Nephrol"},{"key":"3780_CR2","doi-asserted-by":"crossref","unstructured":"Hodson EM, Willis NS, Craig JC (2007) Corticosteroid therapy for nephrotic syndrome in children. Cochrane Database Syst Rev (4):CD001533","DOI":"10.1002\/14651858.CD001533.pub4"},{"key":"3780_CR3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1681\/ASN.2012070646","volume":"24","author":"N Teeninga","year":"2012","unstructured":"Teeninga N (2012) Extending prednisolone treatment does not reduce relapses in childhood nephrotic syndrome. J Am Soc Nephrol 24:149\u2013159","journal-title":"J Am Soc Nephrol"},{"key":"3780_CR4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/ki.2014.260","volume":"87","author":"N Yoshikawa","year":"2015","unstructured":"Yoshikawa N, Nakanishi K, Sako M, Oba MS, Mori R, Ota E, Ishikura K, Hataya H, Honda M, Ito S, Shima Y, Kaito H, Nozu K, Nakamura H, Igarashi T, Ohashi Y, Iijima K, Japanese Study Group of Kidney Disease in Children (2015) A multicenter randomized trial indicates initial prednisolone treatment for childhood nephrotic syndrome for two months is not inferior to six-month treatment. Kidney Int 87:225\u2013232","journal-title":"Kidney Int"},{"key":"3780_CR5","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1681\/ASN.2005090922","volume":"17","author":"PF Hoyer","year":"2006","unstructured":"Hoyer PF, Brodeh J (2006) Initial treatment of idiopathic nephrotic syndrome in children: prednisone versus prednisone plus cyclosporine a: a prospective, randomized trial. J Am Soc Nephrol 17:1151\u20131157","journal-title":"J Am Soc Nephrol"},{"key":"3780_CR6","unstructured":"Gruppen M, Davin J, Bouts A (2016) Levamisole increases the time to relapse in children with steroid-sensitive idiopathic nephrotic syndrome: results of a multi-center, double-blind, placebo-controlled, randomized clinical trial. Pediatr Nephrol 31:1753"},{"key":"3780_CR7","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1007\/s00467-017-3616-5","volume":"32","author":"AS Abeyagunawardena","year":"2017","unstructured":"Abeyagunawardena AS, Karunadasa U, Jayaweera H, Thalgahagoda S, Tennakoon S, Abeyagunawardena S (2017) Efficacy of higher-dose levamisole in maintaining remission in steroid-dependent nephrotic syndrome. Pediatr Nephrol 32:1363\u20131367","journal-title":"Pediatr Nephrol"},{"key":"3780_CR8","doi-asserted-by":"crossref","unstructured":"Van Husen M, Kemper MJ (2011) New therapies in steroid-sensitive and steroid-resistant idiopathic nephrotic syndrome. Pediatr Nephrol 26:881\u2013892","DOI":"10.1007\/s00467-010-1717-5"},{"key":"3780_CR9","doi-asserted-by":"crossref","unstructured":"Gellermann J, Weber L, Pape L, Tonshoff B, Hoyer P, Querfeld U, Gesellschaft f\u00fcr P\u00e4diatrische Nephrologie (2013) Mycophenolate mofetil versus cyclosporin a in children with frequently relapsing nephrotic syndrome. J Am Soc Nephrol 24:1689\u20131697","DOI":"10.1681\/ASN.2012121200"},{"key":"3780_CR10","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.kint.2017.01.019","volume":"92","author":"A Sinha","year":"2017","unstructured":"Sinha A, Gupta A, Kalaivani M, Hari P, Dinda AK, Bagga A (2017) Mycophenolate mofetil is inferior to tacrolimus in sustaining remission in children with idiopathic steroid-resistant nephrotic syndrome. Kidney Int 92:248\u2013267","journal-title":"Kidney Int"},{"key":"3780_CR11","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1007\/s00467-013-2529-1","volume":"29","author":"MJ Kemper","year":"2014","unstructured":"Kemper MJ, Lehnhardt A, Zawischa A, Oh J (2014) Is rituximab effective in childhood nephrotic syndrome? Yes and no. Pediatr Nephrol 29:1305\u20131311","journal-title":"Pediatr Nephrol"},{"key":"3780_CR12","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s40124-014-0065-5","volume":"3","author":"K Iijima","year":"2015","unstructured":"Iijima K, Sako M, Nozu K (2015) Rituximab treatment for nephrotic syndrome in children. Curr Pediatr Rep 3:71\u201377","journal-title":"Curr Pediatr Rep"},{"key":"3780_CR13","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s10157-016-1313-5","volume":"21","author":"K Iijima","year":"2017","unstructured":"Iijima K, Sako M, Nozu K (2017) Rituximab for nephrotic syndrome in children. Clin Exp Nephrol 21:193\u2013202","journal-title":"Clin Exp Nephrol"},{"key":"3780_CR14","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/ndt\/gfu267","volume":"30","author":"A Sinha","year":"2015","unstructured":"Sinha A, Bhatia D, Gulati A, Rawat M, Dinda AK, Hari P, Bagga A (2015) Efficacy and safety of rituximab in children with difficult-to-treat nephrotic syndrome. Nephrol Dial Transplant 30:96\u2013106","journal-title":"Nephrol Dial Transplant"},{"key":"3780_CR15","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1093\/ndt\/gfr548","volume":"27","author":"MJ Kemper","year":"2012","unstructured":"Kemper MJ, Gellermann J, Habbig S, Krmar RT, Dittrich K, Jungraithmayr T, Pape L, Patzer L, Billing H, Weber L, Pohl M, Rosenthal K, Rosahl A, Mueller-Wiefel DE, Dotsch J (2012) Long-term follow-up after rituximab for steroid-dependent idiopathic nephrotic syndrome. Nephrol Dial Transplant 27:1910\u20131915","journal-title":"Nephrol Dial Transplant"},{"key":"3780_CR16","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S0140-6736(14)60541-9","volume":"384","author":"K Iijima","year":"2014","unstructured":"Iijima K, Sako M, Nozu K, Mori R, Tuchida N, Kamei K, Miura K, Aya K, Nakanishi K, Ohtomo Y, Takahashi S, Tanaka R, Kaito H, Nakamura H, Ishikura K, Ito S, Ohashi Y, Rituximab for Childhood-onset Refractory Nephrotic Syndrome Study Group (2014) Rituximab for childhood-onset, complicated, frequently relapsing nephrotic syndrome or steroid-dependent nephrotic syndrome: a multicentre, double-blind, randomised, placebo-controlled trial. Lancet 384:1273\u20131281","journal-title":"Lancet"},{"key":"3780_CR17","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1007\/s00467-009-1191-0","volume":"24","author":"K Kamei","year":"2009","unstructured":"Kamei K, Ito S, Nozu K, Fujinaga S, Nakayama M, Sako M, Saito M, Yoneko M, Iijima K (2009) Single dose of rituximab for refractory steroid-dependent nephrotic syndrome in children. Pediatr Nephrol 24:1321\u20131328","journal-title":"Pediatr Nephrol"},{"key":"3780_CR18","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1093\/ndt\/gfr405","volume":"27","author":"AL Sellier-Leclerc","year":"2012","unstructured":"Sellier-Leclerc AL, Baudouin V, Kwon T, Macher MA, Guerin V, Lapillonne H, Deschenes G, Ulinski T (2012) Rituximab in steroid-dependent idiopathic nephrotic syndrome in childhood\u2014follow-up after CD19 recovery. Nephrol Dial Transplant 27:1083\u20131089","journal-title":"Nephrol Dial Transplant"},{"key":"3780_CR19","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1681\/ASN.2015050523","volume":"27","author":"M Colucci","year":"2016","unstructured":"Colucci M, Carsetti R, Cascioli S, Casiraghi F, Perna A, Rava L, Ruggiero B, Emma F, Vivarelli M (2016) B cell reconstitution after rituximab treatment in idiopathic nephrotic syndrome. J Am Soc Nephrol 27:1811\u20131822","journal-title":"J Am Soc Nephrol"},{"key":"3780_CR20","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00467-012-2319-1","volume":"28","author":"S Ito","year":"2013","unstructured":"Ito S, Kamei K, Ogura M, Udagawa T, Fujinaga S, Saito M, Sako M, Iijima K (2013) Survey of rituximab treatment for childhood-onset refractory nephrotic syndrome. Pediatr Nephrol 28:257\u2013264","journal-title":"Pediatr Nephrol"},{"key":"3780_CR21","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00467-007-0596-x","volume":"23","author":"J Dotsch","year":"2008","unstructured":"Dotsch J, Muller-Wiefel DE, Kemper MJ (2008) Rituximab: is replacement of cyclophosphamide and calcineurin inhibitors in steroid-dependent nephrotic syndrome possible? Pediatr Nephrol 23:3\u20137","journal-title":"Pediatr Nephrol"},{"key":"3780_CR22","doi-asserted-by":"crossref","first-page":"2259","DOI":"10.1681\/ASN.2014080799","volume":"26","author":"P Ravani","year":"2015","unstructured":"Ravani P, Rossi R, Bonanni A, Quinn RR, Sica F, Bodria M, Pasini A, Montini G, Edefonti A, Belingheri M, De Giovanni D, Barbano G, Degl'Innocenti L, Scolari F, Murer L, Reiser J, Fornoni A, Ghiggeri GM (2015) Rituximab in children with steroid-dependent nephrotic syndrome: a multicenter, open-label, noninferiority, randomized controlled trial. J Am Soc Nephrol 26:2259\u20132266","journal-title":"J Am Soc Nephrol"},{"key":"3780_CR23","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1517\/14740338.4.3.599","volume":"4","author":"Y Tsutsumi","year":"2005","unstructured":"Tsutsumi Y, Kanamori H, Mori A, Tanaka J, Asaka M, Imamura M, Masauzi N (2005) Reactivation of hepatitis B virus with rituximab. Expert Opin Drug Saf 4:599\u2013608","journal-title":"Expert Opin Drug Saf"},{"key":"3780_CR24","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1007\/s00467-009-1195-9","volume":"24","author":"MC Chaumais","year":"2009","unstructured":"Chaumais MC, Garnier A, Chalard F, Peuchmaur M, Dauger S, Jacqz-Agrain E, Deschenes G (2009) Fatal pulmonary fibrosis after rituximab administration. Pediatr Nephrol 24:1753\u20131755","journal-title":"Pediatr Nephrol"},{"key":"3780_CR25","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00467-014-2765-z","volume":"29","author":"K Kamei","year":"2014","unstructured":"Kamei K, Okada M, Sato M, Fujimaru T, Ogura M, Nakayama M, Kaito H, Iijima K, Ito S (2014) Rituximab treatment combined with methylprednisolone pulse therapy and immunosuppressants for childhood steroid-resistant nephrotic syndrome. Pediatr Nephrol 29:1181\u20131187","journal-title":"Pediatr Nephrol"},{"key":"3780_CR26","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/ki.2011.195","volume":"80","author":"DS Gipson","year":"2011","unstructured":"Gipson DS, Trachtman H, Kaskel FJ, Greene TH, Radeva MK, Gassman JJ, Moxey-Mims MM, Hogg RJ, Watkins SL, Fine RN, Hogan SL, Middleton JP, Vehaskari VM, Flynn PA, Powell LM, Vento SM, McMahan JL, Siegel N, D\u2019Agati VD, Friedman AL (2011) Clinical trial of focal segmental glomerulosclerosis in children and young adults. Kidney Int 80:868\u2013878","journal-title":"Kidney Int"},{"key":"3780_CR27","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1007\/s00467-008-0794-1","volume":"23","author":"C Plank","year":"2008","unstructured":"Plank C, Kalb V, Hinkes B, Hildebrandt F, Gefeller O, Rascher W (2008) Cyclosporin A is superior to cyclophosphamide in children with steroid-resistant nephrotic syndrome\u2014a randomized controlled multicentre trial by the Arbeitsgemeinschaft f\u00fcr P\u00e4diatrische Nephrologie. Pediatr Nephrol 23:1483","journal-title":"Pediatr Nephrol"},{"key":"3780_CR28","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.2215\/CJN.01190210","volume":"5","author":"AK B\u00fcscher","year":"2010","unstructured":"B\u00fcscher AK, Kranz B, B\u00fcscher R, Hildebrandt F, Dworniczak B, Pennekamp P, Kuwertz-Broking E, Wingen AM, John U, Kemper M, Monnens L, Hoyer PF, Weber S, Konrad M (2010) Immunosuppression and renal outcome in congenital and pediatric steroid-resistant nephrotic syndrome. Clin J Am Soc Nephrol 5:2075\u20132084","journal-title":"Clin J Am Soc Nephrol"},{"key":"3780_CR29","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1007\/s00467-015-3109-3","volume":"30","author":"I Klaassen","year":"2015","unstructured":"Klaassen I, Ozgoren B, Sadowski CE, Moller K, van Husen M, Lehnhardt A, Timmermann K, Freudenberg F, Helmchen U, Oh J, Kemper MJ (2015) Response to cyclosporine in steroid-resistant nephrotic syndrome: discontinuation is possible. Pediatr Nephrol 30:1477\u20131483","journal-title":"Pediatr Nephrol"},{"key":"3780_CR30","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1056\/NEJMc063706","volume":"356","author":"A Bagga","year":"2007","unstructured":"Bagga A, Sinha A, Moudgil A (2007) Rituximab in patients with the steroid-resistant nephrotic syndrome. N Engl J Med 356:2751\u20132752","journal-title":"N Engl J Med"},{"key":"3780_CR31","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1681\/ASN.2011080775","volume":"23","author":"A Magnasco","year":"2012","unstructured":"Magnasco A, Ravani P, Edefonti A, Murer L, Ghio L, Belingheri M, Benetti E, Murtas C, Messina G, Massella L, Porcellini MG, Montagna M, Regazzi M, Scolari F, Ghiggeri GM (2012) Rituximab in children with resistant idiopathic nephrotic syndrome. J Am Soc Nephrol 23:1117\u20131124","journal-title":"J Am Soc Nephrol"},{"key":"3780_CR32","doi-asserted-by":"crossref","first-page":"e132","DOI":"10.1542\/peds.2015-0486","volume":"136","author":"B Basu","year":"2015","unstructured":"Basu B, Mahapatra TK, Mondal N (2015) Mycophenolate mofetil following rituximab in children with steroid-resistant nephrotic syndrome. Pediatrics 136:e132\u2013e139","journal-title":"Pediatrics"},{"key":"3780_CR33","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nm.1857","volume":"14","author":"C Faul","year":"2008","unstructured":"Faul C, Donnelly M, Merscher-Gomez S, Chang YH, Franz S, Delfgaauw J, Chang JM, Choi HY, Campbell KN, Kim K, Reiser J, Mundel P (2008) The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A. Nat Med 14:931\u2013938","journal-title":"Nat Med"},{"key":"3780_CR34","doi-asserted-by":"crossref","first-page":"85ra46","DOI":"10.1126\/scitranslmed.3002231","volume":"3","author":"A Fornoni","year":"2011","unstructured":"Fornoni A, Sageshima J, Wei C, Merscher-Gomez S, Aguillon-Prada R, Jauregui AN, Li J, Mattiazzi A, Ciancio G, Chen L, Zilleruelo G, Abitbol C, Chandar J, Seeherunvong W, Ricordi C, Ikehata M, Rastaldi MP, Reiser J, Burke GW 3rd (2011) Rituximab targets podocytes in recurrent focal segmental glomerulosclerosis. Sci Transl Med 3:85ra46","journal-title":"Sci Transl Med"},{"key":"3780_CR35","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2215\/CJN.07370715","volume":"11","author":"AK B\u00fcscher","year":"2016","unstructured":"B\u00fcscher AK, Beck BB, Melk A, Hoefele J, Kranz B, Bamborschke D, Baig S, Lange-Sperandio B, Jungraithmayr T, Weber LT, Kemper MJ, Tonshoff B, Hoyer PF, Konrad M, Weber S, German Pediatric Nephrology A (2016) Rapid response to Cyclosporin A and favorable renal outcome in nongenetic versus genetic steroid-resistant nephrotic syndrome. Clin J Am Soc Nephrol 11:245\u2013253","journal-title":"Clin J Am Soc Nephrol"},{"key":"3780_CR36","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1056\/NEJMc1308488","volume":"370","author":"B Basu","year":"2014","unstructured":"Basu B (2014) Ofatumumab for rituximab-resistant nephrotic syndrome. N Engl J Med 370:1268\u20131270","journal-title":"N Engl J Med"},{"key":"3780_CR37","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-013319","volume":"7","author":"P Ravani","year":"2017","unstructured":"Ravani P, Bonanni A, Ghiggeri GM (2017) Randomised controlled trial comparing ofatumumab to rituximab in children with steroid-dependent and calcineurin inhibitor-dependent idiopathic nephrotic syndrome: study protocol. BMJ Open 7:e013319","journal-title":"BMJ Open"},{"key":"3780_CR38","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00467-016-3498-y","volume":"32","author":"M Vivarelli","year":"2017","unstructured":"Vivarelli M, Colucci M, Bonanni A, Verzani M, Serafinelli J, Emma F, Ghiggeri G (2017) Ofatumumab in two pediatric nephrotic syndrome patients allergic to rituximab. Pediatr Nephrol 32:181\u2013184","journal-title":"Pediatr Nephrol"},{"key":"3780_CR39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0138343","volume":"10","author":"A Bonanni","year":"2015","unstructured":"Bonanni A, Bertelli R, Rossi R, Bruschi M, Di Donato A, Ravani P, Ghiggeri GM (2015) A pilot study of IL2 in drug-resistant idiopathic nephrotic syndrome. PLoS One 10:e0138343","journal-title":"PLoS One"},{"key":"3780_CR40","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1038\/ki.2011.33","volume":"79","author":"H Trachtman","year":"2011","unstructured":"Trachtman H, Fervenza FC, Gipson DS, Heering P, Jayne DR, Peters H, Rota S, Remuzzi G, Rump LC, Sellin LK, Heaton JP, Streisand JB, Hard ML, Ledbetter SR, Vincenti F (2011) A phase 1, single-dose study of fresolimumab, an anti-TGF-beta antibody, in treatment-resistant primary focal segmental glomerulosclerosis. Kidney Int 79:1236\u20131243","journal-title":"Kidney Int"},{"key":"3780_CR41","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1056\/NEJMoa1304572","volume":"369","author":"CC Yu","year":"2013","unstructured":"Yu CC, Fornoni A, Weins A, Hakroush S, Maiguel D, Sageshima J, Chen L, Ciancio G, Faridi MH, Behr D, Campbell KN, Chang JM, Chen HC, Oh J, Faul C, Arnaout MA, Fiorina P, Gupta V, Greka A, Burke GW 3rd, Mundel P (2013) Abatacept in B7-1-positive proteinuric kidney disease. N Engl J Med 369:2416\u20132423","journal-title":"N Engl J Med"},{"key":"3780_CR42","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1681\/ASN.2015091002","volume":"27","author":"M Delville","year":"2016","unstructured":"Delville M, Baye E, Durrbach A, Audard V, Kofman T, Braun L, Olagne J, Nguyen C, Deschenes G, Moulin B, Delahousse M, Kesler-Roussey G, Beaudreuil S, Martinez F, Rabant M, Grimbert P, Gallazzini M, Terzi F, Legendre C, Canaud G (2016) B7-1 blockade does not improve post-transplant nephrotic syndrome caused by recurrent FSGS. J Am Soc Nephrol 27:2520\u20132527","journal-title":"J Am Soc Nephrol"},{"key":"3780_CR43","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s40620-016-0308-3","volume":"30","author":"KV Lieberman","year":"2017","unstructured":"Lieberman KV, Pavlova-Wolf A (2017) Adrenocorticotropic hormone therapy for the treatment of idiopathic nephrotic syndrome in children and young adults: a systematic review of early clinical studies with contemporary relevance. J Nephrol 30:35\u201344","journal-title":"J Nephrol"},{"key":"3780_CR44","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/ckj\/sfw045","volume":"9","author":"W Kittanamongkolchai","year":"2016","unstructured":"Kittanamongkolchai W, Cheungpasitporn W, Zand L (2016) Efficacy and safety of adrenocorticotropic hormone treatment in glomerular diseases: a systematic review and meta-analysis. Clin Kidney J 9:387\u2013396","journal-title":"Clin Kidney J"},{"key":"3780_CR45","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12882-016-0241-7","volume":"17","author":"A Madan","year":"2016","unstructured":"Madan A, Mijovic-Das S, Stankovic A, Teehan G, Milward AS, Khastgir A (2016) Acthar gel in the treatment of nephrotic syndrome: a multicenter retrospective case series. BMC Nephrol 17:37","journal-title":"BMC Nephrol"},{"key":"3780_CR46","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12882-015-0094-5","volume":"16","author":"H Trachtman","year":"2015","unstructured":"Trachtman H, Vento S, Herreshoff E, Radeva M, Gassman J, Stein DT, Savin VJ, Sharma M, Reiser J, Wei C, Somers M, Srivastava T, Gipson DS (2015) Efficacy of galactose and adalimumab in patients with resistant focal segmental glomerulosclerosis: report of the font clinical trial group. BMC Nephrol 16:111","journal-title":"BMC Nephrol"},{"key":"3780_CR47","doi-asserted-by":"publisher","unstructured":"Lemley KV, Faul C, Schramm K, Meyers K, Kaskel F, Dell KM, Gipson DS, Gibson K, Trachtman H (2016) The effect of a gluten-free diet in children with difficult-to-manage nephrotic syndrome. Pediatrics. 138(1):e20154528. https:\/\/doi.org\/10.1542\/peds.2015-4528","DOI":"10.1542\/peds.2015-4528"},{"key":"3780_CR48","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S0140-6736(77)92603-4","volume":"1","author":"DH Sandberg","year":"1977","unstructured":"Sandberg DH, Bernstein CW, McIntosh RM, Carr R, Strauss J (1977) Severe steroid-responsive nephrosis associated with hypersensitivity. Lancet 1:388\u2013391","journal-title":"Lancet"},{"key":"3780_CR49","doi-asserted-by":"crossref","first-page":"21","DOI":"10.5414\/CN108915","volume":"87","author":"J Deng","year":"2017","unstructured":"Deng J, Zheng X, Xie H, Chen L (2017) Calcitriol in the treatment of IgA nephropathy with non-nephrotic range proteinuria: a meta-analysis of randomized controlled trials. Clin Nephrol 87:21\u201327","journal-title":"Clin Nephrol"},{"key":"3780_CR50","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1007\/s00467-013-2511-y","volume":"28","author":"S Banerjee","year":"2013","unstructured":"Banerjee S, Basu S, Sengupta J (2013) Vitamin D in nephrotic syndrome remission: a case-control study. Pediatr Nephrol 28:1983\u20131989","journal-title":"Pediatr Nephrol"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-017-3780-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-017-3780-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-017-3780-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T05:54:47Z","timestamp":1570082087000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-017-3780-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,6]]},"references-count":50,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["3780"],"URL":"https:\/\/doi.org\/10.1007\/s00467-017-3780-7","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,6]]}}}