{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:48:41Z","timestamp":1790038121820,"version":"4.0.1"},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T00:00:00Z","timestamp":1549584000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1007\/s00467-018-4190-1","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T15:23:42Z","timestamp":1549639422000},"page":"925-941","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Pediatric intradialytic hypotension: recommendations from the Pediatric Continuous Renal Replacement Therapy (PCRRT) Workgroup"],"prefix":"10.1007","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3892-8376","authenticated-orcid":false,"given":"Rupesh","family":"Raina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hershita","family":"Raheja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod","family":"Krishnappa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daljit","family":"Hothi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Davenport","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Chand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Kapur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franz","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidharth Kumar","family":"Sethi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mignon","family":"McCulloch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Bagga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Bunchman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley A.","family":"Warady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,2,8]]},"reference":[{"issue":"6","key":"4190_CR1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1007\/s00467-010-1661-4","volume":"26","author":"W Hayes","year":"2011","unstructured":"Hayes W, Hothi DK (2011) Intradialytic hypotension. Pediatr Nephrol 26(6):867\u2013879","journal-title":"Pediatr Nephrol"},{"issue":"5 2 suppl","key":"4190_CR2","first-page":"797","volume":"59","author":"S Blumenthal","year":"1977","unstructured":"Blumenthal S, Epps RP, Heavenrich R, Lauer RM, Lieberman E, Mirkin B, Mitchell SC, Boyar Naito V, O'Hare D, McFate Smith W, Tarazi RC, Upson D (1977) Report of the task force on blood pressure control in children. Pediatrics 59(5 2 suppl):I-ii):797\u2013820","journal-title":"Pediatrics"},{"key":"4190_CR3","unstructured":"Hothi DK (2009) An investigation into the mechanisms, consequences and moderators of intradialytic hypotension in paediatric haemodialysis. University College London, London discovery.ucl.ac.uk \/17442\/1\/17442.pdf. Accessed 3 Apr 2018"},{"issue":"3","key":"4190_CR4","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/ki.1994.84","volume":"45","author":"AI Arieff","year":"1994","unstructured":"Arieff AI (1994) Dialysis disequilibrium syndrome: current concepts on pathogenesis and prevention. Kidney Intl 45(3):629\u2013635","journal-title":"Kidney Intl"},{"issue":"10","key":"4190_CR5","doi-asserted-by":"crossref","first-page":"3315","DOI":"10.1093\/ndt\/gfq855","volume":"26","author":"A Merouani","year":"2011","unstructured":"Merouani A, Kechaou W, Litalien C, Ducruet T, Jouvet P (2011) Impact of blood volume monitoring on fluid removal during intermittent hemodialysis of critically ill children with acute kidney injury. Nephrol Dial Transplant 26(10):3315\u20133319","journal-title":"Nephrol Dial Transplant"},{"issue":"5","key":"4190_CR6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3109\/15563650.2012.683436","volume":"50","author":"V Lavergne","year":"2012","unstructured":"Lavergne V, Nolin TD, Hoffman RS, Roberts D, Gosselin S, Goldfarb DS, Kielstein JT, Mactier R, Maclaren R, Mowry JB, Bunchman TE, Juurlink D, Megarbane B, Anseeuw K, Winchester JF, Dargan PI, Liu KD, Hoegberg LC, Li Y, Calello DP, Burdmann EA, Yates C, Laliberte M, Decker BS, Mello-Da-Silva CA, Lavonas E, Ghannoum M (2012) The EXTRIP (EXtracorporeal TReatments In Poisoning) workgroup: guideline methodology. Clin Toxicol (Phila) 50(5):403\u2013413","journal-title":"Clin Toxicol (Phila)"},{"key":"4190_CR7","unstructured":"Fitch K, Bernstein SJ, Aguilar MD, Burnand B, LaCalle JR, L\u00e1zaro P, Mvh L, McDonnell J, Vader JP, Kahan JP (2001) The RAND\/UCLA appropriateness method user\u2019s manual. Rand Publication https:\/\/www.rand.org\/content\/dam\/rand\/pubs\/monograph_reports\/2011\/MR1269.pdf . Accessed 10 Apr 2018"},{"issue":"2","key":"4190_CR8","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jclinepi.2011.12.007","volume":"66","author":"J Thornton","year":"2013","unstructured":"Thornton J, Alderson P, Tan T, Turner C, Latchem S, Shaw E, Ruiz F, Reken S, Mugglestone MA, Hill J, Neilson J, Westby M, Francis K, Whittington C, Siddiqui F, Sharma T, Kelly V, Ayiku L, Chamberlain K (2013) Introducing GRADE across the NICE clinical guideline program. J Clin Epidemiol 66(2):124\u2013131","journal-title":"J Clin Epidemiol"},{"issue":"4","key":"4190_CR9","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00467-007-0716-7","volume":"23","author":"DK Hothi","year":"2008","unstructured":"Hothi DK, Harvey E, Goia CM, Geary DF (2008) Evaluating methods for improving ultrafiltration in pediatric hemodialysis. Pediatr Nephrol 23(4):631\u2013638","journal-title":"Pediatr Nephrol"},{"issue":"5","key":"4190_CR10","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.4103\/1319-2442.139916","volume":"25","author":"FI Fadel","year":"2014","unstructured":"Fadel FI, Makar SH, Eskander AE, Aon AH (2014) Decreasing intra-dialytic morbid events and assessment of dry weight in children on chronic hemodialysis using non-invasive changes in hematocrit. Saudi J Kidney Dis Transpl 25(5):1030\u20131037","journal-title":"Saudi J Kidney Dis Transpl"},{"issue":"5","key":"4190_CR11","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s00467-007-0724-7","volume":"23","author":"DK Hothi","year":"2008","unstructured":"Hothi DK, Harvey E, Goia CM, Geary D (2008) Blood-volume monitoring in paediatric haemodialysis. Pediatr Nephrol 23(5):813\u2013820","journal-title":"Pediatr Nephrol"},{"issue":"1","key":"4190_CR12","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0272-6386(96)90142-0","volume":"28","author":"DL Blowey","year":"1996","unstructured":"Blowey DL, Balfe JW, Gupta I, Gajaria MM, Koren G (1996) Midodrine efficacy and pharmacokinetics in a patient with recurrent intradialytic hypotension. Am J Kidney Dis 28(1):132\u2013136","journal-title":"Am J Kidney Dis"},{"issue":"8","key":"4190_CR13","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1007\/s00467-009-1151-8","volume":"24","author":"DK Hothi","year":"2009","unstructured":"Hothi DK, Harvey E, Goia CM, Geary D (2009) The value of sequential dialysis, mannitol and midodrine in managing children prone to dialysis failure. Pediatr Nephrol 24(8):1587\u20131591","journal-title":"Pediatr Nephrol"},{"issue":"3","key":"4190_CR14","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1053\/j.jrn.2007.11.008","volume":"18","author":"ER Brooks","year":"2008","unstructured":"Brooks ER, Fatallah-Shaykh SA, Langman CB, Wolf KM, Price HE (2008) Bioelectric impedance predicts total body water, blood pressure, and heart rate during hemodialysis in children and adolescents. J Ren Nutr 18(3):304\u2013311","journal-title":"J Ren Nutr"},{"key":"4190_CR15","unstructured":"Hegazy RA, Sharaf IA, Fadel F, Bazaraa H, Esam R (2011) Heart rate variability in pediatric patients on regular hemodialysis. Europace Conference: EHRA. Europace 13 https:\/\/insights.ovid.com\/europ\/201106003\/00127069-201106003-00638 . Accessed 5 Apr 2018"},{"issue":"1","key":"4190_CR16","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1046\/j.1492-7535.2003.01282.x","volume":"7","author":"E Levtchenko","year":"2003","unstructured":"Levtchenko E, Creemers D, Schaijk DV, Rijbroek I, Schroder C (2003) Use of NIMH for determination of dry weight and prevention of dialysis associated morbidity in children. Hemodial Int 7(1):104","journal-title":"Hemodial Int"},{"issue":"1","key":"4190_CR17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00467-007-0649-1","volume":"23","author":"SL Goldstein","year":"2008","unstructured":"Goldstein SL, Silverstein DM, Leung JC, Feig DI, Soletsky B, Knight C, Warady BA (2008) Frequent hemodialysis with NxStage system in pediatric patients receiving maintenance hemodialysis. Pediatr Nephrol 23(1):129\u2013135","journal-title":"Pediatr Nephrol"},{"issue":"1","key":"4190_CR18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s004670000504","volume":"16","author":"SR Jain","year":"2001","unstructured":"Jain SR, Smith L, Brewer ED, Goldstein SL (2001) Non-invasive intravascular monitoring in the pediatric hemodialysis population. Pediatr Nephrol 16(1):15\u201318","journal-title":"Pediatr Nephrol"},{"issue":"8","key":"4190_CR19","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1007\/s00467-014-2776-9","volume":"29","author":"J Thumfart","year":"2014","unstructured":"Thumfart J, Puttkamer CV, Wagner S, Querfeld U, Muller D (2014) Hemodiafiltration in a pediatric nocturnal dialysis program. Pediatr Nephrol 29(8):1411\u20131416","journal-title":"Pediatr Nephrol"},{"issue":"9","key":"4190_CR20","first-page":"1639","volume":"30","author":"A Zarauza-Santovena","year":"2015","unstructured":"Zarauza-Santovena A, Alonso-Melgar A, Gonzalez-Perez P, Lopez-Font M, Hernandez-Zuniga L, Ruiz-Hernandez F, Fernandez-Camblor C, Melgosa-Hijosa M, Espinosa-Roman L (2015) Safety and efficacy of online-hemodiafiltration in pediatric population. Pediatr Nephrol 30(9):1639\u20131640","journal-title":"Pediatr Nephrol"},{"issue":"9","key":"4190_CR21","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1093\/ndt\/gfh403","volume":"19","author":"M Fischbach","year":"2004","unstructured":"Fischbach M, Terzic J, Laugel V, Dheu C, Menouer S, Helms P, Livolsi A (2004) Daily on-line haemodiafiltration: a pilot trial in children. Nephrol Dial Transplant 19(9):2360\u20132367","journal-title":"Nephrol Dial Transplant"},{"key":"4190_CR22","first-page":"228","volume":"15","author":"CA Baldamus","year":"1978","unstructured":"Baldamus CA, Schoeppe W, Koch KM (1978) Comparison of haemodialysis (HD) and post dilution haemofiltration (HF) on an unselected dialysis population. Proc Eur Dial Transplant Assoc 15:228\u2013235","journal-title":"Proc Eur Dial Transplant Assoc"},{"issue":"Suppl 1","key":"4190_CR23","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1111\/j.1542-4758.2011.00600.x","volume":"15","author":"A Davenport","year":"2011","unstructured":"Davenport A (2011) Using dialysis machine technology to reduce intradialytic hypotension. Hemodial Int 15(Suppl 1):S37\u2013S42","journal-title":"Hemodial Int"},{"issue":"7","key":"4190_CR24","doi-asserted-by":"crossref","first-page":"2162","DOI":"10.1681\/ASN.2004121053","volume":"16","author":"DN Reddan","year":"2005","unstructured":"Reddan DN, Szczech LA, Hasselblad V, Lowrie EG, Lindsay RM, Himmelfarb J, Toto RD, Stivelman J, Winchester JF, Zillman LA, Califf RM, Owen WF Jr (2005) Intradialytic blood volume monitoring in ambulatory hemodialysis patients: a randomized trial. J Am Soc Nephrol 16(7):2162\u20132169","journal-title":"J Am Soc Nephrol"},{"key":"4190_CR25","unstructured":"Fresenius Medical Care Crit-Line III user manual. https:\/\/fmcna.com\/wp-content\/uploads\/documents\/CL80020031_Rev_H.pdf . Accessed 20 Apr 2018"},{"issue":"3","key":"4190_CR26","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1525-139X.2009.00614.x","volume":"22","author":"A Davenport","year":"2009","unstructured":"Davenport A (2009) Can advances in hemodialysis machine technology prevent intradialytic hypotension? Semin Dial 22(3):231\u2013236","journal-title":"Semin Dial"},{"issue":"2","key":"4190_CR27","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/01.ASN.0000108970.48370.33","volume":"15","author":"S Mitra","year":"2004","unstructured":"Mitra S, Chamney P, Greenwood R, Farrington K (2004) The relationship between systemic and whole-body hematocrit is not constant during ultrafiltration on hemodialysis. J Am Soc Nephrol 15(2):463\u2013469","journal-title":"J Am Soc Nephrol"},{"issue":"8","key":"4190_CR28","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1007\/s00467-005-1876-y","volume":"20","author":"M Fischbach","year":"2005","unstructured":"Fischbach M, Edefonti A, Schr\u00f6der C, Watson A (2005) Hemodialysis in children: general practical guidelines. Pediatr Nephrol 20(8):1054\u20131066","journal-title":"Pediatr Nephrol"},{"issue":"Suppl 2","key":"4190_CR29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/ndt\/11.supp2.35","volume":"11","author":"T Petitclerc","year":"1996","unstructured":"Petitclerc T, Trombert JC, Coevoet B, Jacobs C (1996) Electrolyte modelling: sodium. Is dialysate sodium profiling actually useful? Nephrol Dial Transplant 11(Suppl 2):35\u201338","journal-title":"Nephrol Dial Transplant"},{"key":"4190_CR30","unstructured":"Advanced renal education program: sodium modelling (2015) Fresenius Medical Care. http:\/\/advancedrenaleducation.com\/content\/sodium-modeling . Accessed 15 Apr 2018"},{"key":"4190_CR31","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1016\/S0085-2538(15)47404-6","volume":"76","author":"H Mann","year":"2000","unstructured":"Mann H, Stiller S (2000) Sodium modeling. Kidney Int Suppl 76:S79\u2013S88","journal-title":"Kidney Int Suppl"},{"issue":"5","key":"4190_CR32","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1681\/ASN.V451192","volume":"4","author":"RH Sadowski","year":"1993","unstructured":"Sadowski RH, Allred EN, Jabs K (1993) Sodium modeling ameliorates intradialytic and interdialytic symptoms in young hemodialysis patients. J Am Soc Nephrol 4(5):1192\u20131198","journal-title":"J Am Soc Nephrol"},{"key":"4190_CR33","doi-asserted-by":"publisher","unstructured":"Tangvoraphonkchai K, Davenport A (2018) Why does the choice of dialysate sodium concentration remain controversial? Hemodial Int. https:\/\/doi.org\/10.1111\/hdi.12645","DOI":"10.1111\/hdi.12645"},{"issue":"5","key":"4190_CR34","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1053\/j.ajkd.2015.07.015","volume":"66","author":"Kidney Disease Outcomes Quality Initiative","year":"2015","unstructured":"Kidney Disease Outcomes Quality Initiative\u00a0(2015) KDOQI clinical practice guideline for hemodialysis adequacy: 2015 update. Am J Kidney Dis 66(5):884\u2013930","journal-title":"Am J Kidney Dis"},{"issue":"3","key":"4190_CR35","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1053\/j.ajkd.2017.03.024","volume":"70","author":"M Hecking","year":"2017","unstructured":"Hecking M, Wong MMY, Port FK, Robinson BM, McCullough KP (2017) Regional differences in the associations between prescribed dialysate sodium concentration and Interdialytic weight gain in the dialysis outcomes and practice patterns study. Am J Kidney Dis 70(3):450\u2013451","journal-title":"Am J Kidney Dis"},{"issue":"1","key":"4190_CR36","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000322572","volume":"33","author":"M Hecking","year":"2011","unstructured":"Hecking M, Kainz A, Horl WH, Herkner H, Sunder-Plassmann G (2011) Sodium setpoint and sodium gradient: influence on plasma sodium change and weight gain. Am J Nephrol 33(1):39\u201348","journal-title":"Am J Nephrol"},{"issue":"7","key":"4190_CR37","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1007\/s00467-009-1150-9","volume":"24","author":"C Dheu","year":"2009","unstructured":"Dheu C, Terzic J, Menouer S, Fischbach M (2009) Importance of the curve shape for interpretation of blood volume monitor changes during haemodiafiltration. Pediatr Nephrol 24(7):1419\u20131423","journal-title":"Pediatr Nephrol"},{"issue":"1","key":"4190_CR38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/sdi.12563","volume":"30","author":"JT Daugirdas","year":"2017","unstructured":"Daugirdas JT, Schneditz D (2017) Hemodialysis ultrafiltration rate targets should be scaled to body surface area rather than to body weight. Semin Dial 30(1):15\u201319","journal-title":"Semin Dial"},{"issue":"3","key":"4190_CR39","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1177\/039139888300600306","volume":"6","author":"E Quellhorst","year":"1983","unstructured":"Quellhorst E (1983) Long-term follow up in chronic hemofiltration. Int J Artif Organs 6(3):115\u2013120","journal-title":"Int J Artif Organs"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-018-4190-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-018-4190-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-018-4190-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T16:43:35Z","timestamp":1662914615000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-018-4190-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,8]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["4190"],"URL":"https:\/\/doi.org\/10.1007\/s00467-018-4190-1","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,8]]},"assertion":[{"value":"3 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 November 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 December 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}