{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:12:17Z","timestamp":1793121137354,"version":"4.5.0"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T00:00:00Z","timestamp":1530316800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Argentine Pediatric Society"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s00467-018-3991-6","type":"journal-article","created":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T12:51:30Z","timestamp":1530363090000},"page":"1791-1798","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Hyponatremia: a new predictor of mortality in patients with Shiga toxin-producing Escherichia coli hemolytic uremic syndrome"],"prefix":"10.1007","volume":"33","author":[{"given":"Laura F.","family":"Alconcher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula A.","family":"Coccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela del C.","family":"Suarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta L.","family":"Monteverde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Graciela","family":"Perez y Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula M.","family":"Carlopio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mabel L.","family":"Missoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Balestracci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Illiana","family":"Principi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia B.","family":"Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Estrella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Micelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela C.","family":"Leroy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahir E.","family":"Quijada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Seminara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta I.","family":"Giordano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana B.","family":"Hidalgo Sol\u00eds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Saurit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Caminitti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Arias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Rivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Risso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Liern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,30]]},"reference":[{"key":"3991_CR1","unstructured":"National System of Procurement and Transplant Information of the Argentine Republic. [Home page on Internet]. Report of patients registered on the waiting list. [Update July 1st, 2017] Available from: \n                    http:\/\/www.sintra.incucai.gov.ar"},{"key":"3991_CR2","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1016\/S0022-3476(64)80337-1","volume":"64","author":"C Gianantonio","year":"1964","unstructured":"Gianantonio C, Vitacco M, Mendilaharzu F, Rutty A, Mendilaharzu J (1964) The hemolytic uremic syndrome. J Pediatr 64:478\u2013491","journal-title":"J Pediatr"},{"key":"3991_CR3","doi-asserted-by":"publisher","first-page":"1656","DOI":"10.1542\/peds.2005-0785","volume":"117","author":"RS Oakes","year":"2006","unstructured":"Oakes RS, Siegler RL, McReynolds MA, Pysher T, Pavia AT (2006) Predictors of fatality in postdiarrheal hemolytic uremic syndrome. Pediatrics 117:1656\u20131662","journal-title":"Pediatrics"},{"key":"3991_CR4","doi-asserted-by":"crossref","unstructured":"Mody RK, Gu W, Griffin PM, Jones TF, Rounds J, Shiferaw B, Tobin-D\u2019Angelo M, Smith G, Spina S, Hurd S, Lathrop S, Palmer A, Boothe E, Luna-Gierke RE, Hoekstra RM (2015) Post diarrheal hemolytic uremic syndrome in United States children: clinical spectrum and predictors of in-hospital death. J Pediatr 166:1022\u20131029","DOI":"10.1016\/j.jpeds.2014.12.064"},{"key":"3991_CR5","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/s00467-011-1973-z","volume":"27","author":"RC Rahman","year":"2012","unstructured":"Rahman RC, Cobe\u00f1as CJ, Drut R, Amoreo OR, Ruscasso JD, Spizzirri AP, Suarez A, Zalba JH, Ferrari C, Gatti M (2012) Hemorragic colitis in post diarrheal hemolityc uremic syndrome: retrospective analysis of 54 children. Pediatr Nephrol 27:229\u2013233","journal-title":"Pediatr Nephrol"},{"key":"3991_CR6","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.2215\/CJN.08921209","volume":"5","author":"S Nathanson","year":"2010","unstructured":"Nathanson S, Kwon T, Launay Elmaleh M, Charbit EA, Harambat J, Brun M, Ranchin B, Bandin F, Cloarec S, Bourdat-Michele G, Pi\u00e8trement C, Champion G, Ulinski T, Desch\u00eanes G (2010) Acute neurological involvement in diarrhea-associated hemolytic uremic syndrome. Clin J Am Soc Nephrol 5:1218\u20131288","journal-title":"Clin J Am Soc Nephrol"},{"key":"3991_CR7","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s00467-014-2918-0","volume":"30","author":"G Ardissino","year":"2015","unstructured":"Ardissino G, Dacc\u00f2 V, Testa S, Civitillo CF, Tel F, Possenti I, Belingheri M, Castorina P, Bolsa-Ghirenghelli N, Tedeschi S, Paglialonga F, Salardi S, Consonni D, Zoia E, Salice P, Chidini G (2015) Hemoconcentration: a major risk factor for neurological involvement in hemolytic uremic syndrome. Pediatr Nephrol 30:345\u2013352","journal-title":"Pediatr Nephrol"},{"key":"3991_CR8","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1111\/j.1442-200X.2008.02605.x","volume":"50","author":"I Kamioka","year":"2008","unstructured":"Kamioka I, Yoshiya K, Satomura K, Kaito H, Fujita T, Iijima K, Nakanishi K, Yoshikawa N, Nozu K, Matsuo M, Japanese Society for Pediatric Nephrology (2008) Risk factor for developing severe clinical course in HUS patients: a national survey in Japan. Pediatr Int 50:441\u2013446","journal-title":"Pediatr Int"},{"key":"3991_CR9","doi-asserted-by":"crossref","unstructured":"Mildford D, Taylor CM (1989) Hyponatremia and haemolytic uraemic syndrome. [Letter] Lancet 25: 439","DOI":"10.1016\/S0140-6736(89)90033-0"},{"key":"3991_CR10","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1681\/ASN.2012020128","volume":"23","author":"HJ Adrogu\u00e9","year":"2012","unstructured":"Adrogu\u00e9 HJ, Madias NE (2012) The challenge of hyponatremia. J Am Soc Nephrol 23:1140\u20131148","journal-title":"J Am Soc Nephrol"},{"key":"3991_CR11","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1007\/s00467-012-2158-0","volume":"27","author":"A Balestracci","year":"2012","unstructured":"Balestracci A, Martin SM, Toledo I, Alvarado C, Wainstein RE (2012) Dehydration at admission increased the need for dialysis in hemolytic uremic syndrome children. Pediatr Nephrol 27:1407\u20131410","journal-title":"Pediatr Nephrol"},{"key":"3991_CR12","doi-asserted-by":"crossref","unstructured":"Grisaru S, Xle J, Samuel S, Hartling L, Tarr PE, Schnadower D, Freedman SB (2017) Associations between hydration status, intravenous fluid administration, and outcomes of patients infected with Shiga toxin-producing Escherichia coli A systematic review and meta-analysis. JAMA Pediatr Jan1;171(1):68\u201376","DOI":"10.1001\/jamapediatrics.2016.2952"},{"issue":"1","key":"3991_CR13","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1203\/01.pdr.0000250037.47169.55","volume":"61","author":"GC Fern\u00e1ndez","year":"2007","unstructured":"Fern\u00e1ndez GC, G\u00f3mez SA, Ramos MV, Betancor LV, Fernandez Brando RJ, Landoni VI, Lopez L, Ramirez F, Diaz M, Alduncin M, Grimoldi I, Exeni R, Isturiz MA, Palermo MS (2007) The functional state of neutrophils correlates with the severity of renal dysfunction in children with hemolytic uremic syndrome. Pediatr Res 61(1):123\u2013128","journal-title":"Pediatr Res"},{"key":"3991_CR14","doi-asserted-by":"crossref","unstructured":"Ninchoji T, Nozu1 K, Nakanishi K, Horinouchi T, Fujimura J, Yamamura T, Minamikawa S, Ishimori S, Nakanishi K, Yoshikawa N, Ninchoji T, Nozu1 K, Nakanishi K, Horinouchi T, Fujimura J, Yamamura T, Minamikawa S, Ishimori S, Nakanishi K, Yoshikawa N (2017) Clinical characteristics and long-term outcome of diarrhea associated hemolytic uremic syndrome: a single center experience. Clin Exp Nephrol 21:889\u2013894","DOI":"10.1007\/s10157-016-1376-3"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-018-3991-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-018-3991-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-018-3991-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T19:26:01Z","timestamp":1561836361000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-018-3991-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,30]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["3991"],"URL":"https:\/\/doi.org\/10.1007\/s00467-018-3991-6","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,30]]},"assertion":[{"value":"13 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 May 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 June 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This was a multicentric, observational, retrospective and cross-sectional study. This study was approved by the Review Boards and Ethics Committees of the hospitals. The requirement to obtain informed consent was waived by the institutional review boards.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}