{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T07:29:38Z","timestamp":1759390178392,"version":"3.37.3"},"reference-count":15,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1007\/s00467-019-04234-6","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T12:02:35Z","timestamp":1554724955000},"page":"1289-1293","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Escherichia coli-associated hemolytic uremic syndrome and severe chronic hepatocellular cholestasis: complication or side effect of eculizumab?"],"prefix":"10.1007","volume":"34","author":[{"given":"Mathilde","family":"Mauras","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justine","family":"Bacchetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Duncan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Pierre","family":"Lavocat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Rohmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Javouhey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"Collardeau-Frachon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9902-0850","authenticated-orcid":false,"given":"Anne-Laure","family":"Sellier-Leclerc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,4,8]]},"reference":[{"key":"4234_CR1","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/S0140-6736(17)30062-4","volume":"390","author":"F Fakhouri","year":"2017","unstructured":"Fakhouri F, Zuber J, Fr\u00e9meaux-Bacchi V, Loirat C (2017) Haemolytic uraemic syndrome. Lancet 390:681\u2013696. \n                    https:\/\/doi.org\/10.1016\/S0140-6736(17)30062-4","journal-title":"Lancet"},{"key":"4234_CR2","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1055\/s-2007-965013","volume":"17","author":"AS Buys Roessingh de","year":"2007","unstructured":"de Buys Roessingh AS, de Lagausie P, Baudoin V, Loirat C, Aigrain Y (2007) Gastrointestinal complications of post-diarrheal hemolytic uremic syndrome. Eur J Pediatr Surg 17:328\u2013334. \n                    https:\/\/doi.org\/10.1055\/s-2007-965013","journal-title":"Eur J Pediatr Surg"},{"key":"4234_CR3","doi-asserted-by":"publisher","first-page":"2561","DOI":"10.1056\/NEJMc1100859","volume":"364","author":"A-L Lapeyraque","year":"2011","unstructured":"Lapeyraque A-L, Malina M, Fremeaux-Bacchi V, Boppel T, Kirschfink M, Oualha M, Proulx F, Clermont MJ, Le Deist F, Niaudet P, Schaefer F (2011) Eculizumab in severe Shiga-toxin-associated HUS. N Engl J Med 364:2561\u20132563. \n                    https:\/\/doi.org\/10.1056\/NEJMc1100859","journal-title":"N Engl J Med"},{"key":"4234_CR4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.21767\/2472-5056.100011","volume":"1","author":"TM Brady","year":"2016","unstructured":"Brady TM, Pruette C, Loeffler LF, Weidemann D, Strouse JJ, Gavriilaki E, Brodsky RA (2016) Typical Hus: evidence of acute phase complement activation from a daycare outbreak. J Clin Exp Nephrol 1:11","journal-title":"J Clin Exp Nephrol"},{"key":"4234_CR5","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1053\/jpsu.2001.28858","volume":"36","author":"N Urushihara","year":"2001","unstructured":"Urushihara N, Ariki N, Oyama T, Chouda Y, Yagi T, Inoue T, Tomiyama Y, Nishiuchi R, Oda M, Tanaka N (2001) Secondary sclerosing cholangitis and portal hypertension after O157 enterocolitis: extremely rare complications of hemolytic uremic syndrome. J Pediatr Surg 36:1838\u20131840. \n                    https:\/\/doi.org\/10.1053\/jpsu.2001.28858","journal-title":"J Pediatr Surg"},{"key":"4234_CR6","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1055\/s-0042-108444","volume":"228","author":"J Matthies","year":"2016","unstructured":"Matthies J, H\u00fcnseler C, Ehren R, Volland R, K\u00f6rber F, Hoppe B, Weber LT, Habbig S (2016) Extrarenal manifestations in Shigatoxin-associated haemolytic uremic syndrome. Klin Padiatr 228:181\u2013188. \n                    https:\/\/doi.org\/10.1055\/s-0042-108444","journal-title":"Klin Padiatr"},{"key":"4234_CR7","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1097\/00005176-200403000-00022","volume":"38","author":"MR Riley","year":"2004","unstructured":"Riley MR, Lee KK (2004) Escherichia coli O157:H7-associated hemolytic uremic syndrome and acute hepatocellular cholestasis: a case report. J Pediatr Gastroenterol Nutr 38:352\u2013354","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"4234_CR8","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/S0022-3468(00)90223-9","volume":"35","author":"DW McCarthy","year":"2000","unstructured":"McCarthy DW, Mutabagani K, Mahan JD, Caniano DA, Cooney DR (2000) Infarction of the choledochus, liver, gallbladder, and pancreas: a unique complication of the hemolytic uremic syndrome. J Pediatr Surg 35:502\u2013504. \n                    https:\/\/doi.org\/10.1016\/S0022-3468(00)90223-9","journal-title":"J Pediatr Surg"},{"key":"4234_CR9","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1177\/0009922815580406","volume":"55","author":"K Anastaze Stelle","year":"2016","unstructured":"Anastaze Stelle K, Cachat F, Perez M-H, Chehade H (2016) Streptococcus pneumoniae-associated hemolytic and uremic syndrome with cholestasis: a case report and brief literature review. Clin Pediatr (Phila) 55:189\u2013191. \n                    https:\/\/doi.org\/10.1177\/0009922815580406","journal-title":"Clin Pediatr (Phila)"},{"key":"4234_CR10","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1007\/BF00858990","volume":"9","author":"EG Gallo","year":"1995","unstructured":"Gallo EG, Gianantonio CA (1995) Extrarenal involvement in diarrhoea-associated haemolytic-uraemic syndrome. Pediatr Nephrol 9:117\u2013119","journal-title":"Pediatr Nephrol"},{"key":"4234_CR11","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1093\/ndt\/gft470","volume":"29","author":"Y Delmas","year":"2014","unstructured":"Delmas Y, Vendrely B, Clouzeau B, Bachir H, Bui HN, Lacraz A, H\u00e9lou S, Bordes C, Reffet A, Llanas B, Skopinski S, Rolland P, Gruson D, Combe C (2014) Outbreak of Escherichia coli O104:H4 haemolytic uraemic syndrome in France: outcome with eculizumab. Nephrol Dial Transplant 29:565\u2013572. \n                    https:\/\/doi.org\/10.1093\/ndt\/gft470","journal-title":"Nephrol Dial Transplant"},{"key":"4234_CR12","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1007\/s00467-017-3642-3","volume":"32","author":"KL Wijnsma","year":"2017","unstructured":"Wijnsma KL, Schijvens AM, Rossen JWA, Kooistra-Smid AMDM, Schreuder MF, van de Kar NCAJ (2017) Unusual severe case of hemolytic uremic syndrome due to Shiga toxin 2d-producing E. coli O80:H2. Pediatr Nephrol 32:1263\u20131268. \n                    https:\/\/doi.org\/10.1007\/s00467-017-3642-3","journal-title":"Pediatr Nephrol"},{"key":"4234_CR13","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1007\/s00467-014-2990-5","volume":"30","author":"W Hayes","year":"2015","unstructured":"Hayes W, Tschumi S, Ling SC, Feber J, Kirschfink M, Licht C (2015) Eculizumab hepatotoxicity in pediatric aHUS. Pediatr Nephrol 30:775\u2013781. \n                    https:\/\/doi.org\/10.1007\/s00467-014-2990-5","journal-title":"Pediatr Nephrol"},{"key":"4234_CR14","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/2162-3619-1-26","volume":"1","author":"A Brodsky","year":"2012","unstructured":"Brodsky A, Mazzocchi O, S\u00e1nchez F, Khursigara G, Malhotra S, Volpacchio M (2012) Eculizumab in paroxysmal nocturnal hemoglobinuria with Budd-Chiari syndrome progressing despite anticoagulation. Exp Hematol Oncol 1:26. \n                    https:\/\/doi.org\/10.1186\/2162-3619-1-26","journal-title":"Exp Hematol Oncol"},{"key":"4234_CR15","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1038\/ng1599","volume":"37","author":"S Hillebrandt","year":"2005","unstructured":"Hillebrandt S, Wasmuth HE, Weiskirchen R, Hellerbrand C, Keppeler H, Werth A, Schirin-Sokhan R, Wilkens G, Geier A, Lorenzen J, K\u00f6hl J, Gressner AM, Matern S, Lammert F (2005) Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Nat Genet 37:835\u2013843. \n                    https:\/\/doi.org\/10.1038\/ng1599","journal-title":"Nat Genet"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-019-04234-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00467-019-04234-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-019-04234-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T23:28:45Z","timestamp":1586215725000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00467-019-04234-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,8]]},"references-count":15,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["4234"],"URL":"https:\/\/doi.org\/10.1007\/s00467-019-04234-6","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"type":"print","value":"0931-041X"},{"type":"electronic","value":"1432-198X"}],"subject":[],"published":{"date-parts":[[2019,4,8]]},"assertion":[{"value":"23 September 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 March 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 April 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This retrospective series of cases was approved by the local IRB (Comit\u00e9 d\u2019\u00e9thique des Hospices Civils de Lyon, session May 3, 2017).","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"Justine Bacchetta and Anne-Laure Sellier-Leclerc received travel grants and honoraria from Alexion (2013, 2014).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}