{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T11:42:50Z","timestamp":1787053370576,"version":"build-2736575974"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:00:00Z","timestamp":1591315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T00:00:00Z","timestamp":1591315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Comit\u00e9 Nacional de Productores de Az\u00facar"},{"name":"Fundaci\u00f3n Renal I\u00f1igo Alvarez de Toledo (FRIAT)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s00467-020-04595-3","type":"journal-article","created":{"date-parts":[[2020,6,5]],"date-time":"2020-06-05T14:03:10Z","timestamp":1591365790000},"page":"387-396","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Biomarkers of kidney injury among children in a high-risk region for chronic kidney disease of uncertain etiology"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0605-0928","authenticated-orcid":false,"given":"Jessica H.","family":"Leibler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriana","family":"Ramirez-Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jos\u00e9 Amador","family":"Vel\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damaris L\u00f3pez","family":"Pilarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassim","family":"Obeid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chirag R.","family":"Parikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salini","family":"Gadupudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine K.","family":"Scammell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Friedman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,5]]},"reference":[{"key":"4595_CR1","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1053\/j.ajkd.2012.01.005","volume":"59","author":"DR Brooks","year":"2012","unstructured":"Brooks DR, Ramirez-Rubio O, Amador JJ (2012) CKD in Central America: a hot issue. Am J Kidney Dis Off J Natl Kidney Found 59:481\u2013484. https:\/\/doi.org\/10.1053\/j.ajkd.2012.01.005","journal-title":"Am J Kidney Dis Off J Natl Kidney Found"},{"key":"4595_CR2","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1053\/j.ajkd.2013.10.062","volume":"63","author":"R Correa-Rotter","year":"2014","unstructured":"Correa-Rotter R, Wesseling C, Johnson RJ (2014) CKD of unknown origin in Central America: the case for a Mesoamerican nephropathy. Am J Kidney Dis 63:506\u2013520","journal-title":"Am J Kidney Dis"},{"key":"4595_CR3","first-page":"294","volume":"40","author":"M Lozier","year":"2016","unstructured":"Lozier M, Turcios-Ruiz RM, Noonan G, Ordunez P (2016) Chronic kidney disease of nontraditional etiology in Central America: a provisional epidemiologic case definition for surveillance and epidemiologic studies. Rev Panam Salud Publica Pan Am J Public Health 40:294\u2013300","journal-title":"Rev Panam Salud Publica Pan Am J Public Health"},{"key":"4595_CR4","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1056\/NEJMra1813869","volume":"380","author":"RJ Johnson","year":"2019","unstructured":"Johnson RJ, Wesseling C, Newman LS (2019) Chronic kidney disease of unknown cause in agricultural communities. N Engl J Med 380:1843\u20131852. https:\/\/doi.org\/10.1056\/NEJMra1813869","journal-title":"N Engl J Med"},{"key":"4595_CR5","doi-asserted-by":"publisher","first-page":"626","DOI":"10.1053\/j.ajkd.2016.10.036","volume":"69","author":"J Wijkstrom","year":"2017","unstructured":"Wijkstrom J, Gonzalez-Quiroz M, Hernandez M et al (2017) Renal morphology, clinical findings, and progression rate in Mesoamerican nephropathy. Am J Kidney Dis Off J Natl Kidney Found 69:626\u2013636. https:\/\/doi.org\/10.1053\/j.ajkd.2016.10.036","journal-title":"Am J Kidney Dis Off J Natl Kidney Found"},{"key":"4595_CR6","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/s12882-016-0422-4","volume":"18","author":"M Gonzalez-Quiroz","year":"2017","unstructured":"Gonzalez-Quiroz M, Camacho A, Faber D et al (2017) Rationale, description and baseline findings of a community-based prospective cohort study of kidney function amongst the young rural population of Northwest Nicaragua. BMC Nephrol 18:16. https:\/\/doi.org\/10.1186\/s12882-016-0422-4","journal-title":"BMC Nephrol"},{"key":"4595_CR7","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1093\/ckj\/sfx136","volume":"11","author":"M Gonzalez-Quiroz","year":"2018","unstructured":"Gonzalez-Quiroz M, Pearce N, Caplin B, Nitsch D (2018) What do epidemiological studies tell us about chronic kidney disease of undetermined cause in Meso-America? A systematic review and meta-analysis. Clin Kidney J 11:496\u2013506. https:\/\/doi.org\/10.1093\/ckj\/sfx136","journal-title":"Clin Kidney J"},{"key":"4595_CR8","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1053\/j.ackd.2017.01.001","volume":"24","author":"CM Orantes-Navarro","year":"2017","unstructured":"Orantes-Navarro CM, Herrera-Valdes R, Almaguer-Lopez M et al (2017) Toward a comprehensive hypothesis of chronic interstitial nephritis in agricultural communities. Adv Chronic Kidney Dis 24:101\u2013106. https:\/\/doi.org\/10.1053\/j.ackd.2017.01.001","journal-title":"Adv Chronic Kidney Dis"},{"key":"4595_CR9","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1053\/j.ajkd.2011.11.039","volume":"59","author":"S Peraza","year":"2012","unstructured":"Peraza S, Wesseling C, Aragon A et al (2012) Decreased kidney function among agricultural workers in El Salvador. Am J Kidney Dis Off J Natl Kidney Found 59:531\u2013540. https:\/\/doi.org\/10.1053\/j.ajkd.2011.11.039","journal-title":"Am J Kidney Dis Off J Natl Kidney Found"},{"key":"4595_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1136\/jech-2012-201141","volume":"67","author":"O Ramirez-Rubio","year":"2013","unstructured":"Ramirez-Rubio O, McClean MD, Amador JJ, Brooks DR (2013) An epidemic of chronic kidney disease in Central America: an overview. J Epidemiol Community Health 67:1\u20133. https:\/\/doi.org\/10.1136\/jech-2012-201141","journal-title":"J Epidemiol Community Health"},{"key":"4595_CR11","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.4269\/ajtmh.17-0260","volume":"97","author":"RSB Fischer","year":"2017","unstructured":"Fischer RSB, Mandayam S, Chavarria D et al (2017) Clinical evidence of acute Mesoamerican nephropathy. Am J Trop Med Hyg 97:1247\u20131256. https:\/\/doi.org\/10.4269\/ajtmh.17-0260","journal-title":"Am J Trop Med Hyg"},{"key":"4595_CR12","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/j.envres.2015.07.007","volume":"142","author":"R Garcia-Trabanino","year":"2015","unstructured":"Garcia-Trabanino R, Jarquin E, Wesseling C et al (2015) Heat stress, dehydration, and kidney function in sugarcane cutters in El Salvador--a cross-shift study of workers at risk of Mesoamerican nephropathy. Environ Res 142:746\u2013755. https:\/\/doi.org\/10.1016\/j.envres.2015.07.007","journal-title":"Environ Res"},{"key":"4595_CR13","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1053\/j.ajkd.2015.08.021","volume":"67","author":"C Roncal-Jimenez","year":"2016","unstructured":"Roncal-Jimenez C, Garcia-Trabanino R, Barregard L et al (2016) Heat stress nephropathy from exercise-induced uric acid Crystalluria: a perspective on Mesoamerican nephropathy. Am J Kidney Dis Off J Natl Kidney Found 67:20\u201330. https:\/\/doi.org\/10.1053\/j.ajkd.2015.08.021","journal-title":"Am J Kidney Dis Off J Natl Kidney Found"},{"key":"4595_CR14","doi-asserted-by":"publisher","first-page":"77","DOI":"10.37757\/MR2014.V16.N2.14","volume":"16","author":"MI Rodriguez","year":"2014","unstructured":"Rodriguez MI (2014) Chronic kidney disease in our farming communities: implications of an epidemic. MEDICC Rev 16:77\u201378","journal-title":"MEDICC Rev"},{"key":"4595_CR15","doi-asserted-by":"publisher","first-page":"66","DOI":"10.37757\/MR2014.V16.N2.11","volume":"16","author":"LC Silva","year":"2014","unstructured":"Silva LC, Ordunez P (2014) Chronic kidney disease in central American agricultural communities: challenges for epidemiology and public health. MEDICC Rev 16:66\u201371","journal-title":"MEDICC Rev"},{"key":"4595_CR16","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1053\/j.ajkd.2016.06.012","volume":"68","author":"J Kupferman","year":"2016","unstructured":"Kupferman J, Amador JJ, Lynch KE et al (2016) Characterization of Mesoamerican nephropathy in a kidney failure hotspot in Nicaragua. Am J Kidney Dis Off J Natl Kidney Found 68:716\u2013725. https:\/\/doi.org\/10.1053\/j.ajkd.2016.06.012","journal-title":"Am J Kidney Dis Off J Natl Kidney Found"},{"key":"4595_CR17","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1136\/oemed-2014-102799","volume":"72","author":"C Wesseling","year":"2015","unstructured":"Wesseling C, van Wendel de Joode B, Crowe J et al (2015) Mesoamerican nephropathy: geographical distribution and time trends of chronic kidney disease mortality between 1970 and 2012 in Costa Rica. Occup Environ Med 72:714\u2013721. https:\/\/doi.org\/10.1136\/oemed-2014-102799","journal-title":"Occup Environ Med"},{"key":"4595_CR18","doi-asserted-by":"publisher","first-page":"269","DOI":"10.5414\/CNP68269","volume":"68","author":"P Dennen","year":"2007","unstructured":"Dennen P, Parikh CR (2007) Biomarkers of acute kidney injury: can we replace serum creatinine? Clin Nephrol 68:269\u2013278","journal-title":"Clin Nephrol"},{"key":"4595_CR19","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1093\/ndt\/gfv467","volume":"31","author":"C Pontillo","year":"2016","unstructured":"Pontillo C, Mischak H (2016) Urinary biomarkers to predict CKD: is the future in multi-marker panels? Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc - Eur Ren Assoc 31:1373\u20131375. https:\/\/doi.org\/10.1093\/ndt\/gfv467","journal-title":"Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc - Eur Ren Assoc"},{"key":"4595_CR20","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1038\/nrneph.2013.108","volume":"9","author":"MG Shlipak","year":"2013","unstructured":"Shlipak MG, Day EC (2013) Biomarkers for incident CKD: a new framework for interpreting the literature. Nat Rev Nephrol 9:478\u2013483. https:\/\/doi.org\/10.1038\/nrneph.2013.108","journal-title":"Nat Rev Nephrol"},{"key":"4595_CR21","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.cca.2014.08.039","volume":"438","author":"ME Wasung","year":"2015","unstructured":"Wasung ME, Chawla LS, Madero M (2015) Biomarkers of renal function, which and when? Clin Chim Acta Int J Clin Chem 438:350\u2013357. https:\/\/doi.org\/10.1016\/j.cca.2014.08.039","journal-title":"Clin Chim Acta Int J Clin Chem"},{"key":"4595_CR22","doi-asserted-by":"publisher","first-page":"481","DOI":"10.2215\/CJN.03520807","volume":"3","author":"SG Coca","year":"2008","unstructured":"Coca SG, Parikh CR (2008) Urinary biomarkers for acute kidney injury: perspectives on translation. Clin J Am Soc Nephrol CJASN 3:481\u2013490. https:\/\/doi.org\/10.2215\/CJN.03520807","journal-title":"Clin J Am Soc Nephrol CJASN"},{"key":"4595_CR23","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1053\/j.ajkd.2015.10.010","volume":"67","author":"C Wesseling","year":"2016","unstructured":"Wesseling C, Garcia-Trabanino R, Wegman DH (2016) Mesoamerican nephropathy: do novel biomarkers of kidney damage have a role to play? Am J Kidney Dis Off J Natl Kidney Found 67:173\u2013175. https:\/\/doi.org\/10.1053\/j.ajkd.2015.10.010","journal-title":"Am J Kidney Dis Off J Natl Kidney Found"},{"key":"4595_CR24","unstructured":"McClean M, Amador JJ, Laws RL, et al. (2012) Biological sampling report: investigating biomarkers of kidney injury and chronic kidney disease among workers in Western Nicaragua. Boston University School of public health, Boston"},{"key":"4595_CR25","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1053\/j.ajkd.2015.08.022","volume":"67","author":"RL Laws","year":"2016","unstructured":"Laws RL, Brooks DR, Amador JJ et al (2016) Biomarkers of kidney injury among Nicaraguan sugarcane workers. Am J Kidney Dis Off J Natl Kidney Found 67:209\u2013217. https:\/\/doi.org\/10.1053\/j.ajkd.2015.08.022","journal-title":"Am J Kidney Dis Off J Natl Kidney Found"},{"key":"4595_CR26","doi-asserted-by":"publisher","first-page":"e0004979","DOI":"10.1371\/journal.pntd.0004979","volume":"10","author":"PMCS De Silva","year":"2016","unstructured":"De Silva PMCS, Mohammed Abdul KS, Eakanayake EMDV et al (2016) Urinary biomarkers KIM-1 and NGAL for detection of chronic kidney disease of uncertain etiology (CKDu) among agricultural communities in Sri Lanka. PLoS Negl Trop Dis 10:e0004979. https:\/\/doi.org\/10.1371\/journal.pntd.0004979","journal-title":"PLoS Negl Trop Dis"},{"key":"4595_CR27","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1093\/ndt\/gfv292","volume":"31","author":"O Ramirez-Rubio","year":"2016","unstructured":"Ramirez-Rubio O, Amador JJ, Kaufman JS et al (2016) Urine biomarkers of kidney injury among adolescents in Nicaragua, a region affected by an epidemic of chronic kidney disease of unknown aetiology. Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc - Eur Ren Assoc 31:424\u2013432. https:\/\/doi.org\/10.1093\/ndt\/gfv292","journal-title":"Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc - Eur Ren Assoc"},{"key":"4595_CR28","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1186\/1471-2458-13-350","volume":"13","author":"O Ramirez-Rubio","year":"2013","unstructured":"Ramirez-Rubio O, Brooks DR, Amador JJ et al (2013) Chronic kidney disease in Nicaragua: a qualitative analysis of semi-structured interviews with physicians and pharmacists. BMC Public Health 13:350. https:\/\/doi.org\/10.1186\/1471-2458-13-350","journal-title":"BMC Public Health"},{"key":"4595_CR29","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1007\/s00394-015-0905-2","volume":"55","author":"SA Kavouras","year":"2016","unstructured":"Kavouras SA, Johnson EC, Bougatsas D et al (2016) Validation of a urine color scale for assessment of urine osmolality in healthy children. Eur J Nutr 55:907\u2013915. https:\/\/doi.org\/10.1007\/s00394-015-0905-2","journal-title":"Eur J Nutr"},{"key":"4595_CR30","doi-asserted-by":"publisher","first-page":"10425","DOI":"10.1016\/S0021-9258(18)82217-7","volume":"268","author":"L Kjeldsen","year":"1993","unstructured":"Kjeldsen L, Johnsen AH, Sengelov H, Borregaard N (1993) Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem 268:10425\u201310432","journal-title":"J Biol Chem"},{"key":"4595_CR31","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1006\/geno.1997.4896","volume":"45","author":"JB Cowland","year":"1997","unstructured":"Cowland JB, Borregaard N (1997) Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans. Genomics 45:17\u201323. https:\/\/doi.org\/10.1006\/geno.1997.4896","journal-title":"Genomics"},{"key":"4595_CR32","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1016\/S0140-6736(05)74811-X","volume":"365","author":"J Mishra","year":"2005","unstructured":"Mishra J, Dent C, Tarabishi R et al (2005) Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet Lond Engl 365:1231\u20131238. https:\/\/doi.org\/10.1016\/S0140-6736(05)74811-X","journal-title":"Lancet Lond Engl"},{"key":"4595_CR33","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1172\/JCI23056","volume":"115","author":"K Mori","year":"2005","unstructured":"Mori K, Lee HT, Rapoport D et al (2005) Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J Clin Invest 115:610\u2013621. https:\/\/doi.org\/10.1172\/JCI23056","journal-title":"J Clin Invest"},{"key":"4595_CR34","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cca.2018.09.011","volume":"487","author":"RN Moresco","year":"2018","unstructured":"Moresco RN, Bochi GV, Stein CS et al (2018) Urinary kidney injury molecule-1 in renal disease. Clin Chim Acta Int J Clin Chem 487:15\u201321. https:\/\/doi.org\/10.1016\/j.cca.2018.09.011","journal-title":"Clin Chim Acta Int J Clin Chem"},{"key":"4595_CR35","doi-asserted-by":"publisher","first-page":"e6106","DOI":"10.1590\/1414-431X20176106","volume":"50","author":"GR Lobato","year":"2017","unstructured":"Lobato GR, Lobato MR, Thome FS, Veronese FV (2017) Performance of urinary kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, and N-acetyl-beta-D-glucosaminidase to predict chronic kidney disease progression and adverse outcomes. Braz J Med Biol Res Rev Bras Pesqui Medicas E Biol 50:e6106. https:\/\/doi.org\/10.1590\/1414-431X20176106","journal-title":"Braz J Med Biol Res Rev Bras Pesqui Medicas E Biol"},{"key":"4595_CR36","doi-asserted-by":"publisher","first-page":"149","DOI":"10.2215\/CJN.01300216","volume":"12","author":"R Malhotra","year":"2017","unstructured":"Malhotra R, Siew ED (2017) Biomarkers for the early detection and prognosis of acute kidney injury. Clin J Am Soc Nephrol CJASN 12:149\u2013173. https:\/\/doi.org\/10.2215\/CJN.01300216","journal-title":"Clin J Am Soc Nephrol CJASN"},{"key":"4595_CR37","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1053\/j.ajkd.2003.10.040","volume":"43","author":"CR Parikh","year":"2004","unstructured":"Parikh CR, Jani A, Melnikov VY et al (2004) Urinary interleukin-18 is a marker of human acute tubular necrosis. Am J Kidney Dis Off J Natl Kidney Found 43:405\u2013414","journal-title":"Am J Kidney Dis Off J Natl Kidney Found"},{"key":"4595_CR38","doi-asserted-by":"publisher","first-page":"2022","DOI":"10.1016\/j.cca.2011.07.023","volume":"412","author":"MJ Kim","year":"2011","unstructured":"Kim MJ, Tam FWK (2011) Urinary monocyte chemoattractant protein-1 in renal disease. Clin Chim Acta Int J Clin Chem 412:2022\u20132030. https:\/\/doi.org\/10.1016\/j.cca.2011.07.023","journal-title":"Clin Chim Acta Int J Clin Chem"},{"key":"4595_CR39","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/1471-2369-15-133","volume":"15","author":"IE Hall","year":"2014","unstructured":"Hall IE, Stern EP, Cantley LG et al (2014) Urine YKL-40 is associated with progressive acute kidney injury or death in hospitalized patients. BMC Nephrol 15:133. https:\/\/doi.org\/10.1186\/1471-2369-15-133","journal-title":"BMC Nephrol"},{"key":"4595_CR40","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1053\/j.ajkd.2017.01.045","volume":"70","author":"SG Mansour","year":"2017","unstructured":"Mansour SG, Verma G, Pata RW et al (2017) Kidney injury and repair biomarkers in Marathon runners. Am J Kidney Dis Off J Natl Kidney Found 70:252\u2013261. https:\/\/doi.org\/10.1053\/j.ajkd.2017.01.045","journal-title":"Am J Kidney Dis Off J Natl Kidney Found"},{"key":"4595_CR41","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1053\/j.ackd.2017.09.011","volume":"24","author":"AN Mian","year":"2017","unstructured":"Mian AN, Schwartz GJ (2017) Measurement and estimation of glomerular filtration rate in children. Adv Chronic Kidney Dis 24:348\u2013356. https:\/\/doi.org\/10.1053\/j.ackd.2017.09.011","journal-title":"Adv Chronic Kidney Dis"},{"key":"4595_CR42","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1053\/j.ajkd.2017.06.031","volume":"70","author":"DG Moledina","year":"2017","unstructured":"Moledina DG, Hall IE, Thiessen-Philbrook H et al (2017) Performance of serum creatinine and kidney injury biomarkers for diagnosing histologic acute tubular injury. Am J Kidney Dis Off J Natl Kidney Found 70:807\u2013816. https:\/\/doi.org\/10.1053\/j.ajkd.2017.06.031","journal-title":"Am J Kidney Dis Off J Natl Kidney Found"},{"key":"4595_CR43","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1080\/1047322X.1990.10389587","volume":"5","author":"RW Hornung","year":"1990","unstructured":"Hornung RW, Reed LD (1990) Estimation of average concentration in the presence of nondetectable values. Appl Occup Environ Hyg 5:46\u201351. https:\/\/doi.org\/10.1080\/1047322X.1990.10389587","journal-title":"Appl Occup Environ Hyg"},{"key":"4595_CR44","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.2215\/CJN.05900611","volume":"6","author":"JJ Fadrowski","year":"2011","unstructured":"Fadrowski JJ, Furth SL (2011) GFR estimation in children: questions and answers (and questions). Clin J Am Soc Nephrol 6:1810. https:\/\/doi.org\/10.2215\/CJN.05900611","journal-title":"Clin J Am Soc Nephrol"},{"key":"4595_CR45","doi-asserted-by":"publisher","first-page":"210","DOI":"10.4038\/cmj.v62i4.8568","volume":"62","author":"K Wanigasuriya","year":"2017","unstructured":"Wanigasuriya K, Jayawardene I, Amarasiriwardena C, Wickremasinghe R (2017) Novel urinary biomarkers and their association with urinary heavy metals in chronic kidney disease of unknown aetiology in Sri Lanka: a pilot study. Ceylon Med J 62:210\u2013217. https:\/\/doi.org\/10.4038\/cmj.v62i4.8568","journal-title":"Ceylon Med J"},{"key":"4595_CR46","doi-asserted-by":"publisher","unstructured":"Butler-Dawson J, Krisher L, Yoder H et al (2019) Evaluation of heat stress and cumulative incidence of acute kidney injury in sugarcane workers in Guatemala. Int Arch Occup Environ Health. https:\/\/doi.org\/10.1007\/s00420-019-01426-3","DOI":"10.1007\/s00420-019-01426-3"},{"key":"4595_CR47","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1007\/s00467-014-2989-y","volume":"30","author":"MR Bennett","year":"2015","unstructured":"Bennett MR, Nehus E, Haffner C et al (2015) Pediatric reference ranges for acute kidney injury biomarkers. Pediatr Nephrol Berl Ger 30:677\u2013685. https:\/\/doi.org\/10.1007\/s00467-014-2989-y","journal-title":"Pediatr Nephrol Berl Ger"},{"key":"4595_CR48","doi-asserted-by":"publisher","first-page":"e269","DOI":"10.1111\/apa.12200","volume":"102","author":"A Rybi-Szuminska","year":"2013","unstructured":"Rybi-Szuminska A, Wasilewska A, Litwin M et al (2013) Paediatric normative data for urine NGAL\/creatinine ratio. Acta Paediatr Oslo Nor 102:e269\u2013e272. https:\/\/doi.org\/10.1111\/apa.12200","journal-title":"Acta Paediatr Oslo Nor"},{"key":"4595_CR49","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1007\/s00467-006-0410-1","volume":"22","author":"BA Warady","year":"2007","unstructured":"Warady BA, Chadha V (2007) Chronic kidney disease in children: the global perspective. Pediatr Nephrol Berl Ger 22:1999\u20132009. https:\/\/doi.org\/10.1007\/s00467-006-0410-1","journal-title":"Pediatr Nephrol Berl Ger"},{"key":"4595_CR50","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nrneph.2012.19","volume":"8","author":"I Helal","year":"2012","unstructured":"Helal I, Fick-Brosnahan GM, Reed-Gitomer B, Schrier RW (2012) Glomerular hyperfiltration: definitions, mechanisms and clinical implications. Nat Rev Nephrol 8:293\u2013300. https:\/\/doi.org\/10.1038\/nrneph.2012.19","journal-title":"Nat Rev Nephrol"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-020-04595-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-020-04595-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-020-04595-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T23:38:44Z","timestamp":1622849924000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-020-04595-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,5]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["4595"],"URL":"https:\/\/doi.org\/10.1007\/s00467-020-04595-3","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,5]]},"assertion":[{"value":"15 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 April 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 April 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"JHL, JJA, DLP, and DRB have received funding from Azucareros del Istmo Centroamericano (AICA) to support a study of agricultural workers in Nicaragua. AICA had no role in the current study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}