{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T21:09:12Z","timestamp":1762808952138,"version":"3.37.3"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1007\/s00467-020-04631-2","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T12:04:39Z","timestamp":1596715479000},"page":"333-340","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Kidney failure risk in type 1 vs. type 2 childhood-onset diabetes mellitus"],"prefix":"10.1007","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0537-4469","authenticated-orcid":false,"given":"Oren","family":"Pleniceanu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilad","family":"Twig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorit","family":"Tzur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noah","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Stern-Zimmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnon","family":"Afek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomer","family":"Erlich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lital","family":"Keinan-Boker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Skorecki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronit","family":"Calderon-Margalit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asaf","family":"Vivante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"key":"4631_CR1","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1056\/NEJMoa1610187","volume":"376","author":"EJ Mayer-Davis","year":"2017","unstructured":"Mayer-Davis EJ, Lawrence JM, Dabelea D, Divers J, Isom S, Dolan L, Imperatore G, Linder B, Marcovina S, Pettitt DJ, Pihoker C, Saydah S, Wagenknecht L, Study SfDiY (2017) Incidence trends of type 1 and type 2 diabetes among youths, 2002-2012. N Engl J Med 376:1419\u20131429","journal-title":"N Engl J Med"},{"key":"4631_CR2","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.2337\/dc11-2312","volume":"35","author":"AB Dart","year":"2012","unstructured":"Dart AB, Sellers EA, Martens PJ, Rigatto C, Brownell MD, Dean HJ (2012) High burden of kidney disease in youth-onset type 2 diabetes. Diabetes Care 35:1265\u20131271","journal-title":"Diabetes Care"},{"key":"4631_CR3","doi-asserted-by":"publisher","first-page":"3863","DOI":"10.2337\/dc12-2455","volume":"36","author":"MI Constantino","year":"2013","unstructured":"Constantino MI, Molyneaux L, Limacher-Gisler F, Al-Saeed A, Luo C, Wu T, Twigg SM, Yue DK, Wong J (2013) Long-term complications and mortality in young-onset diabetes: type 2 diabetes is more hazardous and lethal than type 1 diabetes. Diabetes Care 36:3863\u20133869","journal-title":"Diabetes Care"},{"key":"4631_CR4","doi-asserted-by":"publisher","first-page":"149","DOI":"10.2337\/dc13-1336","volume":"37","author":"AO Luk","year":"2014","unstructured":"Luk AO, Lau ES, So WY, Ma RC, Kong AP, Ozaki R, Chow FC, Chan JC (2014) Prospective study on the incidences of cardiovascular-renal complications in Chinese patients with young-onset type 1 and type 2 diabetes. Diabetes Care 37:149\u2013157","journal-title":"Diabetes Care"},{"key":"4631_CR5","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1056\/NEJM198910193211603","volume":"321","author":"CC Cowie","year":"1989","unstructured":"Cowie CC, Port FK, Wolfe RA, Savage PJ, Moll PP, Hawthorne VM (1989) Disparities in incidence of diabetic end-stage renal disease according to race and type of diabetes. N Engl J Med 321:1074\u20131079","journal-title":"N Engl J Med"},{"key":"4631_CR6","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1001\/jama.2011.1141","volume":"306","author":"A Vivante","year":"2011","unstructured":"Vivante A, Afek A, Frenkel-Nir Y, Tzur D, Farfel A, Golan E, Chaiter Y, Shohat T, Skorecki K, Calderon-Margalit R (2011) Persistent asymptomatic isolated microscopic hematuria in Israeli adolescents and young adults and risk for end-stage renal disease. JAMA 306:729\u2013736","journal-title":"JAMA"},{"key":"4631_CR7","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1093\/ndt\/gfm597","volume":"23","author":"R Calderon-Margalit","year":"2008","unstructured":"Calderon-Margalit R, Gordon ES, Hoshen M, Kark JD, Rotem A, Haklai Z (2008) Dialysis in Israel, 1989-2005--time trends and international comparisons. Nephrol Dial Transplant 23:659\u2013664","journal-title":"Nephrol Dial Transplant"},{"key":"4631_CR8","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1214\/aos\/1176345976","volume":"10","author":"PK Andersen","year":"1982","unstructured":"Andersen PK, Gill RD (1982) Cox\u2019s regression model for counting processes: a large sample study. Ann Stat 10:1100\u20131120","journal-title":"Ann Stat"},{"key":"4631_CR9","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1111\/j.1464-5491.2010.03174.x","volume":"28","author":"T Sella","year":"2011","unstructured":"Sella T, Shoshan A, Goren I, Shalev V, Blumenfeld O, Laron Z, Chodick G (2011) A retrospective study of the incidence of diagnosed type 1 diabetes among children and adolescents in a large health organization in Israel, 2000-2008. Diabet Med 28:48\u201353","journal-title":"Diabet Med"},{"key":"4631_CR10","doi-asserted-by":"publisher","first-page":"420","DOI":"10.2337\/dc17-0906","volume":"41","author":"V Gagnum","year":"2018","unstructured":"Gagnum V, Saeed M, Stene LC, Leivestad T, Joner G, Skrivarhaug T (2018) Low incidence of end-stage renal disease in childhood-onset type 1 diabetes followed for up to 42 years. Diabetes Care 41:420\u2013425","journal-title":"Diabetes Care"},{"key":"4631_CR11","doi-asserted-by":"publisher","first-page":"434","DOI":"10.2337\/dc17-2364","volume":"41","author":"J Helve","year":"2018","unstructured":"Helve J, Sund R, Arffman M, Harjutsalo V, Groop PH, Gronhagen-Riska C, Finne P (2018) Incidence of end-stage renal disease in patients with type 1 diabetes. Diabetes Care 41:434\u2013439","journal-title":"Diabetes Care"},{"key":"4631_CR12","doi-asserted-by":"publisher","first-page":"381","DOI":"10.2337\/dc13-1287","volume":"37","author":"TJ Lecaire","year":"2014","unstructured":"Lecaire TJ, Klein BE, Howard KP, Lee KE, Klein R (2014) Risk for end-stage renal disease over 25 years in the population-based WESDR cohort. Diabetes Care 37:381\u2013388","journal-title":"Diabetes Care"},{"key":"4631_CR13","doi-asserted-by":"publisher","first-page":"27","DOI":"10.2337\/dc18-1276","volume":"42","author":"C Toppe","year":"2019","unstructured":"Toppe C, Mollsten A, Waernbaum I, Schon S, Gudbjornsdottir S, Landin-Olsson M, Dahlquist G, Swedish Childhood Diabetes Study G, the Swedish Renal R (2019) Decreasing cumulative incidence of end-stage renal disease in young patients with type 1 diabetes in Sweden: a 38-year prospective nationwide study. Diabetes Care 42:27\u201331","journal-title":"Diabetes Care"},{"key":"4631_CR14","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1210\/jc.2010-1642","volume":"96","author":"KC Copeland","year":"2011","unstructured":"Copeland KC, Zeitler P, Geffner M, Guandalini C, Higgins J, Hirst K, Kaufman FR, Linder B, Marcovina S, McGuigan P, Pyle L, Tamborlane W, Willi S, Group TS (2011) Characteristics of adolescents and youth with recent-onset type 2 diabetes: the TODAY cohort at baseline. J Clin Endocrinol Metab 96:159\u2013167","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 27","key":"4631_CR15","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/pedi.12719","volume":"19","author":"P Zeitler","year":"2018","unstructured":"Zeitler P, Arslanian S, Fu J, Pinhas-Hamiel O, Reinehr T, Tandon N, Urakami T, Wong J, Maahs DM (2018) ISPAD clinical practice consensus guidelines 2018: type 2 diabetes mellitus in youth. Pediatr Diabetes 19(Suppl 27):28\u201346","journal-title":"Pediatr Diabetes"},{"issue":"Suppl 1","key":"4631_CR16","first-page":"S79","volume":"27","author":"ME Molitch","year":"2004","unstructured":"Molitch ME, DeFronzo RA, Franz MJ, Keane WF, Mogensen CE, Parving HH, Steffes MW, American Diabetes A (2004) Nephropathy in diabetes. Diabetes Care 27(Suppl 1):S79\u2013S83","journal-title":"Diabetes Care"},{"key":"4631_CR17","doi-asserted-by":"publisher","first-page":"844","DOI":"10.2337\/diacare.20.5.844","volume":"20","author":"H Yokoyama","year":"1997","unstructured":"Yokoyama H, Okudaira M, Otani T, Takaike H, Miura J, Saeki A, Uchigata Y, Omori Y (1997) Existence of early-onset NIDDM Japanese demonstrating severe diabetic complications. Diabetes Care 20:844\u2013847","journal-title":"Diabetes Care"},{"key":"4631_CR18","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.2337\/dc12-0306","volume":"35","author":"J Morton","year":"2012","unstructured":"Morton J, Zoungas S, Li Q, Patel AA, Chalmers J, Woodward M, Celermajer DS, Beulens JW, Stolk RP, Glasziou P, Ng MK, Group AC (2012) Low HDL cholesterol and the risk of diabetic nephropathy and retinopathy: results of the ADVANCE study. Diabetes Care 35:2201\u20132206","journal-title":"Diabetes Care"},{"key":"4631_CR19","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1016\/j.numecd.2012.05.005","volume":"23","author":"YH Chang","year":"2013","unstructured":"Chang YH, Chang DM, Lin KC, Hsieh CH, Lee YJ (2013) High-density lipoprotein cholesterol and the risk of nephropathy in type 2 diabetic patients. Nutr Metab Cardiovasc Dis 23:751\u2013757","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"4631_CR20","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.jcjd.2018.08.199","volume":"43","author":"Y Wang","year":"2019","unstructured":"Wang Y, Chen F, Wang J, Wang T, Zhang J, Han Q, Wu Y, Zhang R, Liu F (2019) The relationship between increased ratio of visceral-to-subcutaneous fat area and renal outcome in chinese adults with type 2 diabetes and diabetic kidney disease. Can J Diabetes 43:415\u2013420","journal-title":"Can J Diabetes"},{"key":"4631_CR21","doi-asserted-by":"publisher","first-page":"1157","DOI":"10.2337\/diabetes.51.4.1157","volume":"51","author":"CD Stehouwer","year":"2002","unstructured":"Stehouwer CD, Gall MA, Twisk JW, Knudsen E, Emeis JJ, Parving HH (2002) Increased urinary albumin excretion, endothelial dysfunction, and chronic low-grade inflammation in type 2 diabetes: progressive, interrelated, and independently associated with risk of death. Diabetes 51:1157\u20131165","journal-title":"Diabetes"},{"key":"4631_CR22","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1007\/s00125-006-0586-8","volume":"50","author":"S Araki","year":"2007","unstructured":"Araki S, Haneda M, Koya D, Sugimoto T, Isshiki K, Chin-Kanasaki M, Uzu T, Kashiwagi A (2007) Predictive impact of elevated serum level of IL-18 for early renal dysfunction in type 2 diabetes: an observational follow-up study. Diabetologia 50:867\u2013873","journal-title":"Diabetologia"},{"key":"4631_CR23","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/dme.13114","volume":"34","author":"V Gagnum","year":"2017","unstructured":"Gagnum V, Stene LC, Jenssen TG, Berteussen LM, Sandvik L, Joner G, Njolstad PR, Skrivarhaug T (2017) Causes of death in childhood-onset type 1 diabetes: long-term follow-up. Diabet Med 34:56\u201363","journal-title":"Diabet Med"},{"key":"4631_CR24","doi-asserted-by":"publisher","first-page":"2384","DOI":"10.2337\/diacare.28.10.2384","volume":"28","author":"G Dahlquist","year":"2005","unstructured":"Dahlquist G, Kallen B (2005) Mortality in childhood-onset type 1 diabetes: a population-based study. Diabetes Care 28:2384\u20132387","journal-title":"Diabetes Care"},{"key":"4631_CR25","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/dme.13544","volume":"35","author":"TC Evans-Cheung","year":"2018","unstructured":"Evans-Cheung TC, Bodansky HJ, Parslow RC, Feltbower RG (2018) Mortality and acute complications in children and young adults diagnosed with type 1 diabetes in Yorkshire, UK: a cohort study. Diabet Med 35:112\u2013120","journal-title":"Diabet Med"},{"key":"4631_CR26","doi-asserted-by":"publisher","first-page":"4017","DOI":"10.1093\/ndt\/gfr185","volume":"26","author":"G Wolf","year":"2011","unstructured":"Wolf G, Busch M, Muller N, Muller UA (2011) Association between socioeconomic status and renal function in a population of German patients with diabetic nephropathy treated at a tertiary centre. Nephrol Dial Transplant 26:4017\u20134023","journal-title":"Nephrol Dial Transplant"},{"key":"4631_CR27","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.1001\/jama.294.14.1782","volume":"294","author":"P Finne","year":"2005","unstructured":"Finne P, Reunanen A, Stenman S, Groop PH, Gronhagen-Riska C (2005) Incidence of end-stage renal disease in patients with type 1 diabetes. JAMA 294:1782\u20131787","journal-title":"JAMA"},{"key":"4631_CR28","doi-asserted-by":"publisher","first-page":"426","DOI":"10.2337\/dc17-1118","volume":"41","author":"T Costacou","year":"2018","unstructured":"Costacou T, Orchard TJ (2018) Cumulative kidney complication risk by 50 years of type 1 diabetes: the effects of sex, age, and calendar year at onset. Diabetes Care 41:426\u2013433","journal-title":"Diabetes Care"},{"key":"4631_CR29","doi-asserted-by":"publisher","first-page":"1105","DOI":"10.1136\/bmj.38070.450891.FE","volume":"328","author":"P Hovind","year":"2004","unstructured":"Hovind P, Tarnow L, Rossing P, Jensen BR, Graae M, Torp I, Binder C, Parving HH (2004) Predictors for the development of microalbuminuria and macroalbuminuria in patients with type 1 diabetes: inception cohort study. BMJ 328:1105","journal-title":"BMJ"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-020-04631-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-020-04631-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-020-04631-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,5]],"date-time":"2021-08-05T23:51:35Z","timestamp":1628207495000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-020-04631-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,6]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["4631"],"URL":"https:\/\/doi.org\/10.1007\/s00467-020-04631-2","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"type":"print","value":"0931-041X"},{"type":"electronic","value":"1432-198X"}],"subject":[],"published":{"date-parts":[[2020,8,6]]},"assertion":[{"value":"25 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 May 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The institutional review board of the Israel Defense Forces approved the study and waived the requirement for informed consent on the basis of preserving participants\u2019 anonymity.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}