{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:49:01Z","timestamp":1790038141637,"version":"4.0.1"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T00:00:00Z","timestamp":1594944000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T00:00:00Z","timestamp":1594944000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Pediatr Nephrol"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1007\/s00467-020-04673-6","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T10:31:29Z","timestamp":1594981889000},"page":"103-109","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Fluid restriction versus volume expansion in children with diarrhea-associated HUS: a retrospective observational study"],"prefix":"10.1007","volume":"36","author":[{"given":"Pablo","family":"Bonany","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel D.","family":"Bilkis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Iglesias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"Braun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Tello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Ratto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Jannello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezequiel","family":"Monteverde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,17]]},"reference":[{"key":"4673_CR1","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/S0022-3476(64)80337-1","volume":"64","author":"C Gianantonio","year":"1964","unstructured":"Gianantonio C, Vitacco M, Ruty A, Mendilaharzu F, Mendilaharzu J (1964) The hemolytic-uremic syndrome. J Pediatr 64:479\u2013491","journal-title":"J Pediatr"},{"key":"4673_CR2","unstructured":"Balestracci A, Exeni A, Santiago A (2014) Tratamiento de la injuria renal aguda por s\u00edndrome ur\u00e9mico hemol\u00edtico mediado por Shiga\u2013toxina.- NEFROPED: Modulo S\u00edndrome ur\u00e9mico hemolitico"},{"key":"4673_CR3","doi-asserted-by":"publisher","first-page":"e673","DOI":"10.1542\/peds.2004-2236","volume":"115","author":"JA Ake","year":"2005","unstructured":"Ake JA, Jelacic S, Ciol MA, Watkins SL, Murray KF, Christie DL, Klein EJ, Tarr PI (2005) Relative nephroprotection during Escherichia coli O157:H7 infections: association with intravenous volume expansion. Pediatrics 115:e673\u2013e680","journal-title":"Pediatrics"},{"key":"4673_CR4","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/S0022-3476(68)80427-5","volume":"72","author":"C Gianantonio","year":"1968","unstructured":"Gianantonio C, Vitacco M, Mendilaharzu F, Gallo G (1968) The hemolytic-uremic syndrome. Renal status of 76 patients at long term follow up. J Pediatr 72:757\u2013765","journal-title":"J Pediatr"},{"key":"4673_CR5","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1007\/s00467-012-2158-0","volume":"27","author":"A Balestracci","year":"2012","unstructured":"Balestracci A, Martin S, Toledo I, Alvarado C, Wainsztein R (2012) Dehydration at admission increased the need for dialysis in hemolytic uremic syndrome children. Pediatr Nephrol 27:1407\u20131410","journal-title":"Pediatr Nephrol"},{"key":"4673_CR6","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1001\/archpediatrics.2011.152","volume":"165","author":"CA Hickey","year":"2011","unstructured":"Hickey CA, Beattie TJ, Cowieson J, Miyashita Y, Strife CF, Frem JC, Peterson JM, Butani L, Jones DP, Havens PL, Patel HP, Wong CS, Andreoli SP, Rothbaum RJ, Beck AM, Tarr PI (2011) Early volume expansion during diarrhea and relative nephroprotection during subsequent hemolytic uremic syndrome. Arch Pediatr Adolesc Med 165:884\u2013889","journal-title":"Arch Pediatr Adolesc Med"},{"key":"4673_CR7","doi-asserted-by":"publisher","first-page":"e20152153","DOI":"10.1542\/peds.2015-2153","volume":"137","author":"G Ardissino","year":"2016","unstructured":"Ardissino G, Tel F, Possenti I, Testa S, Consonni D, Paglialonga F, Salardi S, Borsa-Ghiringhelli N, Salice P, Tedeschi S, Castorina P, Colombo RM, Arghittu M, Daprai L, Monzani A, Tozzoli R, Brigotti M, Torresani E (2016) Early volume expansion and outcomes of hemolytic uremic syndrome. Pediatrics 137:e20152153","journal-title":"Pediatrics"},{"key":"4673_CR8","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1542\/peds.19.5.823","volume":"19","author":"MA Holliday","year":"1957","unstructured":"Holliday MA, Segar WE (1957) The maintenance need for water in parenteral fluid therapy. Pediatrics 19:823\u2013832","journal-title":"Pediatrics"},{"key":"4673_CR9","doi-asserted-by":"publisher","first-page":"e20183083","DOI":"10.1542\/peds.2018-3083","volume":"142","author":"LG Feld","year":"2018","unstructured":"Feld LG, Neuspiel DR, Foster BA, Leu MG, Garber MD, Austin K, Basu RK, Conway EE Jr, Fehr JJ, Hawkins C, Kaplan RL, Rowe EV, Waseem M, Moritz ML, Subcommittee On Fluid And Electrolyte Therapy (2018) Clinical practice guideline: maintenance intravenous fluids in children. Pediatrics 142:e20183083","journal-title":"Pediatrics"},{"issue":"Suppl 3","key":"4673_CR10","first-page":"27","volume":"66","author":"M Rivas","year":"2006","unstructured":"Rivas M, Miliwebsky E, Chinen I, Deza N, Leotta GA (2006) The epidemiology of hemolytic uremic syndrome in Argentina. Diagnosis of the etiologic agent, reservoirs and routes of transmission. Medicina (B Aires) 66(Suppl 3):27\u201332","journal-title":"Medicina (B Aires)"},{"key":"4673_CR11","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1128\/JCM.02262-14","volume":"53","author":"LJ Melli","year":"2015","unstructured":"Melli LJ, Ciocchini AE, Caillava AJ, Vozza N, Chinen I, Rivas M, Feldman MF, Ugalde JE, Comerci DJ (2015) Serogroup-specific bacterial engineered glycoproteins as novel antigenic targets for diagnosis of Shiga toxin-producing-escherichia coli-associated hemolytic-uremic syndrome. J Clin Microbiol 53:528\u2013538","journal-title":"J Clin Microbiol"},{"key":"4673_CR12","unstructured":"Cohen J (1988) Statistical power analysis for the behavioral sciences, 2nd edn. Lawrence Erlbaum Associates http:\/\/www.utstat.toronto.edu\/~brunner\/oldclass\/378f16\/readings\/CohenPower.pdf"},{"key":"4673_CR13","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1016\/j.arcped.2011.04.001","volume":"18","author":"A Bertholet-Thomas","year":"2011","unstructured":"Bertholet-Thomas A, Ranchin B, King LA, Bacchetta J, Belot A, Gillet Y, Collardeau-Frachon S, Cochat P (2011) Post-diarrheal haemolytic uremic syndrome: when shall we consider it? Which follow-up? Arch Pediatr 18:823\u2013830","journal-title":"Arch Pediatr"},{"key":"4673_CR14","first-page":"372","volume":"33","author":"J Ojeda","year":"2013","unstructured":"Ojeda J, Kohout I, Cuestas E (2013) La deshidrataci\u00f3n al ingreso es un factor de riesgo para la recuperaci\u00f3n incompleta de la funci\u00f3n renal en ni\u00f1os con s\u00edndrome ur\u00e9mico hemol\u00edtico. Nefrologia 33:372\u2013376","journal-title":"Nefrologia"},{"key":"4673_CR15","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1007\/s00431-018-3198-7","volume":"177","author":"G Ardissino","year":"2018","unstructured":"Ardissino G, Tel F, Testa S, Paglialonga F, Longhi S, Martelli L, Consolo S, Picicco D, Dodaro A, Daprai L, Colombo R, Arghittu M, Perrone M, Chidini G, Scalia Catenacci S, Cropanese I, Consonni D, ItalKid-HUS Network (2018) A simple prognostic index for Shigatoxin-related hemolytic uremic syndrome at onset: data from the ItalKid-HUS network. Eur J Pediatr 177:1667\u20131674","journal-title":"Eur J Pediatr"},{"key":"4673_CR16","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1007\/s00431-018-3240-9","volume":"177","author":"A Balestracci","year":"2018","unstructured":"Balestracci A, Meni Battaglia L, Toledo I, Martin SM, Alvarado C (2018) Comment to: \u201cA simple prognostic index for Shigatoxin-related hemolytic uremic syndrome at onset: data from the ItalKid-HUS network\u201d by Ardissino et al. Eur J Pediatr 177:1869\u20131870","journal-title":"Eur J Pediatr"},{"key":"4673_CR17","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1007\/s00431-016-2846-z","volume":"176","author":"W Keenswijk","year":"2017","unstructured":"Keenswijk W, Vanmassenhove J, Raes A, Dhont E, Vande Walle J (2017) Blood urea nitrogen to serum creatinine ratio is an accurate predictor of outcome in diarrhea-associated hemolytic uremic syndrome, a preliminary study. Eur J Pediatr 176:355\u2013360","journal-title":"Eur J Pediatr"},{"key":"4673_CR18","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1007\/s00431-017-2999-4","volume":"177","author":"A Balestracci","year":"2018","unstructured":"Balestracci A, Meni Battaglia L, Toledo I, Martin S, Alvarado C (2018) Blood urea nitrogen to serum creatinine ratio as a prognostic factor in diarrhea-associated hemolytic uremic syndrome: a validation study. Eur J Pediatr 177:63\u201368","journal-title":"Eur J Pediatr"},{"key":"4673_CR19","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s00467-014-2918-0","volume":"30","author":"G Ardissino","year":"2015","unstructured":"Ardissino G, Dacc\u00f2 V, Testa S, Civitillo CF, Tel F, Possenti I, Belingheri M, Castorina P, Bolsa-Ghiringhelli N, Tedeschi S, Paglialonga F, Salardi S, Consonni D, Zoia E, Salice P, Chidini G (2015) Hemoconcentration: a major risk factor for neurological involvement in hemolytic uremic syndrome. Pediatr Nephrol 30:345\u2013352","journal-title":"Pediatr Nephrol"},{"key":"4673_CR20","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1001\/jamapediatrics.2016.2952","volume":"171","author":"S Grisaru","year":"2017","unstructured":"Grisaru S, Xie J, Samuel S, Hartling L, Tarr PI, Schnadower D, Freedman SB, Alberta Provincial Pediatric Enteric Infection Team (2017) Associations between hydration status, intravenous fluid administration, and outcomes of patients infected with Shiga toxin-producing Escherichia coli: a systematic review and meta-analysis. JAMA Pediatr 171:68\u201376","journal-title":"JAMA Pediatr"},{"key":"4673_CR21","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1111\/j.1442-200X.2008.02605.x","volume":"50","author":"I Kamioka","year":"2008","unstructured":"Kamioka I, Yoshiya K, Satomura K, Kaito H, Fujita T, Iijima K, Nakanishi K, Yoshikawa N, Nozu K, Matsuo M (2008) Risk factors for developing severe clinical course in HUS patients: a national survey in Japan. Japanese Society for Pediatric Nephrology. Pediatr Int 50:441\u2013446","journal-title":"Pediatr Int"},{"key":"4673_CR22","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/j.1442-200X.2008.02672.x","volume":"51","author":"T Teramoto","year":"2009","unstructured":"Teramoto T, Fukao T, Hirayama K, Asano T, Aoki Y, Kondo N (2009) Escherichia coli O-157-induced hemolytic uremic syndrome: usefulness of SCWP score for the prediction of neurological complication. Pediatr Int 51:107\u2013109","journal-title":"Pediatr Int"},{"key":"4673_CR23","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1007\/s00467-018-3991-6","volume":"33","author":"LF Alconcher","year":"2018","unstructured":"Alconcher LF, Coccia PA, Suarez ADC, Monteverde ML, Perez Y, Guti\u00e9rrez MG, Carlopio PM, Missoni ML, Balestracci A, Principi I, Ram\u00edrez FB, Estrella P, Micelli S, Leroy DC, Quijada NE, Seminara C, Giordano MI, Hidalgo Sol\u00eds SB, Saurit M, Caminitti A, Arias A, Rivas M, Risso P, Liern M (2018) Hyponatremia: a new predictor of mortality in patients with Shiga toxin-producing Escherichia coli hemolytic uremic syndrome. Pediatr Nephrol 33:1791\u20131798","journal-title":"Pediatr Nephrol"}],"container-title":["Pediatric Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-020-04673-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00467-020-04673-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00467-020-04673-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,3]],"date-time":"2022-11-03T00:17:16Z","timestamp":1667434636000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00467-020-04673-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,17]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["4673"],"URL":"https:\/\/doi.org\/10.1007\/s00467-020-04673-6","relation":{},"ISSN":["0931-041X","1432-198X"],"issn-type":[{"value":"0931-041X","type":"print"},{"value":"1432-198X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,17]]},"assertion":[{"value":"9 December 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 June 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 June 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 July 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"The research protocol for this study was approved by the Research Ethics Committee from <i>Establecimiento Asistencial Dr. Lucio Molas<\/i> from <i>Santa Rosa City, La Pampa Province, Argentina. This study was carried out under the ethical principles of the declaration of Helsinki<\/i>","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}