{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:41:49Z","timestamp":1790743309428,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2018,9,10]],"date-time":"2018-09-10T00:00:00Z","timestamp":1536537600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1007\/s00467-018-4055-7","type":"journal-article","created":{"date-parts":[[2018,9,9]],"date-time":"2018-09-09T23:33:19Z","timestamp":1536535999000},"page":"129-135","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cinacalcet as rescue therapy for refractory hyperparathyroidism in young children with advanced chronic kidney disease"],"prefix":"10.1007","volume":"34","author":[{"given":"Aura J.","family":"Arenas Morales","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa J.","family":"DeFreitas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chryso P.","family":"Katsoufis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wacharee","family":"Seeherunvong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayanthi","family":"Chandar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaston","family":"Zilleruelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Freundlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0984-3771","authenticated-orcid":false,"given":"Carolyn L.","family":"Abitbol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,9,10]]},"reference":[{"key":"4055_CR1","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1093\/ndt\/gfn542","volume":"24","author":"A Kramer","year":"2009","unstructured":"Kramer A, Stel VS, Tizard J, Verrina E, R\u00f6nnholm K, P\u00e1lsson R, Maxwell H, Jager KJ (2009) Characteristics and survival of young adults who started renal replacement therapy during childhood. Nephrol Dial Transplant 24:926\u2013933","journal-title":"Nephrol Dial Transplant"},{"key":"4055_CR2","doi-asserted-by":"publisher","first-page":"1921","DOI":"10.1001\/jama.2013.4208","volume":"309","author":"MM Mitsnefes","year":"2013","unstructured":"Mitsnefes MM, Laskin BL, Dahhou M, Zhang X, Foster BJ (2013) Mortality risk among children initially treated with dialysis for end-stage kidney disease, 1990\u20132010. JAMA 309:1921\u20131929","journal-title":"JAMA"},{"key":"4055_CR3","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1542\/peds.109.5.909","volume":"109","author":"SL Furth","year":"2002","unstructured":"Furth SL, Stablein D, Fine RN, Powe NR, Fivush BA (2002) Adverse clinical outcomes associated with short stature at dialysis initiation: a report of the North American pediatric renal transplant Cooperative study. Pediatrics 109:909\u2013913","journal-title":"Pediatrics"},{"issue":"7","key":"4055_CR4","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1007\/s00467-017-3579-6","volume":"32","author":"NJA Webb","year":"2017","unstructured":"Webb NJA, Lerner G, Warady BA, Dell KM, Greenbaum LA, Ariceta G, Hoppe B, Linde P, Lee HJ, Eldred A, Dufek MB (2017) Efficacy and safety of paricalcitol in children with stages 3 to 5 chronic kidney disease. Pediatr Nephrol 32(7):1221\u20131232","journal-title":"Pediatr Nephrol"},{"issue":"7","key":"4055_CR5","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1007\/s00467-017-3675-7","volume":"32","author":"M Freundlich","year":"2017","unstructured":"Freundlich M, Abitbol CL (2017) Oral paricalcitol: expanding therapeutic options for pediatric chronic kidney disease patients. Pediatr Nephrol 32(7):1103\u20131108","journal-title":"Pediatr Nephrol"},{"key":"4055_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.kisu.2017.04.001","volume":"7","author":"KDIGO","year":"2017","unstructured":"KDIGO (2017) Clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease-mineral and bone disorder (CKD-MBD). Kidney Int Suppl 7:1\u201359","journal-title":"Kidney Int Suppl"},{"issue":"10","key":"4055_CR7","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1007\/s00467-008-0900-4","volume":"23","author":"G Schlieper","year":"2008","unstructured":"Schlieper G, Floege J (2008) Calcimimetics in CKD-results from recent clinical studies. Pediatr Nephrol 23(10):1721\u20131728","journal-title":"Pediatr Nephrol"},{"key":"4055_CR8","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1007\/s00467-007-0742-5","volume":"23","author":"DM Silverstein","year":"2008","unstructured":"Silverstein DM, Kher KK, Moudgil A, Khurana M, Wilcox J, Moylan K (2008) Cinacalcet is efficacious in paediatric dialysis patients. Pediatr Nephrol 23:1817\u20131822","journal-title":"Pediatr Nephrol"},{"issue":"10","key":"4055_CR9","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1007\/s00467-008-0810-5","volume":"23","author":"J Muscheites","year":"2008","unstructured":"Muscheites J, Wigger M, Drueckler E, Fischer DC, Kundt G, Haffner D (2008) Cinacalcet for secondary hyperparathyroidism in children with end-stage renal disease. Pediatr Nephrol 23(10):1823\u20131829","journal-title":"Pediatr Nephrol"},{"issue":"1","key":"4055_CR10","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1096\/fj.03-0294fje","volume":"18","author":"S Wu","year":"2004","unstructured":"Wu S, Palese T, Mishra OP, Delivoria-Papadopoulos M, De Luca F (2004) Effects of Ca2+ sensing receptor activation in the growth plate. FASEB J 18(1):143\u2013145","journal-title":"FASEB J"},{"key":"4055_CR11","doi-asserted-by":"publisher","first-page":"2761","DOI":"10.1093\/ndt\/gfn143","volume":"23","author":"K Nakagawa","year":"2008","unstructured":"Nakagawa K, P\u00e9rez EC, Oh J, Santos F, Geldyyev A, Gross ML, Schaefer F, Schmitt CP (2008) Cinacalcet does not affect longitudinal growth but increases body weight gain in experimental uraemia. Nephrol Dial Transplant 23:2761\u20132767","journal-title":"Nephrol Dial Transplant"},{"key":"4055_CR12","unstructured":"Edney A (2013) Amgen pediatric trials of Sensipar halted by FDA after death. Businessweek \n                    https:\/\/www.bloomberg.com\/news\/articles\/2013-02-26\/amgen-pediatric-trials-of-sensipar-halted-by-fda-after-death-1-\n                    \n                  . Accessed 11 Dec 2017"},{"issue":"6","key":"4055_CR13","doi-asserted-by":"publisher","first-page":"e20163789","DOI":"10.1542\/peds.2016-3789","volume":"140","author":"Tarak Srivastava","year":"2017","unstructured":"Srivastava T, Jafri S, Truog WE, Sebestyen VanSickle J, Manimtim WM, Alon US (2017) Successful reversal of furosemide-induced secondary hyperparathyroidism with cinacalcet. Pediatrics \n                    https:\/\/doi.org\/10.1542\/peds.2016-3789","journal-title":"Pediatrics"},{"issue":"5","key":"4055_CR14","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s00467-015-3271-7","volume":"31","author":"T Srivastava","year":"2016","unstructured":"Srivastava T, Krudys J, Mardis NJ, Sebestyen-VanSickle J, Alon US (2016) Cinacalcet as adjunctive therapy in pseudohypoparathyroidism type 1b. Pediatr Nephrol 31(5):795\u2013800","journal-title":"Pediatr Nephrol"},{"issue":"5","key":"4055_CR15","doi-asserted-by":"publisher","first-page":"992","DOI":"10.1002\/jbmr.1838","volume":"28","author":"T Srivastava","year":"2013","unstructured":"Srivastava T, Alon US (2013) Cinacalcet as adjunctive therapy for hereditary 1,25-dihydroxyvitamin D-resistant rickets. J Bone Miner Res 28(5):992\u2013996","journal-title":"J Bone Miner Res"},{"issue":"9","key":"4055_CR16","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1007\/s00467-010-1547-5","volume":"25","author":"US Alon","year":"2010","unstructured":"Alon US, VandeVoorde RG (2010) Beneficial effect of cinacalcet in a child with familial hypocalciuric hypercalcemia. Pediatr Nephrol 25(9):1747\u20131750","journal-title":"Pediatr Nephrol"},{"issue":"3","key":"4055_CR17","doi-asserted-by":"publisher","first-page":"658","DOI":"10.2215\/CJN.04981107","volume":"3","author":"US Alon","year":"2008","unstructured":"Alon US, Levy-Olomucki R, Moore WV, Stubbs J, Liu S, Quarles LD (2008) Calcimimetics as an adjuvant treatment for familial hypophosphatemic rickets. Clin J Am Soc Nephrol 3(3):658\u2013664","journal-title":"Clin J Am Soc Nephrol"},{"issue":"S1","key":"4055_CR18","first-page":"1","volume":"46","author":"National Kidney Foundation","year":"2005","unstructured":"National Kidney Foundation (2005) K\/DOQI clinical practice guidelines for bone metabolism and disease in children with chronic kidney disease. Am J Kidney Dis 46(S1):1\u2013121","journal-title":"Am J Kidney Dis"},{"key":"4055_CR19","unstructured":"National Center for Health Statistics: Centers for Disease Control and World health Organization growth charts: \n                    http:\/\/www.cdc.gov\/growthcharts"},{"issue":"12","key":"4055_CR20","doi-asserted-by":"publisher","first-page":"4834","DOI":"10.1210\/jc.2013-2975","volume":"98","author":"PS Parfrey","year":"2013","unstructured":"Parfrey PS, Chertow GM, Block GA, Correa-Rotter R, Dr\u00fceke TB, Floege J, Herzog CA, London GM, Mahaffey KW, Moe SM, Wheeler DC, Dehmel B, Trotman ML, Modafferi DM, Goodman WG (2013) The clinical course of treated hyperparathyroidism among patients receiving hemodialysis and the effect of cinacalcet: the EVOLVE trial. J Clin Endocrinol Metab 98(12):4834\u20134844","journal-title":"J Clin Endocrinol Metab"},{"key":"4055_CR21","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s00467-009-1294-7","volume":"25","author":"C Platt","year":"2010","unstructured":"Platt C, Inward C, McGraw M, Dudley J, Tizard J, Burren C, Saleem MA (2010) Middle-term use of Cinacalcet in paediatric dialysis patients. Pediatr Nephrol 25:143\u2013148","journal-title":"Pediatr Nephrol"},{"issue":"2","key":"4055_CR22","doi-asserted-by":"publisher","first-page":"e4012","DOI":"10.1097\/MD.0000000000000401","volume":"94","author":"AA Alharthi","year":"2015","unstructured":"Alharthi AA, Kamal NM, Abukhatwah MW, Sherief LM (2015) Cinacalcet in pediatric and adolescent chronic kidney disease: a single-center experience. Medicine 94(2):e4012","journal-title":"Medicine"},{"key":"4055_CR23","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s00467-007-0684-y","volume":"23","author":"L Rees","year":"2008","unstructured":"Rees L (2008) What parathyroid hormone levels should we aim for in children with stage 5 chronic kidney disease; what is the evidence? Pediatr Nephrol 23:179\u2013184","journal-title":"Pediatr Nephrol"},{"key":"4055_CR24","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1007\/s00467-012-2270-1","volume":"28","author":"D Haffner","year":"2013","unstructured":"Haffner D, Schaefer F (2013) Searching the optimal PTH target range in children undergoing peritoneal dialysis: new insights from international cohort studies. Pediatr Nephrol 28:537\u2013545","journal-title":"Pediatr Nephrol"},{"key":"4055_CR25","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/ki.1994.31","volume":"45","author":"IB Salusky","year":"1994","unstructured":"Salusky IB, Ramirez JA, Oppenheim W, Gales B, Segre GV, Goodman WG (1994) Biochemical markers of renal osteodystrophy in pediatric patients undergoing CAPD\/CCPD. Kidney Int 45:253\u2013258","journal-title":"Kidney Int"},{"key":"4055_CR26","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1038\/ki.1994.380","volume":"46","author":"WG Goodman","year":"1994","unstructured":"Goodman WG, Ramirez JA, Belin TR, Chon Y, Gales B, Segre GV, Salusky IB (1994) Development of adynamic bone in patients with secondary hyperparathyroidism after intermittent calcitriol therapy. Kidney Int 46:1160\u20131166","journal-title":"Kidney Int"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-018-4055-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-018-4055-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-018-4055-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T19:05:01Z","timestamp":1568055901000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-018-4055-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,10]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["4055"],"URL":"https:\/\/doi.org\/10.1007\/s00467-018-4055-7","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,10]]},"assertion":[{"value":"15 February 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 August 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 August 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The study was approved by the University of Miami Institutional Review Board. Patient confidentiality was protected in compliance with the HIPAA (Health Insurance Portability & Accountability Act).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}